Citation Impact
Citing Papers
HIFα Targeted for VHL-Mediated Destruction by Proline Hydroxylation: Implications for O 2 Sensing
2001 StandoutScienceNobel
A unique type of GSK-3 inhibitor brings new opportunities to the clinic
2016
Phosphorylation of Dishevelled by Protein Kinase RIPK4 Regulates Wnt Signaling
2013 Science
Pharmacological Inhibition of the Wnt Acyltransferase PORCN Prevents Growth of WNT-Driven Mammary Cancer
2012
A Novel Tankyrase Small-Molecule Inhibitor Suppresses APC Mutation–Driven Colorectal Tumor Growth
2013
Nuclear-cytoplasmic shuttling of APC regulates β-catenin subcellular localization and turnover
2000
Hereditary desmoid disease due to a frameshift mutation at codon 1924 of the APC gene.
1996
β-Catenin Controls Hair Follicle Morphogenesis and Stem Cell Differentiation in the Skin
2001 Standout
The Xenopus Wnt effector XTcf-3 interacts with Groucho-related transcriptional repressors
1998 Nature
Hallmarks of Cancer: The Next Generation
2011 Standout
Drosophila Tcf and Groucho interact to repress Wingless signalling activity
1998 Nature
-Catenin degradation mediated by the CID domain of APC provides a model for the selection of APC mutations in colorectal, desmoid and duodenal tumours
2008
PDGF β-receptor stimulates tyrosine phosphorylation of GAP and association of GAP with a signaling complex
1990
Chapter 2 PI3K/PTEN Signaling in Angiogenesis and Tumorigenesis
2009
Switching of the coupling of the β2-adrenergic receptor to different G proteins by protein kinase A
1997 StandoutNatureNobel
Small-molecule antagonists of the oncogenic Tcf/β-catenin protein complex
2004
Proteins regulating Ras and its relatives
1993 StandoutNature
Caught up in a Wnt storm: Wnt signaling in cancer
2003
S. cerevisiae genes IRA1 and IRA2 encode proteins that may be functionally equivalent to mammalian ras GTPase activating protein
1990
β-Catenin regulates expression of cyclin D1 in colon carcinoma cells
1999 StandoutNature
Axin and Frat1 interact with Dvl and GSK, bridging Dvl to GSK in Wnt-mediated regulation of LEF-1
1999
Structural basis of the Axin–adenomatous polyposis coli interaction
2000
Wnt Regulates Spindle Asymmetry to Generate Asymmetric Nuclear β-Catenin in C. elegans
2011
Can we safely target the WNT pathway?
2014
Desmosomal Cadherin Binding Domains of Plakoglobin
1996
Glycogen synthase kinase-3β regulates cyclin D1 proteolysis and subcellular localization
1998 Standout
Tumor-suppressor gene products in cell contacts: the cad herin-APC-armadillo connection
1994
The β-Catenin/TCF-4 Complex Imposes a Crypt Progenitor Phenotype on Colorectal Cancer Cells
2002 Standout
β-catenin: a key mediator of Wnt signaling
1998
ras and GAP—Who's controlling whom?
1990
Cytoplasmically Anchored Plakoglobin Induces a WNT-like Phenotype inXenopus
1997
SCFbeta-TrCP ubiquitin ligase-mediated processing of NF-kappaB p105 requires phosphorylation of its C-terminus by IkappaB kinase
2000
Loss of Apc in vivo immediately perturbs Wnt signaling, differentiation, and migration
2004
The SH2 and SH3 domain-containing protein GRB2 links receptor tyrosine kinases to ras signaling
1992 Standout
Functional interaction of β-catenin with the transcription factor LEF-1
1996 StandoutNature
The PH domain: a common piece in the structural pathcwork of signalling proteins
1993
The GTPase superfamily: a conserved switch for diverse cell functions
1990 StandoutNature
Overexpression of cadherins and underexpression of ?-catenin inhibit dorsal mesoderm induction in early Xenopus embryos
1994
Control of β-Catenin Phosphorylation/Degradation by a Dual-Kinase Mechanism
2002 Standout
Serine Phosphorylation-regulated Ubiquitination and Degradation of β-Catenin
1997
Induction of Pluripotent Stem Cells from Mouse Embryonic and Adult Fibroblast Cultures by Defined Factors
2006 StandoutNobel
Roles of Axin in the Wnt Signalling Pathway
1999
The human F box protein β-Trcp associates with the Cul1/Skp1 complex and regulates the stability of β-catenin
1999
