Citation Impact
Citing Papers
In Vivo Activation of the p53 Pathway by Small-Molecule Antagonists of MDM2
2004 StandoutScience
Hypoxia Response Elements in the Aldolase A, Enolase 1, and Lactate Dehydrogenase A Gene Promoters Contain Essential Binding Sites for Hypoxia-inducible Factor 1
1996 StandoutNobel
Repression of c-fos gene expression by thyroid hormone and retinoic acid receptors.
1993
All-trans and 9-cis retinoic acid induction of CRABPII transcription is mediated by RAR-RXR heterodimers bound to DR1 and DR2 repeated motifs
1992
Defects of B-cell lymphopoiesis and bone-marrow myelopoiesis in mice lacking the CXC chemokine PBSF/SDF-1
1996 StandoutNature
Retinoic acid receptors: From molecular mechanisms to cancer therapy
2014
Inhibition of Estrogen Receptor Activity by the Tumor Promoter 12-O-Tetradeconylphorbol-13-Acetate: A Molecular Analysis
1991
The peroxisome proliferator-activated receptor-γ is a negative regulator of macrophage activation
1998 StandoutNature
Selection and evolution of enzymes from a partially randomized non-catalytic scaffold
2007 StandoutNatureNobel
Cyclo-oxygenase-2-derived prostacyclin mediates embryo implantation in the mouse via PPARdelta
1999
A role for nucleosome assembly in both silencing and activation of the Xenopus TR beta A gene by the thyroid hormone receptor.
1995
Ligand-induced Peroxisome Proliferator-activated Receptor α Conformational Change
1997
Retinoid regulation of the phosphoenolpyruvate carboxykinase gene in liver
2002
Thyroid Hormone Receptors: Multiple Forms, Multiple Possibilities*
1993
A signature motif in transcriptional co-activators mediates binding to nuclear receptors
1997 StandoutNature
The basis for half-site specificity explored through a non-cognate steroid receptor-DNA complex
1995
A novel cis element mediating ligand-independent activation by c-ErbA: Implications for hormonal regulation
1993
High-resolution solution structure of the retinoid X receptor DNA-binding domain
1998
Convergence of 9-cis retinoic acid and peroxisome proliferator signalling pathways through heterodimer formation of their receptors
1992 StandoutNature
A new class of retinoids with selective inhibition of AP-1 inhibits proliferation
1994 Nature
PPAR: a mediator of peroxisome proliferator action
1995
Function of retinoic acid receptor γ in the mouse
1993
A Novel Multifunctional Motif in the Amino-terminal A/B Domain of T3Rα Modulates DNA Binding and Receptor Dimerization
1998
Thyroid Hormone-mediated Enhancement of Heterodimer Formation between Thyroid Hormone Receptor β and Retinoid X Receptor
1997
Ligand binding and co-activator assembly of the peroxisome proliferator-activated receptor-γ
1998 StandoutNature
New advances in understanding the molecular mechanisms of thyroid hormone action
1994
Ectopic Expression of Nonliganded Retinoic Acid Receptor β Abrogates AP-1 Activity by Selective Degradation of c-Jun in Cervical Carcinoma Cells
2004 StandoutNobel
Defective Release of Corepressor by Hinge Mutants of the Thyroid Hormone Receptor Found in Patients with Resistance to Thyroid Hormone
1998
PPAR-γ agonists inhibit production of monocyte inflammatory cytokines
1998 StandoutNature
Identification of a retinoic acid responsive enhancer 3′ of the murine homeobox gene Hox-1.6
1992
Fluorescence lifetime and polarization-resolved imaging in cell biology
2009
Inhibition of Peroxisome Proliferator Signaling Pathways by Thyroid Hormone Receptor
1997
A transcriptional co-repressor that interacts with nuclear hormone receptors
1995 StandoutNature
Characterization of the Promoter of the Rat Sarcoplasmic Endoplasmic Reticulum Ca2+-ATPase 1 Gene and Analysis of Thyroid Hormone Responsiveness
1996
Serum retinol binding protein 4 contributes to insulin resistance in obesity and type 2 diabetes
2005 StandoutNature
Hydration and DNA Recognition by Homeodomains
1996 StandoutNobel
Purification and Characterization of Hypoxia-inducible Factor 1
1995 StandoutNobel
Ligand-independent repression by the thyroid hormone receptor mediated by a nuclear receptor co-repressor
1995 StandoutNature
9-cis retinoic acid signaling: changing partners causes some excitement.
