Citation Impact
Citing Papers
Partitioning of Lipid-Modified Monomeric GFPs into Membrane Microdomains of Live Cells
2002 StandoutScienceNobel
Regulation of phosphoinositide 3-kinase expression in health and disease
2009
Switching of the coupling of the β2-adrenergic receptor to different G proteins by protein kinase A
1997 StandoutNatureNobel
Insulin Stimulates the Phosphorylation of the 66- and 52-Kilodalton Shc Isoforms by Distinct Pathways1
1997
Magnesium metabolism in type 2 diabetes mellitus, metabolic syndrome and insulin resistance
2006
Inflammation and metabolic disorders
2006 StandoutNature
The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism
2006 Standout
The p65 protein is a calmodulin-binding protein present in several types of secretory vesicles
1989
Reversal of Insulin Resistance Postpartum Is Linked to Enhanced Skeletal Muscle Insulin Signaling
2004
Gestational diabetes mellitus
2005 Standout
Molecular and physiologic actions of insulin related to production of nitric oxide in vascular endothelium
2003
Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B
1995 StandoutNature
Genetic and Pharmacological Evidence for a Novel, Intermediate Phase of Long-Term Potentiation Suppressed by Calcineurin
1998 StandoutNobel
The language of covalent histone modifications
2000 StandoutNature
Distinct Pathways of Gi- and Gq-mediated Mitogen-activated Protein Kinase Activation
1995 StandoutNobel
Epidermal growth factor receptor: mechanisms of activation and signalling
2003
The Signal-Dependent Coactivator CBP Is a Nuclear Target for pp90RSK
1996
Magnesium Replacement Improves the Metabolic Profile in Obese and Pre-Diabetic Patients with Mild-to-Moderate Chronic Kidney Disease: A 3-Month, Randomised, Double-Blind, Placebo-Controlled Study
2017 Standout
Insulin action in vascular endothelium: potential mechanisms linking insulin resistance with hypertension
2000
Visualizing the mechanical activation of Src
2005 StandoutNatureNobel
Characterization of selective resistance to insulin signaling in the vasculature of obese Zucker (fa/fa) rats
1999
Gβγ Subunits Mediate Mitogen-activated Protein Kinase Activation by the Tyrosine Kinase Insulin-like Growth Factor 1 Receptor
1995 StandoutNobel
Insulin and insulin-like growth factor signalling in neoplasia
2008 Standout
Phosphatidylinositol 3-Kinase Mediates the Inhibitory Effect of Epidermal Growth Factor on Calcium-dependent Chloride Secretion
1996
Involvement of the Ca2+-dependent Phosphatase Calcineurin in Gene Transcription That Is Stimulated by cAMP through cAMP Response Elements
1995
Cholesterol Depletion Disrupts Caveolae and Insulin Receptor Signaling for Metabolic Control via Insulin Receptor Substrate-1, but Not for Mitogen-activated Protein Kinase Control
2001
Insulin Regulation of Phosphoenolpyruvate Carboxykinase Gene Expression Does Not Require Activation of the Ras/Mitogen-activated Protein Kinase Signaling Pathway
1996
Mechanisms linking obesity to insulin resistance and type 2 diabetes
2006 StandoutNature
Insulin resistance in spontaneously hypertensive rats is associated with endothelial dysfunction characterized by imbalance between NO and ET-1 production
2005
Mitogenic Signaling via G Protein-Coupled Receptors
1996 StandoutNobel
Insulin signalling and the regulation of glucose and lipid metabolism
2001 StandoutNature
Oxidants, oxidative stress and the biology of ageing
2000 StandoutNature
Insulin resistance differentially affects the PI 3-kinase– and MAP kinase–mediated signaling in human muscle
2000
Prediction of preadipocyte differentiation by gene expression reveals role of insulin receptor substrates and necdin
2005
Mammalian MAP kinase signalling cascades
2001 StandoutNature
The PtdIns(3,4)P2 phosphatase INPP4A is a suppressor of excitotoxic neuronal death
