Standout Papers
- Methylator resistance mediated by mismatch repair deficiency in a glioblastoma multiforme xenograft. (1997)
Citation Impact
Citing Papers
Activity-Dependent Internalization of Smoothened Mediated by ß-Arrestin 2 and GRK2
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Molecular Study of Malignant Gliomas Treated with Epidermal Growth Factor Receptor Inhibitors: Tissue Analysis from North American Brain Tumor Consortium Trials 01-03 and 00-01
2005
Mammalian Target of Rapamycin Inhibition Promotes Response to Epidermal Growth Factor Receptor Kinase Inhibitors in PTEN-Deficient and PTEN-Intact Glioblastoma Cells
2006
MET Amplification Leads to Gefitinib Resistance in Lung Cancer by Activating ERBB3 Signaling
2007 StandoutScience
MutL traps MutS at a DNA mismatch
2015 StandoutNobel
Sox11 Prevents Tumorigenesis of Glioma-Initiating Cells by Inducing Neuronal Differentiation
2009
A t(1;19)(q10;p10) Mediates the Combined Deletions of 1p and 19q and Predicts a Better Prognosis of Patients with Oligodendroglioma
2006
EGFR Mutations in Lung Cancer: Correlation with Clinical Response to Gefitinib Therapy
2004 StandoutScience
Coactivation of Receptor Tyrosine Kinases Affects the Response of Tumor Cells to Targeted Therapies
2007 Science
Epidermal Growth Factor Receptor Variant III Status Defines Clinically Distinct Subtypes of Glioblastoma
2007
Protein roadblocks and helix discontinuities are barriers to the initiation of mismatch repair
2007 StandoutNobel
Marked Genomic Differences Characterize Primary and Secondary Glioblastoma Subtypes and Identify Two Distinct Molecular and Clinical Secondary Glioblastoma Entities
2006
Stem Cell–like Glioma Cells Promote Tumor Angiogenesis through Vascular Endothelial Growth Factor
2006
Loss of the chromosomal region 10q23-25 in prostate cancer.
1995
Olig2-Regulated Lineage-Restricted Pathway Controls Replication Competence in Neural Stem Cells and Malignant Glioma
2007
Mismatch Repair-dependent Iterative Excision at Irreparable O6-Methylguanine Lesions in Human Nuclear Extracts
2006 StandoutNobel
Gefitinib in patients with progressive high-grade gliomas: a multicentre phase II study by Gruppo Italiano Cooperativo di Neuro-Oncologia (GICNO)
2007
Analysis of the 10q23 chromosomal region and the PTEN gene in human sporadic breast carcinoma
1999
Comprehensive genomic characterization defines human glioblastoma genes and core pathways
2008 StandoutNature
Glioma stem cells promote radioresistance by preferential activation of the DNA damage response
2006 StandoutNature
Genetic Alterations of Phosphoinositide 3‐kinase Subunit Genes in Human Glioblastomas
2004
IDH1andIDH2Mutations in Gliomas
2009 Standout
Stem cells, cancer, and cancer stem cells
2001 StandoutNature
The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism
2006 Standout
RNA interference against a glioma-derived allele of EGFR induces blockade at G2M
2004
Loss of Arf causes tumor progression of PDGFB-induced oligodendroglioma
2007
PDGF autocrine stimulation dedifferentiates cultured astrocytes and induces oligodendrogliomas and oligoastrocytomas from neural progenitors and astrocytes in vivo
2001
Genetic Pathways to Primary and Secondary Glioblastoma
2007
Mutational Spectra of PTEN/MMAC1 Gene: a Tumor Suppressor With Lipid Phosphatase Activity
