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Citing Papers
Insulin Resistance and a Diabetes Mellitus-Like Syndrome in Mice Lacking the Protein Kinase Akt2 (PKBβ)
2001 StandoutScience
Obesity and Metabolic Syndrome in Circadian Clock Mutant Mice
2005 StandoutScience
Fat Metabolism Links Germline Stem Cells and Longevity in C. elegans
2008 StandoutScienceNobel
TOR Signaling in Growth and Metabolism
2006 Standout
Two New Substrates in Insulin Signaling, IRS5/DOK4 and IRS6/DOK5
2003
A stomatin-like protein necessary for mechanosensation in C. elegans
1995 StandoutNatureNobel
Insights into insulin resistance and type 2 diabetes from knockout mouse models
2000
Targeted Gene Mutations Define the Roles of Insulin and IGF-I Receptors in Mouse Embryonic Development
1999
Molecular Cloning and Functional Characterization of Murine Sphingosine Kinase
1998
Proteins regulating Ras and its relatives
1993 StandoutNature
SH2 and SH3 domains: From structure to function
1992
mTOR Signaling in Growth Control and Disease
2012 Standout
Inflammation and metabolic disorders
2006 StandoutNature
Syndromes Associated with Insulin Resistance and Acanthosis Nigricans
1998
The Phosphotyrosine Phosphatase PTP1D, but not PTP1C, Is an Essential Mediator of Fibroblast Proliferation Induced by Tyrosine Kinase and G Protein-coupled Receptors
1995
The gene involved in X-linked agammaglobulinaemia is a member of the src family of protein-tyrosine kinases
1993 StandoutNature
Central nervous system control of food intake and body weight
2006 StandoutNature
Cell Signaling by Receptor Tyrosine Kinases
2010 Standout
Insulin Enhances Macrophage Scavenger Receptor-mediated Endocytic Uptake of Advanced Glycation End Products
1998
A phosphatidylinositol-3-OH kinase family member regulating longevity and diapause in Caenorhabditis elegans
1996 StandoutNatureNobel
Recognition of microorganisms and activation of the immune response
2007 StandoutNature
Regional differences of insulin action in adipose tissue: insights from in vivo and in vitro studies
2005
Insulin Stimulates Hypoxia-inducible Factor 1 through a Phosphatidylinositol 3-Kinase/Target of Rapamycin-dependent Signaling Pathway
2002 StandoutNobel
Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1
2004 StandoutNature
SH2 and SH3 domains
1993
Adipocytes as regulators of energy balance and glucose homeostasis
2006 StandoutNature
Distinct Pathways of Gi- and Gq-mediated Mitogen-activated Protein Kinase Activation
1995 StandoutNobel
IRS-2 pathways integrate female reproduction and energy homeostasis
2000 Nature
The lymphocyte chemoattractant SDF-1 is a ligand for LESTR/fusin and blocks HIV-1 entry
1996 StandoutNature
Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction
1995 StandoutNature
Insights into G Protein Structure, Function, and Regulation
2003
Stem cells find their niche
2001 StandoutNature
PRDM16 controls a brown fat/skeletal muscle switch
2008 StandoutNature
mTOR Signaling in Growth, Metabolism, and Disease
2017 Standout
Phosphorylation and Desensitization of the Human β1-Adrenergic Receptor
1995 StandoutNobel
The COOH-terminal Tyrosine Phosphorylation Sites on IRS-1 Bind SHP-2 and Negatively Regulate Insulin Signaling
1998
Regulation of adipocyte differentiation and insulin action with rapamycin
2004
Phosphorylation of the Type 1A Angiotensin II Receptor by G Protein-coupled Receptor Kinases and Protein Kinase C
1996 StandoutNobel
Serum retinol binding protein 4 contributes to insulin resistance in obesity and type 2 diabetes
2005 StandoutNature
Differential regulation of insulin receptor substrates-1 and -2 (IRS-1 and IRS-2) and phosphatidylinositol 3-kinase isoforms in liver and muscle of the obese diabetic (ob/ob) mouse.
