Citation Impact
Citing Papers
Computational Thermostabilization of an Enzyme
2005 StandoutScienceNobel
Alteration of enzyme specificity by computational loop remodeling and design
2009 StandoutNobel
Modulation of aflatoxin metabolism, aflatoxin-N7-guanine formation, and hepatic tumorigenesis in rats fed ethoxyquin: role of induction of glutathione S-transferases.
1986
The structures of human glutathione transferase P1-1 in complex with glutathione and various inhibitors at high resolution
1997
Atopic Dermatitis
2008 Standout
Foxo Transcription Factors Induce the Atrophy-Related Ubiquitin Ligase Atrogin-1 and Cause Skeletal Muscle Atrophy
2004 Standout
Short-Term Effects of Nose-Only Cigarette Smoke Exposure on Glutathione Redox Homeostasis, Cytochrome P450 1A1/2 and Respiratory Enzyme Activities in Mice Tissues
2013 Standout
Mechanisms of Muscle Wasting — The Role of the Ubiquitin–Proteasome Pathway
1996
Targeting hypoxia in cancer therapy
2011 Standout
Human glutathione S-transferases
1994
Glutathione conjugation of the fluorophotometric epoxide substrate, 7- glycidoxycoumarin (GOC), by rat liver glutathione transferase isoenzymes
1989
Enzyme-Catalyzed Activation of Anticancer Prodrugs
2004
The subunit structure of a major glutathione S‐transferase form, MT, in rat testis
1988
Muscle Protein Breakdown and the Critical Role of the Ubiquitin-Proteasome Pathway in Normal and Disease States
1999
Paraneoplastic Syndromes Involving the Nervous System
2003 Standout
Formation and Fate of Nephrotoxic and Cytotoxic Glutathione S-Conjugates: Cysteine Conjugate β-Lyase Pathway
1994
Amino Acid Differences at Positions 10, 11, and 104 Explain the Profound Catalytic Differences between Two Murine Pi-Class Glutathione S-Transferases
1995
Structure and function of glutathione S-transferases
1994
Glutathione Transferases—Structure and Catalytic Activit
1988 Standout
Glutathione S-Transferases: Biomedical Applications
1993
Mutations in a member of the ADAMTS gene family cause thrombotic thrombocytopenic purpura
2001 StandoutNature
Comparison of the aflatoxin B1-8,9-epoxide conjugating activities of two bacterially expressed alpha class glutathione S-transferase isozymes from mouse and rat,
1992
Mechanisms for Generating the Autonomous cAMP-Dependent Protein Kinase Required for Long-Term Facilitation in Aplysia
1999 StandoutNobel
Caffeinated and decaffeinated coffee and tea intakes and risk of colorectal cancer in a large prospective study
2012 Standout
Epoxidation of aflatoxin B1 by Aspergillus flavus microsomes in vitro: Interaction with DNA and formation of aflatoxin B1-glutathione conjugate
1991
Epigenetics in Cancer
2008 Standout
Targeted Disruption of the Nuclear Receptor FXR/BAR Impairs Bile Acid and Lipid Homeostasis
2000 Standout
Exploiting tumour hypoxia in cancer treatment
2004 Standout
Regulation of β-Adrenergic Receptor Signaling by S-Nitrosylation of G-Protein-Coupled Receptor Kinase 2
2007 StandoutNobel
High-affinity Binding of Basic Fibroblast Growth Factor and Platelet-derived Growth Factor-AA to the Core Protein of the NG2 Proteoglycan
1999
Protein S-nitrosylation: a physiological signal for neuronal nitric oxide
2001
Coffee Intake and Risk of Colorectal Cancer Among Chinese in Singapore: The Singapore Chinese Health Study
2009
Gene directed enzyme/prodrug therapy of cancer: Historical appraisal and future prospectives
2001
Enzymatic activation of nitro-aryl fluorogens in live bacterial cells for enzymatic turnover-activated localization microscopy
2012 StandoutNobel
Polymorphism in the glutathione conjugation activity of human erythrocytes towards ethylene dibromide and 1,2-epoxy-3-(p-nitrophenoxy)-propane
1995
Organocatalytic Asymmetric Hydrolysis of Epoxides
2014 StandoutNobel
Glutathione and glutathione S-transferases in a human plasma cell line resistant to melphalan
1989
Significance of an unusually lowKmfor glutathione in glutathione transferases of the α μ and π classes
1993
Nucleotide sequence of a class μ glutathione S-transferase from chicken liver
1991
Roles of UDP-Glucuronosyltransferases in Chemical Carcinogenesi
1991
The Chemical Form of Selenium Influences 3,2′-Dimethyl-4-aminobiphenyl-DNA Adduct Formation in Rat Colon
1999
Inflammation and cancer: back to Virchow?
