Citation Impact
Citing Papers
Multiplex Genome Engineering Using CRISPR/Cas Systems
2013 StandoutScience
Structures of Cas9 Endonucleases Reveal RNA-Mediated Conformational Activation
2014 StandoutScienceNobel
High-throughput characterization of protein–protein interactions by reprogramming yeast mating
2017 StandoutNobel
Generation of ordered protein assemblies using rigid three-body fusion
2021 StandoutNobel
Generation of knock-in primary human T cells using Cas9 ribonucleoproteins
2015 StandoutNobel
High-throughput biochemical profiling reveals sequence determinants of dCas9 off-target binding and unbinding
2017 StandoutNobel
Topological control of cytokine receptor signaling induces differential effects in hematopoiesis
2019 StandoutScienceNobel
Molecular Mechanism of Action of Microtubule-Stabilizing Anticancer Agents
2013 Science
RNA-Guided Human Genome Engineering via Cas9
2013 StandoutScience
A Programmable Dual-RNA–Guided DNA Endonuclease in Adaptive Bacterial Immunity
2012 StandoutScienceNobel
Designed protein logic to target cells with precise combinations of surface antigens
2020 StandoutScienceNobel
Near-atomic cryo-EM imaging of a small protein displayed on a designed scaffolding system
2018
Rapid and automated design of two-component protein nanomaterials using ProteinMPNN
2024 StandoutNobel
Hierarchical design of pseudosymmetric protein nanocages
2024 StandoutNatureNobel
Synergistic and tunable human gene activation by combinations of synthetic transcription factors
2013
DNA interrogation by the CRISPR RNA-guided endonuclease Cas9
2014 StandoutNatureNobel
Engineered receptors for soluble cellular communication and disease sensing
2024 StandoutNatureNobel
Highly specific zinc finger proteins obtained by directed domain shuffling and cell-based selection
2003
Rigidly connected multispecific artificial binders with adjustable geometries
2017
The promise and challenge of therapeutic genome editing
2020 StandoutNatureNobel
Optical control of mammalian endogenous transcription and epigenetic states
2013 Nature
Efficient programmable gene silencing by Cascade
2014
RNA-guided gene activation by CRISPR-Cas9–based transcription factors
2013
Efficient construction of sequence-specific TAL effectors for modulating mammalian transcription
2011
Programmable repression and activation of bacterial gene expression using an engineered CRISPR-Cas system
2013
Engineering proteins that bind, move, make and break DNA
2003 StandoutNobel
Synthetic Zinc Finger Transcription Factor Action at an Endogenous Chromosomal Site
2000
Genome-scale transcriptional activation by an engineered CRISPR-Cas9 complex
2014 StandoutNature
Targeted genome editing in human cells with zinc finger nucleases constructed via modular assembly
2009
Programmable RNA Tracking in Live Cells with CRISPR/Cas9
2016 StandoutNobel
Modular system for the construction of zinc-finger libraries and proteins
2010
Transformation by the (R)-enantiomer of 2-hydroxyglutarate linked to EGLN activation
2012 StandoutNatureNobel
CRISPR-Cas9 Circular Permutants as Programmable Scaffolds for Genome Modification
2019 StandoutNobel
ZFN, TALEN, and CRISPR/Cas-based methods for genome engineering
2013 Standout
Genome-Scale CRISPR-Mediated Control of Gene Repression and Activation
2014 Standout
Epigenome editing by a CRISPR-Cas9-based acetyltransferase activates genes from promoters and enhancers
2015
Role of the Biomolecular Energy Gap in Protein Design, Structure, and Evolution
2012 StandoutNobel
Simple screening method for improving membrane protein thermostability
2011
Designed ankyrin repeat proteins are effective targeting elements for chimeric antigen receptors
2015
Is there a code for protein–DNA recognition? Probab(ilistical)ly…
2002
Enhanced proofreading governs CRISPR–Cas9 targeting accuracy
2017 StandoutNatureNobel
Rational design of α-helical tandem repeat proteins with closed architectures
2015 StandoutNatureNobel
