Citation Impact
Citing Papers
International Union of Pharmacology nomenclature of adrenoceptors.
1994 StandoutNobel
A revision of the Biginelli reaction under solid acid catalysis. Solvent-free synthesis of dihydropyrimidines over montmorillonite KSF
1999
Biologically active dihydropyrimidones of the Biginelli-type — a literature survey
2000 Standout
Molecular biology of α-adrenergic receptors: implications for receptor classification and for structure-function relationships
1991 StandoutNobel
(+)-Niguldipine binds with very high affinity to Ca2+ channels and to a subtype of α1-adrenoceptors
1989
Recent developments in asymmetric multicomponent reactions
2012
Catalytic Carbophilic Activation: Catalysis by Platinum and Gold π Acids
2007 Standout
Highly versatile solid phase synthesis of biofunctional 4-aryl-3,4-dihydropyrimidines using resin-bound isothiourea building blocks and multidirectional resin cleavage
2000
Asymmetric Disulfonimide‐Catalyzed Synthesis of δ‐Amino‐β‐Ketoester Derivatives by Vinylogous Mukaiyama–Mannich Reactions
2014 StandoutNobel
The tethered Biginelli condensation in natural product synthesis
2004
Alternative energy input: mechanochemical, microwave and ultrasound-assisted organic synthesis
2011
Synthesis and Evaluation of 3,4‐Dihydropyrimidin‐2(1H)‐ones as Sodium Iodide Symporter Inhibitors
2012
Microwaves in organic synthesis. Thermal and non-thermal microwave effects
2005 Standout
Pyrrolidinyl‐Spirooxindole Natural Products as Inspirations for the Development of Potential Therapeutic Agents
2007 Standout
Synthesis and anti-inflammatory activities of some thiazolo[3,2-a]pyrimidine derivatives
1999
Multicomponent Synthesis of Dihydropyrimidines and Thiazines
2006
Determination of absolute configuration in 4-aryl-3,4-dihydro-2(1H)-pyrimidones by high performance liquid chromatography and CD spectroscopy
1999
Advancing chemistry and biology through diversity-oriented synthesis of natural product-like libraries
2005
A practical and green approach towards synthesis of dihydropyrimidinones: Using heteropoly acids as efficient catalysts
2006
Continuous‐Flow Technology—A Tool for the Safe Manufacturing of Active Pharmaceutical Ingredients
2015 Standout
A novel four-component reaction for the synthesis of functionalised dihydropyrimidinesElectronic supplementary information (ESI) available: 1H and 13C NMR data for 9 and 10. See http://www.rsc.org/suppdata/cc/b3/b308243a
2003
Highly enantioselective Biginelli reaction catalyzed by SPINOL-phosphoric acids
2012
Building Dihydropyrimidine Libraries via Microwave-Assisted Biginelli Multicomponent Reactions
2003
Transition‐Metal‐Catalyzed Direct Arylation of (Hetero)Arenes by CH Bond Cleavage
2009 Standout
Solid‐Phase Synthesis of Tetrahydro‐β‐carbolines and Tetrahydroisoquinolines by Stereoselective Intramolecular N‐Carbamyliminium Pictet–Spengler Reactions
2006 StandoutNobel
Asymmetric Organocatalytic Biginelli Reactions: A New Approach To Quickly Access Optically Active 3,4‐Dihydropyrimidin‐2‐(1H)‐ones
2007
Asymmetric Multicomponent Reactions (AMCRs): The New Frontier
2005 Standout
Controlled Microwave Heating in Modern Organic Synthesis
2004 Standout
Multicomponent Reaction Design in the Quest for Molecular Complexity and Diversity
2011 Standout
Nano-magnetite (Fe3O4) as a support for recyclable catalysts in the development of sustainable methodologies
2013 Standout
5 Amidines and Guanidines in Medicinal Chemistry
1993
Iron Catalysis in Organic Synthesis
2015 Standout
Iron(III) tosylate catalyzed synthesis of 3,4-dihydropyrimidin-2(1H)-ones/thiones via the Biginelli reaction
2012
Enantioselective Synthesis of SNAP-7941: Chiral Dihydropyrimidone Inhibitor of MCH1-R
2008
1,3-Dicarbonyl compounds in stereoselective domino and multicomponent reactions
2010
Separation of enantiomers of 4-aryldihydropyrimidines by direct enantioselective HPLC. A critical comparison of chiral stationary phases
1997
A solid phase protocol of the biginelli dihydropyrimidine synthesis suitable for combinatorial chemistry
1995
Natural Product Synthesis Using Multicomponent Reaction Strategies
2009 Standout
Synthesis of the tricyclic portions of batzelladines A, B and D. Revision of the stereochemistry of batzelladines A and D
1996
Enantioselective α-Hydroxylation of 2-Arylacetic Acid Derivatives and Buspirone Catalyzed by Engineered Cytochrome P450 BM-3
2006 StandoutNobel
Organic Photoredox Catalysis
2016 Standout
Synthesis and reactions of “biginelli‐compounds”. Part I
1989
The Use of Molecular Oxygen in Pharmaceutical Manufacturing: Is Flow the Way to Go?
