Standout Papers
Citation Impact
Citing Papers
High-throughput characterization of protein–protein interactions by reprogramming yeast mating
2017 StandoutNobel
TFEB Links Autophagy to Lysosomal Biogenesis
2011 StandoutScience
Phosphorylation of ULK1 (hATG1) by AMP-Activated Protein Kinase Connects Energy Sensing to Mitophagy
2010 StandoutScience
A Gene Network Regulating Lysosomal Biogenesis and Function
2009 StandoutScience
Modulation of immune cell reactivity with cis -binding Siglec agonists
2021 StandoutNobel
Intrinsic evolutionary constraints on protease structure, enzyme acylation, and the identity of the catalytic triad
2013
Directed Evolution Mimics Allosteric Activation by Stepwise Tuning of the Conformational Ensemble
2018 StandoutNobel
Transferrin receptor targeting by de novo sheet extension
2021 StandoutNobel
De novo design of self-assembling helical protein filaments
2018 StandoutScienceNobel
Hallucinating symmetric protein assemblies
2022 StandoutScienceNobel
Designed protein logic to target cells with precise combinations of surface antigens
2020 StandoutScienceNobel
Contribution of Bcl-2 Phosphorylation to Bak Binding and Drug Resistance
2013
NLRP4 Negatively Regulates Autophagic Processes through an Association with Beclin1
2011
Imperfect interface of Beclin1 coiled-coil domain regulates homodimer and heterodimer formation with Atg14L and UVRAG
2012
De novo design of modular and tunable protein biosensors
2021 StandoutNatureNobel
A Non-canonical MEK/ERK Signaling Pathway Regulates Autophagy via Regulating Beclin 1
2009
Hallmarks of Cancer: The Next Generation
2011 Standout
Ambra1 regulates autophagy and development of the nervous system
2007 Nature
HSV-1 ICP34.5 Confers Neurovirulence by Targeting the Beclin 1 Autophagy Protein
2007
Autophagy in Viral Replication and Pathogenesis
2010
Autophagosomes form at ER–mitochondria contact sites
2013 StandoutNature
Autophagy in infection, inflammation and immunity
2013 Standout
A Neuron-Specific Role for Autophagy in Antiviral Defense against Herpes Simplex Virus
2012
Inhibition of autophagy by TAB2 and TAB3
2011
Autophagy in the liver
2008
Crystal Structure of the Bcl-XL-Beclin 1 Peptide Complex
2007
Intestinal homeostasis and its breakdown in inflammatory bowel disease
2011 StandoutNature
ULK1 induces autophagy by phosphorylating Beclin-1 and activating VPS34 lipid kinase
2013
Mammalian phosphoinositide kinases and phosphatases
2009 StandoutNobel
Functions of autophagy in normal and diseased liver
2013
Bcl-2 family members: Dual regulators of apoptosis and autophagy
2008
BID-induced structural changes in BAK promote apoptosis
2013
A role for mitochondria in NLRP3 inflammasome activation
2010 StandoutNature
Autophagy fights disease through cellular self-digestion
2008 StandoutNature
Molecular basis of the regulation of Beclin 1-dependent autophagy by the γ-herpesvirus 68 Bcl-2 homolog M11
2008
The Beclin 1 interactome
2010
Two Beclin 1-binding proteins, Atg14L and Rubicon, reciprocally regulate autophagy at different stages
2009
BCL-2 family proteins: changing partners in the dance towards death
2017
Unveiling the roles of autophagy in innate and adaptive immunity
2007
Matrix Protein 2 of Influenza A Virus Blocks Autophagosome Fusion with Lysosomes
2009
Autophagy-deficient mice develop multiple liver tumors
2011
Bif-1 interacts with Beclin 1 through UVRAG and regulates autophagy and tumorigenesis
2007
Decoding ALS: from genes to mechanism
2016 StandoutNature
Network organization of the human autophagy system
2010 StandoutNature
Viral evasion of autophagy
2008
