Citation Impact
Citing Papers
The PINK1/Parkin pathway regulates mitochondrial morphology
2008
The Parkinson's disease genes pink1 and parkin promote mitochondrial fission and/or inhibit fusion in Drosophila
2008
Global phosphorylation analysis of β-arrestin–mediated signaling downstream of a seven transmembrane receptor (7TMR)
2010 StandoutNobel
In vivo imaging of hydrogen peroxide production in a murine tumor model with a chemoselective bioluminescent reporter
2010 StandoutNobel
Dishevelled 2 Recruits ß-Arrestin 2 to Mediate Wnt5A-Stimulated Endocytosis of Frizzled 4
2003 StandoutScienceNobel
Parkinson-like syndrome induced by continuous MPTP infusion: Convergent roles of the ubiquitin-proteasome system and α-synuclein
2005 StandoutNobel
Strategy for Dual-Analyte Luciferin Imaging: In Vivo Bioluminescence Detection of Hydrogen Peroxide and Caspase Activity in a Murine Model of Acute Inflammation
2013 StandoutNobel
Dystroglycan is required for polarizing the epithelial cells and the oocyte in Drosophila
2002
Orientation of Asymmetric Stem Cell Division by the APC Tumor Suppressor and Centrosome
2003 Science
Parkin overexpression during aging reduces proteotoxicity, alters mitochondrial dynamics, and extends lifespan
2013
Parkin-catalyzed Ubiquitin-Ester Transfer Is Triggered by PINK1-dependent Phosphorylation
2013
Molecular interaction between parkin and PINK1 in mammalian neuronal cells
2009
Parkinson's disease mutations in PINK1 result in decreased Complex I activity and deficient synaptic function
2009
Par complex cluster formation mediated by phase separation
2020
PINK1-mediated phosphorylation of the Parkin ubiquitin-like domain primes mitochondrial translocation of Parkin and regulates mitophagy
2012
A Dimeric PINK1-containing Complex on Depolarized Mitochondria Stimulates Parkin Recruitment
2013
Three-dimensional tracking of single mRNA particles in Saccharomyces cerevisiae using a double-helix point spread function
2010 StandoutNobel
The PINK1–Parkin pathway is involved in the regulation of mitochondrial remodeling process
2008
Mitochondrial dynamics-fusion, fission, movement, and mitophagy-in neurodegenerative diseases
2009
Mitofusin 1 and mitofusin 2 are ubiquitinated in a PINK1/parkin-dependent manner upon induction of mitophagy
2010
Asymmetric Rab11 Endosomes Regulate Delta Recycling and Specify Cell Fate in the Drosophila Nervous System
2005
The Ubiquitin Proteasome System in Neurodegenerative Diseases
2003 StandoutNobel
Ferroptosis as a p53-mediated activity during tumour suppression
2015 StandoutNature
PINK1 controls mitochondrial localization of Parkin through direct phosphorylation
2008
Intercellular junctions and cellular polarity: the PAR–aPKC complex, a conserved core cassette playing fundamental roles in cell polarity
2001
Respiratory Chain Complexes in Dynamic Mitochondria Display a Patchy Distribution in Life Cells
2010
RBR Ubiquitin Ligases: Diversification and Streamlining in Animal Lineages
2009
The AMPK signalling pathway coordinates cell growth, autophagy and metabolism
2011 Standout
PINK1 Is Selectively Stabilized on Impaired Mitochondria to Activate Parkin
2010 Standout
The Roles of PINK1, Parkin, and Mitochondrial Fidelity in Parkinson’s Disease
2015 Standout
Parkin and PINK1: much more than mitophagy
2014
Genome-wide analysis of Notch signalling in Drosophila by transgenic RNAi
2009 Nature
Phosphorylation of parkin by Parkinson disease-linked kinase PINK1 activates parkin E3 ligase function and NF- B signaling
2009
Parkin and mitochondrial quality control: toward assembling the puzzle
2014
Inclusion Body Formation and Neurodegeneration Are Parkin Independent in a Mouse Model of α-Synucleinopathy
2006
Socializing with the Neighbors
2004 Standout
Increased Mitochondrial Calcium Sensitivity and Abnormal Expression of Innate Immunity Genes Precede Dopaminergic Defects in Pink1-Deficient Mice
2011
Electrical signals control wound healing through phosphatidylinositol-3-OH kinase-γ and PTEN
2006 StandoutNatureNobel
Apical–basal polarity and the control of epithelial form and function
2022
TRAP1 rescues PINK1 loss-of-function phenotypes
2013
Broad activation of the ubiquitin–proteasome system by Parkin is critical for mitophagy
2011
A journey into space
2001 StandoutNobel
Role of the Biomolecular Energy Gap in Protein Design, Structure, and Evolution
2012 StandoutNobel
p62/SQSTM1 cooperates with Parkin for perinuclear clustering of depolarized mitochondria
2010
