Standout Papers
Citation Impact
Citing Papers
TFEB Links Autophagy to Lysosomal Biogenesis
2011 StandoutScience
Phosphorylation of ULK1 (hATG1) by AMP-Activated Protein Kinase Connects Energy Sensing to Mitophagy
2010 StandoutScience
Kruppel-Like Factor 8 Induces Epithelial to Mesenchymal Transition and Epithelial Cell Invasion
2007
Trained immunity: A program of innate immune memory in health and disease
2016 StandoutScience
The C9orf72 protein interacts with Rab1a and the ULK 1 complex to regulate initiation of autophagy
2016
Nutrient-dependent mTORC1 Association with the ULK1–Atg13–FIP200 Complex Required for Autophagy
2009 Standout
Ferroptosis regulation by the NGLY1/NFE2L1 pathway
2022 StandoutNobel
TOR Signaling in Growth and Metabolism
2006 Standout
Activation of the NRF2 antioxidant program generates an imbalance in central carbon metabolism in cancer
2017
Hallmarks of Cancer: The Next Generation
2011 Standout
Reactive Oxygen Species in Normal and Tumor Stem Cells
2014
ULK1·ATG13·FIP200 Complex Mediates mTOR Signaling and Is Essential for Autophagy
2009
HIF1α and HIF2α: sibling rivalry in hypoxic tumour growth and progression
2011
Hypoxia-Inducible Factors in Physiology and Medicine
2012 StandoutNobel
BRCA1-IRIS inactivation overcomes paclitaxel resistance in triple negative breast cancers
2015
The tumor suppressor kinase LKB1: lessons from mouse models
2011
The role of the Atg1/ULK1 complex in autophagy regulation
2010 Standout
Regulation and function of mTOR signalling in T cell fate decisions
2012
mTOR Signaling in Growth Control and Disease
2012 Standout
AMPK: guardian of metabolism and mitochondrial homeostasis
2017 Standout
Autophagy and the Integrated Stress Response
2010 Standout
Derailed endocytosis: an emerging feature of cancer
2008
The tuberous sclerosis gene products hamartin and tuberin are multifunctional proteins with a wide spectrum of interacting partners
2008
Epithelial-Mesenchymal Transitions in Development and Disease
2009 Standout
Metabolic control of adult neural stem cell activity by Fasn-dependent lipogenesis
2012 Nature
Canonical and noncanonical functions of ULK/Atg1
2017
YAP/TAZ at the Roots of Cancer
2016
Targeting Ferroptosis to Iron Out Cancer
2019 Standout
Autophagy in mammalian development and differentiation
2010 Standout
The chemical basis of ferroptosis
2019
Metabolic Regulation of Hematopoietic Stem Cells in the Hypoxic Niche
2011 StandoutNobel
Ferroptosis at the crossroads of cancer-acquired drug resistance and immune evasion
2019
Ferroptosis turns 10: Emerging mechanisms, physiological functions, and therapeutic applications
2022 Standout
MDM2 and MDMX promote ferroptosis by PPARα-mediated lipid remodeling
2020
ALOX12 is required for p53-mediated tumour suppression through a distinct ferroptosis pathway
2019
Physiological role of autophagy as an intracellular recycling system: With an emphasis on nutrient metabolism
2010
The molecular machinery of regulated cell death
2019 Standout
Lkb1 regulates cell cycle and energy metabolism in haematopoietic stem cells
2010 Nature
Parkin Mediates Proteasome-dependent Protein Degradation and Rupture of the Outer Mitochondrial Membrane
2011
Axis of ageing: telomeres, p53 and mitochondria
2012
Intercellular interaction dictates cancer cell ferroptosis via NF2–YAP signalling
2019 Nature
The bone marrow niche for haematopoietic stem cells
2014 StandoutNature
Hippo Pathway in Organ Size Control, Tissue Homeostasis, and Cancer
2015 Standout
Autophagy: Renovation of Cells and Tissues
2011 Standout
Structures containing Atg9A and the ULK1 complex independently target depolarized mitochondria at initial stages of Parkin-mediated mitophagy
2012
Decoding ALS: from genes to mechanism
2016 StandoutNature
MAP4K family kinases act in parallel to MST1/2 to activate LATS1/2 in the Hippo pathway
2015
Breakdown of an Ironclad Defense System: The Critical Role of NRF2 in Mediating Ferroptosis
2020
YAP and TAZ: a nexus for Hippo signaling and beyond