2016
Fluorine and Fluorinated Motifs in the Design and Application of Bioisosteres for Drug Design
2018 Standout
An expedient protocol of the Biginelli dihydropyrimidine synthesis using carbonyl equivalents
1999
Homogeneous and heterogeneous catalysts for multicomponent reactions
2011
Medicinal agents incorporating the 1,2-diamine functionality
1989
Synthesis of vicinal diamines from cyclic sulfates
1995 StandoutNobel
Ring conformation and ester orientation in dihydropyrimidinecarboxylates: a combined theoretical (ab initio, density functional) and X-ray crystallographic study
1998
Industry Perspectives on Process Analytical Technology: Tools and Applications in API Development
2014
The Hitchhiker’s Guide to Flow Chemistry
2017 Standout
A Partially Fluorinated, Water-Stable Cu(II)–MOF Derived via Transmetalation: Significant Gas Adsorption with High CO2 Selectivity and Catalysis of Biginelli Reactions
2016
Concise Synthesis of Guanidine-Containing Heterocycles Using the Biginelli Reaction
2006
Fe(HSO4)3 as an efficient catalyst for the preparation of 3,4-dihydropyrimidin-2(1H)-ones in solution and under solvent-free conditions
2008
A New Convenient Synthesis of 5-Acyl-1,2,3,4-tetrahydropyrimidine-2-thiones/ones
1998
Recent advances in the synthesis of pyrroles by multicomponent reactions
2014 Standout
Practical Methodologies for the Synthesis of Indoles
2006 Standout
Mechanistic Studies on the Cu-Catalyzed Three-Component Reactions of Sulfonyl Azides, 1-Alkynes and Amines, Alcohols, or Water: Dichotomy via a Common Pathway
2008 StandoutNobel
Dihydropyrimidine calcium channel blockers 51: bicyclic dihydropyrimidines as potent mimics of dihydropyridines
1991
Unprecedented Catalytic Three Component One-Pot Condensation Reaction: An Efficient Synthesis of 5-Alkoxycarbonyl- 4-aryl-3,4-dihydropyrimidin-2(1H)-ones
1998
A Combinatorial Approach to Recognition of Chirality: Preparation of Highly Enantioselective Aryl-Dihydropyrimidine Selectors for Chiral HPLC
1998
Metal–Organic Frameworks for Water Harvesting from Air
2018 StandoutNobel
Additions to Metal-Activated Organonitriles
2002 Standout
Merobatzelladines A and B, Anti-Infective Tricyclic Guanidines from a Marine Sponge Monanchora sp.
2009 StandoutNobel
Microwave‐Assisted Dimroth Rearrangement of Thiazines to Dihydropyrimidinethiones: Synthetic and Mechanistic Aspects
2006
Iron-Catalyzed Vinylogous Aldol Condensation of Biginelli Products and Its Application toward Pyrido[4,3-d]pyrimidinones
2014
Microwave-mediated Biginelli reactions revisited. On the nature of rate and yield enhancements
2000
One-Pot Synthesis and Conformational Features ofN,N‘-Disubstituted Ketene Aminals
2003
Highly Enantioselective Organocatalytic Biginelli and Biginelli-Like Condensations: Reversal of the Stereochemistry by Tuning the 3,3′-Disubstituents of Phosphoric Acids
2009
Three-Component Biginelli Cyclocondensation Reaction Using C-Glycosylated Substrates. Preparation of a Collection of Dihydropyrimidinone Glycoconjugates and the Synthesis of C-Glycosylated Monastrol Analogues
2002
Recent Advances in Polyoxometalate-Catalyzed Reactions
2015 Standout
Synthesis of fluorinated ethyl 4-aryl-6-methyl-1,2,3,4-tetrahydropyrimidin-2-one/thione-5-carboxylates under microwave irradiation
1998
Indium(III) Chloride-Catalyzed One-Pot Synthesis of Dihydropyrimidinones by a Three-Component Coupling of 1,3-Dicarbonyl Compounds, Aldehydes, and Urea: An Improved Procedure for the Biginelli Reaction
2000
Protic Ionic Liquids: Properties and Applications
2007 Standout
Aerobic Copper-Catalyzed Organic Reactions
2013 Standout
A Reexamination of the Mechanism of the Biginelli Dihydropyrimidine Synthesis. Support for an N-Acyliminium Ion Intermediate1
1997
Development and Scale-Up of Three Consecutive Continuous Reactions for Production of 6-Hydroxybuspirone
2008
Towards the synthesis of C-glycosylated dihydropyrimidine libraries via the three-component Biginelli reaction. A novel approach to artificial nucleosides
2001
The Combinatorial Synthesis of Bicyclic Privileged Structures or Privileged Substructures
2003 Standout