Deciphering the role of heterozygous mutations in genes associated with parkinsonism
2007
The KLHL12–Cullin-3 ubiquitin ligase negatively regulates the Wnt–β-catenin pathway by targeting Dishevelled for degradation
2006
Mitochondrial fusion and fission in cell life and death
2010 Standout
Mono- and double-mutant mouse models of Parkinson's disease display severe mitochondrial damage
2007
The Par complex directs asymmetric cell division by phosphorylating the cytoskeletal protein Lgl
2003 Nature
Polarized endosome dynamics by spindle asymmetry during asymmetric cell division
2015 Nature
The mitochondrial deubiquitinase USP30 opposes parkin-mediated mitophagy
2014 Nature
Dissecting muscle and neuronal disorders in a Drosophila model of muscular dystrophy
2007 StandoutNobel
SRC-1 and Wnt Signaling Act Together to Specify Endoderm and to Control Cleavage Orientation in Early C. elegans Embryos
2002 StandoutNobel
Rho GTPases in cell biology
2002 StandoutNature
Sticky Business
2003
PINK1 is activated by mitochondrial membrane potential depolarization and stimulates Parkin E3 ligase activity by phosphorylating Serine 65
2012
PINK1 cleavage at position A103 by the mitochondrial protease PARL
2010
ASPM is a major determinant of cerebral cortical size
2002
PINK1 and Parkin Target Miro for Phosphorylation and Degradation to Arrest Mitochondrial Motility
2011
Loss of Parkin or PINK1 Function Increases Drp1-dependent Mitochondrial Fragmentation
2009
Mitochondrial fragmentation in neurodegeneration
2008
Loss-of-Function of Human PINK1 Results in Mitochondrial Pathology and Can Be Rescued by Parkin
2007
Control of Actin Reorganization by Slingshot, a Family of Phosphatases that Dephosphorylate ADF/Cofilin
2002
Ubiquitin-dependent regulation of COPII coat size and function
2012 StandoutNatureNobel
Cdk5 deregulation in the pathogenesis of Alzheimer's disease
2004
PINK1 is recruited to mitochondria with parkin and associates with LC3 in mitophagy
2010
The Mitochondrial Phosphatase PGAM5 Functions at the Convergence Point of Multiple Necrotic Death Pathways
2012
Design of biologically active binary protein 2D materials
2021 StandoutNatureNobel
Parkinson's disease
2015 Standout
Mitophagy is triggered by mild oxidative stress in a mitochondrial fission dependent manner
2012
Asymmetric cell division: recent developments and their implications for tumour biology
2010
Synthetic Par polarity induces cytoskeleton asymmetry in unpolarized mammalian cells
2023 StandoutNobel
Adhesion-GPCRs: emerging roles for novel receptors
2008
Parkinson's Disease: Gene Therapies
2012
The Yeast Complex I Equivalent NADH Dehydrogenase Rescues pink1 Mutants
2012
Linking Cell Cycle to Asymmetric Division: Aurora-A Phosphorylates the Par Complex to Regulate Numb Localization
2008
Loss-of-Function Analysis Suggests ThatOmi/HtrA2Is Not an Essential Component of thepink1/parkinPathwayIn Vivo
2008
Drosophila Trap1 protects against mitochondrial dysfunction in a PINK1/parkin model of Parkinson’s disease
2013
Dividing cellular asymmetry: asymmetric cell division and its implications for stem cells and cancer
2009
Mechanisms of mitophagy
2010 Standout
Ribosomal Protein s15 Phosphorylation Mediates LRRK2 Neurodegeneration in Parkinson’s Disease
2014
PINK1 Protects against Oxidative Stress by Phosphorylating Mitochondrial Chaperone TRAP1
2007
Drosophila, the golden bug, emerges as a tool for human genetics
2005
Mitochondrial Quality Control Mediated by PINK1 and Parkin: Links to Parkinsonism
2012 Nobel
A tale on animal models of Parkinson's disease
2011
Non-coding RNAs in human disease
2011 Standout
Mutations in PINK1 and Parkin Impair Ubiquitination of Mitofusins in Human Fibroblasts
2011
Stem cells in the skin: waste not, Wnt not
2003
Role of the Ubiquitin Conjugation System in the Maintenance of Mitochondrial Homeostasis
2008
Parkin-deficient Mice Exhibit Nigrostriatal Deficits but Not Loss of Dopaminergic Neurons
2003
Ret rescues mitochondrial morphology and muscle degeneration of Drosophila Pink1 mutants
2014
Functional interplay between Parkin and Drp1 in mitochondrial fission and clearance
2014
Loss of autophagy in the central nervous system causes neurodegeneration in mice
2006 StandoutNature
Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases
2006 StandoutNature
Neurogenesis and the Cell Cycle
2003
The Parkinson-associated protein PINK1 interacts with Beclin1 and promotes autophagy
2010
Are Ubiquitination Pathways Central to Parkinson's Disease?