2001 Standout
Comparative Genomics Search for Losses of Long-Established Genes on the Human Lineage
2007
Restoring function in exhausted CD8 T cells during chronic viral infection
2005 StandoutNatureNobel
Molecular Cloning of a Gene Encoding a New Type of Metalloproteinase-disintegrin Family Protein with Thrombospondin Motifs as an Inflammation Associated Gene
1997
Effects of coffee and its chemopreventive components kahweol and cafestol on cytochrome P450 and sulfotransferase in rat liver
2007
Glutathione Transferases As Markers Of Preneoplasia And Neoplasia
1989
The Functional Expression of Sodium-dependent Bile Acid Transport in Madin-Darby Canine Kidney Cells Transfected with the cDNA for Microsomal Epoxide Hydrolase
1996
Relationships Between Descriptors for Hydrophobicity and Soft Electrophilicity in Predicting Toxicity
1993
Targeting tumors with hypoxia-activated cytotoxins
2007
Cancer Anorexia-Cachexia Syndrome: Current Issues in Research and Management
2002
Effects of Dietary Oltipraz and Ethoxyquin on Aflatoxin B1 Biotransformation in Non-Human Primates
2000
Class π glutathione S‐transferase from pig lung
1991
Repertoires of Autophagy in the Pathogenesis of Ocular Diseases
2015 Standout
Tumor-activated Prodrugs—A New Approach to Cancer Therapy
2004
Proteins encoded by an auxin-regulated gene family of tobacco share limited but significant homology with glutathione S-transferases and one member indeed shows in vitro GST activity
1993
Differential induction of glutathione S-transferase subunits by phenobarbital, 3-methylcholanthrene and ethoxyquin in rat liver and kidney
1993
Umbilical Arterial S-nitrosothiols in Stressed Newborns: Role in Perinatal Circulatory Transition
1998 StandoutNobel
The bioactivation of CB 1954 and its use as a prodrug in antibody-directed enzyme prodrug therapy (ADEPT)
1993
Bcl-2 inhibition of neural death: decreased generation of reactive oxygen species
1993 StandoutScience
The Glut athione S-Transferase Supergene Family: Regulation of GST and the Contribution of the lsoenzymes to Cancer Chemoprotection and Drug Resistance Part I
1995 Standout
The major glutathione S-transferase in salmonid fish livers is homologous to the mammalian pi-class GST
1991
lincRNAs act in the circuitry controlling pluripotency and differentiation
2011 StandoutNature
Zebrafish heart regeneration occurs by cardiomyocyte dedifferentiation and proliferation
2010 StandoutNature
Free radicals, antioxidant enzymes, and carcinogenesis
1990
Conjugation of microsome generated and synthetic aflatoxin B1-8,9 epoxide and styrene oxide to glutathione by purified glutathione S-transferases from hamster and mouse livers
1994
Metabolism of AZO Dyes: Implication for Detoxication and Activation
1991
Purified NAD(P)H‐quinone oxidoreductase enhances the mutagenicity of dinitropyrenes in vitro
1991
Conditional targeted cell ablation in zebrafish: A new tool for regeneration studies
2007
Molecular Mechanisms of 4-Hydroxy-2-nonenal and Acrolein Toxicity: Nucleophilic Targets and Adduct Formation
2009
Preferential increase of glutathione S-transferase class alpha transcripts in cultured human hepatocytes by phenobarbital, 3-methylcholanthrene, and dithiolethiones.
1993
Regulation of aflatoxin B1-metabolizing aldehyde reductase and glutathione S-transferase by chemoprotectors
1994
Regulation of tumor angiogenesis by p53-induced degradation of hypoxia-inducible factor 1α
2000 StandoutNobel
Two murine GSTpi genes are arranged in tandem and are differentially expressed.