1995
Ligand-dependent Heterodimerization of Thyroid Hormone Receptor and Retinoid X Receptor
1997
Ligand-independent and -dependent Functions of Thyroid Hormone Receptor Isoforms Depend upon Their Distinct Amino Termini
1995
Nuclear Receptor/AP-1 Interaction*
1993
Direct repeats as selective response elements for the thyroid hormone, retinoic acid, and vitamin D3 receptors
1991 Standout
Sensitization of diabetic and obese mice to insulin by retinoid X receptor agonists
1997 Nature
Multiplicity generates diversity in the retinoic acid signalling pathways
1992
Activation of the Nuclear Receptor LXR by Oxysterols Defines a New Hormone Response Pathway
1997
Tissue- and cell-specific distribution of proteins that interact with the human thyroid hormone receptor-β
1995
Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-γ
2004 StandoutNature
The hormone resistin links obesity to diabetes
2001 StandoutNature
Deletion of the Thyroid Hormone β1 Receptor Increases Basal and Triiodothyronine-Induced Growth Hormone Messenger Ribonucleic Acid in GH3Cells*
1997
Differential Recognition of Target Genes by Nuclear Receptor Monomers, Dimers, and Heterodimers*
1994
Isolation of proteins that interact specifically with the retinoid X receptor: two novel orphan receptors.
1995
A CBP Integrator Complex Mediates Transcriptional Activation and AP-1 Inhibition by Nuclear Receptors
1996 Standout
Divergent dimerization properties of mutant beta 1 thyroid hormone receptors are associated with different dominant negative activities.
1994
Ligand Modulates the Interaction of Thyroid Hormone Receptor β with the Basal Transcription Machinery
1995
The RXR heterodimers and orphan receptors
1995 Standout
Identification of a nuclear receptor that is activated by farnesol metabolites
1995
An Antidiabetic Thiazolidinedione Is a High Affinity Ligand for Peroxisome Proliferator-activated Receptor γ (PPARγ)
1995 Standout
Peroxisome proliferator-activated receptors: finding the orphan a home
1994
Retinoids: present role and future potential
1999
The Steroid/Nuclear Receptors: From Three-Dimensional Structure to Complex Function
1994
Mechanisms of transactivation by retinoic acid receptors
1993
Roles of PPARs in health and disease
2000 StandoutNature
Vitamin D3-thyroid hormone receptor heterodimer polarity directs ligand sensitivity of transactivation
1994 Nature
Regulation of retinoid signalling by receptor polarity and allosteric control of ligand binding
1994 Nature
9-Cis retinoic acid stereoisomer binds and activates the nuclear receptor RXRα
1992 Nature
Thyroid Hormone Regulation of Thyrotropin Gene Expression
1993
Unique response pathways are established by allosteric interactions among nuclear hormone receptors
1995
High affinity and specificity of dimeric binding of thyroid hormone receptors to DNA and their ligand-dependent dissociation.
1993
A conserved retinoic acid response element required for early expression of the homeobox gene Hoxb-1
1994 StandoutNatureNobel
The Nonconserved Hinge Region and Distinct Amino-Terminal Domains of the RORα Orphan Nuclear Receptor Isoforms are Required for Proper DNA Bending and RORα-DNA Interactions
1995
Roles of 3,5,3'-triiodothyronine and deoxyribonucleic acid binding on thyroid hormone receptor complex formation.
1994
Retinoic acid receptors and retinoid X receptor-alpha down-regulate the transforming growth factor-beta 1 promoter by antagonizing AP-1 activity.
1993
Alteration of reproductive function but not prenatal sexual development after insertional disruption of the mouse estrogen receptor gene.
1993 StandoutNobel
Ligand-dependent synergy of thyroid hormone and retinoid X receptors.
1992
The orphan receptors NGFI-B and steroidogenic factor 1 establish monomer binding as a third paradigm of nuclear receptor-DNA interaction.
1993
Repression of glucocorticoid receptor-mediated transcriptional activation by unliganded thyroid hormone receptor (TR) is TR isoform-specific.
1995
The mouse and human genes encoding the recognition component of the N-end rule pathway
1998 StandoutNobel
Ligand Modulates the Conversion of DNA-Bound Vitamin D3 Receptor (VDR) Homodimers into VDR-Retinoid X Receptor Heterodimers
1994
Novel location and function of a thyroid hormone response element.
1995
Thyroid hormone resistance syndrome: correlation of dominant negative activity and location of mutations.
1993
Ligand-dependent occupancy of the retinoic acid receptor beta 2 promoter in vivo.