1999
Overexpression of the EGF Receptor and p53 Mutations are Mutually Exclusive in the Evolution of Primary and Secondary Glioblastomas
1996
Allelic losses on chromosome arm 10q and mutation of the PTEN ( MMAC1 ) tumour suppressor gene in primary and metastatic malignant melanomas
2000
Reduced Expression of PTEN Protein and Its Prognostic Implications in Invasive Ductal Carcinoma of the Breast
2005
Phosphorylation of Human MAD1 by the BUB1 Kinasein Vitro
1999
Identification of the transforming EML4–ALK fusion gene in non-small-cell lung cancer
2007 StandoutNature
Malignant astrocytic glioma: genetics, biology, and paths to treatment
2007 Standout
Early inactivation of p53 tumor suppressor gene cooperating with NF1 loss induces malignant astrocytoma
2005
The hedgehog signaling network
2003
Degradation of Cdc25A by β-TrCP during S phase and in response to DNA damage
2003 StandoutNatureNobel
Accumulation of allelic losses on chromosome 10 in human gliomas at recurrence
1996
The Hallmarks of Cancer
2000 Standout
Endonucleolytic Function of MutLα in Human Mismatch Repair
2006 StandoutNobel
High cancer susceptibility and embryonic lethality associated with mutation of the PTEN tumor suppressor gene in mice
1998 StandoutNobel
Inhibition of angiogenesis and invasion in malignant gliomas
2007
Brain tumors: molecular biology and targeted therapies
2006
PTEN Mutation, EGFR Amplification, and Outcome in Patients With Anaplastic Astrocytoma and Glioblastoma Multiforme
2001
Molecularly targeted therapy for malignant glioma
2007
Nf1;Trp53 mutant mice develop glioblastoma with evidence of strain-specific effects
2000
The 1p-Encoded Protein Stathmin and Resistance of Malignant Gliomas to Nitrosoureas
2007
Redefinition of the coding sequence of the MXI1 gene and identification of a polymorphic repeat in the 3? non-coding region that allows the detection of loss of heterozygosity of chromosome 10q25 in glioblastomas
1995
The SCFbeta -TRCP-ubiquitin ligase complex associates specifically with phosphorylated destruction motifs in Ikappa Balpha and beta -catenin and stimulates Ikappa Balpha ubiquitination in vitro
1999
Colorectal carcinomas in mice lacking the catalytic subunit of PI(3)Kγ
2000 StandoutNatureNobel
Brain tumour stem cells
2006
Negative Regulation of PKB/Akt-Dependent Cell Survival by the Tumor Suppressor PTEN
1998 StandoutNobel
Epidemiology of Brain Tumors
2007
Oncogenic Mutations Counteract Intrinsic Disorder in the EGFR Kinase and Promote Receptor Dimerization
2012 StandoutNobel
Anaplastic Oligodendroglioma and Oligoastrocytoma
2007
Malignant Gliomas in Adults
2008 Standout
A tiger behind many doors: multiple genetic pathways to malignant glioma
1995
Inhibiting kinases in malignant gliomas
2007
Exclusion of a major role for the PTEN tumour-suppressor gene in breast carcinomas
1999
Glioma Stem Cells: A Midterm Exam
2008
Characterization of an imatinib-sensitive subset of high-grade human glioma cultures
2006
Human glioblastoma xenografts overexpressing a tumor-specific mutant epidermal growth factor receptor sensitized to cisplatin by the AG1478 tyrosine kinase inhibitor
2001
Oligodendroglioma: Toward Molecular Definitions in Diagnostic Neuro-Oncology
2003
Microsatellite Instability in Human Cancer: A Prognostic Marker for Chemotherapy?