1994
Metabolic Activation of the Antitumor Drug 5-(Aziridin-1-yl)-2,4-Dinitrobenzamide (CB1954) by NO Synthases
2008
Glutathione-S-transferase pi as a determinant of drug resistance in transfectant cell lines.
1990
Effect of lead acetate and carbon particles on the expression of glutathione S-transferase YfYf in rat liver
1993
Purification and subunit-structural and immunological characterization of five glutathione S-transferases in human liver, and the acidic form as a hepatic tumor marker
1986
Enzyme Sensitive Synthetic Polymer Micelles Based on the Azobenzene Motif
2013
Human intestinal glutathione S-transferases
1989
Electrophilicity Index
1999 Standout
The unique physiology of solid tumors: opportunities (and problems) for cancer therapy.
1998
Effects of consumption of Brussels sprouts on intestinal and lymphocytic glutathione S-transferases in humans
1995
Glutathione S-Transferase Subunits in the Mouse and Their Catalytic Activities Towards Reactive Electrophiles
1987
An evolutionary perspective on glutathione transferases inferred from class-theta glutathione transferase cDNA sequences
1992
Multiple sites of control of glutathione S-transferase P1-1 in rat liver.
1994
The catalytic mechanism of glutathione S-transferase (GST). Spectroscopic determination of the pKa of Tyr-9 in rat alpha 1-1 GST.
1993
The effects of selenium and copper deficiencies on glutathione S-transferase and glutathione peroxidase in rat liver
1987
Thermal radical cyclization of non-conjugated aromatic enyne-allenes: Synthesis of a Cyclobuta[a]naphthalene skeleton
1998
A novel glutathione transferase (13–13) isolated from the matrix of rat liver mitochondria having structural similarity to class theta enzymes
1991
Degradable Controlled-Release Polymers and Polymeric Nanoparticles: Mechanisms of Controlling Drug Release
2016 Standout
Oxidative Nucleobase Modifications Leading to Strand Scission
1998 Standout
Involvement of Jun and Fos proteins in regulating transcriptional activation of the human pi class glutathione S-transferase gene in multidrug-resistant MCF7 breast cancer cells.
1994
Electrophilicity Index
2006 Standout
Nanotechnology for Multimodal Synergistic Cancer Therapy
2017 Standout
The human glutathione S-transferase P1-1 gene: modulation of expression by retinoic acid and insulin
1993
Hypoxia-inducible factor 1-dependent expression of adenosine receptor 2B promotes breast cancer stem cell enrichment
2018 StandoutNobel
The separation of glutathione transferase subunits by using reverse-phase high-pressure liquid chromatography
1987
Alkylation of 2‘-Deoxynucleosides and DNA by Quinone Methides Derived from 2,6-Di-tert-butyl-4-methylphenol
1996
The three-dimensional structure of class pi glutathione S-transferase in complex with glutathione sulfonate at 2.3 A resolution.
1991 Nobel
The extracellular matrix geneFrem1is essential for the normal adhesion of the embryonic epidermis
2004 StandoutNobel
Human glutathione S-transferase theta (GSTT1): cDNA cloning and the characterization of a genetic polymorphism
1994
Interaction of rat glutathione S-transferases 7-7 and 8-8 with γ-glutamyl- or glycyl-modified glutathione analogues
1989
Retrovirus-mediated gene transfer of rat glutathione S-transferase Yc confers alkylating drug resistance in NIH 3T3 mouse fibroblasts.
1994
Reactions and significance of cytochrome P-450 enzymes
1991
Therapeutic Vaccines for Chronic Infections
2004 Science
Anomalous electrophoretic behaviour of the glutathione S-transferase Ya and Yk subunits isolated from man and rodents. A potential pitfall for nomenclature
1986
The Isoenzymes of Glutathione Transferase
1985
Ethoxyquin-induced resistance to aflatoxin B1 in the rat is associated with the expression of a novel Alpha-class glutathione S-transferase subunit, Yc2, which possesses high catalytic activity for aflatoxin B1-8,9-epoxide
1991
The role of mitochondrial glutathione and cellular protein sulfhydryls in formaldehyde toxicity in glutathione-depleted rat hepatocytes
1986
GLUTATHIONE TRANSFERASES
2004 Standout
Isolation and characterization of two mouse Pi-class glutathione S-transferase genes
1994
Rational Tuning of Fluorobenzene Probes for Cysteine‐Selective Protein Modification
2018 StandoutNobel
Preferential over-expression of the class alpha rat Ya2 glutathione S-transferase subunit in livers bearing aflatoxin-induced pre-neoplastic nodules. Comparison of the primary structures of Ya1 and Ya2 with cloned class alpha glutathione S-transferase cDNA sequences
1990
Cellular responses to oxidative stress: the [Ah] gene battery as a paradigm.