2003
Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization
2013 Nature
Role of PINK1 Binding to the TOM Complex and Alternate Intracellular Membranes in Recruitment and Activation of the E3 Ligase Parkin
2012
Alpha-synuclein-induced neurodegeneration is exacerbated in PINK1 knockout mice
2014
Surrogate Wnt agonists that phenocopy canonical Wnt and β-catenin signalling
2017 StandoutNatureNobel
β1 integrins and neural stem cells: making sense of the extracellular environment
2005
C-terminal truncation and Parkinson's disease-associated mutations down-regulate the protein serine/threonine kinase activity of PTEN-induced kinase-1
2006
Expanding insights of mitochondrial dysfunction in Parkinson's disease
2006
Dynamic Spatial Regulation in the Bacterial Cell
2000
The Drosophila Myosin VI Jaguar Is Required for Basal Protein Targeting and Correct Spindle Orientation in Mitotic Neuroblasts
2003
The Mitochondrial Fusion-Promoting Factor Mitofusin Is a Substrate of the PINK1/Parkin Pathway
2010
Pink1, Parkin, DJ-1 and mitochondrial dysfunction in Parkinson's disease
2007
PINK1-Mediated Phosphorylation of Parkin Boosts Parkin Activity in Drosophila
2014
Asymmetric Sorting of Ash1p in Yeast Results from Inhibition of Translation by Localization Elements in the mRNA
2002
The role of parkin in familial and sporadic Parkinson's disease
2010
Recent advances into the understanding of mitochondrial fission
2012
Characterization of PINK1 processing, stability, and subcellular localization
2008
Mice cloned from olfactory sensory neurons
2004 StandoutNatureNobel
Rac1 orientates epithelial apical polarity through effects on basolateral laminin assembly
2001
Regulation of mitochondrial permeability transition pore by PINK1
2012
Experimental and theoretical study of mitotic spindle orientation
2007 Nature
Genetics of Parkinson's disease and parkinsonism
2006
Variants in eukaryotic translation initiation factor 4G1 in sporadic Parkinson’s disease
2012
Absence of nigral degeneration in aged parkin/DJ‐1/PINK1 triple knockout mice
2009
Molecular pathways to neurodegeneration
2004
Frizzled regulates localization of cell-fate determinants and mitotic spindle rotation during asymmetric cell division
2000
The Interplay Between Mitochondrial Dynamics and Mitophagy
2010
Mitochondrial Quality Control and Dynamics in Parkinson's Disease
2011
β-Arrestin2 mediates the initiation and progression of myeloid leukemia
2012 StandoutNobel
β-Arrestin inhibits NF-κB activity by means of its interaction with the NF-κB inhibitor IκBα
2004 StandoutNobel
The genetics of P arkinson's disease: Progress and therapeutic implications
2013
Proteasome and p97 mediate mitophagy and degradation of mitofusins induced by Parkin
2010
Depletion of PINK1 affects mitochondrial metabolism, calcium homeostasis and energy maintenance
2011
Analysis of neural subtypes reveals selective mitochondrial dysfunction in dopaminergic neurons from parkin mutants
2012
Ramshackle (Brwd3) promotes light-induced ubiquitylation of Drosophila Cryptochrome by DDB1-CUL4-ROC1 E3 ligase complex
2013 StandoutNobel
