Citation Impact
Citing Papers
CTLA-4 Control over Foxp3 + Regulatory T Cell Function
2008 StandoutScienceNobel
Generation of knock-in primary human T cells using Cas9 ribonucleoproteins
2015 StandoutNobel
Programmed cell death 1 forms negative costimulatory microclusters that directly inhibit T cell receptor signaling by recruiting phosphatase SHP2
2012
Genome-wide CRISPR screens reveal a specific ligand for the glycan-binding immune checkpoint receptor Siglec-7
2021 StandoutNobel
Dual function of CTLA-4 in regulatory T cells and conventional T cells to prevent multiorgan autoimmunity
2010
Construction of self-recognizing regulatory T cells from conventional T cells by controlling CTLA-4 and IL-2 expression
2013 StandoutNobel
CD4+ regulatory T cells require CTLA-4 for the maintenance of systemic tolerance
2009
PD-1 + regulatory T cells amplified by PD-1 blockade promote hyperprogression of cancer
2019 StandoutNobel
CTLA-4 Controls Regulatory T Cell Peripheral Homeostasis and Is Required for Suppression of Pancreatic Islet Autoimmunity
2009
Confusing signals: Recent progress in CTLA-4 biology
2015
GROα regulates human embryonic stem cell self-renewal or adoption of a neuronal fate
2011
CTLA‐4 is required by CD4+CD25+ Treg to control CD4+ T‐cell lymphopenia‐induced proliferation
2009
The role of CD28 and cytotoxic T‐lymphocyte antigen‐4 (CTLA‐4) in regulatory T‐cell biology
2006
Elements of cancer immunity and the cancer–immune set point
2017 StandoutNature
Detailed analysis of immunologic effects of the cytotoxic T lymphocyte-associated antigen 4-blocking monoclonal antibody tremelimumab in peripheral blood of patients with melanoma
2008
Physical Principles of Membrane Shape Regulation by the Glycocalyx
2019 StandoutNobel
The reverse stop-signal model for CTLA4 function
2008
TCR/CD3 mediated stop-signal is decoupled in T-cells from Ctla4 deficient mice
2007
The biology and management of non-small cell lung cancer
2018 StandoutNature
Mechanism of tumor rejection with doublets of CTLA-4, PD-1/PD-L1, or IDO blockade involves restored IL-2 production and proliferation of CD8+ T cells directly within the tumor microenvironment
2014
Regulatory T Cells and Immune Tolerance
2008 StandoutNobel
Influence of tumour micro-environment heterogeneity on therapeutic response
2013 StandoutNature
Cell-autonomous and -non-autonomous roles of CTLA-4 in immune regulation
2011 StandoutNobel
Ipilimumab: Unleashing the Power of the Immune System Through CTLA-4 Blockade
2010
Foxp3+CD25+CD4+ natural regulatory T cells in dominant self‐tolerance and autoimmune disease
2006 StandoutNobel
Immune Checkpoint Targeting in Cancer Therapy: Toward Combination Strategies with Curative Potential
2015 StandoutNobel
Neo-antigens predicted by tumor genome meta-analysis correlate with increased patient survival
2014
PD-1 and PD-L1 Immune Checkpoint Blockade to Treat Breast Cancer
2016 Standout
The emerging role of CTLA4 as a cell-extrinsic regulator of T cell responses
2011
T cell sensing of antigen dose governs interactive behavior with dendritic cells and sets a threshold for T cell activation
2008
Acne vulgaris
2011 Standout
Adult Neurogenesis in the Mammalian Brain: Significant Answers and Significant Questions
2011 Standout
Combination CTLA-4 Blockade and 4-1BB Activation Enhances Tumor Rejection by Increasing T-Cell Infiltration, Proliferation, and Cytokine Production
2011 StandoutNobel
CTLA-4 suppresses the pathogenicity of self antigen–specific T cells by cell-intrinsic and cell-extrinsic mechanisms
2009
Interactions between PD-1 and PD-L1 promote tolerance by blocking the TCR–induced stop signal
2009
Negative regulators of T‐cell activation: potential targets for therapeutic intervention in cancer, autoimmune disease, and persistent infections
2009 StandoutNobel
The blockade of immune checkpoints in cancer immunotherapy
2012 Standout
Control of peripheral T‐cell tolerance and autoimmunity via the CTLA‐4 and PD‐1 pathways
2008
Control of TH17/Treg Balance by Hypoxia-Inducible Factor 1
2011 StandoutNobel
CD28 and CTLA‐4 coreceptor expression and signal transduction
2009
Genetics and pathogenesis of inflammatory bowel disease
2011 StandoutNature
Melanoma-intrinsic β-catenin signalling prevents anti-tumour immunity
2015 StandoutNature
The role of senescent cells in ageing
2014 StandoutNature
Distinct Cellular Mechanisms Underlie Anti-CTLA-4 and Anti-PD-1 Checkpoint Blockade
2017 StandoutNobel
Metabolism, Cell Surface Organization, and Disease
2009
ICER/CREM‐mediated transcriptional attenuation of IL‐2 and its role in suppression by regulatory T cells
2007 StandoutNobel
Immune Checkpoint Protein Inhibition for Cancer: Preclinical Justification for CTLA-4 and PD-1 Blockade and New Combinations
2015
Immune Checkpoint Blockade: A Common Denominator Approach to Cancer Therapy
2015 Standout
A guide to cancer immunotherapy: from T cell basic science to clinical practice
2020 Standout
Enhanced selection of FoxP3 + T-regulatory cells protects CTLA-4-deficient mice from CNS autoimmune disease
2009
Murine regulatory T cells differ from conventional T cells in resisting the CTLA-4 reversal of TCR stop-signal
2012
Computational design of a synthetic PD-1 agonist
2021 StandoutNobel
Detection of self-reactive CD8 + T cells with an anergic phenotype in healthy individuals
2014 StandoutScienceNobel
CD4+CD25−LAG3+regulatory T cells controlled by the transcription factor Egr-2
2009 StandoutNobel
At the Bench: Preclinical rationale for CTLA-4 and PD-1 blockade as cancer immunotherapy
2013
Nonoverlapping roles of PD-1 and FoxP3 in maintaining immune tolerance in a novel autoimmune pancreatitis mouse model
2016 StandoutNobel
T follicular regulatory cells
2016
Cell intrinsic mechanisms of T‐cell inhibition and application to cancer therapy
2008 StandoutNobel
CTLA-4 blockade in tumor models: an overview of preclinical and translational research.