1990
Small-Molecule Labeling of Live Cell Surfaces for Three-Dimensional Super-Resolution Microscopy
2014 StandoutNobel
Cytidine methylation of regulatory sequences near the pi-class glutathione S-transferase gene accompanies human prostatic carcinogenesis.
1994
Distinct oxidoresistance phenotype of human T47D cells transfected by rat glutathione S-transferase Yc expression vectors.
1992
Amplification and increased expression of alpha class glutathione S-transferase-encoding genes associated with resistance to nitrogen mustards.
1988
The ubiquitin-proteasome pathway: on protein death and cell life
1998 StandoutNobel
Enzyme-Responsive Snap-Top Covered Silica Nanocontainers
2008 StandoutNobel
Chemistry of Biologically Important Synthetic Organoselenium Compounds
2001 Standout
Reactive Oxygen Species (ROS)-Based Nanomedicine
2019 Standout
The structure of the human glutathione S-transferase π gene
1988
Fluorescent Chemosensors Based on Spiroring-Opening of Xanthenes and Related Derivatives
2011 Standout
Modification of N‐Acetyltransferases and Glutathione S‐Transferases by Coffee Components: Possible Relevance for Cancer Risk
2005
DNA Cross-Linking Agents as Antitumor Drugs
1998
A new class of rat glutathione S-transferase Yrs-Yrs inactivating reactive sulfate esters as metabolites of carcinogenic arylmethanols.
1990
Cloning and expression of a chick liver glutathione S-transferase CL 3 subunit with the use of a baculovirus expression system
1992
Cloning of cDNAs from fetal rat liver encoding glutathione S-transferase Yc polypeptides. The Yc2 subunit is expressed in adult rat liver resistant to the hepatocarcinogen aflatoxin B1.
1994
A basis for differentiating among the multiple human Mu-glutathione S-transferases and molecular cloning of brain GSTM5.
1993
Tissue-specific contributions of Tmem79 to atopic dermatitis and mast cell-mediated histaminergic itch
2018 StandoutNobel
A Large Prospective Study of Meat Consumption and Colorectal Cancer Risk: An Investigation of Potential Mechanisms Underlying this Association
2010
Purification and characterization of a labile rat glutathione transferase of the Mu class
1989
The Allylic Azide Rearrangement: Achieving Selectivity
2005 StandoutNobel
The Ubiquitin-Proteasome Proteolytic Pathway: Destruction for the Sake of Construction
2002 StandoutNobel
Expression of glutathione S-transferase during rat liver development
1992
Some Typical Advances in the Synthetic Applications of Allenes
2005 Standout
Soluble glutathione transferase isoenzymes in Daphnia magna straus and their interaction with 2,4-dichlorophenoxyacetic acid and 1,4-benzoquinone
1987
Photopharmacology: Beyond Proof of Principle
2014 StandoutNobel
Mitochondrial activation chemicals synergize with surface receptor PD-1 blockade for T cell-dependent antitumor activity
2017 StandoutNobel
Organoselenium and Organotellurium Compounds: Toxicology and Pharmacology
2004 Standout
Biology of Cachexia
1997
Site-directed mutagenesis of glutathione S-transferase YaYa. Mapping the glutathione-binding site.
