Citation Impact
Citing Papers
SuFEx-enabled, agnostic discovery of covalent inhibitors of human neutrophil elastase
2019 StandoutNobel
Topological control of cytokine receptor signaling induces differential effects in hematopoiesis
2019 StandoutScienceNobel
Nuclear Lamin-A Scales with Tissue Stiffness and Enhances Matrix-Directed Differentiation
2013 StandoutScience
Sulfur [ 18 F]Fluoride Exchange Click Chemistry Enabled Ultrafast Late-Stage Radiosynthesis
2021 StandoutNobel
Diversity oriented clicking delivers β-substituted alkenyl sulfonyl fluorides as covalent human neutrophil elastase inhibitors
2022 StandoutNobel
Structural modifications of N-arylamide oxadiazoles: Identification of N-arylpiperidine oxadiazoles as potent and selective agonists of CB2
2008
The Concept of Synthetic Lethality in the Context of Anticancer Therapy
2005 StandoutNobel
Reaching for high-hanging fruit in drug discovery at protein–protein interfaces
2007 StandoutNature
Dynamic Covalent Chemistry
2002 StandoutNobel
Cell cycle proteins as promising targets in cancer therapy
2017 Standout
Drug discovery approaches targeting the PI3K/Akt pathway in cancer
2008
Inhibitors of Protein Tyrosine Phosphatases: Next‐Generation Drugs?
2005
Carbon–heteroatom bond formation catalysed by organometallic complexes
2008 StandoutNature
Structural Analysis of E. coli hsp90 Reveals Dramatic Nucleotide-Dependent Conformational Rearrangements
2006
Automated ligand fitting by core-fragment fitting and extension into density
2006
Treatment of Obesity with Celastrol
2015 Standout
New approaches to molecular cancer therapeutics
2006
Heat shock protein 90: The cancer chaperone
2007
HSP90 and the chaperoning of cancer
2005 Standout
Crystal structure of an Hsp90–nucleotide–p23/Sba1 closed chaperone complex
2006 Nature
In Vitro Characterization of a Purified NS2/3 Protease Variant of Hepatitis C Virus
2001
Anchor extension: a structure-guided approach to design cyclic peptides targeting enzyme active sites
2021 StandoutNobel
Molecular chaperones in protein folding and proteostasis
2011 StandoutNature
Targeting the Hsp90 Chaperone: Synthesis of Novel Resorcylic Acid Macrolactone Inhibitors of Hsp90
2010
Oncogenic Mutations Counteract Intrinsic Disorder in the EGFR Kinase and Promote Receptor Dimerization
2012 StandoutNobel
Synthesis and biological activity of macrocyclic inhibitors of hepatitis C virus (HCV) NS3 protease
2005
Recent Developments in Fragment-Based Drug Discovery
2008
Amplification of Dynamic Chiral Crown Ether Complexes During Cyclic Acetal Formation
2003 StandoutNobel
Transforming fragments into candidates: small becomes big in medicinal chemistry
2009
Interpretation of ensembles created by multiple iterative rebuilding of macromolecular models
2007
Targeting multiple signal transduction pathways through inhibition of Hsp90
2004
Features and development of Coot
2010 Standout
PHENIX: a comprehensive Python-based system for macromolecular structure solution
2010 Standout
Fragment-based lead discovery: leads by design
2005
Efficient Synthesis of a Novel Resorcyclide as Anticancer Agent Based on Hsp90 Inhibition
2008
Principles of Cancer Therapy: Oncogene and Non-oncogene Addiction
2009 Standout
Redox-Sensitive Materials for Drug Delivery: Targeting the Correct Intracellular Environment, Tuning Release Rates, and Appropriate Predictive Systems
2013
Binding Site Detection and Druggability Index from First Principles
2009
Click Chemistry for Drug Development and Diverse Chemical–Biology Applications
2013 Standout
Copper-Mediated Coupling Reactions and Their Applications in Natural Products and Designed Biomolecules Synthesis
2008 Standout
3d Transition Metals for C–H Activation
2018 Standout
Fluorine in medicinal chemistry
2007 Standout
SuFEx Click Chemistry Enabled Late-Stage Drug Functionalization
2018 StandoutNobel
Heat-shock protein 90 inhibitors as novel cancer chemotherapeutics – an update
2005
Discovery and Structure−Activity Relationship of P1−P3 Ketoamide Derived Macrocyclic Inhibitors of Hepatitis C Virus NS3 Protease
2008
Bond Formations between Two Nucleophiles: Transition Metal Catalyzed Oxidative Cross-Coupling Reactions
2011 Standout
Fluorine in Pharmaceutical Industry: Fluorine-Containing Drugs Introduced to the Market in the Last Decade (2001–2011)
2013 Standout
Cu and Cu-Based Nanoparticles: Synthesis and Applications in Catalysis
2016 Standout
JAK2 activation by growth hormone and other cytokines
2015
Chemie und Biologie der Saragossasäuren/Squalestatine
1996
Inhibitoren der Proteintyrosinphosphatasen: Kandidaten für zukünftige Wirkstoffe?