1994
Ligand-dependent, Pit-1/growth hormone factor-1 (GHF-1)-independent transcriptional stimulation of rat growth hormone gene expression by thyroid hormone receptors in vitro.
1993
Delineation of three different thyroid hormone-response elements in promoter of rat sarcoplasmic reticulum Ca2+ATPase gene. Demonstration that retinoid X receptor binds 5' to thyroid hormone receptor in response element 1.
1994
Investigating Cell Surface Galectin-Mediated Cross-Linking on Glycoengineered Cells
2012 StandoutNobel
General involvement of hypoxia-inducible factor 1 in transcriptional response to hypoxia.
1993 StandoutNobel
Ligand-dependent interactions of coactivators steroid receptor coactivator-1 and peroxisome proliferator-activated receptor binding protein with nuclear hormone receptors can be imaged in live cells and are required for transcription
2000 StandoutNobel
Differential orientations of the DNA-binding domain and carboxy-terminal dimerization interface regulate binding site selection by nuclear receptor heterodimers.
1993
Structure of the STRA6 receptor for retinol uptake
2016 StandoutScienceNobel
Inhibition of estrogen-responsive gene activation by the retinoid X receptor beta: evidence for multiple inhibitory pathways.
1993
A dominant negative retinoic acid receptor blocks neutrophil differentiation at the promyelocyte stage.
1993
Orphan Nuclear Receptors: From Gene to Function*
1999
Mechanisms for synergistic activation of thyroid hormone receptor and retinoid X receptor on different response elements.
1994
Identification of a domain required for oncogenic activity and transcriptional suppression by v-erbA and thyroid-hormone receptor alpha.
1993
Immunosuppression by Glucocorticoids: Inhibition of NF-κB Activity Through Induction of IκB Synthesis
1995 StandoutScience
Ligand-Dependent and -Independent Transactivation by Thyroid Hormone Receptor β2 Is Determined by the Structure of the Hormone Response Element
1995
DAF-16 recruits the CREB-binding protein coactivator complex to the insulin-like growth factor binding protein 1 promoter in HepG2 cells
2000 StandoutNobel
Two distinct dimerization interfaces differentially modulate target gene specificity of nuclear hormone receptors.
1996
Nuclear Receptors and Lipid Physiology: Opening the X-Files
2001 StandoutScience
Heterodimerization and deoxyribonucleic acid-binding properties of a retinoid X receptor-related factor.
1994
Transcriptional Silencing by Unliganded Thyroid Hormone Receptor β Requires a Soluble Corepressor That Interacts with the Ligand-Binding Domain of the Receptor
1996
Determinants for selective RAR and TR recognition of direct repeat HREs.
1993
Structure of the Retinoid X Receptor α DNA Binding Domain: a Helix Required for Homodimeric DNA Binding
1993 Science
Characterization and tissue expression of multiple triiodothyronine receptor-auxiliary proteins and their relationship to the retinoid X-receptors.
1993
Thyroid hormone receptor-beta mutants associated with generalized resistance to thyroid hormone show defects in their ligand-sensitive repression function.
1995
Quality Control by DNA Repair
1999 StandoutScienceNobel
The Monomer-Binding Orphan Receptor Rev-Erb Represses Transcription as a Dimer on a Novel Direct Repeat
1995
Expression of multiple thyroid hormone receptor isoforms in rat femoral and vertebral bone and in bone marrow osteogenic cultures
1999
Overexpression of angiotensin AT 1 receptor transgene in the mouse myocardium produces a lethal phenotype associated with myocyte hyperplasia and heart block
1997 StandoutNobel
Evidence that phosphorylation events participate in thyroid hormone action.
1994
Multiple mechanisms of chicken ovalbumin upstream promoter transcription factor-dependent repression of transactivation by the vitamin D, thyroid hormone, and retinoic acid receptors.
1993
Triiodothyronine (T3) differentially affects T3-receptor/retinoic acid receptor and T3-receptor/retinoid X receptor heterodimer binding to DNA
1992
A shift in the Ligand Responsiveness of Thyroid Hormone Receptor α Induced by Heterodimerization with Retinoid X Receptor α
1996
The Orphan Receptor Rev-ErbAα Activates Transcription via a Novel Response element
1993
Extreme hydrops fetalis and cardiovascular abnormalities in mice lacking a functional Adrenomedullin gene
2001 StandoutNobel
Transgenic analysis of the thyroid-responsive elements in the alpha-cardiac myosin heavy chain gene promoter.
1993
Specificity and mechanism of thyroid hormone induction from an octamer response element.
1994
Alteration of a single amino acid residue in retinoic acid receptor causes dominant-negative phenotype.