CRISPR RNA–guided activation of endogenous human genes
2013
Design and applications of a clamp for Green Fluorescent Protein with picomolar affinity
2017
Improving CRISPR-Cas nuclease specificity using truncated guide RNAs
2014 Standout
The coming of age of de novo protein design
2016 StandoutNatureNobel
Design of biologically active binary protein 2D materials
2021 StandoutNatureNobel
Cas9 as a versatile tool for engineering biology
2013
A Broad-Spectrum Inhibitor of CRISPR-Cas9
2017 StandoutNobel
Programmable RNA recognition and cleavage by CRISPR/Cas9
2014 StandoutNatureNobel
Multiplexed activation of endogenous genes by CRISPR-on, an RNA-guided transcriptional activator system
2013
Multiplexed and Programmable Regulation of Gene Networks with an Integrated RNA and CRISPR/Cas Toolkit in Human Cells
2014
A Simple Physical Model for the Prediction and Design of Protein–DNA Interactions
2004 StandoutNobel
Therapeutic modulation of endogenous gene function by agents with designed DNA-sequence specificities
2003
Nucleotide-Dependent Lateral and Longitudinal Interactions in Microtubules
2013
Rearrangement of side-chains in a zif268 mutant highlights the complexities of zinc finger-DNA recognition
2001
Computational redesign of endonuclease DNA binding and cleavage specificity
2006 StandoutNatureNobel
Engineering polydactyl zinc-finger transcription factors
2002
Revealing off-target cleavage specificities of zinc-finger nucleases by in vitro selection
2011
Development and Applications of CRISPR-Cas9 for Genome Engineering
2014 Standout
Conformational control of DNA target cleavage by CRISPR–Cas9
2015 StandoutNatureNobel
De novo design of bioactive protein switches
2019 StandoutNatureNobel
High-Resolution Microtubule Structures Reveal the Structural Transitions in αβ-Tubulin upon GTP Hydrolysis
2014 StandoutNobel
A synthetic homing endonuclease-based gene drive system in the human malaria mosquito
2011 StandoutNatureNobel
Attenuation of HIV-1 Replication in Primary Human Cells with a Designed Zinc Finger Transcription Factor
2004
DARPins and other repeat protein scaffolds: advances in engineering and applications
2011
DARPin-Based Crystallization Chaperones Exploit Molecular Geometry as a Screening Dimension in Protein Crystallography
2016
Biology and Applications of CRISPR Systems: Harnessing Nature’s Toolbox for Genome Engineering
2016 StandoutNobel
A light-inducible CRISPR-Cas9 system for control of endogenous gene activation
2015
An improved zinc-finger nuclease architecture for highly specific genome editing
2007
Bispecific Designed Ankyrin Repeat Proteins (DARPins) Targeting Epidermal Growth Factor Receptor Inhibit A431 Cell Proliferation and Receptor Recycling
2011
CRISPR-Mediated Modular RNA-Guided Regulation of Transcription in Eukaryotes
2013 StandoutNobel
DARPins Recognizing the Tumor-Associated Antigen EpCAM Selected by Phage and Ribosome Display and Engineered for Multivalency
2011
A 3.8 Å resolution cryo-EM structure of a small protein bound to an imaging scaffold
2019
The Human Condition—A Molecular Approach
2014 StandoutNobel
Genome editing with engineered zinc finger nucleases
2010 Standout
Repurposing CRISPR as an RNA-Guided Platform for Sequence-Specific Control of Gene Expression
2013 StandoutNobel
Exploitation of binding energy for catalysis and design
2009 StandoutNatureNobel
Genome-editing revolution: My whirlwind year with CRISPR
2015 StandoutNatureNobel
A Cas9–guide RNA complex preorganized for target DNA recognition
2015 StandoutScienceNobel
Targeted Chromosomal Cleavage and Mutagenesis in Drosophila Using Zinc-Finger Nucleases
2002
Synthetic gene expression perturbation systems with rapid, tunable, single-gene specificity in yeast
2012
Stimulation of Homologous Recombination through Targeted Cleavage by Chimeric Nucleases
2001
Dynamics of CRISPR-Cas9 genome interrogation in living cells
2015 StandoutScienceNobel
Structure of the STRA6 receptor for retinol uptake
2016 StandoutScienceNobel