Wnt/β-Catenin Signaling Induces the Expression and Activity of βTrCP Ubiquitin Ligase Receptor
2000
A common human skin tumour is caused by activating mutations in β-catenin
1999
The neurofibromatosis type 1 gene encodes a protein related to GAP
1990 Standout
Wnt Signaling and an APC-Related Gene Specify Endoderm in Early C. elegans Embryos
1997 StandoutNobel
Differential molecular interactions of β-catenin and plakoglobin in adhesion, signaling and cancer
1998
The R-spondin/Lgr5/Rnf43 module: regulator of Wnt signal strength
2014
Carcinogenesis: A balance between β-catenin and APC
1997
Rabbit intestine contains a protein that inhibits the dissociation of GDP from and the subsequent binding of GTP to rhoB p20, a ras p21-like GTP-binding protein
1989
Propagation and localization of Wnt signaling
1998
Restricted High Level Expression of Tcf-4 Protein in Intestinal and Mammary Gland Epithelium
1999
Crystal Structure of Glycogen Synthase Kinase 3β
2001
WNTs modulate cell fate and behavior during vertebrate development
1997
Regulation of β-Catenin Signaling in the Wnt Pathway
2000
Nuclear localization of β-catenin by interaction with transcription factor LEF-1
1996
The GAP-related domain of the neurofibromatosis type 1 gene product interacts with ras p21
1990
A yeast GTPase-activating protein that interacts specifically with a member of the Ypt/Rab family
1993 Nature
The renaissance of GSK3
2001
Regulators and Effectors of ras Proteins
1991
Structure of the guanine-nucleotide-binding domain of the Ha-ras oncogene product p21 in the triphosphate conformation
1989 Nature
A GSK3β Phosphorylation Site in Axin Modulates Interaction with β-Catenin and Tcf-Mediated Gene Expression
1999
Wnt Signaling through Inhibition of β-Catenin Degradation in an Intact Axin1 Complex
2012
Lessons from Hereditary Colorectal Cancer
1996 Standout
Tumor suppressor genes
1991 Standout
Axis determination in Xenopus involves biochemical interactions of axin, glycogen synthase kinase 3 and β-catenin
1998
Molecular cloning of cDNAs encoding the GAP-associated protein p190: Implications for a signaling pathway from ras to the nucleus
1992
Wnt genes and vertebrate development
1994
Suppression of c-ras transformation by GTPase-activating protein
1990 Nature
Three-Dimensional Structure of the Armadillo Repeat Region of β-Catenin
1997
Signal transduction by β-catenin
1995
Crystal structure of a β-catenin/Axin complex suggests a mechanism for the β-catenin destruction complex
2003
Substrate Targeting in the Ubiquitin System
1999
β-catenin is a target for the ubiquitin–proteasome pathway
1997 Standout
Cadherins, catenins and APC protein: interplay between cytoskeletal complexes and signaling pathways
1997
CKI, there's more than one: casein kinase I family members in Wnt and Hedgehog signaling
2006
Single Amino Acid Substitutions in Proteins of the armadillo Gene Family Abolish Their Binding to α-Catenin
1996
A GSK3‐binding peptide from FRAT1 selectively inhibits the GSK3‐catalysed phosphorylation of Axin and β‐catenin
1999
The SCFbeta -TRCP-ubiquitin ligase complex associates specifically with phosphorylated destruction motifs in Ikappa Balpha and beta -catenin and stimulates Ikappa Balpha ubiquitination in vitro
1999
Drosophila CBP represses the transcription factor TCF to antagonize Wingless signalling
1998 Nature
E-cadherin, β-catenin, and ZEB1 in malignant progression of cancer
2009
Wnt/β-Catenin Signaling and Disease
2012 Standout
Wnt/β-Catenin Signaling: Components, Mechanisms, and Diseases
2009 Standout
SNAP receptors implicated in vesicle targeting and fusion
1993 StandoutNatureNobel
Armadillo Coactivates Transcription Driven by the Product of the Drosophila Segment Polarity Gene dTCF
1997
Crystal structure of the β2 adrenergic receptor–Gs protein complex
2011 StandoutNatureNobel
Association between GTPase activators for Rho and Ras families
1992 Nature
Signal transduction through beta-catenin and specification of cell fate during embryogenesis.