1999
The mitochondrial permeability transition
1995 Standout
Inactivation of thePTEN/MMAC1/TEP1 gene in human lung cancers
1998
Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers
1997 Standout
Identification of human brain tumour initiating cells
2004 StandoutNature
Exosomes from marrow stromal cells expressing miR-146b inhibit glioma growth
2013
Infrequent Mutations in the PTEN/MMAC1 Gene among Primary Breast Cancers
1998
Cancer-related inflammation
2008 StandoutNature
A constitutively active epidermal growth factor receptor cooperates with disruption of G1 cell-cycle arrest pathways to induce glioma-like lesions in mice
1998 Nobel
Clinical evidence of distinct subgroups of astrocytic tumors defined by comparative genomic hybridization
2000
A comprehensive analysis of protein–protein interactions in Saccharomyces cerevisiae
2000 StandoutNature
Human cancer, PTEN and the PI-3 kinase pathway
2004
Genetic Alterations of Cyclins, Cyclin-Dependent Kinases, and Cdk Inhibitors in Human Cancer
1996
Diagnosis and Treatment of High-Grade Astrocytoma
2007
Activating Mutations in the Epidermal Growth Factor Receptor Underlying Responsiveness of Non–Small-Cell Lung Cancer to Gefitinib
2004 Standout
PCNA function in the activation and strand direction of MutLα endonuclease in mismatch repair
2010 StandoutNobel
Tumor spectrum in ARF-deficient mice.
1999
Mammalian DNA Mismatch Repair
1999
Sporadic breast cancers exhibit loss of heterozygosity on chromosome segment 10q23 close to the Cowden disease locus
1998
New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway
1999 Standout
Interaction of the Tumor Suppressor PTEN/MMAC with a PDZ Domain of MAGI3, a Novel Membrane-associated Guanylate Kinase
2000 Standout
Mutation of the PTEN (MMAC1) tumor suppressor gene in a subset of glioblastomas but not in meningiomas with loss of chromosome arm 10q.
1998
PTEN/MMAC1 mutations and EGFR amplification in glioblastomas.
1997
Mismatch Repair Deficiency Does Not Mediate Clinical Resistance to Temozolomide in Malignant Glioma
2008 StandoutNobel
Bevacizumab and chemotherapy for recurrent glioblastoma
2009
The Protein Kinase Complement of the Human Genome
2002 StandoutScience
Molecular Predictors in Glioblastoma
2008
Rbx1, a Component of the VHL Tumor Suppressor Complex and SCF Ubiquitin Ligase
1999 StandoutScienceNobel
Therapeutic Application of Noncytotoxic Molecular Targeted Therapy in Gliomas: Growth Factor Receptors and Angiogenesis Inhibitors
2008
Cancer Cell Cycles
1996 StandoutScience
Diagnosis and Treatment of Recurrent High-Grade Astrocytoma
2006
Two tumor suppressive loci on chromosome 10 involved in human glioblastomas
1995
Phase II Study of Imatinib Mesylate Plus Hydroxyurea in Adults With Recurrent Glioblastoma Multiforme
2005
DNA Mismatch Repair: Functions and Mechanisms
2005 StandoutNobel
Mice carrying a human GLUD2 gene recapitulate aspects of human transcriptome and metabolome development
2016 StandoutNobel
EGFR Activation Results in Enhanced Cyclooxygenase-2 Expression through p38 Mitogen-Activated Protein Kinase–Dependent Activation of the Sp1/Sp3 Transcription Factors in Human Gliomas
2007
The Biology and Clinical Relevance of the PTEN Tumor Suppressor Pathway
2004
Somatic mutations of PTEN in glioblastoma multiforme.
1997
Impaired Fas Response and Autoimmunity in Pten +/− Mice
1999 Science
Amplification and overexpression of the MDM4 (MDMX) gene from 1q32 in a subset of malignant gliomas without TP53 mutation or MDM2 amplification.
1999
Phase II Trial of Bevacizumab and Irinotecan in Recurrent Malignant Glioma
2007
PMS2 endonuclease activity has distinct biological functions and is essential for genome maintenance
2010 StandoutNobel
Growth suppression of glioma cells by PTEN requires a functional phosphatase catalytic domain
1997
The biology , function , and biomedical applications of exosomes
2020 StandoutScience
Chemoradiotherapy in Malignant Glioma: Standard of Care and Future Directions
2007
The Release of Cytochrome c from Mitochondria: A Primary Site for Bcl-2 Regulation of Apoptosis
1997 StandoutScience
Combination therapy of inhibitors of epidermal growth factor receptor/vascular endothelial growth factor receptor 2 (AEE788) and the mammalian target of rapamycin (RAD001) offers improved glioblastoma tumor growth inhibition
2005
The lipid phosphatase activity of PTEN is critical for its tumor supressor function
1998
Cancer Genome Landscapes
2013 StandoutScience
Interfocal heterogeneity of PTEN/MMAC1 gene alterations in multiple metastatic prostate cancer tissues.
