Standout Papers
Citation Impact
Citing Papers
Highly Recurrent TERT Promoter Mutations in Human Melanoma
2013 StandoutScience
Computational Stabilization of a Non‐Heme Iron Enzyme Enables Efficient Evolution of New Function
2024 StandoutNobel
Kinetic Investigations of the Role of Factor Inhibiting Hypoxia-inducible Factor (FIH) as an Oxygen Sensor
2015
Improved gRNA secondary structures allow editing of target sites resistant to CRISPR-Cas9 cleavage
2022 StandoutNobel
Tight Control of Hypoxia-inducible Factor-α Transient Dynamics Is Essential for Cell Survival in Hypoxia
2014
The EGLN-HIF O 2 -Sensing System: Multiple Inputs and Feedbacks
2017 StandoutNobel
Engineered receptors for soluble cellular communication and disease sensing
2024 StandoutNatureNobel
Protein Hydroxylation Catalyzed by 2-Oxoglutarate-dependent Oxygenases
2015
The promise and challenge of therapeutic genome editing
2020 StandoutNatureNobel
Tuning the Transcriptional Response to Hypoxia by Inhibiting Hypoxia-inducible Factor (HIF) Prolyl and Asparaginyl Hydroxylases
2016 StandoutNobel
Potent and Selective Triazole-Based Inhibitors of the Hypoxia-Inducible Factor Prolyl-Hydroxylases with Activity in the Murine Brain
2015 StandoutNobel
Structural perspective of cooperative transcription factor binding
2017
Cancer Invasion and the Microenvironment: Plasticity and Reciprocity
2011 Standout
Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases
2016 StandoutNobel
A Mechanical Checkpoint Controls Multicellular Growth through YAP/TAZ Regulation by Actin-Processing Factors
2013 Standout
Mechanisms of hypoxia signalling: new implications for nephrology
2019 StandoutNobel
Epithelial-Mesenchymal Transitions in Development and Disease
2009 Standout
Signaling by members of the TGF-β family in vascular morphogenesis and disease
2010
Inhibition of 2-oxoglutarate dependent oxygenases
2011
Regulation of Smad activities
2006
New Insights into Protein Hydroxylation and Its Important Role in Human Diseases
2016
The Functional Consequences of Variation in Transcription Factor Binding
2014
Actions of TGF-β as tumor suppressor and pro-metastatic factor in human cancer
2006
Lymphangiogenesis: Molecular Mechanisms and Future Promise
2010 Standout
Cellular Senescence in Cancer and Aging
2007 Standout
Endoglin in angiogenesis and vascular diseases
2008
Tumor Metastasis: Molecular Insights and Evolving Paradigms
2011 Standout
Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders
2011 StandoutNature
The Human Transcription Factors
2018 Standout
SMAD proteins control DROSHA-mediated microRNA maturation
2008 Nature
Nonmyelinating Schwann Cells Maintain Hematopoietic Stem Cell Hibernation in the Bone Marrow Niche
2011
The bone marrow niche for haematopoietic stem cells
2014 StandoutNature
HIF prolyl hydroxylase inhibitors for the treatment of renal anaemia and beyond
2015
Photoactivatable fluorescent proteins for diffraction-limited and super-resolution imaging
2009
TREM2 Lipid Sensing Sustains the Microglial Response in an Alzheimer’s Disease Model
2015 Standout
Hypoxia drives glucose transporter 3 expression through hypoxia-inducible transcription factor (HIF)–mediated induction of the long noncoding RNA NICI
2019 StandoutNobel
Interpretation of BMP signaling in early Xenopus development
2007 StandoutNobel
Coupled Reversible and Irreversible Bistable Switches Underlying TGFβ-induced Epithelial to Mesenchymal Transition
2013
Hypoxia and the extracellular matrix: drivers of tumour metastasis
2014 StandoutNobel
Differential Sensitivity of Hypoxia Inducible Factor Hydroxylation Sites to Hypoxia and Hydroxylase Inhibitors
2011 StandoutNobel
Regulation of the INK4b–ARF–INK4a tumour suppressor locus: all for one or one for all
2006
Blinded by the Light: The Growing Complexity of p53
2009 Standout
The role of enhancers in cancer
2016
Quantitative Mass Spectrometry Reveals Dynamics of Factor-inhibiting Hypoxia-inducible Factor-catalyzed Hydroxylation
2011 StandoutNobel
Localized and reversible TGFβ signalling switches breast cancer cells from cohesive to single cell motility
2009
Senescence Is a Developmental Mechanism that Contributes to Embryonic Growth and Patterning
2013
TGF-β signaling in vascular biology and dysfunction
2008
How to make a melanoma: what do we know of the primary clonal events?