1996
AXIN1 mutations but not deletions in cerebellar medulloblastomas
2003
Differential Regulation of Glycogen Synthase Kinase 3β by Insulin and Wnt Signaling
2000
BUD2 encodes a GTPase-activating protein for Budl/Rsrl necessary for proper bud-site selection in yeast
1993 Nature
Wnt-induced dephosphorylation of Axin releases beta -catenin from the Axin complex
1999
Evidence that Fold-Change, and Not Absolute Level, of β-Catenin Dictates Wnt Signaling
2009
Familial infiltrative fibromatosis (desmoid tumours) (MIM135290) caused by a recurrent 3' APC gene mutation
1996
A role for Wnt signalling in self-renewal of haematopoietic stem cells
2003 StandoutNature
Wnt addiction of genetically defined cancers reversed by PORCN inhibition
2015
C2-domains, Structure and Function of a Universal Ca2+-binding Domain
1998 StandoutNobel
Systematic Mapping of WNT-FZD Protein Interactions Reveals Functional Selectivity by Distinct WNT-FZD Pairs
2015
Axin, a negative regulator of the Wnt signaling pathway, forms a complex with GSK-3beta and beta -catenin and promotes GSK-3beta -dependent phosphorylation of beta -catenin
1998
Genetic analysis of mammalian GAP expressed in yeast
1989
Cell–cell signalling: Wingless lands at last
1996
Armadillo and dTCF: a marriage made in the nucleus
1997 Standout
Wnt Signaling Controls the Phosphorylation Status of β-Catenin
2002
Generation of germline-competent induced pluripotent stem cells
2007 StandoutNatureNobel
Linking Colorectal Cancer to Wnt Signaling
2000
The Yin-Yang of TCF/β-Catenin Signaling
1999
Control of β-Catenin Stability
2000
Regulation of LEF-1/TCF transcription factors by Wnt and other signals
1999
Catenins, Wnt signaling and cancer
2000
Regulation of Armadillo by a Drosophila APC Inhibits Neuronal Apoptosis during Retinal Development
1998 Nobel
Wnt/β-Catenin Signaling in Development and Disease
2006 Standout
TCF/LEF factors earn their wings
1997
Chromosome localization and cDNA sequence of murine and human genes forras p21 GTPase activating protein (GAP)
1989
The adenomatous polyposis coli (APC) tumor suppressor
1997
CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice
1994 Standout
The Roles of APC and Axin Derived from Experimental and Theoretical Analysis of the Wnt Pathway
2003
Distinct β-catenins mediate adhesion and signalling functions in C. elegans
2000 Nature
A β-catenin/XTcf-3 complex binds to thesiamois promoter to regulate dorsal axis specification in Xenopus
1997
Expression of CD44 in Apc and TcfMutant Mice Implies Regulation by the WNT Pathway
1999
Use of MMTV-Wnt-1 transgenic mice for studying the genetic basis of breast cancer
2000 Nobel
Lithium inhibits glycogen synthase kinase-3 activity and mimics Wingless signalling in intact cells
1996
cAMP Activates MAP Kinase and Elk-1 through a B-Raf- and Rap1-Dependent Pathway
1997 Standout
β-catenin in Epithelial Morphogenesis: Conversion of Part of Avian Foot Scales into Feather Buds with a Mutated β-Catenin
2000
De Novo Hair Follicle Morphogenesis and Hair Tumors in Mice Expressing a Truncated β-Catenin in Skin
1998 Standout
Probing the canonicity of the Wnt/Wingless signaling pathway
2017
Cellular and Molecular Biology of the Presynaptic Nerve Terminal
1991
Missing Links in GSK3 Regulation
2001
Cell adhesion and signal transduction: the Armadillo connection
1995
SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27
1999 StandoutNobel
Ras-dependent activation of MAP kinase pathway mediated by G-protein βγ subunits
1994 Nature
An F-box protein, FWD1, mediates ubiquitin-dependent proteolysis of β-catenin
1999
The NF1 locus encodes a protein functionally related to mammalian GAP and yeast IRA proteins
1990
TSC2 Integrates Wnt and Energy Signals via a Coordinated Phosphorylation by AMPK and GSK3 to Regulate Cell Growth
2006 Standout
β-catenin directly displaces Groucho/TLE repressors from Tcf/Lef in Wnt-mediated transcription activation
2005
SH3 — an abundant protein domain in search of a function
1992
β-Catenin signals regulate cell growth and the balance between progenitor cell expansion and differentiation in the nervous system
2003
Wnt signalling in stem cells and cancer
2005 StandoutNature
Serpentine Proteins Slither into the Wingless and Hedgehog Fields
1996
ras p21 and GAP inhibit coupling of muscarinic receptors to atrial K+ channels
1990
Phosphorylation of GAP and GAP-associated proteins by transforming and mitogenic tyrosine kinases
1990 Nature
Wnt signaling: why is everything so negative?