1998
PTEN , a Putative Protein Tyrosine Phosphatase Gene Mutated in Human Brain, Breast, and Prostate Cancer
1997 StandoutScience
The Developmental Biology of Brain Tumors
2001
The tumor-suppressor activity of PTEN is regulated by its carboxyl-terminal region
1999
BRCA1-IRIS promotes human tumor progression through PTEN blockade and HIF-1α activation
2018 StandoutNobel
Mutation ofPten/Mmac1in mice causes neoplasia in multiple organ systems
1999
Astrocyte-specific expression of activated p21-ras results in malignant astrocytoma formation in a transgenic mouse model of human gliomas.
2001
Genetic Pathways to Glioblastoma
2004
Serum IgE, Tumor Epidermal Growth Factor Receptor Expression, and Inherited Polymorphisms Associated with Glioma Survival
2006
Extrahelical (CAG)/(CTG) triplet repeat elements support proliferating cell nuclear antigen loading and MutLα endonuclease activation
2013 StandoutNobel
High rate of CAD gene amplification in human cells deficient in MLH1 or MSH6
2001 StandoutNobel
Human DNA Repair Genes
2001 StandoutScienceNobel
Genetics of Cowden syndrome: through the looking glass of oncology.
1998
Integrating Genetic Approaches into the Discovery of Anticancer Drugs
1997 StandoutScienceNobel
A genetically tractable model of human glioma formation.
2001
Molecular Profiling Identifies Prognostic Subgroups of Pediatric Glioblastoma and Shows Increased YB-1 Expression in Tumors
2007
hMutSα- and hMutLα-dependent phosphorylation of p53 in response to DNA methylator damage
1999 StandoutNobel
Normal development is an integral part of tumorigenesis in T cell-specific PTEN-deficient mice
2008 StandoutNobel
Early onset of neoplasia in the prostate and skin of mice with tissue-specific deletion of Pten
2004 StandoutNobel
Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation
2009 StandoutScience
High incidence of breast and endometrial neoplasia resembling human Cowden syndrome in pten+/- mice.
2000 StandoutNobel
Works of Binish Rasheed being referenced
Gene Expression Profiling and Genetic Markers in Glioblastoma Survival
2005
Loss of heterozygosity for 10q loci in human gliomas
1992
Molecular pathogenesis of malignant gliomas
1999
Survival analysis of presumptive prognostic markers among oligodendrogliomas
2005
Morphologic and molecular genetic aspects of oligodendroglialneoplasms
1999
Molecular Genetic Aspects of Oligodendrogliomas Including Analysis by Comparative Genomic Hybridization
1999
Methylator resistance mediated by mismatch repair deficiency in a glioblastoma multiforme xenograft.
1997 StandoutNobel
Oncogenes and anti-oncogenes in human central nervous system tumors.
1994
ZD6474, a Novel Tyrosine Kinase Inhibitor of Vascular Endothelial Growth Factor Receptor and Epidermal Growth Factor Receptor, Inhibits Tumor Growth of Multiple Nervous System Tumors
2005
AAL881, a Novel Small Molecule Inhibitor of RAF and Vascular Endothelial Growth Factor Receptor Activities, Blocks the Growth of Malignant Glioma
2006
Activation of potassium ion transport in mitochondria by cadmium ion
1984
Chromosome 10 deletion mapping in human gliomas: a common deletion region in 10q25.
1995
PTEN gene mutations are seen in high-grade but not in low-grade gliomas.
1997
Alterations of the TP53 gene in human gliomas.
1994
Phase II Trial of Gefitinib in Recurrent Glioblastoma
2003
Genetic alterations in glioma and medulloblastoma
1991