2010 StandoutNatureNobel
Biochemistry and molecular cell biology of diabetic complications
2001 StandoutNature
Activation of the glucose transporter GLUT4 by insulin
2002
Substitution of three amino acids switches receptor specificity of Gqα to that of Giα
1993 StandoutNatureNobel
Adipocyte differentiation from the inside out
2006 Standout
The Hallmarks of Aging
2013 Standout
Insulin Signalling
1999
Phosphatidylinositol 3-Kinase Is an Early Intermediate in the Gβγ-mediated Mitogen-activated Protein Kinase Signaling Pathway
1996 StandoutNobel
Activating Mutations in the Epidermal Growth Factor Receptor Underlying Responsiveness of Non–Small-Cell Lung Cancer to Gefitinib
2004 Standout
Mitogen-activated Protein Kinase Kinase Inhibition Does Not Block the Stimulation of Glucose Utilization by Insulin
1995
Insulin-like Growth Factor-I Receptor Internalization Regulates Signaling via the Shc/Mitogen-activated Protein Kinase Pathway, but Not the Insulin Receptor Substrate-1 Pathway
1998
A β-Arrestin-dependent Scaffold Is Associated with Prolonged MAPK Activation in Pseudopodia during Protease-activated Receptor-2-induced Chemotaxis
2003
Insulin stimulates tyrosine phosphorylation of the proto-oncogene product of c-Cbl in 3T3-L1 adipocytes
1997
Dual modulation of cell survival and cell death by β 2 -adrenergic signaling in adult mouse cardiac myocytes
2001 StandoutNobel
Role of the Src Homology 2 (SH2) Domain and C-Terminus Tyrosine Phosphorylation Sites of SH2-Containing Inositol Phosphatase (SHIP) in the Regulation of Insulin-Induced Mitogenesis1
1999
Association of Insulin Receptor Substrate 1 with Simian Virus 40 Large T Antigen
1995
Reciprocal Relationships Between Insulin Resistance and Endothelial Dysfunction
2006 Standout
DAF-16 recruits the CREB-binding protein coactivator complex to the insulin-like growth factor binding protein 1 promoter in HepG2 cells
2000 StandoutNobel
Receptor-tyrosine-kinase- and Gβγ-mediated MAP kinase activation by a common signalling pathway
1995 StandoutNatureNobel
Sirtuin 1 and Sirtuin 3: Physiological Modulators of Metabolism
2012
β-Arrestin-Dependent Formation of β 2 Adrenergic Receptor-Src Protein Kinase Complexes
1999 StandoutScienceNobel
Insulin-Dependent Activation of Endothelial Nitric Oxide Synthase Is Impaired by O-Linked Glycosylation Modification of Signaling Proteins in Human Coronary Endothelial Cells
2002
Targeting G βγ signaling in arterial vascular smooth muscle proliferation: A novel strategy to limit restenosis
1999 StandoutNobel
Loss of Insulin Signaling in Hepatocytes Leads to Severe Insulin Resistance and Progressive Hepatic Dysfunction
2000
Phosphoinositide 3-Kinase Catalytic Subunit Deletion and Regulatory Subunit Deletion Have Opposite Effects on Insulin Sensitivity in Mice
2005
Cyclosporin A stimulation of glucose-induced insulin secretion in MIN6 cells.
1996
β-arrestin- but not G protein-mediated signaling by the “decoy” receptor CXCR7
2009 StandoutNobel
Insulin Resistance and the Polycystic Ovary Syndrome: Mechanism and Implications for Pathogenesis*
1997 Standout
G protein beta gamma subunits stimulate phosphorylation of Shc adapter protein.
1995 StandoutNobel
Phosphoinositide 3-kinase: the key switch mechanism in insulin signalling
1998
A chemical approach for identifying O -GlcNAc-modified proteins in cells
2003 StandoutNobel
Hypoxia-inducible factor 1-dependent expression of adenosine receptor 2B promotes breast cancer stem cell enrichment
2018 StandoutNobel
Insulin Receptor Substrate-1 and Phosphoinositide-Dependent Kinase-1 Are Required for Insulin-Stimulated Production of Nitric Oxide in Endothelial Cells
2002
The IRS-signalling system: A network of docking proteins that mediate insulin action
1998
Promotion of the GTP-liganded state of the Go alpha protein by deletion of the C terminus.