1998
A ubiquitin-like system mediates protein lipidation
2000 StandoutNatureNobel
Granulocyte–Macrophage Progenitors as Candidate Leukemic Stem Cells in Blast-Crisis CML
2004
cDNA cloning of the type 1 neurofibromatosis gene: Complete sequence of the NF1 gene product
1991
Nuclear localization signal-independent and importin/karyopherin-independent nuclear import of β-catenin
1998
AXIN1 mutations in hepatocellular carcinomas, and growth suppression in cancer cells by virus-mediated transfer of AXIN1
2000
The APC tumour suppressor has a nuclear export function
2000 Nature
A Common Phosphate Binding Site Explains the Unique Substrate Specificity of GSK3 and Its Inactivation by Phosphorylation
2001
Casein kinase I transduces Wnt signals
1999 Nature
Wnt/β-Catenin Signaling, Disease, and Emerging Therapeutic Modalities
2017 Standout
The synaptic vesicle cycle: a cascade of protein–protein interactions
1995 StandoutNatureNobel
Intestinal polyposis in mice with a dominant stable mutation of the beta -catenin gene
1999
Structure at 2.8 Â resolution of F1-ATPase from bovine heart mitochondria
1994 StandoutNatureNobel
Mechanisms of intracellular protein transport
1994 StandoutNatureNobel
Activation of the cloned muscarinic potassium channel by G protein βγ subunits
1994 StandoutNatureNobel
Modes of regulation of ubiquitin-mediated protein degradation
2000 StandoutNobel
Identification and partial purification of GTPase‐activating proteins from yeast and mammalian cells that preferentially act on Ypt1/Rab1 proteins
1991
Depletion of epithelial stem-cell compartments in the small intestine of mice lacking Tcf-4
1998
Phosphorylation of Axin, a Wnt Signal Negative Regulator, by Glycogen Synthase Kinase-3β Regulates Its Stability
1999
Inhibition of NF-kappa B cellular function via specific targeting of the Ikappa B-ubiquitin ligase
1997
CRYSTAL STRUCTURE OF THE SH3 DOMAIN IN HUMAN FYN; COMPARISON OF THE THREE-DIMENSIONAL STRUCTURES OF SH3 DOMAINS IN TYROSINE KINASES AND SPECTRIN
1993
Selective small molecule inhibitors of glycogen synthase kinase-3 modulate glycogen metabolism and gene transcription
2000
Attenuated familial adenomatous polyposis due to a mutation in the 3′ part of the APC gene. A clue for understanding the function of the APC protein
1996
SH2 and SH3 Domains: Elements that Control Interactions of Cytoplasmic Signaling Proteins
1991 StandoutScience
Identification of connexin43 as a functional target for Wnt signalling
1998
Wnt/β-Catenin/Tcf Signaling Induces the Transcription of Axin2, a Negative Regulator of the Signaling Pathway
2002
Identification and structure of four yeast genes (SLY) that are able to suppress the functional loss of YPT1, a member of the RAS superfamily.
1991
β-Trcp couples β-catenin phosphorylation-degradation and regulates Xenopus axis formation
1999
Biochemical characterization of Wnt-Frizzled interactions using a soluble, biologically active vertebrate Wnt protein
1999
Mutagenic analysis of the v-crk oncogene: requirement for SH2 and SH3 domains and correlation between increased cellular phosphotyrosine and transformation
1990
A Drosophila Axin homolog, Daxin, inhibits Wnt signaling
1999
Oncogenic homeodomain transcription factor E2A-Pbx1 activates a novel WNT gene in pre-B acute lymphoblastoid leukemia
1999
Two Members of the Tcf Family Implicated in Wnt/β-Catenin Signaling during Embryogenesis in the Mouse
1998
Assembly of the cadherin-catenin complex in vitro with recombinant proteins
1994
Mutation of the mouse klotho gene leads to a syndrome resembling ageing.
