Citation Impact
Citing Papers
Glycolytic Enzymes Can Modulate Cellular Life Span
2005
Mitochondrial Dysfunction Contributes to Oncogene-Induced Senescence
2009
Extension of Murine Life Span by Overexpression of Catalase Targeted to Mitochondria
2005 StandoutScience
Sequential Activation of the MEK-Extracellular Signal-Regulated Kinase and MKK3/6-p38 Mitogen-Activated Protein Kinase Pathways Mediates Oncogenic ras -Induced Premature Senescence
2002
Suppression of Reactive Oxygen Species and Neurodegeneration by the PGC-1 Transcriptional Coactivators
2006 Standout
On-target efficacy of a HIF-2α antagonist in preclinical kidney cancer models
2016 StandoutNatureNobel
Hallmarks of Cancer: The Next Generation
2011 Standout
Genome-wide Association of Hypoxia-inducible Factor (HIF)-1α and HIF-2α DNA Binding with Expression Profiling of Hypoxia-inducible Transcripts
2009 StandoutNobel
AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity
2009 StandoutNature
Regulation of Reactive Oxygen Species Homeostasis by Peroxiredoxins and c-Myc
2008
Cellular senescence: unravelling complexity
2009
Rac1 Activity Is Required for the Activation of Hypoxia-inducible Factor 1
2001 StandoutNobel
MYC on the Path to Cancer
2012 Standout
HIF-α Effects on c-Myc Distinguish Two Subtypes of Sporadic VHL-Deficient Clear Cell Renal Carcinoma
2008
Obesity-induced gut microbial metabolite promotes liver cancer through senescence secretome
2013 StandoutNature
Mitogen‐activated protein kinase p38 defines the common senescence‐signalling pathway
2003
BRAFE600-associated senescence-like cell cycle arrest of human naevi
2005 StandoutNature
Tumor suppressors and oncogenes in cellular senescence☆
2000
DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis
2005 StandoutNature
HIF-1 mediates metabolic responses to intratumoral hypoxia and oncogenic mutations
2013 StandoutNobel
HIF2α cooperates with RAS to promote lung tumorigenesis in mice
2009 StandoutNobel
Modulation of oxidative stress as an anticancer strategy
2013 Standout
Adipocytes as regulators of energy balance and glucose homeostasis
2006 StandoutNature
Chemokine Signaling via the CXCR2 Receptor Reinforces Senescence
2008
Putting the stress on senescence
2001
Uric Acid and Cardiovascular Risk
2008 Standout
Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders
2011 StandoutNature
Oxidant signals and oxidative stress
2003
IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice
2002 StandoutNature
HIF-1-mediated expression of pyruvate dehydrogenase kinase: A metabolic switch required for cellular adaptation to hypoxia
2006 StandoutNobel
Senescent Cells, Tumor Suppression, and Organismal Aging: Good Citizens, Bad Neighbors
2005 Standout
NF-κB inhibition delays DNA damage–induced senescence and aging in mice
2012
Autophagy: Renovation of Cells and Tissues
2011 Standout
Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis
2011 StandoutNature
Biological Functions of Autophagy Genes: A Disease Perspective
2019 Standout
Mitochondria, Oxidants, and Aging
2005 Standout
Blinded by the Light: The Growing Complexity of p53
2009 Standout
p38MAPK in the Senescence of Human and Murine Fibroblasts
2010
Cellular senescence and chromatin structure
2007
Mammalian SIRT1 limits replicative life span in response to chronic genotoxic stress
2005
Mitogenic signalling and the p16INK4a–Rb pathway cooperate to enforce irreversible cellular senescence
2006
The essence of senescence: Figure 1.