1992
Induction of p130cas Signaling Complex Formation upon Integrin-Mediated Cell Adhesion: a Role for Src Family Kinases
1996
G972R IRS-1 Variant Impairs Insulin Regulation of Endothelial Nitric Oxide Synthase in Cultured Human Endothelial Cells
2004
Synthesis of an organoinsulin molecule that can be activated by antibody catalysis
2001 StandoutNobel
CELLULAR FUNCTIONS REGULATED BY SRC FAMILY KINASES
1997 Standout
1997 StandoutNobel
Activation of cJun NH2-Terminal Kinase/Stress-Activated Protein Kinase by Insulin
1996
Dehydroepiandrosterone Mimics Acute Actions of Insulin to Stimulate Production of Both Nitric Oxide and Endothelin 1 via Distinct Phosphatidylinositol 3-Kinase- and Mitogen-Activated Protein Kinase-Dependent Pathways in Vascular Endothelium
2005
Critical nodes in signalling pathways: insights into insulin action
2006 Standout
Repeated pulses of serotonin required for long-term facilitation activate mitogen-activated protein kinase in sensory neurons of Aplysia
1998 StandoutNobel
Cyclosporine A-induced hypertension involves synapsin in renal sensory nerve endings
2000 StandoutNobel
An Adenosine-Mediated Signaling Pathway Suppresses Prenylation of the GTPase Rap1B and Promotes Cell Scattering
2013
Synaptotagmin: a Calcium Sensor on the Synaptic Vesicle Surface
1992 StandoutScienceNobel
Aquaglyceroporin AQP9: Solute permeation and metabolic control of expression in liver
2003 StandoutNobel
Mitogen-Activated Protein Kinase: Conservation of a Three-Kinase Module From Yeast to Human
1999 Standout
Activation and targeting of extracellular signal-regulated kinases by β-arrestin scaffolds
2001 StandoutNobel
Regulation of Mitogen-Activated Protein Kinase Signaling Networks by G Protein-Coupled Receptors
2000
β-Cell Deficit and Increased β-Cell Apoptosis in Humans With Type 2 Diabetes
2003 Standout
Shc adaptor proteins are key transducers of mitogenic signaling mediated by the G protein-coupled thrombin receptor.
1996
Phosphoinositide 3-kinase regulatory subunit p85α suppresses insulin action via positive regulation of PTEN
2006
The p85 regulatory subunit of phosphoinositide 3-kinase down-regulates IRS-1 signaling via the formation of a sequestration complex
2005
Insulin signal transduction through protein kinase cascades
1998
Modulation of Muscle Regeneration, Myogenesis, and Adipogenesis by the Rho Family Guanine Nucleotide Exchange Factor GEFT
2005
The IRS-signalling system: A network of docking proteins that mediate insulin action
1998
CREB: A Stimulus-Induced Transcription Factor Activated by A Diverse Array of Extracellular Signals
1999 Standout
Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation
2009 StandoutScience
Role of Brain Insulin Receptor in Control of Body Weight and Reproduction
2000 StandoutScience
Phosphotyrosine-Dependent Interaction of SHC and Insulin Receptor Substrate 1 with the NPEY Motif of the Insulin Receptor via a Novel Non-SH2 Domain
1995
Phosphatidylinositol 3-kinase is necessary and sufficient for insulin-stimulated stress fiber breakdown.