1994
The dimerization interfaces formed between the DNA binding domains of RXR, RAR and TR determine the binding specificity and polarity of the full-length receptors to direct repeats.
1994
The Conserved Ninth C-Terminal Heptad in Thyroid Hormone and Retinoic Acid Receptors Mediates Diverse Responses by Affecting Heterodimer but Not Homodimer Formation
1993
Physiological and Molecular Basis of Thyroid Hormone Action
2001 Standout
Reconstitution of retinoid X receptor function and combinatorial regulation of other nuclear hormone receptors in the yeast Saccharomyces cerevisiae.
1993
Multiple parameters control the selectivity of nuclear receptors for their response elements. Selectivity and promiscuity in response element recognition by retinoic acid receptors and retinoid X receptors.
1993
Essential role of β-adrenergic receptor kinase 1 in cardiac development and function
1996 StandoutNobel
Thyroid hormone receptor dimerization is required for dominant negative inhibition by mutations that cause thyroid hormone resistance
1993
Functional evidence for ligand-dependent dissociation of thyroid hormone and retinoic acid receptors from an inhibitory cellular factor.
1994
Malignant transformation of immortalized transgenic hepatocytes after transfection with hepatitis B virus DNA.
1990
Retinoid-dependent in vitro transcription mediated by the RXR/RAR heterodimer.
1994
Functional Evidence for Ligand-Dependent Dissociation of Thyroid Hormone and Retinoic Acid Receptors from an Inhibitory Cellular Factor
1994
Human nuclear receptor heterodimers: opportunities for detecting targets of transcriptional regulation using yeast.
1996
RXR alpha mutant mice establish a genetic basis for vitamin A signaling in heart morphogenesis.
1994
A Nuclear Hormone Receptor Corepressor Mediates Transcriptional Silencing by Receptors with Distinct Repression Domains
1996
Thyroid hormone alters in vitro DNA binding of monomers and dimers of thyroid hormone receptors.
1992
RAR-specific agonist/antagonists which dissociate transactivation and AP1 transrepression inhibit anchorage-independent cell proliferation.
1995
Unique anti-activator protein-1 activity of retinoic acid receptor beta.
2000
Synergistic Activation of Retinoic Acid (RA)-Responsive Genes and Induction of Embryonal Carcinoma Cell Differentiation by an RA Receptor α (RARα)-, RARβ-, or RARγ-Selective Ligand in Combination with a Retinoid X Receptor-Specific Ligand
1995
Binding characteristics of the thyroid hormone receptor homo- and heterodimers to consensus AGGTCA repeat motifs.
1992
Down-regulation of retinoic acid receptor beta in mammary carcinoma cell lines and its up-regulation in senescing normal mammary epithelial cells.
1994
Oxygen-regulated control elements in the phosphoglycerate kinase 1 and lactate dehydrogenase A genes: similarities with the erythropoietin 3' enhancer.
1994 StandoutNobel
Positive and negative modulation of Jun action by thyroid hormone receptor at a unique AP1 site.
1993
Bile Acids: Natural Ligands for an Orphan Nuclear Receptor
1999 StandoutScience
Unliganded thyroid hormone receptor inhibits formation of a functional preinitiation complex: implications for active repression.
1993
Liver Regeneration
1997 StandoutScience
Viruses in Human Cancers
1991 StandoutScienceNobel
Hypolipidemic drugs, polyunsaturated fatty acids, and eicosanoids are ligands for peroxisome proliferator-activated receptors α and δ
1997 Standout
Fatty acids and retinoids control lipid metabolism through activation of peroxisome proliferator-activated receptor-retinoid X receptor heterodimers.
1993
Specificity of a retinoic acid response element in the phosphoenolpyruvate carboxykinase gene promoter: consequences of both retinoic acid and thyroid hormone receptor binding.
1991
Deuterium Relaxation in a Uniformly 15N-Labeled Homeodomain and Its DNA Complex1
1997 StandoutNobel
Retinoic acid-mediated repression of human papillomavirus 18 transcription and different ligand regulation of the retinoic acid receptor beta gene in non-tumorigenic and tumorigenic HeLa hybrid cells.
1992 StandoutNobel
A 10-Amino-Acid Sequence in the N-Terminal A/B Domain of Thyroid Hormone Receptor α Is Essential for Transcriptional Activation and Interaction with the General Transcription Factor TFIIB
1995
Hypoxic induction of the human erythropoietin gene: cooperation between the promoter and enhancer, each of which contains steroid receptor response elements.
