Standout Papers
Citation Impact
Citing Papers
Normal development and behaviour of mice lacking the neuronal cell-surface PrP protein
1992 StandoutNatureNobel
Regulation of telomere length and function by a Myb-domain protein in fission yeast
1997 NatureNobel
The proline-rich transcriptional activator of CTF/NF-I is distinct from the replication and DNA binding domain
1989
Essential role of mouse telomerase in highly proliferative organs
1998 StandoutNatureNobel
RAP1 protein interacts with yeast telomeres in vivo: Overproduction alters telomere structure and decreases chromosome stability
1990
Tetrahymenamicronuclear sequences that function as telomeres in yeast
1989 StandoutNobel
Oxytrichatelomeric nucleoprotein complexes reconstituted with synthetic DNA
1989 StandoutNobel
Instability and decay of the primary structure of DNA
1993 StandoutNatureNobel
An alternative pathway for yeast telomere maintenance rescues est1− senescence
1993 StandoutNobel
A mutant with a defect in telomere elongation leads to senescence in yeast
1989 StandoutNobel
Telomere states and cell fates
2000 StandoutNatureNobel
The nuclear envelope prevents reinitiation of replication by regulating the binding of MCM3 to chromatin in Xenopus egg extracts
1995
A regulatory hierarchy for cell specialization in yeast
1989 Nature
Addition of telomere-associated HeT DNA sequences “heals” broken chromosome ends in Drosophila
1990
The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14
1993 StandoutNobel
Telomeres shorten during ageing of human fibroblasts
1990 StandoutNatureNobel
Binding of yeast al and α2 as a heterodimer to the operator DNA of a haploid-specific gene
1990 Nature
hCDC47, a Human Member of the MCM Family
1996
On/off blinking and switching behaviour of single molecules of green fluorescent protein
1997 StandoutNatureNobel
Runaway telomere elongation caused by telomerase RNA gene mutations
1995 StandoutNatureNobel
A physical comparison of chromosome III in six strains of Saccharomyces cerevisiae
1994
The chromosome ends of Saccharomyces cerevisiae
1995
Physical maps of the six smallest chromosomes of Saccharomyces cerevisiae at a resolution of 2.6 kilobase pairs.
1993
Structure and polymorphism of human telomere-associated DNA
1990
Purification of an MCM-containing complex as a component of the DNA replication licensing system
1995 Nature
ORC and Cdc6p interact and determine the frequency of initiation of DNA replication in the genome
1995
Two steps in the assembly of complexes at yeast replication origins in vivo
1994
Control of telomere growth by interactions of RAP1 with the most distal telomeric repeats
1996 StandoutNatureNobel
Preferential recognition of I·T base-pairs in the initiation of excision-repair by hypoxanthine-DNA glycosylase
1991
Identification of the yeast MCM3-related protein as a component of xenopus DNA replication licensing factor
1995
Kemp elimination catalysts by computational enzyme design
2008 StandoutNatureNobel
The war of the whorls: genetic interactions controlling flower development
1991 StandoutNature
A short, disordered protein region mediates interactions between the homeodomain of the yeast α2 protein and the MCM1 protein
1993
Position effect at S. cerevisiae telomeres: Reversible repression of Pol II transcription
1990
Cloning of human telomeres by complementation in yeast
1989 Nature
Complilation and characteristics of dedicated transcription factors in Saccharomyces cerevisiae
1995
TRF1 is a dimer and bends telomeric DNA
1997
A telomeric sequence in the RNA of Tetrahymena telomerase required for telomere repeat synthesis
1989 StandoutNatureNobel
Evolutionarily recent transfer of a group I mitochondrial intron to telomere regions in Saccharomyces cerevisiae
1991
Genetics and Molecular Biology of Telomeres
1992
Homeodomain-DNA recognition
1994 StandoutNobel
Mitotic recombination among subtelomeric Y' repeats in Saccharomyces cerevisiae.