Lysosomal activity regulatesCaenorhabditis elegansmitochondrial dynamics through vitamin B12 metabolism
2020 StandoutNobel
Impaired mitochondrial transport and Parkin-independent degeneration of respiratory chain-deficient dopamine neurons in vivo
2011
Electrical cues regulate the orientation and frequency of cell division and the rate of wound healing in vivo
2002
What Genetics Tells us About the Causes and Mechanisms of Parkinson's Disease
2011
Parkin negatively regulates JNK pathway in the dopaminergic neurons ofDrosophila
2005
Mitochondrial Fission, Fusion, and Stress
2012 StandoutScience
Mitochondrial membrane potential regulates PINK1 import and proteolytic destabilization by PARL
2010
ROS-based lethality of Caenorhabditis elegans mitochondrial electron transport mutants grown on Escherichia coli siderophore iron release mutants
2019 StandoutNobel
Parkin overexpression selects against a deleterious mtDNA mutation in heteroplasmic cybrid cells
2010
The cell-adhesion G protein-coupled receptor BAI3 is a high-affinity receptor for C1q-like proteins
2011 StandoutNobel
The dynamin-related GTPase Drp1 is required for embryonic and brain development in mice
2009
Rhomboid-7 and HtrA2/Omi act in a common pathway with the Parkinson’s disease factors Pink1 and Parkin
2008
MUL1 acts in parallel to the PINK1/parkin pathway in regulating mitofusin and compensates for loss of PINK1/parkin
2014
Regulation of Caenorhabditis elegans neuronal polarity by heterochronic genes
2019 StandoutNobel
β-Arrestin1 modulates lymphoid enhancer factor transcriptional activity through interaction with phosphorylated dishevelled proteins
2001 StandoutNobel
Mindbomb 1, an E3 ubiquitin ligase, forms a complex with RYK to activate Wnt/β-catenin signaling
2011
Polarized endosome dynamics engage cytoplasmic Par-3 that recruits dynein during asymmetric cell division
2021
Aspm specifically maintains symmetric proliferative divisions of neuroepithelial cells
2006 StandoutNobel
PINK1 drives Parkin self-association and HECT-like E3 activity upstream of mitochondrial binding
2013
LRRK2 and vesicle trafficking
2012
Loss of PINK1 causes mitochondrial functional defects and increased sensitivity to oxidative stress
2008
Control of stem cell self-renewal and differentiation by the heterochronic genes and the cellular asymmetry machinery in Caenorhabditis elegans
2015 StandoutNobel
β-Arrestin is a necessary component of Wnt/β-catenin signaling in vitro and in vivo
2007
THE WNT SIGNALING PATHWAY IN DEVELOPMENT AND DISEASE
2004 Standout
Cell Biology of the Mitochondrion
2017
The Partner of Inscuteable/Discs-Large Complex Is Required to Establish Planar Polarity during Asymmetric Cell Division in Drosophila
2001
Mutations in mouse Aspm (abnormal spindle-like microcephaly associated) cause not only microcephaly but also major defects in the germline
2010 StandoutNobel
Parkin is activated by PINK1-dependent phosphorylation of ubiquitin at Ser65
2014
A Localized Wnt Signal Orients Asymmetric Stem Cell Division in Vitro
2013 StandoutScienceNobel
Adhesion molecules in the stem cell niche – more than just staying in shape?