1992
Hormone and antihormone induce distinct conformational changes which are central to steroid receptor activation.
1992
Thyroid hormone receptor-alpha inhibits retinoic acid-responsive gene expression and modulates retinoic acid-stimulated neural differentiation in mouse embryonic stem cells.
1994
Isoform-specific retinoid-X receptor (RXR) antibodies detect differential expression of RXR proteins in the pituitary gland.
1995
Exogenous retinoic acid rapidly induces anterior ectopic expression of murine Hox-2 genes in vivo
1992
Functional Regulation of Thyroid Hormone Receptor Variant TRα2 by Phosphorylation
1995
3,5,3'-L-triiodothyronine (thyroid hormone)-induced protein-DNA interactions in the thyroid hormone response elements and cell type-specific elements of the rat growth hormone gene revealed by in vivo dimethyl sulfate footprinting
1994
Identification of a retinoic acid response element upstream of the murine Hox-4.2 gene.
1993
A novel pathway for vitamin A signaling mediated by RXR heterodimerization with NGFI-B and NURR1.
1995
The Ligand-Binding Domains of the Thyroid Hormone/Retinoid Receptor Gene Subfamily Function in Vivo To Mediate Heterodimerization, Gene Silencing, and Transactivation
1995
mPPAR gamma 2: tissue-specific regulator of an adipocyte enhancer.
1994 Standout
Differential capacity of wild type promoter elements for binding and trans-activation by retinoic acid and thyroid hormone receptors.
1992
Expression of retinoic acid receptor beta mediates retinoic acid-induced growth arrest and apoptosis in breast cancer cells.
1995
Sequence and Characterization of a Coactivator for the Steroid Hormone Receptor Superfamily
1995 StandoutScience
Dominant inheritance of resistance to thyroid hormone not linked to defects in the thyroid hormone receptor alpha or beta genes may be due to a defective cofactor.
1996
p48 Activates a UV-Damaged-DNA Binding Factor and Is Defective in Xeroderma Pigmentosum Group E Cells That Lack Binding Activity
1998
Thyroid Hormone Receptor Can Modulate Retinoic Acid-Mediated Axis Formation in Frog Embryogenesis
1993
Vitamin D Interferes with Transactivation of the Growth Hormone Gene by Thyroid Hormone and Retinoic Acid
1996
Thyroid hormone alters the DNA binding properties of chicken thyroid hormone receptors α and β
1992
Functional characterization of a natural retinoic acid responsive element.
1991
Rat Rev-erbA alpha, an orphan receptor related to thyroid hormone receptor, binds to specific thyroid hormone response elements.
1994
Exclusive Homodimerization of the Orphan Receptor Hepatocyte Nuclear Factor 4 Defines a New Subclass of Nuclear Receptors
1995
Selective antagonism of thyroid hormone action by retinoic acid.
1992
Identification of a Nuclear Receptor for Bile Acids
1999 StandoutScience
Recombinant thyroid hormone receptor and retinoid Xreceptor stimulate ligand-dependent transcription in vitro.
1994
LXR, a nuclear receptor that defines a distinct retinoid response pathway.
1995
Normal development and growth of mice carrying a targeted disruption of the alpha 1 retinoic acid receptor gene.
1993
The Connectivity Map: Using Gene-Expression Signatures to Connect Small Molecules, Genes, and Disease
2006 StandoutScience
In Vivo Genomic Footprinting of Thyroid Hormone-Responsive Genes in Pituitary Tumor Cell Lines
1996
Heterodimeric interaction of the retinoic acid and thyroid hormone receptors in transcriptional regulation on the gamma F-crystallin everted retinoic acid response element.
1994
A tissue-specific enhancer confers Pit-1-dependent morphogen inducibility and autoregulation on the pit-1 gene.
1993
Works of Birgit Hoffmann being referenced
Proliferation of fetal rat hepatocytes in response to growth factors and hormones in primary culture
1989
Genomic organization of the retinoic acid receptor gamma gene
1991
Prolonged irradiation of enhanced cyan fluorescent protein or Cerulean can invalidate Forster resonance energy transfer measurements
2008
Retinoid X receptor is an auxiliary protein for thyroid hormone and retinoic acid receptors
1992 Nature
Homodimer formation of retinoid X receptor induced by 9-cis retinoic acid
1992 Nature
A retinoic acid response element from the rat CRBPI promoter is activated by an RARRXR heterodimer
1992
A Retinoic Acid Receptor-Specific Element Controls the Retinoic Acid Receptor-β Promoter
1990
Antagonism between Retinoic Acid Receptors
1991