1990
Determination of the subunit stoichiometry of a voltage-activated potassium channel
1991 StandoutNatureNobel
Fission yeastcdc21+belongs to a family of proteins involved in an early step of chromosome replication
1992
The specificities of sex combs reduced and Antennapedia are defined by a distinct portion of each protein that includes the homeodomain
1990
The structure and evolution of subtelomeric Y' repeats in Saccharomyces cerevisiae.
1992
The yeast cell-type-specific repressor α2 acts cooperatively with a non-cell-type-specific protein
1988
Developmentally regulated telomere addition inTetrahymena thermophila
1988 StandoutNobel
Isolation and properties of cDNA clones encoding SRF, a transcription factor that binds to the c-fos serum response element
1988
Universal control mechanism regulating onset of M-phase
1990 StandoutNatureNobel
The Telobox, a Myb-Related Telomeric DNA Binding Motif Found in Proteins from Yeast, Plants and Human
1996
The subtelomeric Y' repeat family in Saccharomyces cerevisiae: an experimental system for repeated sequence evolution.
1990
Properties of the telomeric DNA-binding protein from Oxytricha nova
1989 StandoutNobel
The protein encoded by the Arabidopsis homeotic gene agamous resembles transcription factors
1990 Nature
Unusual DNA sequences associated with the ends of yeast chromosomes
1984 Nature
Autonomously replicating sequences from the non transcribed spacers ofTetrahymena thermophilaribosomal DNA
1985
Role of uracil-DNA glycosylase in mutation avoidance by Streptococcus pneumoniae
1991
Identification, purification, and cloning of a polypeptide (PRTF/GRM) that binds to mating-specific promoter elements in yeast.
1990
Conservation of sequences adjacent to the telomeric C4A2repeats of ciliate macronuclear ribosomal RNA gene molecules
1986 StandoutNobel
Enzymatic excision of free hypoxanthine from polydeoxynucleotides and DNA containing deoxyinosine monophosphate residues.
1978 StandoutNobel
Checkpoints: Controls That Ensure the Order of Cell Cycle Events
1989 StandoutScienceNobel
DNA sequences of telomeres maintained in yeast
1984 StandoutNatureNobel
Deficiens, a homeotic gene involved in the control of flower morphogenesis in Antirrhinum majus: the protein shows homology to transcription factors.
1990
STRUCTURE AND FUNCTION OF TELOMERES
1989
Rap1 protein regulates telomere turnover in yeast
1998 StandoutNobel
Size threshold for Saccharomyces cerevisiae chromosomes: generation of telocentric chromosomes from an unstable minichromosome.
1986
Telomere structure in Euplotes crassus: characterization of DNA-protein interactions and isolation of a telomere-binding protein.
1990
Rearrangements of Highly Polymorphic Regions Near Telomeres of Saccharomyces cerevisiae
1984
Mutagenic deamination of cytosine residues in DNA
1980 Nature
Single-Stranded DNA Arising at Telomeres in cdc13 Mutants May Constitute a Specific Signal for the RAD9 Checkpoint
1995 StandoutNobel
Insertion of nucleotides opposite apurinic apyrimidinic sites in deoxyribonucleic acid during in vitro synthesis: uniqueness of adenine nucleotides
1983
Mutation of the mouse klotho gene leads to a syndrome resembling ageing.
1997 Standout
Plasmid screening at high colony density
1980
Many yeast chromosomes lack the telomere-specific Y' sequence.
1989
In vitrodeletion analysis of ARS elements spanning tfae replication origin in the 5' non-transcribed spacer of Tetrahymena thermophila ribosomal DNA
1986
An overhanging 3' terminus is a conserved feature of telomeres.
1989 StandoutNobel
Elaboration of telomeres in yeast: recognition and modification of termini from Oxytricha macronuclear DNA.
1984
DNA packaging by the double-stranded DNA bacteriophages
1980
Molecular basis of base substitution hotspots in Escherichia coli
1978 StandoutNatureNobel
Introduction of extra telomeric DNA sequences into Saccharomyces cerevisiae results in telomere elongation.
