Citation Impact
Citing Papers
Control of the DNA Damage Checkpoint by Chk1 and Rad53 Protein Kinases Through Distinct Mechanisms
1999 Science
Loading of the human 9-1-1 checkpoint complex onto DNA by the checkpoint clamp loader hRad17-replication factor C complex in vitro
2003 StandoutNobel
Uracil DNA Glycosylase Activity Is Dispensable for Immunoglobulin Class Switch
2004 StandoutScienceNobel
Fork Reversal and ssDNA Accumulation at Stalled Replication Forks Owing to Checkpoint Defects
2002 Science
The budding yeast Rad9 checkpoint protein is subjected to Mec1/Tel1-dependent hyperphosphorylation and interacts with Rad53 after DNA damage
1998
Cassava brown streak disease: historical timeline, current knowledge and future prospects
2017
CRISPR-Cas12a target binding unleashes indiscriminate single-stranded DNase activity
2018 StandoutScienceNobel
GEPIA: a web server for cancer and normal gene expression profiling and interactive analyses
2017 Standout
The many substrates and functions of ATM
2000
The DNA-damage response in human biology and disease
2009 StandoutNature
Glioma stem cells promote radioresistance by preferential activation of the DNA damage response
2006 StandoutNature
A Suppressor of Two Essential Checkpoint Genes Identifies a Novel Protein that Negatively Affects dNTP Pools
1998
Ataxia telangiectasia mutant protein activates c-Abl tyrosine kinase in response to ionizing radiation
1997 NatureNobel
Genomic Libraries and a Host Strain Designed for Highly Efficient Two-Hybrid Selection in Yeast
1996 Standout
Arrest, Adaptation, and Recovery following a Chromosome Double-strand Break in Saccharomyces cerevisiae
2000
Control of cell cycle arrest by the Mec1sc/Rad3sp DNA structure checkpoint pathway
1997
The DNA Replication and Damage Checkpoint Pathways Induce Transcription by Inhibition of the Crt1 Repressor
1998
MEC1-Dependent Phosphorylation of Rad9p in Response to DNA Damage
1998
New CRISPR–Cas systems from uncultivated microbes
2016 StandoutNatureNobel
Lcd1p Recruits Mec1p to DNA Lesions In Vitro and In Vivo
2002
Mrc1 channels the DNA replication arrest signal to checkpoint kinase Cds1
2001
A Rad3–Rad26 complex responds to DNA damage independently of other checkpoint proteins
1999
ATM-related Tel1 associates with double-strand breaks through an Xrs2-dependent mechanism
2003
CRISPR-Cas9 Circular Permutants as Programmable Scaffolds for Genome Modification
2019 StandoutNobel
Telomere states and cell fates
2000 StandoutNatureNobel
Mrc1 transduces signals of DNA replication stress to activate Rad53
2001
When Checkpoints Fail
1997 StandoutNobel
Functional interactions between BRCA1 and the checkpoint kinase ATR during genotoxic stress
2000
ATR: an essential regulator of genome integrity
2008
A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage
2000 Standout
Altering telomere structure allows telomerase to act in yeast lacking ATM kinases
2001 StandoutNobel
Gene Ontology: tool for the unification of biology
2000 Standout
Involvement of Brca2 in DNA Repair
1998 StandoutNobel
G2 / M checkpoint genes of Saccharomyces cerevisiae : further evidence for roles in DNA replication and / or repair
1997
Overexpression of a kinase-inactive ATR protein causes sensitivity to DNA-damaging agents and defects in cell cycle checkpoints
1998
hCds1-mediated phosphorylation of BRCA1 regulates the DNA damage response
2000 Nature
The set1Δ mutation unveils a novel signaling pathway relayed by the Rad53-dependent hyperphosphorylation of replication protein A that leads to transcriptional activation of repair genes
2001
LCD1: an essential gene involved in checkpoint control and regulation of the MEC1 signalling pathway in Saccharomyces cerevisiae
2000
Short Telomeres, even in the Presence of Telomerase, Limit Tissue Renewal Capacity
2005 StandoutNobel
Dynamic Interaction of DNA Damage Checkpoint Protein Rad53 with Chromatin Assembly Factor Asf1
2001 StandoutNobel
Tel2 mediates activation and localization of ATM/Tel1 kinase to a double-strand break
2008 StandoutNobel
A role for Saccharomyces cerevisiae histone H2A in DNA repair
2000 Nature
Requirement for Atr in phosphorylation of Chk1 and cell cycle regulation in response to DNA replication blocks and UV-damaged DNA in Xenopus egg extracts
2000