2010 Standout
Common genetic variants at the 11q13.3 renal cancer susceptibility locus influence binding of HIF to an enhancer of cyclin D1 expression
2012 StandoutNobel
Stem cells, ageing and the quest for immortality
2006 StandoutNature
Mutant KRas-Induced Mitochondrial Oxidative Stress in Acinar Cells Upregulates EGFR Signaling to Drive Formation of Pancreatic Precancerous Lesions
2016
Genome maintenance mechanisms for preventing cancer
2001 StandoutNature
Oxidants, oxidative stress and the biology of ageing
2000 StandoutNature
Regulation of cellular response to oncogenic and oxidative stress by Seladin-1
2004 Nature
Autophagy maintains stemness by preventing senescence
2016 Nature
Imaging Dynamic Redox Changes in Mammalian Cells with Green Fluorescent Protein Indicators
2004 StandoutNobel
Akt Determines Replicative Senescence and Oxidative or Oncogenic Premature Senescence and Sensitizes Cells to Oxidative Apoptosis
2008
c-Myc Can Induce DNA Damage, Increase Reactive Oxygen Species, and Mitigate p53 Function
2002
Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis
2005 StandoutNature
Cellular senescence and its effector programs
2014
Genes involved in senescence and immortalization
2000
A systematic RNAi screen identifies a critical role for mitochondria in C. elegans longevity
2002 StandoutNobel
The role of senescent cells in ageing
2014 StandoutNature
Tumor Stroma-Derived TGF-β Limits Myc-Driven Lymphomagenesis via Suv39h1-Dependent Senescence
2010
Resveratrol Improves Mitochondrial Function and Protects against Metabolic Disease by Activating SIRT1 and PGC-1α
2006 Standout
The Hallmarks of Aging
2013 Standout
Free radicals and senescence
2008
Cellular mechanisms and physiological consequences of redox-dependent signalling
2014 Standout
Is β-Galactosidase Staining a Marker of Senescence in Vitro and in Vivo?
2000
Involvement of MINK, a Ste20 Family Kinase, in Ras Oncogene-Induced Growth Arrest in Human Ovarian Surface Epithelial Cells
2005
The DNA damage signaling pathway is a critical mediator of oncogene-induced senescence
2007
Cellular senescence: from physiology to pathology
2014 Standout
Principles of Cancer Therapy: Oncogene and Non-oncogene Addiction
2009 Standout
Reactive Species-Mediated Regulation of Cell Signaling and the Cell Cycle: The Role of MAPK
2005
Redox state is a central modulator of the balance between self-renewal and differentiation in a dividing glial precursor cell
2000
DNA Damage Signaling and p53-dependent Senescence after Prolonged β-Interferon Stimulation
2006
The Senescence-Associated Secretory Phenotype: The Dark Side of Tumor Suppression
2010 Standout
Cyclin-dependent kinases regulate lysosomal degradation of hypoxia-inducible factor 1α to promote cell-cycle progression
2014 StandoutNobel
Glycated Collagen I Induces Premature Senescence-Like Phenotypic Changes in Endothelial Cells
2002
Mitochondrial Fission, Fusion, and Stress
2012 StandoutScience
Role for Mitochondrial Oxidants as Regulators of Cellular Metabolism
2000
High-Dose Allopurinol Improves Endothelial Function by Profoundly Reducing Vascular Oxidative Stress and Not by Lowering Uric Acid
2006
Retrograde signaling from autophagy modulates stress responses
2017
Synthesis, cellular evaluation, and mechanism of action of piperlongumine analogs
2012
Spermidine in health and disease
2018 StandoutScience
Broken Limits to Life Expectancy
2002 StandoutScience
Normal Human Fibroblasts Are Resistant to RAS-Induced Senescence
2004
Metabolic reprogramming and cancer progression
2020 StandoutScience
Integrins engage mitochondrial function for signal transduction by a mechanism dependent on Rho GTPases
2002
The signals and pathways activating cellular senescence
2004
Lipotoxicity versus adipotoxicity—The deleterious effects of adipose tissue on beta cells in the pathogenesis of type 2 diabetes
2006
The Superoxide-Generating Oxidase Nox1 Is Functionally Required for Ras Oncogene Transformation
2004
A Heck–Matsuda Process for the Synthesis of β‐Arylethenesulfonyl Fluorides: Selectively Addressable Bis‐electrophiles for SuFEx Click Chemistry
2016 StandoutNobel
Palladium‐Catalyzed Fluorosulfonylvinylation of Organic Iodides
2017 StandoutNobel
Ras‐dependent and ‐independent regulation of reactive oxygen species by mitogenic growth factors and TGF‐β1
2000
Inhibition of the Rac1 GTPase protects against nonlethal ischemia/reperfusion‐induced necrosis and apoptosis in vivo
2000
Free Radicals in the Physiological Control of Cell Function
2002 Standout
IL1- and TGFβ-Nox4 signaling, oxidative stress and DNA damage response are shared features of replicative, oncogene-induced, and drug-induced paracrine ‘Bystander senescence’
2012
Real-time in vivo imaging of p16Ink4a reveals cross talk with p53
2009
Influence of Induced Reactive Oxygen Species in p53-Mediated Cell Fate Decisions
2003
Murine Models of Life Span Extension
2004
Works of Brett E. Fenster being referenced
Ras Proteins Induce Senescence by Altering the Intracellular Levels of Reactive Oxygen Species
1999
Endothelial dysfunction: clinical strategies for treating oxidant stress
2003
Novel Role for the Potent Endogenous Inotrope Apelin in Human Cardiac Dysfunction
2003