1993
“Inverse Drug Discovery” Strategy To Identify Proteins That Are Targeted by Latent Electrophiles As Exemplified by Aryl Fluorosulfates
2017 StandoutNobel
Recent advances in the preparation and synthetic applications of oxiranes
1983
Deficiency of Dermcidin-Derived Antimicrobial Peptides in Sweat of Patients with Atopic Dermatitis Correlates with an Impaired Innate Defense of Human Skin In Vivo
2005
Cytochrome P450 and Chemical Toxicology
2007
Sex-specific constitutive expression of the pre-neoplastic marker glutathione S-transferase, YfYf, in mouse liver
1987
Glutathione conjugation of styrene 7,8-oxide enantiomers by major glutathione transferase isoenzymes isolated from rat livers
1989
Mass spectrometric analysis of rat liver cytosolic glutathione S-transferases: modifications are limited to N-terminal processing
1995
Immunodetection with a monoclonal antibody of glutathione S-transferase mu in patients with and without carcinomas
1990
Structure and Chemistry of Cytochrome P450
2005 Standout
Meat, Meat Cooking Methods and Preservation, and Risk for Colorectal Adenoma
2005
Chemical Implications for Antitumor and Antiviral Prostaglandins: Reaction of Δ7-Prostaglandin A1 and Prostaglandin A1 Methyl Esters with Thiols
1997 StandoutNobel
Works of Brian Coles being referenced
The nitroreductase enzyme in walker cells that activates 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB 1954) to 5-(aziridin-1-YL)-4-hydroxylamino-2-nitrobenzamide is a form of NAD(P)H dehydrogenase (quinone) (EC 1.6.99.2)
1988
The bioactivation of 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB1954)—I
1992
Identification of a naturally processed HLA A0201‐restricted viral peptide from cells expressing human papillomavirus type 16 E6 oncoprotein
1994
Gene and Protein Characterization of the Human Glutathione S-Transferase Kappa and Evidence for a Peroxisomal Localization
2004
In vivo and in vitro formation of glutathione conjugates from the K-region epoxides of 1-nitropyrene
1987
Quantitation of tissue- and sex-specific induction of rat GSH transferase subunits by dietary 1,2-dithiole-3-thiones
1993
Characterization of a cancer cachectic factor
1996 Nature
Effect of polymorphism in the human glutathione S-transferase A1 promoter on hepatic GSTA1 and GSTA2 expression
2001
The Role of Glutathione and Glutathione Transferases in Chemical Cardnogenesi
1990
Novel markers of susceptibility to carcinogens in diet: associations with colorectal cancer
2002
Detoxification of electrophilic compounds by glutathione S‐transferase catalysis: Determinants of individual response to chemical carcinogens and chemotherapeutic drugs?
2003
The human glutathione transferase alpha locus: genomic organization of the gene cluster and functional characterization of the genetic polymorphism in the hGSTA1 promoter.
2002
Biological and chemical studies on 8,9-dihydroxy-8,9-dihydro-aflatoxin B1 and some of its esters
1980
The isolation and characterization of the major glutathione S-transferase from the squid Loligo vulgaris
1991
The chondroitin sulfate proteoglycan NG2 is a tumour-specific antigen on the chemically induced rat chondrosarcoma HSN
1994
Kinetics and equilibria of S‐nitrosothiol—thiol exchange between glutathione, cysteine, penicillamines and serum albumin
1994
Analysis of total meat intake and exposure to individual heterocyclic amines in a case-control study of colorectal cancer: contribution of metabolic variation to risk
2002
The endo-8,9-epoxide of aflatoxin B1: a new metabolite
1992
Induction of Rat Liver GSH Transferases by 1,2-Dithiole-3-Thione Illustrates Both Anticarcinogenic and Tumor-Promoting Properties
1993
Potential chemoprotective effects of the coffee components kahweol and cafestol palmitates via modification of hepatic N‐acetyltransferase and glutathione S‐transferase activities
2004
Human glutathione S-transferase A2 polymorphisms
2003
Glutathione Transferases and Carcinogenesis
1986
Effects of Modifying Structure on Electrophilic Reactions with Biological Nucleophiles
1984
The Preparation of Silyl-Protected Functional Penta-1,3-diynes
1975
Studies on the detoxication of microsomally-activated aflatoxin B1 by glutathione and glutathione transferases in vitro
1985
The halogenation and attempted epoxidation of 3a,8a-dihydrofuro[2,3-b]benzofuran and aflatoxin B1
1979
The Role of Glutathione in Detoxication
1983
Glutathione transferases in primary rat hepatomas: the isolation of a form with GSH peroxidase activity
1985
The major role of glutathione in the metabolism and excretion of N,N-dimethyl-4-aminoazobenzene in the rat
1983
DNA Adduction by the Potent Carcinogen Aflatoxin B1: Mechanistic Studies
1994
The role of glutathione in detoxication
1983