2010
Mitochondrial Dysfunction and Oxidative Damage in parkin-deficient Mice
2004
Reducing Endogenous Tau Ameliorates Amyloid ß-Induced Deficits in an Alzheimer's Disease Mouse Model
2007 StandoutScience
Increased glutathione S -transferase activity rescues dopaminergic neuron loss in a Drosophila model of Parkinson's disease
2005
Eb1 Proteins Regulate Microtubule Dynamics, Cell Polarity, and Chromosome Stability
2000
MOLECULAR PATHOPHYSIOLOGY OF PARKINSON'S DISEASE
2005
Transcriptomes of germinal zones of human and mouse fetal neocortex suggest a role of extracellular matrix in progenitor self-renewal
2012 StandoutNobel
Mutations in Fis1 disrupt orderly disposal of defective mitochondria
2013
Phosphorylation of Parkin at Serine65 is essential for activation: elaboration of a Miro1 substrate-based assay of Parkin E3 ligase activity
2014
Mitophagy confers resistance to siderophore-mediated killing by Pseudomonas aeruginosa
2015 StandoutNobel
Cell shape and Wnt signaling redundantly control the division axis ofC. elegansepithelial stem cells
2011
Drosophila Parkin requires PINK1 for mitochondrial translocation and ubiquitinates Mitofusin
2010
PINK1 stabilized by mitochondrial depolarization recruits Parkin to damaged mitochondria and activates latent Parkin for mitophagy
2010 Standout
Inducible proteolytic inactivation of OPA1 mediated by the OMA1 protease in mammalian cells
2009
E3 ubiquitin ligase Mindbomb 1 facilitates nuclear delivery of adenovirus genomes
2020 StandoutNobel
The PINK1–Parkin pathway promotes both mitophagy and selective respiratory chain turnover in vivo
2013
Transduction of Receptor Signals by ß-Arrestins
2005 StandoutScienceNobel
Nucleotide Exchange Factor ECT2 Interacts with the Polarity Protein Complex Par6/Par3/Protein Kinase Cζ (PKCζ) and Regulates PKCζ Activity
2004
Sara endosomes and the asymmetric division of intestinal stem cells
2014
Parkin is recruited selectively to impaired mitochondria and promotes their autophagy
2008 Standout
Drosophila parkinmutants have decreased mass and cell size and increased sensitivity to oxygen radical stress
2004
Works of Bingwei Lu being referenced
Parkinson's Disease–Associated Kinase PINK1 Regulates Miro Protein Level and Axonal Transport of Mitochondria
2012
Adherens junctions inhibit asymmetric division in the Drosophila epithelium
2001 Nature
Polo inhibits progenitor self-renewal and regulates Numb asymmetry by phosphorylating Pon
2007 Nature
Drosophila par-1 is required for oocyte differentiation and microtubule organization
2001
Pathogenic LRRK2 negatively regulates microRNA-mediated translational repression
2010 Nature
Parkin Suppresses Dopaminergic Neuron-Selective Neurotoxicity Induced by Pael-R in Drosophila
2003
Modes of Protein Movement that Lead to the Asymmetric Localization of Partner of Numb during Drosophila Neuroblast Division
1999
Phosphorylation of 4E‐BP by LRRK2 affects the maintenance of dopaminergic neurons in Drosophila
2008
Tricornered/NDR kinase signaling mediates PINK1-directed mitochondrial quality control and tissue maintenance
2013
PAR-1 is a Dishevelled-associated kinase and a positive regulator of Wnt signalling
2001
Flamingo controls the planar polarity of sensory bristles and asymmetric division of sensory organ precursors in Drosophila
1999
Reduction of Protein Translation and Activation of Autophagy Protect against PINK1 Pathogenesis in Drosophila melanogaster
2010
Asymmetric cell division: lessons from flies and worms
1998
Partner of Numb Colocalizes with Numb during Mitosis and Directs Numb Asymmetric Localization in Drosophila Neural and Muscle Progenitors
1998
LRRK2 Kinase Regulates Synaptic Morphology through Distinct Substrates at the Presynaptic and Postsynaptic Compartments of theDrosophilaNeuromuscular Junction
2010
The Loss of PGAM5 Suppresses the Mitochondrial Degeneration Caused by Inactivation of PINK1 in Drosophila
2010
Mitochondrial dynamics and neurodegeneration
2009
Polo Kinase Phosphorylates Miro to Control ER-Mitochondria Contact Sites and Mitochondrial Ca 2+ Homeostasis in Neural Stem Cell Development
2016
PAR-1 Kinase Plays an Initiator Role in a Temporally Ordered Phosphorylation Process that Confers Tau Toxicity in Drosophila
2004
The PINK1/Parkin pathway regulates mitochondrial dynamics and function in mammalian hippocampal and dopaminergic neurons
2011
Leucine-rich repeat kinase 2 interacts with Parkin, DJ-1 and PINK-1 in a Drosophila melanogaster model of Parkinson's disease
2009
HSP induction mediates selective clearance of tau phosphorylated at proline‐directed Ser/Thr sites but not KXGS (MARK) sites
2006
Drosophila Models of Neurodegenerative Diseases
2008
Inactivation of Drosophila DJ-1 leads to impairments of oxidative stress response and phosphatidylinositol 3-kinase/Akt signaling
2005
Pink1 regulates the oxidative phosphorylation machinery via mitochondrial fission
2011
Mitochondrial pathology and muscle and dopaminergic neuron degeneration caused by inactivation of Drosophila Pink1 is rescued by Parkin
2006
Control of Cell Divisions in the Nervous System: Symmetry and Asymmetry
2000
Pink1 regulates mitochondrial dynamics through interaction with the fission/fusion machinery
2008
The synaptic function of LRRK2
2012