1997 Standout
Modulation of guanine nucleotides bound to Ras in NIH3T3 cells by oncogenes, growth factors, and the GTPase activating protein (GAP)
1990
Pontin52, an interaction partner of β-catenin, binds to the TATA box binding protein
1998
Analysis of the Signaling Activities of Localization Mutants of β-Catenin during Axis Specification in Xenopus
1997
The bovine papillomavirus E5 oncogene can cooperate with ras: identification of p21 amino acids critical for transformation by c-rasH but not v-rasH.
1991
p21(WAF1/cip1) is an important determinant of intestinal cell response to sulindac in vitro and in vivo.
2001
The tyrosine phosphorylated carboxyterminus of the EGF receptor is a binding site for GAP and PLC-gamma.
1990
The noncatalytic src homology region 2 segment of abl tyrosine kinase binds to tyrosine-phosphorylated cellular proteins with high affinity.
1991 Nobel
Presence of SH2 domains of phospholipase C gamma 1 enhances substrate phosphorylation by increasing the affinity toward the epidermal growth factor receptor.
1992
SH2 domains prevent tyrosine dephosphorylation of the EGF receptor: identification of Tyr992 as the high-affinity binding site for SH2 domains of phospholipase C gamma.
1992
Gap Domains Responsible for Ras P21-Dependent Inhibition of Muscarinic Atrial K + Channel Currents
1992 Science
β-Arrestin-Dependent Formation of β 2 Adrenergic Receptor-Src Protein Kinase Complexes
1999 StandoutScienceNobel
The N-terminal region of GAP regulates cytoskeletal structure and cell adhesion.
1993
Deconstructing the ßcatenin destruction complex: mechanistic roles for the tumor suppressor APC in regulating Wnt signaling
2011
Crystal structure of an active form of RAS protein, a complex of a GTP analog and the HRAS p21 catalytic domain.
1990
Interaction of phosphatidylinositol 3-kinase-associated p85 with epidermal growth factor and platelet-derived growth factor receptors.
1992
A Wnt signaling pathway controls Hox gene expression and neuroblast migration in C. elegans
1999
Bridging of β-catenin and glycogen synthase kinase-3β by Axin and inhibition of β-catenin-mediated transcription
1998
Constitutive activation of Mek1 by mutation of serine phosphorylation sites.
1994
The axis-inducing activity, stability, and subcellular distribution of beta-catenin is regulated in Xenopus embryos by glycogen synthase kinase 3.
1996
SCF and Cullin/RING H2-Based Ubiquitin Ligases
1999
Lack of β-catenin affects mouse development at gastrulation
1995
Direct evidence that Gi-coupled receptor stimulation of mitogen-activated protein kinase is mediated by G beta gamma activation of p21ras.
1994 StandoutNobel
Wnt signaling and cancer
2000 Standout
β-catenin signalling modulates proliferative potential of human epidermal keratinocytes independently of intercellular adhesion
1999
cAMP and beta gamma subunits of heterotrimeric G proteins stimulate the mitogen-activated protein kinase pathway in COS-7 cells.
1994
Wnt-1 modulates cell-cell adhesion in mammalian cells by stabilizing beta-catenin binding to the cell adhesion protein cadherin
1994
Binding of SH2 Domains of Phospholipase Cγ1, GAP, and Src to Activated Growth Factor Receptors
1990 Science
Interactions of phosphatidylinositol kinase, GTPase-activating protein (GAP), and GAP-associated proteins with the colony-stimulating factor 1 receptor.
1990
Molecular cloning of the cDNA for stimulatory GDP/GTP exchange protein for smg p21s (ras p21-like small GTP-binding proteins) and characterization of stimulatory GDP/GTP exchange protein.
1991
Negative Feedback Loop of Wnt Signaling through Upregulation of Conductin/Axin2 in Colorectal and Liver Tumors
2002
Receptor protein tyrosine phosphatase PTPmu associates with cadherins and catenins in vivo.
1995
Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMP
1998 StandoutNature
Homeodomain-interacting protein kinases (Hipks) promote Wnt/Wg signaling through stabilization of β-catenin/Arm and stimulation of target gene expression
2008
The ras oncogene--an important regulatory element in lower eucaryotic organisms
1989
Proteins with SH2 domains: transducers in the tyrosine kinase signaling pathway.