1989
Involvement of the Silencer and UAS Binding Protein RAP1 in Regulation of Telomere Length
1990 Science
Transfer of yeast telomeres to linear plasmids by recombination
1984 StandoutNobel
A genetic and molecular model for flower development in Arabidopsis thaliana
1991
Identification of yeast mutants with altered telomere structure.
1986
Cloning of Large Segments of Exogenous DNA into Yeast by Means of Artificial Chromosome Vectors
1987 Science
AGL1-AGL6, an Arabidopsis gene family with similarity to floral homeotic and transcription factor genes.
1991
Formation of Okazaki fragments in polyoma DNA synthesis caused by misincorporation of uracil
1978
Escherichia coli K-12 mutants deficient in uracil-DNA glycosylase
1978
Life with 6000 Genes
1996 StandoutScience
Genetic control of chromosome length in yeast.
1985
Cell Cycle Control and Cancer
1994 StandoutScienceNobel
Caenorhabditis elegans DNA that directs segregation in yeast cells.
1985 StandoutNobel
Complete DNA sequence of yeast chromosome II.
1994
Telomeric properties of C4A4-homologous sequences in micronuclear DNA of Oxytricha fallax
1984
Two DNA-binding factors recognize specific sequences at silencers, upstream activating sequences, autonomously replicating sequences, and telomeres in Saccharomyces cerevisiae.
1988 StandoutNobel
S Phase of the Cell Cycle
1989 Science
Human replication proteins hCdc21, hCdc46 and P1Mcm3 bind chromatin uniformly before S-phase and are displaced locally during DNA replication
1996
DNA sequence analysis of Tn10 insertions: Origin and role of 9 bp flanking repetitions during Tn10 translocation
1979
Restoration of the biological activity of in vitro synthesized øX DNA by transfection of ung— spheroplasts or dUTPase treatment
1980
Novel Proteinaceous Infectious Particles Cause Scrapie
1982 StandoutScienceNobel
Identification of autonomously replicating circular subtelomeric Y' elements in Saccharomyces cerevisiae.
1985
Aromatic-dependent Salmonella typhimurium are non-virulent and effective as live vaccines
1981 StandoutNature
Two DNA-Binding Factors Recognize Specific Sequences at Silencers, Upstream Activating Sequences, Autonomously Replicating Sequences, and Telomeres in Saccharomyces cerevisiae
1988 StandoutNobel
Structure and variability of human chromosome ends.
1990
The RAD9 Gene Controls the Cell Cycle Response to DNA Damage in Saccharomyces cerevisiae
1988 StandoutScienceNobel
Most of the yeast genomic sequences are not essential for cell growth and division
1986
Uninterrupted MCM2-7 Function Required for DNA Replication Fork Progression
2000 Science
Telomeric DNA-protein interactions of Oxytricha macronuclear DNA.
1987 StandoutNobel
The Saccharomyces cerevisiae chromosome III left telomere has a type X, but not a type Y', ARS region.
1986
DNA sequence of a mutation in the leader region of the yeast iso-1-cytochrome c mRNA
1981 StandoutNobel
Deoxyuridine triphosphatase of Escherichia coli. Purification, properties, and use as a reagent to reduce uracil incorporation into DNA.
1978
The origin recognition complex in silencing, cell cycle progression, and DNA replication.
1995
Progressive loss of DNA sequences from terminal chromosome deficiencies in Drosophila melanogaster.
1988
Generation of telomere-length heterogeneity in Saccharomyces cerevisiae.
1988 StandoutNobel
Yeast chromosome replication and segregation
1988
The ORC1 homolog orp1 in fission yeast plays a key role in regulating onset of S phase.
1996 StandoutNobel
Telomere proteins: Specific recognition and protection of the natural termini of Oxytricha macronuclear DNA
1986
A general method for site-directed mutagenesis in prokaryotes
1981 StandoutNatureNobel
Chromosome length controls mitotic chromosome segregation in yeast
1986 StandoutNobel
Two versions of the gene encoding the 41-kilodalton subunit of the telomere binding protein of Oxytricha nova.