Amino acid changes in Xrs2p, Dun1p, and Rfa2p that remove the preferred targets of the ATM family of protein kinases do not affect DNA repair or telomere length in Saccharomyces cerevisiae
2003
Foundations in Cancer Research p53 and ATM: Cell Cycle, Cell Death, and Cancer
1997
The tyrosine kinase c-Abl regulates p73 in apoptotic response to cisplatin-induced DNA damage
1999 StandoutNatureNobel
Choreography of the DNA Damage Response
2004
Cdk1-Dependent Phosphorylation of Cdc13 Coordinates Telomere Elongation during Cell-Cycle Progression
2009 StandoutNobel
Mitotic DNA damage and replication checkpoints in yeast
1998
Sensing and responding to DNA damage
2000
The FHA Domain Is a Modular Phosphopeptide Recognition Motif
1999
Checking on the fork: the DNA-replication stress-response pathway
2002
The ATM-related Tel1 protein of Saccharomyces cerevisiae controls a checkpoint response following phleomycin treatment
2003
Hus1p, a conserved fission yeast checkpoint protein, interacts with Rad1p and is phosphorylated in response to DNA damage
1998
Switching and Signaling at the Telomere
2001 StandoutNobel
Two checkpoint complexes are independently recruited to sites of DNA damage in vivo
2001
Dynamic Changes of BRCA1 Subnuclear Location and Phosphorylation State Are Initiated by DNA Damage
1997
The FHA Domain, a Phosphoamino Acid Binding Domain Involved in the DNA Damage Response Pathway
2000
The DNA damage response: putting checkpoints in perspective
2000 StandoutNature
Receptor-mediated selective autophagy degrades the endoplasmic reticulum and the nucleus
2015 StandoutNatureNobel
The yeast Xrs2 complex functions in S phase checkpoint regulation
2001
CDC5 and CKII Control Adaptation to the Yeast DNA Damage Checkpoint
1997 StandoutNobel
Enzymatic photoreactivation: 50 years and counting
2000
The absence of ribonuclease H1 or H2 alters the sensitivity of Saccharomyces cerevisiae to hydroxyurea, caffeine and ethyl methanesulphonate: implications for roles of RNases H in DNA replication and repair
2000
Mammalian Chk2 is a downstream effector of the ATM-dependent DNA damage checkpoint pathway
1999
MEP-1 and a Homolog of the NURD Complex Component Mi-2 Act Together to Maintain Germline-Soma Distinctions in C. elegans
2002 StandoutNobel
A human homologue of the checkpoint kinase Cds1 directly inhibits Cdc25 phosphatase
1999
AID is required to initiate Nbs1/γ-H2AX focus formation and mutations at sites of class switching
2001 StandoutNatureNobel
A Signaling Pathway to Translational Control
1996
A Transient, Neuron-Wide Form of CREB-Mediated Long-Term Facilitation Can Be Stabilized at Specific Synapses by Local Protein Synthesis
1999 StandoutNobel
Trex1 Exonuclease Degrades ssDNA to Prevent Chronic Checkpoint Activation and Autoimmune Disease
2007 StandoutNobel
A trithorax-group complex purified from Saccharomyces cerevisiae is required for methylation of histone H3
2001 StandoutNobel
DNA Repair Protein Rad55 Is a Terminal Substrate of the DNA Damage Checkpoints
2000
The ATM homologue MEC1 is required for phosphorylation of replication protein A in yeast
1996
Haploinsufficiency of mTR results in defects in telomere elongation
2002 StandoutNobel
β-Arrestin inhibits NF-κB activity by means of its interaction with the NF-κB inhibitor IκBα
2004 StandoutNobel
Inactivation of mouse Hus1 results in genomic instability and impaired responses to genotoxic stress
2000
Roles of the Two Drosophila CRYPTOCHROME Structural Domains in Circadian Photoreception
2004 StandoutScienceNobel
Telomerase core components protect Candida telomeres from aberrant overhang accumulation
2007 StandoutNobel
The Xenopus Chk1 Protein Kinase Mediates a Caffeine-sensitive Pathway of Checkpoint Control in Cell-free Extracts
1998
Purification and characterization of human DNA damage checkpoint Rad complexes
2001 StandoutNobel
Chk1 is an essential kinase that is regulated by Atr and required for the G2/M DNA damage checkpoint
2000
Reconstitution of a human ATR-mediated checkpoint response to damaged DNA
2007 StandoutNobel
Reconstitution of RPA-covered single-stranded DNA-activated ATR-Chk1 signaling
2010 StandoutNobel
Interactions of TLC1 (Which Encodes the RNA Subunit of Telomerase), TEL1, and MEC1 in Regulating Telomere Length in the Yeast Saccharomyces cerevisiae
1999
Ataxia telangiectasia mutated (Atm) is not required for telomerase-mediated elongation of short telomeres
2006 StandoutNobel