1992
Dishevelled interacts with the DIX domain polymerization interface of Axin to interfere with its function in down-regulating β-catenin
2011
Axil, a Member of the Axin Family, Interacts with Both Glycogen Synthase Kinase 3β and β-Catenin and Inhibits Axis Formation ofXenopus Embryos
1998
Requirement for a GTPase-Activating Protein in Vesicle Budding from the Endoplasmic Reticulum
1993 StandoutScienceNobel
Judging a Protein by More Than Its Name: GSK-3
2001
Purification and Characterization from Bovine Brain Cytosol of Two Gtpase-Activating Proteins Specific for smg p21, a GTP-binding Protein Having the Same Effector Domain as c-ras p21s
1989
Inhibition of GTPase Activating Protein Stimulation of Ras-p21 GTPase by the K rev -1 Gene Product
1990 Science
Identification of a nucleotide exchange-promoting activity for p21ras.
1990
Identification and Structure of Four Yeast Genes (SLY) That Are Able To Suppress the Functional Loss of YPT1, a Member of the RAS Superfamily
1991
Inhibition of the ras p21 GTPase-activating protein-stimulated GTPase activity of c-Ha-ras p21 by smg p21 having the same putative effector domain as ras p21s.
1990
Functional Interaction of an Axin Homolog, Conductin, with β-Catenin, APC, and GSK3β
1998 Science
Cell adhesion and the integrin-linked kinase regulate the LEF-1 and β-catenin signaling pathways
1998
Binding of APC to the Human Homolog of the Drosophila Discs Large Tumor Suppressor Protein
1996 Science
Transformation by pp60src or stimulation of cells with epidermal growth factor induces the stable association of tyrosine-phosphorylated cellular proteins with GTPase-activating protein.
1991
Association of p120, a tyrosine kinase substrate, with E-cadherin/catenin complexes.
1995
The roles of catenins in the cadherin-mediated cell adhesion: functional analysis of E-cadherin-alpha catenin fusion molecules.
1994
Constitutive Transcriptional Activation by a β-Catenin-Tcf Complex in APC −/− Colon Carcinoma
1997 StandoutScience
Protein-tyrosine kinases regulate the phosphorylation, protein interactions, subcellular distribution, and activity of p21ras GTPase-activating protein.
1991
Somatic mutations of the β-catenin gene are frequent in mouse and human hepatocellular carcinomas
1998
Characterization of cadherin-4 and cadherin-5 reveals new aspects of cadherins
1994
Wnt proteins synergize to activate β-catenin signaling
2017
A novel GSK3-regulated APC:Axin interaction regulates Wnt signaling by driving a catalytic cycle of efficient βcatenin destruction
2015
Shared Pathways of IκB Kinase-Induced SCFβTrCP-Mediated Ubiquitination and Degradation for the NF-κB Precursor p105 and IκBα
2001
Physiological regulation of β-catenin stability by Tcf3 and CK1ϵ
2001
Down-regulation of beta-catenin TCF signaling is linked to colonic epithelial cell differentiation.
2001
Impaired mammary gland and lymphoid development caused by inducible expression of Axin in transgenic mice
2001
E-Cadherin–dependent Growth Suppression is Mediated by the Cyclin-dependent Kinase Inhibitor p27KIP1
1998
Variable β-catenin expression in colorectal cancers indicates tumor progression driven by the tumor environment
2001
E-cadherin and APC compete for the interaction with beta-catenin and the cytoskeleton.
1994
cAMP abrogates the p21ras-mitogen-activated protein kinase pathway in fibroblasts.
1994
The ubiquitin ligase Hyperplastic discs negatively regulateshedgehoganddecapentaplegicexpression by independent mechanisms
2002
MECHANISMS OF WNT SIGNALING IN DEVELOPMENT
1998 Standout
γ-Catenin is regulated by the APC tumor suppressor and its oncogenic activity is distinct from that of β-catenin
2000
The ubiquitin-proteasome pathway: on protein death and cell life
1998 StandoutNobel
Interaction among Gsk-3, Gbp, Axin, and APC in Xenopus Axis Specification
2000
Characterization of the interactions of α-catenin with α-actinin and β-catenin/plakoglobin
1997
beta-Catenin regulates vascular endothelial growth factor expression in colon cancer.
2003
THE WNT SIGNALING PATHWAY IN DEVELOPMENT AND DISEASE
2004 Standout
beta-Catenin associates with the actin-bundling protein fascin in a noncadherin complex.
1996 StandoutNobel
Wnt-induced transcriptional activation is exclusively mediated by TCF/LEF
2014
Xenopus oocyte germinal-vesicle breakdown induced by [Val12]Ras is inhibited by a cytosol-localized Ras mutant.
1989
Inhibition by cAMP of Ras-Dependent Activation of Raf
1993 Science
Shc adaptor proteins are key transducers of mitogenic signaling mediated by the G protein-coupled thrombin receptor.