2015
FOXOs: signalling integrators for homeostasis maintenance
2013
Selective autophagy mediated by autophagic adapter proteins
2011 Standout
Characterization of autophagosome formation site by a hierarchical analysis of mammalian Atg proteins
2010
Metazoan MicroRNAs
2018 Standout
The Lkb1 metabolic sensor maintains haematopoietic stem cell survival
2010 Nature
Malignant Glioma: Lessons from Genomics, Mouse Models, and Stem Cells
2012
AMPK at the Nexus of Energetics and Aging
2014
Conformational changes in the G protein Gs induced by the β2 adrenergic receptor
2011 StandoutNatureNobel
Disruption of Fnip1 Reveals a Metabolic Checkpoint Controlling B Lymphocyte Development
2012 StandoutNobel
Redox regulation of FoxO transcription factors
2015
Paracrine Induction of HIF by Glutamate in Breast Cancer: EglN1 Senses Cysteine
2016 StandoutNobel
Rapamycin fed late in life extends lifespan in genetically heterogeneous mice
2009 StandoutNature
Cellular energy stress induces AMPK-mediated regulation of YAP and the Hippo pathway
2015
Integrating Physiological Regulation with Stem Cell and Tissue Homeostasis
2011
Stress and mTORture signaling
2006
Methods in Mammalian Autophagy Research
2010 Standout
Oxidative Stress in Cancer
2020 Standout
PBRM1 Regulates the Expression of Genes Involved in Metabolism and Cell Adhesion in Renal Clear Cell Carcinoma
2016
Autophagy and Aging
2011 Standout
GEFs and GAPs: Critical Elements in the Control of Small G Proteins
2007
Exosomes facilitate therapeutic targeting of oncogenic KRAS in pancreatic cancer
2017 StandoutNature
The Noncanonical Role of ULK/ATG1 in ER-to-Golgi Trafficking Is Essential for Cellular Homeostasis
2016
Ferroptosis: mechanisms, biology and role in disease
2021 Standout
The Hallmarks of Aging
2013 Standout
Optical Pooled Screens in Human Cells
2019
Energy Metabolism in the Liver
2014 Standout
Metabolic determinants of cancer cell sensitivity to canonical ferroptosis inducers
2020
The PI3K Pathway in Human Disease
2017 Standout
Ras, PI(3)K and mTOR signalling controls tumour cell growth
2006 StandoutNature
Artemisinin compounds sensitize cancer cells to ferroptosis by regulating iron homeostasis
2019
Hematopoietic AMPK β1 reduces mouse adipose tissue macrophage inflammation and insulin resistance in obesity
2011
A restricted cell population propagates glioblastoma growth after chemotherapy
2012 StandoutNature
The ubiquitin kinase PINK1 recruits autophagy receptors to induce mitophagy
2015 StandoutNature
Autophagy in immunity and inflammation
2011 StandoutNature
Modeling neurodevelopmental disorder-associated humanAGO1mutations inCaenorhabditis elegansArgonautealg-1
2024 StandoutNobel
Metabolic Regulation of Redox Status in Stem Cells
2014
FIP200 is required for the cell-autonomous maintenance of fetal hematopoietic stem cells
2010
Mice with mutations of Dock7 have generalized hypopigmentation and white-spotting but show normal neurological function
2009 StandoutNobel
Inactivation of the PBRM1 tumor suppressor gene amplifies the HIF-response in VHL −/− clear cell renal carcinoma
2017 StandoutNobel
Mitochondrial Fission, Fusion, and Stress
2012 StandoutScience
Role of AMPK-mTOR-Ulk1/2 in the Regulation of Autophagy: Cross Talk, Shortcuts, and Feedbacks
2011
EglN3 hydroxylase stabilizes BIM-EL linking VHL type 2C mutations to pheochromocytoma pathogenesis and chemotherapy resistance
2019 StandoutNobel
Differential control of Yorkie activity by LKB1/AMPK and the Hippo/Warts cascade in the central nervous system
2015
Human TKTL1 implies greater neurogenesis in frontal neocortex of modern humans than Neanderthals
2022 StandoutScienceNobel
pVHL suppresses kinase activity of Akt in a proline-hydroxylation–dependent manner
2016 StandoutScienceNobel
Copper induces cell death by targeting lipoylated TCA cycle proteins
2022 StandoutScience
Loss of the cystine/glutamate antiporter in melanoma abrogates tumor metastasis and markedly increases survival rates of mice