1997
Protein modules and signalling networks
1995 StandoutNature
Phosphatidylinositol 3-Kinase, but Not p70/p85 Ribosomal S6 Protein Kinase, Is Required for the Regulation of Phosphoenolpyruvate Carboxykinase (PEPCK) Gene Expression by Insulin
1995
Insulin resistance and growth retardation in mice lacking insulin receptor substrate-1
1994 Nature
Insulin signalling and the regulation of glucose and lipid metabolism
2001 StandoutNature
Increased Activation of the Mammalian Target of Rapamycin Pathway in Liver and Skeletal Muscle of Obese Rats: Possible Involvement in Obesity-Linked Insulin Resistance
2004
Surfing the insulin signaling web
2001
Inappropriate Activation of the TSC/Rheb/mTOR/S6K Cassette Induces IRS1/2 Depletion, Insulin Resistance, and Cell Survival Deficiencies
2004
Ras-dependent Mitogen-activated Protein Kinase Activation by G Protein-coupled Receptors
1997 StandoutNobel
Insulin Stimulates Adipogenesis through the Akt-TSC2-mTORC1 Pathway
2009
Reactive oxygen species have a causal role in multiple forms of insulin resistance
2006 StandoutNature
Biochemistry and molecular cell biology of diabetic complications
2001 StandoutNature
Phosphoinositides in cell regulation and membrane dynamics
2006 StandoutNature
Stem Cells and Their Progeny Respond to Nutritional Changes during Drosophila Oogenesis
2001
Tissue-specific insulin resistance in mice with mutations in the insulin receptor, IRS-1, and IRS-2
2000
Ras, PI(3)K and mTOR signalling controls tumour cell growth
2006 StandoutNature
Protein–protein interaction in insulin signaling and the molecular mechanisms of insulin resistance
1999
Role of c-Src Tyrosine Kinase in G Protein-coupled Receptorand Gβγ Subunit-mediated Activation of Mitogen-activated Protein Kinases
1996 StandoutNobel
Gβγ Subunits Mediate Src-dependent Phosphorylation of the Epidermal Growth Factor Receptor
1997 StandoutNobel
Phosphatidylinositol 3-Kinase Is an Early Intermediate in the Gβγ-mediated Mitogen-activated Protein Kinase Signaling Pathway
1996 StandoutNobel
Phorbol ester-induced stimulation and phosphorylation of adenylyl cyclase 2.
1994
Elevated basal PI 3-kinase activity and reduced insulin signaling in sucrose-induced hepatic insulin resistance
2002
Homologous desensitization of HEL cell thrombin receptors. Distinguishable roles for proteolysis and phosphorylation.
1992
Identification of Major Tyrosine Phosphorylation Sites in the Human Insulin Receptor Substrate Gab-1 by Insulin Receptor Kinase in Vitro
2000
Mice lacking insulin receptor substrate 4 exhibit mild defects in growth, reproduction, and glucose homeostasis
2000
Receptor-tyrosine-kinase- and Gβγ-mediated MAP kinase activation by a common signalling pathway
1995 StandoutNatureNobel
The Structure and Function of P55PIK Reveal a New Regulatory Subunit for Phosphatidylinositol 3-Kinase
1995
Pleiotropic insulin signals are engaged by multisite phosphorylation of IRS-1.
1993
β-Arrestin-Dependent Formation of β 2 Adrenergic Receptor-Src Protein Kinase Complexes
1999 StandoutScienceNobel
Differential Roles of Insulin Receptor Substrates in Brown Adipocyte Differentiation
2004
A Point Mutation of the α 2 -Adrenoceptor that Blocks Coupling to Potassium but not Calcium Currents
1992 Science
Dynamics of Insulin Signaling in 3T3-L1 Adipocytes
1998
Signaling Through Scaffold, Anchoring, and Adaptor Proteins
1997 StandoutScience
Direct evidence that Gi-coupled receptor stimulation of mitogen-activated protein kinase is mediated by G beta gamma activation of p21ras.
1994 StandoutNobel
Heterozygous α 2A -adrenergic receptor mice unveil unique therapeutic benefits of partial agonists
2002 StandoutNobel
Activation of the SH2-containing protein tyrosine phosphatase, SH-PTP2, by phosphotyrosine-containing peptides derived from insulin receptor substrate-1.
1994
Impaired insulin secretion and glucose intolerance in synaptotagmin-7 null mutant mice
2008 StandoutNobel
β-arrestin- but not G protein-mediated signaling by the “decoy” receptor CXCR7
2009 StandoutNobel
Functional domains of the insulin receptor responsible for chemotactic signaling.
1994
G protein beta gamma subunits stimulate phosphorylation of Shc adapter protein.
1995 StandoutNobel
Phosphoinositide 3-kinase: the key switch mechanism in insulin signalling
1998
Binding of G protein beta gamma-subunits to pleckstrin homology domains.