1996
Role of endocytosis in the activation of the extracellular signal-regulated kinase cascade by sequestering and nonsequestering G protein-coupled receptors
2000 StandoutNobel
Transduction of Receptor Signals by ß-Arrestins
2005 StandoutScienceNobel
Increased p85/55/50 Expression and Decreased Phosphotidylinositol 3-Kinase Activity in Insulin-Resistant Human Skeletal Muscle
2005
Works of Boris Draznin being referenced
Molecular Biology of Diabetes
1994
Insulin-induced Adipocyte Differentiation
2001
Inhibition of Phosphatidylinositol 3-Kinase Enhances Mitogenic Actions of Insulin in Endothelial Cells
2002
Regulation of GLUT-4 Phosphorylation by Intracellular Calcium in Adipocytes*
1991
Increased P85α Is a Potent Negative Regulator of Skeletal Muscle Insulin Signaling and Induces in Vivo Insulin Resistance Associated with Growth Hormone Excess
2005
Effect of Insulin on Farnesyltransferase Gene Transcription and mRNA Stability
1999
Cyclosporin-induced inhibition of insulin release
1988
Differential Requirement for p21 Activation in the Metabolic Signaling by Insulin
1995
Insulin Signals to Prenyltransferases via the Shc Branch of Intracellular Signaling
2001
Insulin and glucose modulate protein kinase C activity in rat adipocytes
1988
Functional Interactions of Phosphatidylinositol 3-Kinase with GTPase-Activating Protein in 3T3-L1 Adipocytes
1996
Human Placental Growth Hormone Increases Expression of the P85 Regulatory Unit of Phosphatidylinositol 3-Kinase and Triggers Severe Insulin Resistance in Skeletal Muscle
2003
GLUT-4 phosphorylation and its intrinsic activity. Mechanism of Ca(2+)-induced inhibition of insulin-stimulated glucose transport.
1993
The signaling pathway coupling epidermal growth factor receptors to activation of p21ras.
1994
Mechanism of impaired metabolic signaling by a truncated human insulin receptor. Decreased activation of protein phosphatase 1 by insulin.
1993
Growth Hormone Regulation of p85α Expression and Phosphoinositide 3-Kinase Activity in Adipose Tissue
2007
Cytosolic Free-Calcium Concentrations in Normal Pancreatic Islet Cells: Effect of Secretagogues and Somatostatin
1987
Insulin activates p21Ras and guanine nucleotide releasing factor in cells expressing wild type and mutant insulin receptors.
1993
Insulin and insulin-like growth factor-I signal transduction requires p21ras.
1994
Shc is the predominant signaling molecule coupling insulin receptors to activation of guanine nucleotide releasing factor and p21ras-GTP formation.
1994
Signal Transduction Pathways Leading to Insulin-Induced Early Gene Induction
1995
Evidence that p21ras mediates the neurotrophic effects of insulin and insulin-like growth factor I in chick forebrain neurons.
1994
Somatostatin inhibits fusion of pituitary secretion vesicles with the plasma membranes
1986
Clinical Research in Diabetes and Obesity
1997
Insulin Potentiates Platelet-Derived Growth Factor Action in Vascular Smooth Muscle Cells**This work was supported by grants from the VA Research Service, the NIH (HL-48920 to R.N., HD-24497–06 to J.S.), PO-1-HL-55798 (to J.N. and R.N.), jointly funded by the NIH and the Juvenile Diabetes Foundation, the American Heart Association, a fellowship support from the American Heart Association (to M.G.), HealthONE Foundation: Diabetes and Endocrine Research and Education Fund, and Foundation for Biomedical Education and Research.
1998
Phosphatidylinositol 3-Kinase Redistribution Is Associated With Skeletal Muscle Insulin Resistance in Gestational Diabetes Mellitus
2002
Molecular Mechanisms of Insulin Resistance: Serine Phosphorylation of Insulin Receptor Substrate-1 and Increased Expression of p85α
2006
Inverse relationship between GLUT-4 phosphorylation and its intrinsic activity.
1993
Evidence for a functional role of Shc proteins in mitogenic signaling induced by insulin, insulin-like growth factor-1, and epidermal growth factor.
1994
Insulin inhibits dephosphorylation of adenosine 3',5'-monophosphate response element-binding protein/activating transcription factor-1: effect on nuclear phosphoserine phosphatase-2a.
1994