A Computationally Designed Inhibitor of an Epstein-Barr Viral Bcl-2 Protein Induces Apoptosis in Infected Cells
2014 StandoutNobel
Autophagy, Immunity, and Microbial Adaptations
2009
Physiological functions of Atg6/Beclin 1: a unique autophagy-related protein
2007
Viral interactions with macroautophagy: A double-edged sword
2010
Design of biologically active binary protein 2D materials
2021 StandoutNatureNobel
Tumor suppressors and cell metabolism: a recipe for cancer growth
2009
Autophagy in the Pathogenesis of Disease
2008 Standout
Mutation to Bax beyond the BH3 Domain Disrupts Interactions with Pro-survival Proteins and Promotes Apoptosis
2011
Cell Death
2009
Structure of the Novel C-terminal Domain of Vacuolar Protein Sorting 30/Autophagy-related Protein 6 and Its Specific Role in Autophagy
2012 StandoutNobel
Autophagy in Human Health and Disease
2013 Standout
The Beclin 1 network regulates autophagy and apoptosis
2011 Standout
A Unified Model of Mammalian BCL-2 Protein Family Interactions at the Mitochondria
2011
The emerging mechanisms of isoform-specific PI3K signalling
2010
Signalling and autophagy regulation in health, aging and disease
2006
De novo design of bioactive protein switches
2019 StandoutNatureNobel
Autophagy modulation as a potential therapeutic target for diverse diseases
2012 Standout
Beclin1-binding UVRAG targets the class C Vps complex to coordinate autophagosome maturation and endocytic trafficking
2008
Down‐regulation of Bax‐interacting factor‐1 in colorectal adenocarcinoma
2008
Viral Bcl-2-Mediated Evasion of Autophagy Aids Chronic Infection of γHerpesvirus 68
2009
Control of apoptosis by the BCL-2 protein family: implications for physiology and therapy
2013 Standout
Inflammatory caspases are innate immune receptors for intracellular LPS
2014 StandoutNature
Anti-Vascular Endothelial Growth Factors Protect Retinal Pigment Epithelium Cells Against Oxidation by Modulating Nitric Oxide Release and Autophagy
2017 Standout
Anti- and pro-tumor functions of autophagy
2009
The PtdIns(3,4)P2 phosphatase INPP4A is a suppressor of excitotoxic neuronal death
2010 StandoutNatureNobel
hvps34, an ancient player, enters a growing game: mTOR Complex1/S6K1 signaling
2007
Self-eating and self-killing: crosstalk between autophagy and apoptosis
2007 Standout
A Picky Eater: Exploring the Mechanisms of Selective Autophagy in Human Pathologies
2007
DAP‐kinase‐mediated phosphorylation on the BH3 domain of beclin 1 promotes dissociation of beclin 1 from Bcl‐XL and induction of autophagy
2009
The Beclin 1–VPS34 complex – at the crossroads of autophagy and beyond
2010
Autophagy and pattern recognition receptors in innate immunity
2008
Autophagic pathways as new targets for cancer drug development
2010
Repertoires of Autophagy in the Pathogenesis of Ocular Diseases
2015 Standout
Autophagy: process and function
2007 Standout
The Hallmarks of Aging
2013 Standout
The Pancreatitis-induced Vacuole Membrane Protein 1 Triggers Autophagy in Mammalian Cells
2007
Toward unraveling membrane biogenesis in mammalian autophagy
2008
Crystal structure and biochemical analyses reveal Beclin 1 as a novel membrane binding protein
2012
Termination of autophagy and reformation of lysosomes regulated by mTOR
2010 StandoutNature
The autophagy-related protein beclin 1 shows reduced expression in early Alzheimer disease and regulates amyloid β accumulation in mice
2008
Involvement of autophagy in viral infections: antiviral function and subversion by viruses
2007
FLIP-mediated autophagy regulation in cell death control
2009
TMEM41B Is a Pan-flavivirus Host Factor
2020 StandoutNobel