2008
Search-and-replace genome editing without double-strand breaks or donor DNA
2019 StandoutNature
Genome editing with CRISPR–Cas nucleases, base editors, transposases and prime editors
2020 Standout
Molecular Basis of the Light-driven Switching of the Photochromic Fluorescent Protein Padron
2010 StandoutNobel
Multiparameter functional diversity of human C2H2 zinc finger proteins
2016
Programmed Cell Senescence during Mammalian Embryonic Development
2013 Standout
EMT: 2016
2016 Standout
Signaling molecules and transcription factors involved in the development of the sympathetic nervous system, with special emphasis on the superior cervical ganglion
2014
TGFβ in Cancer
2008 Standout
Mechanisms of human histone and nucleic acid demethylases
2012
Amazing Diversity in Biochemical Roles of Fe(II)/2-Oxoglutarate Oxygenases
2018
Therapeutic potential of superoxide dismutase mimetics as therapeutic agents in critical care medicine
2003
Dynamic Combinatorial Chemistry Employing Boronic Acids/Boronate Esters Leads to Potent Oxygenase Inhibitors
2012 StandoutNobel
Nuclear receptor NR4A1 promotes breast cancer invasion and metastasis by activating TGF-β signalling
2014
Basic and Therapeutic Aspects of Angiogenesis
2011 Standout
TGF-β1 blockade of microglial chemotaxis toward Aβ aggregates involves SMAD signaling and down-regulation of CCL5
2010
The role of senescent cells in ageing
2014 StandoutNature
Factor‐inhibiting hypoxia‐inducible factor (FIH) catalyses the post‐translational hydroxylation of histidinyl residues within ankyrin repeat domains
2011 StandoutNobel
PPM1A Functions as a Smad Phosphatase to Terminate TGFβ Signaling
2006
FAM/USP9x, a Deubiquitinating Enzyme Essential for TGFβ Signaling, Controls Smad4 Monoubiquitination
2009
Naturally occurring p16Ink4a-positive cells shorten healthy lifespan
2016 StandoutNature
Metastatic colonization by circulating tumour cells
2016 StandoutNature
Combinatorial Signal Perception in the BMP Pathway
2017
Molecular mechanisms and clinical applications of angiogenesis
2011 StandoutNature
Studies on the catalytic domains of multiple JmjC oxygenases using peptide substrates
2014
Delivering the Messenger: Advances in Technologies for Therapeutic mRNA Delivery
2019
Role of YAP/TAZ in mechanotransduction
2011 StandoutNature
DNA-dependent formation of transcription factor pairs alters their binding specificity
2015 Nature
LRG1 promotes angiogenesis by modulating endothelial TGF-β signalling
2013 StandoutNature
Intrathecal bone marrow stromal cells inhibit neuropathic pain via TGF-β secretion
2015
Ionizable Lipid Nanoparticles for In Vivo mRNA Delivery to the Placenta during Pregnancy
2023 StandoutNobel
HIF-1α is required for development of the sympathetic nervous system
2019 StandoutNobel
Zeb1 links epithelial-mesenchymal transition and cellular senescence
2008
Impact of cytosine methylation on DNA binding specificities of human transcription factors
2017 Science
Conservation of transcription factor binding specificities across 600 million years of bilateria evolution
2015
Pain regulation by non-neuronal cells and inflammation
2016 StandoutScience
Biology of Vascular Malformations of the Brain
2009
Non-targeted transcription factors motifs are a systemic component of ChIP-seq datasets
2014
Nuclear entry and export of FIH are mediated by HIF1α and exportin1, respectively
2018 StandoutNobel
2-Oxoglutarate-Dependent Oxygenases
2018
ALK1 as an emerging target for antiangiogenic therapy of cancer
2011
Factor Inhibiting HIF-1 (FIH-1) modulates protein interactions of Apoptosis-Stimulating p53 binding Protein 2 (ASPP2)
2013
Genetic and pharmacological targeting of activin receptor-like kinase 1 impairs tumor growth and angiogenesis
2010
Epithelial Plasticity: A Common Theme in Embryonic and Cancer Cells
2013 StandoutScience
Chromatin-Bound p53 Anchors Activated Smads and the mSin3A Corepressor To Confer Transforming Growth Factor β-Mediated Transcription Repression
2008
Rational Design of Bisphosphonate Lipid-like Materials for mRNA Delivery to the Bone Microenvironment
2022 StandoutNobel
Targeting Protein–Protein Interactions in the HIF System
2016
De novo design of protein logic gates
2020 StandoutScienceNobel
Proton-Coupled Electron Transfer
2012 Standout
Works of Bernhard Schmierer being referenced
Mathematical modeling identifies Smad nucleocytoplasmic shuttling as a dynamic signal-interpreting system
2008
Hypoxia-dependent sequestration of an oxygen sensor by a widespread structural motif can shape the hypoxic response - a predictive kinetic model
2010
TGFβ–SMAD signal transduction: molecular specificity and functional flexibility
2007
Transcription Factor Binding in Human Cells Occurs in Dense Clusters Formed around Cohesin Anchor Sites
2013
CRISPR–Cas9 genome editing induces a p53-mediated DNA damage response
2018
Structural insights into the DNA-binding specificity of E2F family transcription factors
2015
Asparagine and Aspartate Hydroxylation of the Cytoskeletal Ankyrin Family Is Catalyzed by Factor-inhibiting Hypoxia-inducible Factor
2010 StandoutNobel
Catecholamines up‐regulate lipopolysaccharide‐induced IL‐6 production in human microvascular endothelial cells
2000
Kinetic Analysis of Smad Nucleocytoplasmic Shuttling Reveals a Mechanism for Transforming Growth Factor β-Dependent Nuclear Accumulation of Smads
2005
Upregulation of chicken p15INK4b at senescence and in the developing brain
2006
Analysis of Smad nucleocytoplasmic shuttling in living cells
2004