Chk2/hCds1 functions as a DNA damage checkpoint in G1by stabilizing p53
2000
The genome-wide expression response to telomerase deletion in Saccharomyces cerevisiae
2002 StandoutNobel
Small Genomes and Sparse Metabolisms of Sediment-Associated Bacteria from Four Candidate Phyla
2013
Functional and Physical Interaction between Rad24 and Rfc5 in the Yeast Checkpoint Pathways
1998
Rfc4 Interacts with Rpa1 and Is Required for Both DNA Replication and DNA Damage Checkpoints in Saccharomyces cerevisiae
2001
MCM Proteins in DNA Replication
1999
Rfc5, a Replication Factor C Component, Is Required for Regulation of Rad53 Protein Kinase in the Yeast Checkpoint Pathway
1997
β-Arrestin1 modulates lymphoid enhancer factor transcriptional activity through interaction with phosphorylated dishevelled proteins
2001 StandoutNobel
Tof1p Regulates DNA Damage Responses During S Phase in Saccharomyces cerevisiae
2001
The Role of Stn1p inSaccharomyces cerevisiaeTelomere Capping Can Be Separated From Its Interaction With Cdc13p
2007
The checkpoint protein Ddc2, functionally related to S. pombe Rad26, interacts with Mec1 and is regulated by Mec1-dependent phosphorylation in budding yeast
2000
Cancer Genome Landscapes
2013 StandoutScience
Surviving the Breakup: The DNA Damage Checkpoint
2006
Short Telomeres Induce a DNA Damage Response inSaccharomyces cerevisiae
2003 StandoutNobel
Cdc13 Telomere Capping Decreases Mec1 Association but Does Not Affect Tel1 Association with DNA Ends
2007
Increased Replicative Fitness Can Lead to Decreased Drug Sensitivity of Hepatitis C Virus
2014 StandoutNobel
Pie1, a Protein Interacting with Mec1, Controls Cell Growth and Checkpoint Responses in Saccharomyces cerevisiae
2001
Role of a Complex Containing Rad17, Mec3, and Ddc1 in the Yeast DNA Damage Checkpoint Pathway
1999
Phosphorylation of Ser-20 mediates stabilization of human p53 in response to DNA damage
1999
Genomic Expression Responses to DNA-damaging Agents and the Regulatory Role of the Yeast ATR Homolog Mec1p
2001
Chromatin remodeling by nucleosome disassembly in vitro
2006 StandoutNobel
RAD9 and DNA polymerase epsilon form parallel sensory branches for transducing the DNA damage checkpoint signal in Saccharomyces cerevisiae.
1996
Toward Maintaining the Genome: DNA Damage and Replication Checkpoints
2002
Identification of the endophilins (SH3p4/p8/p13) as novel binding partners for the β1-adrenergic receptor
1999 StandoutNobel
ATR and ATRIP: Partners in Checkpoint Signaling
2001 Science
Human DNA Repair Genes
2001 StandoutScienceNobel
Rad53 FHA Domain Associated with Phosphorylated Rad9 in the DNA Damage Checkpoint
1998 Science
Integrating Genetic Approaches into the Discovery of Anticancer Drugs
1997 StandoutScienceNobel
hMutSα- and hMutLα-dependent phosphorylation of p53 in response to DNA methylator damage
1999 StandoutNobel
The Mre11p/Rad50p/Xrs2p Complex and the Tel1p Function in a Single Pathway for Telomere Maintenance in Yeast
2000
Preferential binding of ATR protein to UV-damaged DNA
2002 StandoutNobel
Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation
2009 StandoutScience
Cell Cycle Checkpoints: Preventing an Identity Crisis
1996 StandoutScience
Restriction of DNA Replication to the Reductive Phase of the Metabolic Cycle Protects Genome Integrity
2007 Science
Genetic regulation of telomere-telomere fusions in the yeast Saccharomyces cerevisae
2003
A human Cds1-related kinase that functions downstream of ATM protein in the cellular response to DNA damage
1999
Structure and Function of DNA Photolyase and Cryptochrome Blue-Light Photoreceptors
2003 StandoutNobel
De novo protein synthesis is required for activation-induced cytidine deaminase-dependent DNA cleavage in immunoglobulin class switch recombination
2004 StandoutNobel
Works of Brian Desany being referenced
Recovery from DNA replicational stress is the essential function of the S-phase checkpoint pathway
1998
Low-Abundance Drug-Resistant Viral Variants in Chronically HIV-Infected, Antiretroviral Treatment–Naive Patients Significantly Impact Treatment Outcomes
2009
Metabolic streamlining in an open-ocean nitrogen-fixing cyanobacterium
2010 Nature
Bioinformatics and cancer target discovery
2004
The Cassava Genome: Current Progress, Future Directions
2012
Regulation of RAD53 by the ATM -Like Kinases MEC1 and TEL1 in Yeast Cell Cycle Checkpoint Pathways
1996 Science