Autophagy: cellular and molecular mechanisms
2010 Standout
Autophagy in immunity and inflammation
2011 StandoutNature
Proteins evolve on the edge of supramolecular self-assembly
2017 Nature
The cellular pathways of neuronal autophagy and their implication in neurodegenerative diseases
2009
The autophagy effector Beclin 1: a novel BH3-only protein
2008
ATG1, an autophagy regulator, inhibits cell growth by negatively regulating S6 kinase
2007
Simple yet functional phosphate-loop proteins
2018 StandoutNobel
The early autophagic pathway is activated by hepatitis B virus and required for viral DNA replication
2010
Circadian clock disruption improves the efficacy of chemotherapy through p73-mediated apoptosis
2011 StandoutNobel
Detection of self-reactive CD8 + T cells with an anergic phenotype in healthy individuals
2014 StandoutScienceNobel
The regulation and function of Class III PI3Ks: novel roles for Vps34
2008
Autophagy—A double‐edged sword in oncology
2009
Structural mechanism of host Rab1 activation by the bifunctional Legionella type IV effector SidM/DrrA
2010
Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1β production
2008 StandoutNature
ATG Systems from the Protein Structural Point of View
2009 StandoutNobel
Computationally designed high specificity inhibitors delineate the roles of BCL2 family proteins in cancer
2016 StandoutNobel
Membrane proteomics of phagosomes suggests a connection to autophagy
2008 StandoutNobel
α/β-Peptide Foldamers Targeting Intracellular Protein–Protein Interactions with Activity in Living Cells
2015
Coordination of membrane events during autophagy by multiple class III PI3-kinase complexes
2009
Regulation of apoptosis by the circadian clock through NF-κB signaling
2011 StandoutNobel
Beclin 1 Forms Two Distinct Phosphatidylinositol 3-Kinase Complexes with Mammalian Atg14 and UVRAG
2008
Atg13 HORMA domain recruits Atg9 vesicles during autophagosome formation
2015 StandoutNobel
Identification of Barkor as a mammalian autophagy-specific factor for Beclin 1 and class III phosphatidylinositol 3-kinase
2008
Autophagy and Metabolism
2010 StandoutScience
Peptide Ligands for Pro-survival Protein Bfl-1 from Computationally Guided Library Screening
2013
Mitophagy confers resistance to siderophore-mediated killing by Pseudomonas aeruginosa
2015 StandoutNobel
NIX is required for programmed mitochondrial clearance during reticulocyte maturation
2007
Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation
2009 StandoutScience
Regulation of Mammalian Autophagy in Physiology and Pathophysiology
2010 Standout
Evaluation of Diverse α/β-Backbone Patterns for Functional α-Helix Mimicry: Analogues of the Bim BH3 Domain
2011
Autophagy in Health and Disease: A Double-Edged Sword
2004 StandoutScience
Works of Bonsu Ku being referenced
Crystal structure of DeSI‐1, a novel deSUMOylase belonging to a putative isopeptidase superfamily
2012
Autophagic and tumour suppressor activity of a novel Beclin1-binding protein UVRAG
2006 Standout
UVRAG: A New Player in Autophagy and Tumor Cell Growth
2007
Crystal Structures and Enzyme Mechanisms of a Dual Fucose Mutarotase/Ribose Pyranase
2009
Evidence that inhibition of BAX activation by BCL-2 involves its tight and preferential interaction with the BH3 domain of BAX
2010
Structural insights into the dual nucleotide exchange and GDI displacement activity of SidM/DrrA
2009
Structural and Biochemical Bases for the Inhibition of Autophagy and Apoptosis by Viral BCL-2 of Murine γ-Herpesvirus 68
2008
An insight into the mechanistic role of Beclin 1 and its inhibition by prosurvival Bcl-2 family proteins
2008