2005
Multidimensional SuFEx Click Chemistry: Sequential Sulfur(VI) Fluoride Exchange Connections of Diverse Modules Launched From An SOF4 Hub
2017 StandoutNobel
Development of synthetic routes to macrocyclic compounds based on the HSP90 inhibitor radicicol
2006
Docking of Macrocycles: Comparing Rigid and Flexible Docking in Glide
2017
SuFEx Chemistry of Thionyl Tetrafluoride (SOF4) with Organolithium Nucleophiles: Synthesis of Sulfonimidoyl Fluorides, Sulfoximines, Sulfonimidamides, and Sulfonimidates
2018 StandoutNobel
Design and NMR-Based Screening of LEF, a Library of Chemical Fragments with Different Local Environment of Fluorine
2009
Degradable Controlled-Release Polymers and Polymeric Nanoparticles: Mechanisms of Controlling Drug Release
2016 Standout
The Sonogashira Reaction: A Booming Methodology in Synthetic Organic Chemistry
2007 Standout
Adaptive and Maladaptive Cardiorespiratory Responses to Continuous and Intermittent Hypoxia Mediated by Hypoxia-Inducible Factors 1 and 2
2012 StandoutNobel
Iterative in Situ Click Chemistry Assembles a Branched Capture Agent and Allosteric Inhibitor for Akt1
2011 StandoutNobel
Acylvinyl and Vinylogous Synthons
2000
Biocompatible SuFEx Click Chemistry: Thionyl Tetrafluoride (SOF4)‐Derived Connective Hubs for Bioconjugation to DNA and Proteins
2019 StandoutNobel
Selected Patented Cross-Coupling Reaction Technologies
2006 Standout
Anti-Markovnikov hydroarylation of styrenes catalyzed by an in situ generated ruthenium complex
2008
Copper in cross-coupling reactions
2004 Standout
Chemistry and Biology of the Zaragozic Acids (Squalestatins)
1996
Ruthenium(II)-Catalyzed C–H Bond Activation and Functionalization
2012 Standout
Identification of simple arylfluorosulfates as potent agents against resistant bacteria
2021 StandoutNobel
A Heck–Matsuda Process for the Synthesis of β‐Arylethenesulfonyl Fluorides: Selectively Addressable Bis‐electrophiles for SuFEx Click Chemistry
2016 StandoutNobel
Fluorosulfuryl Isocyanate Enabled SuFEx Ligation of Alcohols and Amines
2021 StandoutNobel
Applications of Palladium-Catalyzed C–N Cross-Coupling Reactions
2016 Standout
Palladium‐Catalyzed Fluorosulfonylvinylation of Organic Iodides
2017 StandoutNobel
From 2000 to Mid-2010: A Fruitful Decade for the Synthesis of Pyrazoles
2011 Standout
Arylfluorosulfates Inactivate Intracellular Lipid Binding Protein(s) through Chemoselective SuFEx Reaction with a Binding Site Tyr Residue
2016 StandoutNobel
Discovery of Benzisoxazoles as Potent Inhibitors of Chaperone Heat Shock Protein 90
2008
Chemistry and Biology Of Multicomponent Reactions
2012 Standout
Palladium-Catalyzed Ligand-Directed C−H Functionalization Reactions
2010 Standout
A New Portal to SuFEx Click Chemistry: A Stable Fluorosulfuryl Imidazolium Salt Emerging as an “F−SO2+” Donor of Unprecedented Reactivity, Selectivity, and Scope
2017 StandoutNobel
“Inverse Drug Discovery” Strategy To Identify Proteins That Are Targeted by Latent Electrophiles As Exemplified by Aryl Fluorosulfates
2017 StandoutNobel
Synthesis of Zaragozic Acid A/Squalestatin S1
1995
Structure of the catalytic domain of the hepatitis C virus NS2-3 protease
2006 StandoutNatureNobel
Works of Brian Dymock being referenced
Identification of a novel class of orally active pyrimido[5,4-3][1,2,4]triazine-5,7-diamine-based hypoglycemic agents with protein tyrosine phosphatase inhibitory activity
2003
4-Amino derivatives of the Hsp90 inhibitor CCT018159
2006
TG02, a novel oral multi-kinase inhibitor of CDKs, JAK2 and FLT3 with potent anti-leukemic properties
2011
Structure-based design of nitrogen-linked macrocyclic kinase inhibitors leading to the clinical candidate SB1317/TG02, a potent inhibitor of cyclin dependant kinases (CDKs), Janus kinase 2 (JAK2), and Fms-like tyrosine kinase-3 (FLT3)
2012
Structure-Activity Relationships in Purine-Based Inhibitor Binding to HSP90 Isoforms
2004
The Squalestatins: Synthesis and Biological Activity of Some C3-Modified Analogs; Replacement of a Carboxylic Acid or Methyl Ester with an Isoelectronic Heterocyclic Functionality
1995
The Squalestatins: Novel Inhibitors of Squalene Synthase. Enzyme Inhibitory Activities and in vivo Evaluation of C1-Modified Analogs
1994
Adenine derived inhibitors of the molecular chaperone HSP90—SAR explained through multiple X-ray structures
2003
A fluorescence polarization assay for inhibitors of Hsp90
2006
Hydrogen Sulfide Promotes Adipogenesis in 3T3L1 Cells
2015
Arylsulfonamide CB2 receptor agonists: SAR and optimization of CB2 selectivity
2008
Emerging therapies for hepatitis C virus infection
2001
Novel Approaches to the Treatment of Hepatitis C Virus Infection
2000
The Squalestatins: Decarboxy and 4-Deoxy Analogues as Potent Squalene Synthase Inhibitors
1996
Novel, Potent Small-Molecule Inhibitors of the Molecular Chaperone Hsp90 Discovered through Structure-Based Design
2005
Inhibitors of HSP90 and other chaperones for the treatment of cancer
2004
Selective JAK Inhibitors
2014
A Synthesis of the Hypocholesterolemic Agent 1233A Via Asymmetric [2 + 2] Cycloaddition
1998
Preclinical pharmacokinetics and metabolism of a novel diaryl pyrazole resorcinol series of heat shock protein 90 inhibitors
2006
Design and Characterization of Libraries of Molecular Fragments for Use in NMR Screening against Protein Targets
2004