Natural Products as Sources of New Drugs over the Last 25 Years
2007 Standout
Soluble polymer-supported synthesis of Biginelli compounds
2002
Recent Advances in the Biginelli Dihydropyrimidine Synthesis. New Tricks from an Old Dog
2000 Standout
Microwave assisted organic synthesis—a review
2001 Standout
Disulfonimide-Catalyzed Asymmetric Synthesis of β3-Amino Esters Directly from N-Boc-Amino Sulfones
2013 StandoutNobel
The Generation of Dihydropyrimidine Libraries Utilizing Biginelli Multicomponent Chemistry
2003
100 years of the biginelli dihydropyrimidine synthesis
1993 Standout
The Halogen Bond
2016 Standout
Multifunctional metal–organic framework catalysts: synergistic catalysis and tandem reactions
2016 Standout
Complete Field Guide to Asymmetric BINOL-Phosphate Derived Brønsted Acid and Metal Catalysis: History and Classification by Mode of Activation; Brønsted Acidity, Hydrogen Bonding, Ion Pairing, and Metal Phosphates
2014 Standout
Brønsted Acidic Ionic Liquid: An Efficient and Reusable Catalyst for the Synthesis of 3,4‐Dihydropyrimidin‐2(1H)‐ones
2006
Large-Scale Oxidations in the Pharmaceutical Industry
2006
Highly Enantioseletive Biginelli Reaction Using a New Chiral Ytterbium Catalyst: Asymmetric Synthesis of Dihydropyrimidines
2005
Synthesis and reactions of biginelli compounds −5. Facile preparation and resolution of a stable 5-dihydropyrimidinecarboxylic acid.
1992
Design, Structure−Activity Relationships, X-ray Crystal Structure, and Energetic Contributions of a Critical P1 Pharmacophore: 3-Chloroindole-7-yl-Based Factor Xa Inhibitors
2008
Chemistry and Biology Of Multicomponent Reactions
2012 Standout
Conformational analysis of 4-aryl-dihydropyrimidine calcium channel modulators. A comparison of ab initio, semiempirical and X-ray crystallographic studies
1997
Solar Synthesis: Prospects in Visible Light Photocatalysis
2014 StandoutScience
INSIGHTS FROM IN VIVO MODIFICATION OF ADRENERGIC RECEPTOR GENE EXPRESSION
1998 StandoutNobel
Metal–organic frameworks catalyzed C–C and C–heteroatom coupling reactions
2015
Preparation of (R)- and (S)-6-hydroxybuspirone by enzymatic resolution or hydroxylation
2005
Highly Practical Copper(I)/TEMPO Catalyst System for Chemoselective Aerobic Oxidation of Primary Alcohols
2011 Standout
Natural Products As Sources of New Drugs over the 30 Years from 1981 to 2010
2012 Standout
Design and Synthesis of a Conformationally Rigid Mimic of the Dihydropyrimidine Calcium Channel Modulator SQ 32,926
2000
Aerobic oxidations in flow: opportunities for the fine chemicals and pharmaceuticals industries
2016
Metal–Organic Frameworks for Heterogeneous Basic Catalysis
2017 Standout
Stronger Brønsted Acids
2007 Standout
Synopsis of Some Recent Tactical Application of Bioisosteres in Drug Design
2011 Standout
Metal-Free Multicomponent Syntheses of Pyridines
2014 Standout
Asymmetric Mannich Reaction of Dicarbonyl Compounds with α-Amido Sulfones Catalyzed by Cinchona Alkaloids and Synthesis of Chiral Dihydropyrimidones
2007
Works of Brian C. O'Reilly being referenced
Dihydropyrimidine calcium channel blockers. 4. Basic 3-substituted-4-aryl-1,4-dihydropyrimidine-5-carboxylic acid esters. Potent antihypertensive agents
1992
Dihydropyrimidine calcium channel blockers. 3. 3-Carbamoyl-4-aryl-1,2,3,4-tetrahydro-6-methyl-5-pyrimidinecarboxylic acid esters as orally effective antihypertensive agents
1991 Standout
Synthesis of Substituted 1,2,3,4-Tetrahydro-6-methyl-2-oxo-5-pyrimidinecarboxylic Acid Esters: The Biginelli Condensation Revisited
1987
Substituted 1,2,3,4-tetrahydroaminonaphthols: antihypertensive agents, calcium channel blockers, and adrenergic receptor blockers with catecholamine-depleting effects
1987
Development of a Safe and Scalable Oxidation Process for the Preparation of 6-Hydroxybuspirone: Application of In-Line Monitoring for Process Ruggedness and Product Quality
2004
Synthesis of Substituted 1,2,3,4-Tetrahydro-6-methyl-2-thioxo-5-pyrimidinecarboxylic Acid Esters
1987
Substituted 1,4-dihydropyrimidines. 3. Synthesis of selectively functionalized 2-hetero-1,4-dihydropyrimidines
1989
A facile synthesis of cyanoguanidines from thioureas
1989