1994 StandoutNobel
Integrins and Signal Transduction Pathways: the Road Taken
1995 StandoutScience
The IRS-signalling system: A network of docking proteins that mediate insulin action
1998
A Dominant-Negative Mutant of mSOS1 Inhibits Insulin-Induced Ras Activation and Reveals Ras-Dependent and -Independent Insulin Signaling Pathways
1995
Gi-mediated activation of the p21ras-mitogen-activated protein kinase pathway by alpha 2-adrenergic receptors expressed in fibroblasts.
1993
PD-L1 and PD-L2 are differentially regulated by Th1 and Th2 cells
2003 StandoutNobel
Serine/threonine phosphorylation of insulin receptor substrate 1 modulates insulin receptor signaling.
1994
Defects of the insulin receptor substrate (IRS) system in human metabolic disorders
2001
Critical nodes in signalling pathways: insights into insulin action
2006 Standout
Cellular Function of Phosphoinositide 3-Kinases: Implications for Development, Immunity, Homeostasis, and Cancer
2001
Receptor class desensitization of leukocyte chemoattractant receptors.
1991
Enhanced Basal Activation of Mitogen-Activated Protein Kinases in Adipocytes From Type 2 Diabetes
2003
Antagonism of Catecholamine Receptor Signaling by Expression of Cytoplasmic Domains of the Receptors
1993 StandoutScienceNobel
THE IL-4 RECEPTOR: Signaling Mechanisms and Biologic Functions
1999
The IRS-signalling system: A network of docking proteins that mediate insulin action
1998
Stimulation of Protein Synthesis, Eukaryotic Translation Initiation Factor 4E Phosphorylation, and PHAS-I Phosphorylation by Insulin Requires Insulin Receptor Substrate 1 and Phosphatidylinositol 3-Kinase
1996
Pathophysiology and Pharmacological Treatment of Insulin Resistance*
2000
A Region of Adenylyl Cyclase 2 Critical for Regulation by G Protein βγ Subunits
1995 StandoutScienceNobel
Insulin Receptor Substrate 3 (IRS-3) and IRS-4 Impair IRS-1- and IRS-2-Mediated Signaling
2001
Binding of the Ras Activator Son of Sevenless to Insulin Receptor Substrate-1 Signaling Complexes
1993 Science
IRS-1-Mediated Inhibition of Insulin Receptor Tyrosine Kinase Activity in TNF-α- and Obesity-Induced Insulin Resistance
1996 StandoutScience
1-Phosphatidylinositol 3-kinase activity is required for insulin-stimulated glucose transport but not for RAS activation in CHO cells.
1994
Works of Brian E. Lavan being referenced
Dephosphorylation of insulin receptor substrate 1 by the tyrosine phosphatase PTP2C.
1994 Nobel
Rapamycin partially prevents insulin resistance induced by chronic insulin treatment
2002
The 60-kDa Phosphotyrosine Protein in Insulin-treated Adipocytes Is a New Member of the Insulin Receptor Substrate Family
1997
Insulin and IGF‐I signaling through the insulin receptor substrate 1
1993
Characterization of Insulin Receptor Substrate 4 in Human Embryonic Kidney 293 Cells
1998
Association of Insulin Receptor Substrate 3 with SH2 Domain-Containing Proteins in Rat Adipocytes
1998
A Novel 160-kDa Phosphotyrosine Protein in Insulin-treated Embryonic Kidney Cells Is a New Member of the Insulin Receptor Substrate Family
1997
The association of insulin-elicited phosphotyrosine proteins with src homology 2 domains.
1992
Agonist-dependent, cholera toxin-catalyzed ADP-ribosylation of pertussis toxin-sensitive G-proteins following transfection of the human alpha 2-C10 adrenergic receptor into rat 1 fibroblasts. Evidence for the direct interaction of a single receptor with two pertussis toxin-sensitive G-proteins, Gi2 and Gi3.
1991
Hormonal regulation of Gi2 α-subunit phosphorylation in intact hepatocytes
1990
Cloning, Tissue Expression, and Chromosomal Location of the Mouse Insulin Receptor Substrate 4 Gene*
1999
Okadaic acid identifies a phosphorylation/dephosphorylation cycle controlling the inhibitory guanine-nucleotide-binding regulatory protein Gi2
1991
The insulin-elicited 60-kDa phosphotyrosine protein in rat adipocytes is associated with phosphatidylinositol 3-kinase.
1993