1996
Activation of β-Catenin-Tcf Signaling in Colon Cancer by Mutations in β-Catenin or APC
1997 StandoutScience
Roles of plakoglobin end domains in desmosome assembly
1997
Inflammatory Bowel Disease and Adenomas in Mice Expressing a Dominant Negative N-Cadherin
1995 Science
The cyclin D1 gene is a target of the β-catenin/LEF-1 pathway
1999 Standout
Differential Nuclear Translocation and Transactivation Potential of β-Catenin and Plakoglobin
1998
T cell factor-activated transcription is not sufficient to induce anchorage-independent growth of epithelial cells expressing mutant β-catenin
1999
Membrane Fusion: Grappling with SNARE and SM Proteins
2009 StandoutScienceNobel
Requirement for β-Catenin in Anterior-Posterior Axis Formation in Mice
2000
Suppression of tumorigenicity by plakoglobin: an augmenting effect of N-cadherin.
1996
Essential requirement for Wnt signaling in proliferation of adult small intestine and colon revealed by adenoviral expression of Dickkopf-1
2003
Casein kinase Iɛ in the Wnt pathway: Regulation of β-catenin function
1999
Regulation of β-Catenin Levels and Localization by Overexpression of Plakoglobin and Inhibition of the Ubiquitin-Proteasome System
1997
p120, a p120-related protein (p100), and the cadherin/catenin complex.
1995
Inhibition of β-catenin-mediated transactivation by cadherin derivatives
1998
Structural Motifs Involved in Ubiquitin-Mediated Processing of the NF-κB Precursor p105: Roles of the Glycine-Rich Region and a Downstream Ubiquitination Domain
1999 StandoutNobel
Deletions of AXIN1, a component of the WNT/wingless pathway, in sporadic medulloblastomas.
2001
Purification and characterization from bovine brain cytosol of a novel regulatory protein inhibiting the dissociation of GDP from and the subsequent binding of GTP to rhoB p20, a ras p21-like GTP-binding protein.
1990
Loss of E-Cadherin-Dependent Cell-Cell Adhesion due to Mutation of the β-Catenin Gene in a Human Cancer Cell Line, HSC-39
1995
Identification of a new catenin: the tyrosine kinase substrate p120cas associates with E-cadherin complexes.
1994
The roles of maternal α-catenin and plakoglobin in the early Xenopus embryo
1997
The Ubiquitin-Proteasome Proteolytic Pathway: Destruction for the Sake of Construction
2002 StandoutNobel
Point mutations in the abl SH2 domain coordinately impair phosphotyrosine binding in vitro and transforming activity in vivo.
1992 Nobel
Phosphorylation Meets Ubiquitination: The Control of NF-κB Activity
2000 Standout
Beta-catenin mutations in human prostate cancer.
1998
Regulation of S33/S37 phosphorylated β-catenin in normal and transformed cells
2002
Activation of the beta-catenin gene in primary hepatocellular carcinomas by somatic alterations involving exon 3.
1998
Wild-type but not mutant APC associates with the microtubule cytoskeleton.
1994
Src homology region 2 domains direct protein-protein interactions in signal transduction.
1990
Embryonic axis induction by the armadillo repeat domain of beta-catenin: evidence for intracellular signaling.
1995
Out of Eden: Stem Cells and Their Niches
2000 Science
Molecular Switch for Signal Transduction: Structural Differences Between Active and Inactive Forms of Protooncogenic ras Proteins
1990 Science
G PROTEIN MECHANISMS: Insights from Structural Analysis
1997
THE UBIQUITIN SYSTEM
1998 StandoutNobel
Up-regulation of the ectodermal-neural cortex 1 (ENC1) gene, a downstream target of the beta-catenin/T-cell factor complex, in colorectal carcinomas.
2001
Targeted mutation of plakoglobin in mice reveals essential functions of desmosomes in the embryonic heart.
1996
Negative Regulation of Wingless Signaling by D-Axin, a Drosophila Homolog of Axin
1999 Science
Identification of a New Catenin: the Tyrosine Kinase Substrate p120cas Associates with E-Cadherin Complexes
1994
SIGNALING PATHWAYS IN INTESTINAL DEVELOPMENT AND CANCER
2004
Binding of Transforming Protein, P47 gag-crk , to a Broad Range of Phosphotyrosine-containing Proteins
1990 Science
Forced expression of E-cadherin in the mouse intestinal epithelium slows cell migration and provides evidence for nonautonomous regulation of cell fate in a self-renewing system.