2020
BRCA1-IRIS promotes human tumor progression through PTEN blockade and HIF-1α activation
2018 StandoutNobel
Metabolic Regulation of Immune Responses
2014
Autophagy and Metabolism
2010 StandoutScience
Sudestada1, a Drosophila ribosomal prolyl-hydroxylase required for mRNA translation, cell homeostasis, and organ growth
2014 StandoutNobel
Cystine/glutamate antiporter xCT (SLC7A11) facilitates oncogenic RAS transformation by preserving intracellular redox balance
2019
Genetics and biology of pancreatic ductal adenocarcinoma
2016
Chemotherapy triggers HIF-1–dependent glutathione synthesis and copper chelation that induces the breast cancer stem cell phenotype
2015 StandoutNobel
Top-down design of protein architectures with reinforcement learning
2023 StandoutScienceNobel
Inhibition of the oxygen sensor PHD2 in the liver improves survival in lactic acidosis by activating the Cori cycle
2015 StandoutNobel
Mitochondrial activation chemicals synergize with surface receptor PD-1 blockade for T cell-dependent antitumor activity
2017 StandoutNobel
Works of Boyi Gan being referenced
Ablation of miR-10b Suppresses Oncogene-Induced Mammary Tumorigenesis and Metastasis and Reactivates Tumor-Suppressive Pathways
2016
FoxO Transcription Factors Promote AKT Ser473 Phosphorylation and Renal Tumor Growth in Response to Pharmacologic Inhibition of the PI3K–AKT Pathway
2014
Identification of FIP200 interaction with the TSC1–TSC2 complex and its role in regulation of cell size control
2005
The glutamate/cystine antiporter SLC7A11/xCT enhances cancer cell dependency on glucose by exporting glutamate
2017
FoxOs Enforce a Progression Checkpoint to Constrain mTORC1-Activated Renal Tumorigenesis
2010 StandoutNobel
PLAGL2 Regulates Wnt Signaling to Impede Differentiation in Neural Stem Cells and Gliomas
2010
Suppression of autophagy by FIP200 deletion inhibits mammary tumorigenesis
2011
BAP1 links metabolic regulation of ferroptosis to tumour suppression
2018
mTORC1 couples cyst(e)ine availability with GPX4 protein synthesis and ferroptosis regulation
2021
Sumoylation Delimits KLF8 Transcriptional Activity Associated with the Cell Cycle Regulation
2006
FAK-Mediated Src Phosphorylation of Endophilin A2 Inhibits Endocytosis of MT1-MMP and Promotes ECM Degradation
2005
Antitelomerase Therapy Provokes ALT and Mitochondrial Adaptive Mechanisms in Cancer
2012
FoxO family members in cancer
2011
DHODH-mediated ferroptosis defence is a targetable vulnerability in cancer
2021 Nature
Association of Focal Adhesion Kinase with Tuberous Sclerosis Complex 2 in the Regulation of S6 Kinase Activation and Cell Growth
2006
FIP200, a key signaling node to coordinately regulate various cellular processes
2007
Lkb1 regulates quiescence and metabolic homeostasis of haematopoietic stem cells
2010 Nature
Neural-specific Deletion of FIP200 Leads to Cerebellar Degeneration Caused by Increased Neuronal Death and Axon Degeneration
2009
The FoxO–BNIP3 axis exerts a unique regulation of mTORC1 and cell survival under energy stress
2013
The role of ferroptosis in ionizing radiation-induced cell death and tumor suppression
2020
Energy-stress-mediated AMPK activation inhibits ferroptosis
2020
AMPK modulates Hippo pathway activity to regulate energy homeostasis
2015
Amino acid transporter SLC7A11/xCT at the crossroads of regulating redox homeostasis and nutrient dependency of cancer
2018
Role of FIP200 in cardiac and liver development and its regulation of TNFα and TSC–mTOR signaling pathways
2006
BAP1 inhibits the ER stress gene regulatory network and modulates metabolic stress response
2017
mTORC1-dependent and -independent regulation of stem cell renewal, differentiation, and mobilization
2008
Regulation of H2A ubiquitination and SLC7A11 expression by BAP1 and PRC1
2019
BAP1 suppresses tumor development by inducing ferroptosis upon SLC7A11 repression
2018
Hepatic Suppression of Foxo1 and Foxo3 Causes Hypoglycemia and Hyperlipidemia in Mice
2011