Extreme stability in de novo-designed repeat arrays is determined by unusually stable short-range interactions
2018 StandoutNobel
Regulation of transgene expression in plants with polydactyl zinc finger transcription factors
2002
The new frontier of genome engineering with CRISPR-Cas9
2014 StandoutScienceNobel
Designed Ankyrin Repeat Proteins (DARPins): Binding Proteins for Research, Diagnostics, and Therapy
2011
DNA Recognition by Cys2His2 Zinc Finger Proteins
2000
Rational design of a split-Cas9 enzyme complex
2015 StandoutNobel
De novo design of covalently constrained mesosize protein scaffolds with unique tertiary structures
2017 StandoutNobel
The NMR–Rosetta capsid model of M13 bacteriophage reveals a quadrupled hydrophobic packing epitope
2015 StandoutNobel
Reversible Photocontrol of Biological Systems by the Incorporation of Molecular Photoswitches
2013 StandoutNobel
Enhancing Gene Targeting with Designed Zinc Finger Nucleases
2003 Science
Site-specific selfish genes as tools for the control and genetic engineering of natural populations
2003
Protein Design: Toward Functional Metalloenzymes
2014
Cas9 interrogates DNA in discrete steps modulated by mismatches and supercoiling
2020 StandoutNobel
Two- and three-input TALE-based AND logic computation in embryonic stem cells
2013
A general strategy to construct small molecule biosensors in eukaryotes
2015 StandoutNobel
Phage selection of bicyclic peptides binding Her2
2014
Modulating Hypoxia-Inducible Transcription by Disrupting the HIF-1–DNA Interface
2007
The Discovery of Zinc Fingers and Their Applications in Gene Regulation and Genome Manipulation
2010 Nobel
Filamentous Phage Display in the New Millennium
2005
Design and Selection of Novel Cys2His2 Zinc Finger Proteins
2001
Works of Birgit Dreier being referenced
Efficient Tumor Targeting with High-Affinity Designed Ankyrin Repeat Proteins: Effects of Affinity and Molecular Size
2010
Her2-specific Multivalent Adapters Confer Designed Tropism to Adenovirus for Gene Targeting
2010
Development of a generic adenovirus delivery system based on structure-guided design of bispecific trimeric DARPin adapters
2013
Toward controlling gene expression at will: Specific regulation of the erbB - 2 / HER - 2 promoter by using polydactyl zinc finger proteins constructed from modular building blocks
1998
Development of Zinc Finger Domains for Recognition of the 5′-ANN-3′ Family of DNA Sequences and Their Use in the Construction of Artificial Transcription Factors
2001
Development of Zinc Finger Domains for Recognition of the 5′-CNN-3′ Family DNA Sequences and Their Use in the Construction of Artificial Transcription Factors
2005
Insights into the molecular recognition of the 5′-GNN-3′ family of DNA sequences by zinc finger domains 1 1Edited by M. Yaniv
2000
Chemically Regulated Zinc Finger Transcription Factors
2000
Designed ankyrin repeat proteins: a novel tool for testing epidermal growth factor receptor 2 expression in breast cancer
2010
Crystal Structure and Function of a DARPin Neutralizing Inhibitor of Lactococcal Phage TP901-1
2009
Destabilizing an interacting motif strengthens the association of a designed ankyrin repeat protein with tubulin
2016
Ribosome Display: A Technology for Selecting and Evolving Proteins from Large Libraries
2010
Structure of a kinesin–tubulin complex and implications for kinesin motility
2013
Conformation-Dependent Recognition of HIV gp120 by Designed Ankyrin Repeat Proteins Provides Access to Novel HIV Entry Inhibitors
2013
A designed ankyrin repeat protein selected to bind to tubulin caps the microtubule plus end
2012
Evaluation of a Modular Strategy for the Construction of Novel Polydactyl Zinc Finger DNA-Binding Proteins
2003
Positive and negative regulation of endogenous genes by designed transcription factors
2000
Toward controlling gene expression at will: Selection and design of zinc finger domains recognizing each of the 5′-GNN-3′ DNA target sequences
1999