1996
Binding of GAP to Activated PDGF Receptors
1990 Science
Plakoglobin Suppresses Epithelial Proliferation and Hair Growth in Vivo
2000 StandoutNobel
Separate GTP Binding and GTPase Activating Domains of a Gα Subunit
1993 Science
Mutational and kinetic analyses of the GTPase-activating protein (GAP)-p21 interaction: the C-terminal domain of GAP is not sufficient for full activity.
1992
Apoptosis and APC in colorectal tumorigenesis.
1996
Purification and characterization from bovine brain cytosol of a protein that inhibits the dissociation of GDP from and the subsequent binding of GTP to smg p25A, a ras p21-like GTP-binding protein.
1990
Interaction of Dishevelled and Xenopus Axin-Related Protein Is Required for Wnt Signal Transduction
2000
Synergy Between Tumor Suppressor APC and the β-Catenin-Tcf4 Target Tcf1
1999 Science
Cloning of a 67-kD Neutrophil Oxidase Factor with Similarity to a Noncatalytic Region of p60 c-src
1990 Science
Works of Bonnee Rubinfeld being referenced
The Soluble Wnt Receptor Frizzled8CRD-hFc Inhibits the Growth of Teratocarcinomas In vivo
2007
Downregulation of β-catenin by human Axin and its association with the APC tumor suppressor, β-catenin and GSK3β
1998
Axin-dependent Phosphorylation of the Adenomatous Polyposis Coli Protein Mediated by Casein Kinase 1ε
2001
The F-box protein β-TrCP associates with phosphorylated β-catenin and regulates its activity in the cell
1999
The APC Protein and E-cadherin Form Similar but Independent Complexes with α-Catenin, β-Catenin, and Plakoglobin
1995
Defects in the Regulation of β-Catenin in Colorectal Cancer
1999
Induction of a β-catenin-LEF-1 complex by wnt-1 and transforming mutants of β-catenin
1997
Wnt Isoform-Specific Interactions with Coreceptor Specify Inhibition or Potentiation of Signaling by LRP6 Antibodies
2010
Interaction of ras p21 Proteins with GTPase Activating Protein
1988
The metalloproteinase matrilysin is a target of β-catenin transactivation in intestinal tumors
1999
Molecular cloning of a GTPase activating protein specific for the Krev-1 protein p21rap1
1991
Loss of beta-catenin regulation by the APC tumor suppressor protein correlates with loss of structure due to common somatic mutations of the gene.
1997
Localization of the rap1GAP catalytic domain and sites of phosphorylation by mutational analysis.
1992
Regulation of intracellular beta-catenin levels by the adenomatous polyposis coli (APC) tumor-suppressor protein.
1995
The APC gene product associates with microtubules in vivo and promotes their assembly in vitro.
1994
Effects of Forced Expression of an NH2-terminal Truncated β-Catenin on Mouse Intestinal Epithelial Homeostasis
1998
Stabilization of β-Catenin by Genetic Defects in Melanoma Cell Lines
1997 Science
A Drosophila homolog of the tumor suppressor gene adenomatous polyposis coli down-regulates β-catenin but its zygotic expression is not essential for the regulation of Armadillo
1997 Nobel
RapV12 antagonizes Ras-dependent activation of ERK1 and ERK2 by LPA and EGF in Rat-1 fibroblasts.
1993
Adenomatous Polyposis Coli Tumor Suppressor Protein Has Signaling Activity in Xenopus laevis Embryos Resulting in the Induction of an Ectopic Dorsoanterior Axis
1997
Deletion of an Amino-Terminal Sequence Stabilizes β-Catenin In Vivo and Promotes Hyperphosphorylation of the Adenomatous Polyposis Coli Tumor Suppressor Protein
1996
Molecular Cloning of Two Types of GAP Complementary DNA from Human Placenta
1988 Science
Phosphorylation of rap1GAP in vivo and by cAMP-dependent kinase and the cell cycle p34cdc2 kinase in vitro.
1992
Wnt-1 Regulates Free Pools of Catenins and Stabilizes APC-Catenin Complexes
1996
Association of the APC Gene Product with β-Catenin
1993 Science
Purification of a plasma membrane-associated GTPase-activating protein specific for rap1/Krev-1 from HL60 cells.
1991
Binding of GSK3β to the APC-β-Catenin Complex and Regulation of Complex Assembly
1996 Science