1990 Nobel
Mitotic stability of yeast chromosomes: A colony color assay that measures nondisjunction and chromosome loss
1985
The Saccharomyces cerevisiae Chromosome III Left Telomere Has a Type X, but Not a Type Y′, ARS Region
1986
Distribution of Telomere-Associated Sequences on Natural Chromosomes in Saccharomyces cerevisiae
1988
Sequence characterization ofTetrahymenamacronuclear DNA ends
1986
Genetic engineering in Vivo using translocatable drug-resistance elements
1977
Cell cycle-regulated nuclear import and export of Cdc47, a protein essential for initiation of DNA replication in budding yeast.
1995
Construction and behavior of circularly permuted and telocentric chromosomes in Saccharomyces cerevisiae.
1986 StandoutNobel
Size Threshold for Saccharomyces cerevisiae Chromosomes: Generation of Telocentric Chromosomes from an Unstable Minichromosome
1986
Nucleotide sequence of an insertion element, IS1.
1978
Synthesis and metabolism of uracil-containing deoxyribonucleic acid in Escherichia coli
1981
RAP1 protein activates and silences transcription of mating-type genes in yeast.
1991
DNA N-glycosidases: properties of uracil-DNA glycosidase from Escherichia coli.
1977 StandoutNobel
Structure of the growing telomeres of trypanosomes
1984
Cloning human telomeric DNA fragments into Saccharomyces cerevisiae using a yeast-artificial-chromosome vector.
1989
Rearrangements of highly polymorphic regions near telomeres of Saccharomyces cerevisiae.
1984
BM28, a human member of the MCM2-3-5 family, is displaced from chromatin during DNA replication.
1995
The nucleotide sequence of chromosome I from Saccharomyces cerevisiae.
1995
C-Terminal Truncation of RAP1 Results in the Deregulation of Telomere Size, Stability, and Function in Saccharomyces cerevisiae
1992
Translocatable elements in procaryotes
1977
Genetic analysis of the mitotic transmission of minichromosomes
1985
Cap-prevented recombination between terminal telomeric repeat arrays (telomere CPR) maintains telomeres in Kluyveromyces lactis lacking telomerase.
1996 StandoutNobel
The RNA Component of Human Telomerase
1995 StandoutScienceNobel
Escherichia coli mutants deficient in deoxyuridine triphosphatase
1978
A restriction enzyme cleavage map of Tn5 and location of a region encoding neomycin resistance
1979
Evolution of the Dispersed SUC Gene Family of Saccharomyces by Rearrangements of Chromosome Telomeres
1985
[19] Rapid and efficient site-specific mutagenesis without phenotypic selection
1987 Standout
Telomeres: Beginning to Understand the End
1995 Science
Telomeres in the mouse have large inter-chromosomal variations in the number of T 2 AG 3 repeats
1997
Human DNA Repair Genes
2001 StandoutScienceNobel
Chromosome ends in Drosophila without telomeric DNA sequences.
1990
STRUCTURE, FUNCTION, AND REPLICATION OF SACCHAROMYCES CEREVISIAE TELOMERES
1996
Long insertions within telomeres contribute to chromosome size polymorphism in Plasmodium berghei.
1990
ALTERED FIDELITY OF MITOTIC CHROMOSOME TRANSMISSION IN CELL CYCLE MUTANTS OF S. CEREVISIAE
1985 StandoutNobel
Rapid and efficient site-specific mutagenesis without phenotypic selection.
1985 Standout
Chromatin binding, nuclear localization and phosphorylation of Xenopus cdc21 are cell-cycle dependent and associated with the control of initiation of DNA replication.
1996
Structure and function of telomeres
1991 StandoutNatureNobel
Electron microscopy of DNA crosslinked with trimethylpsoralen: test of the secondary structure of eukaryotic inverted repeat sequences.