2013
Simultaneous inhibition of two regulatory T-cell subsets enhanced Interleukin-15 efficacy in a prostate tumor model
2012 StandoutNobel
Induction of autoimmune disease by deletion of CTLA-4 in mice in adulthood
2016 StandoutNobel
Foxp3+natural regulatory T cells preferentially form aggregates on dendritic cellsin vitroand actively inhibit their maturation
2008 StandoutNobel
Chemotherapy induces enrichment of CD47 + /CD73 + /PDL1 + immune evasive triple-negative breast cancer cells
2018 StandoutNobel
Basis of CTLA-4 function in regulatory and conventional CD4+ T cells
2012
Unique potential of 4-1BB agonist antibody to promote durable regression of HPV + tumors when combined with an E6/E7 peptide vaccine
2015 StandoutNobel
The future of immune checkpoint therapy
2015 StandoutScienceNobel
Precision glycocalyx editing as a strategy for cancer immunotherapy
2016 StandoutNobel
Natural regulatory T cells: mechanisms of suppression
2007 StandoutNobel
PD-1 and CTLA-4 combination blockade expands infiltrating T cells and reduces regulatory T and myeloid cells within B16 melanoma tumors
2010 StandoutNobel
The Soluble CTLA-4 Splice Variant Protects From Type 1 Diabetes and Potentiates Regulatory T-Cell Function
2011
Treg-expressed CTLA-4 depletes CD80/CD86 by trogocytosis, releasing free PD-L1 on antigen-presenting cells
2021 StandoutNobel
CTLA-4 blockade enhances polyfunctional NY-ESO-1 specific T cell responses in metastatic melanoma patients with clinical benefit
2008 StandoutNobel
Neoantigens in cancer immunotherapy
2015 StandoutScience
Real-Time Manipulation of T Cell-Dendritic Cell Interactions In Vivo Reveals the Importance of Prolonged Contacts for CD4+ T Cell Activation
2007
Adaptive Immune Resistance: How Cancer Protects from Immune Attack
2015
A distinct subpopulation of CD25−T-follicular regulatory cells localizes in the germinal centers
2017 StandoutNobel
Immune Checkpoint Blockade in Cancer Therapy
2015 Standout
Cancer immunotherapy using checkpoint blockade
2018 StandoutScience
Indoleamine 2,3-dioxygenase is a critical resistance mechanism in antitumor T cell immunotherapy targeting CTLA-4
2013 StandoutNobel
CTLA-4 and PD-1 Pathways
2015 Standout
Mitochondrial activation chemicals synergize with surface receptor PD-1 blockade for T cell-dependent antitumor activity
2017 StandoutNobel
Distinct influences of peptide-MHC quality and quantity on in vivo T-cell responses
2012 StandoutNobel
Differential control of human Treg and effector T cells in tumor immunity by Fc-engineered anti–CTLA-4 antibody
2018 StandoutNobel
Works of Bin Wei being referenced
Reversal of the TCR Stop Signal by CTLA-4
2006 Science
CTLA-4 up-regulation of lymphocyte function-associated antigen 1 adhesion and clustering as an alternate basis for coreceptor function
2005
The epidemiology of adolescent acne in North East China
2010
Identification and characterization of neuroblasts in the subventricular zone and rostral migratory stream of the adult human brain
2011
CTL-Associated Antigen-4 Ligation Induces Rapid T Cell Polarization That Depends on Phosphatidylinositol 3-Kinase, Vav-1, Cdc42, and Myosin Light Chain Kinase
2007
E-Cadherin-Mediated Cell–Cell Contact Is Critical for Induced Pluripotent Stem Cell Generation
2010