1976 StandoutNobel
CDC17: An essential gene that prevents telomere elongation in yeast
1985
Repair of nitrous acid damage to DNA in Escherichia coli
1977
Inversions and deletions of the Salmonella chromosome generated by the translocatable tetracycline resistance element Tn10
1979
Sequences at the somatic recombination sites of immunoglobulin light-chain genes
1979 StandoutNatureNobel
DNA Glycosylases, Endonucleases for Apurinic/Apyrimidinic Sites, and Base Excision-Repair
1979 StandoutNobel
DNA polymerase alpha associated protein P1, a murine homolog of yeast MCM3, changes its intranuclear distribution during the DNA synthetic period.
1994
Fission yeast cdc21, a member of the MCM protein family, is required for onset of S phase and is located in the nucleus throughout the cell cycle.
1996
Uncapping and Deregulation of Telomeres Lead to Detrimental Cellular Consequences in Yeast
1999 StandoutNobel
Works of Bik‐Kwoon Tye being referenced
Saccharomyces cerevisiae protein involved in plasmid maintenance is necessary for mating of MATα cells
1988
Identification of a telomere-binding activity from yeast.
1986
Uracil incorporation: A source of pulse-labeled DNA fragments in the replication of the Escherichia coli chromosome
1978
The mitotic stability of deletion derivatives of chromosome III in yeast.
1986
[29] Hybridization with synthetic oligonucleotides
1979 StandoutNobel
Autonomously replicating sequences in Saccharomyces cerevisiae.
1980
Packaging of an oversize transducing genome by Salmonella phage P22
1974
Mutagenesis by insertion of a drug-resistance element carrying an inverted repetition
1975
MUTANTS OF S. CEREVISIAE DEFECTIVE IN THE MAINTENANCE OF MINICHROMOSOMES
1984
A protein involved in minichromosome maintenance in yeast binds a transcriptional enhancer conserved in eukaryotes.
1989
Cell cycle-regulated nuclear localization of MCM2 and MCM3, which are required for the initiation of DNA synthesis at chromosomal replication origins in yeast.
1993
RESOLUTION OF DICENTRIC CHROMOSOMES BY TY-MEDIATED RECOMBINATION IN YEAST
1985
CDC46/MCM5, a yeast protein whose subcellular localization is cell cycle-regulated, is involved in DNA replication at autonomously replicating sequences.
1992
Both activation and repression of a-mating-type-specific genes in yeast require transcription factor Mcm1.
1991
Mcm2 and Mcm3, two proteins important for ARS activity, are related in structure and function.
1991
Functional domains of the yeast transcription/replication factor MCM1.
1991
Isolation and Characterization of the Centromere from Chromosome V (CEN5) of Saccharomyces cerevisiae
1984
Transient accumulation of Okazaki fragments as a result of uracil incorporation into nascent DNA.
1977
Construction of telocentric chromosomes in Saccharomyces cerevisiae.
1985
The Phenotype of the Minichromosome Maintenance Mutant mcm3 Is Characteristic of Mutants Defective in DNA Replication
1990
A yeast protein that binds to vertebrate telomeres and conserved yeast telomeric junctions.
1991
The OBF1 protein and its DNA-binding site are important for the function of an autonomously replicating sequence in Saccharomyces cerevisiae.
1989
Non-random circular permutation of phage P22 DNA
1974
Mcm2 and Mcm3 are constitutive nuclear proteins that exhibit distinct isoforms and bind chromatin during specific cell cycle stages of Saccharomyces cerevisiae.
1997
The phenotype of the minichromosome maintenance mutant mcm3 is characteristic of mutants defective in DNA replication.
1990
A family of Saccharomyces cerevisiae repetitive autonomously replicating sequences that have very similar genomic environments
1983
Excision repair of uracil incorporated in DNA as a result of a defect in dUTPase
1977
The OBF1 Protein and Its DNA-Binding Site Are Important for the Function of an Autonomously Replicating Sequence in Saccharomyces cerevisiae†
1989
Organization of DNA sequences and replication origins at yeast telomeres
1983
Isolation and characterization of the centromere from chromosome V (CEN5) of Saccharomyces cerevisiae.
1984
Specific interaction between a Saccharomyces cerevisiae protein and a DNA element associated with certain autonomously replicating sequences.
1988