Citation Impact
Citing Papers
Checkpoint Proteins Control Survival of the Postmitotic Cells in Caenorhabditis elegans
2006 Science
Differential Antigen Processing by Dendritic Cell Subsets in Vivo
2007 StandoutScienceNobel
In vivo imaging of hydrogen peroxide production in a murine tumor model with a chemoselective bioluminescent reporter
2010 StandoutNobel
HIV controllers exhibit potent CD8 T cell capacity to suppress HIV infection ex vivo and peculiar cytotoxic T lymphocyte activation phenotype
2007 StandoutNobel
Strategy for Dual-Analyte Luciferin Imaging: In Vivo Bioluminescence Detection of Hydrogen Peroxide and Caspase Activity in a Murine Model of Acute Inflammation
2013 StandoutNobel
Caveolin-1 Regulates the Antagonistic Pleiotropic Properties of Cellular Senescence through a Novel Mdm2/p53-Mediated Pathway
2009
Loss of cryptochrome reduces cancer risk in p53 mutant mice
2009 StandoutNobel
p53 Regulates Mitochondrial Respiration
2006 Science
Sirtuins as regulators of metabolism and healthspan
2012 Standout
Pro-inflammatory β cell small extracellular vesicles induce β cell failure through activation of the CXCL10/CXCR3 axis in diabetes
2021
Hallmarks of Cancer: The Next Generation
2011 Standout
The DNA-damage response in human biology and disease
2009 StandoutNature
The role of DNA damage and repair in aging through the prism of Koch-like criteria
2012
LMP2+ proteasomes are required for the presentation of specific antigens to cytotoxic T lymphocytes
1995
Ferroptosis as a p53-mediated activity during tumour suppression
2015 StandoutNature
Tumor suppression and normal aging in mice with constitutively high p53 activity
2006
Deleted in breast cancer–1 regulates SIRT1 activity and contributes to high-fat diet–induced liver steatosis in mice
2010
Influence of Metabolism on Epigenetics and Disease
2013 StandoutNobel
New tricks of an old molecule: lifespan regulation by p53
2006
Intestinal homeostasis and its breakdown in inflammatory bowel disease
2011 StandoutNature
Systems Biology Approach Reveals Genome to Phenome Correlation in Type 2 Diabetes
2013
Cellular senescence: when bad things happen to good cells
2007 Standout
Sirtuin 1 in lipid metabolism and obesity
2011
Coordinate Regulation of Complex T Cell Populations Responding to Bacterial Infection
1998
Obesity-induced gut microbial metabolite promotes liver cancer through senescence secretome
2013 StandoutNature
Discrete Proteolytic Intermediates in the MHC Class I Antigen Processing Pathway and MHC I–Dependent Peptide Trimming in the ER
1999
p53 — a Jack of all trades but master of none
2009
BRAFE600-associated senescence-like cell cycle arrest of human naevi
2005 StandoutNature
Characterization of Recombinant REGα, REGβ, and REGγ Proteasome Activators
1997
Unleashing the power of p53: lessons from mice and men: Figure 1.
2006
Cellular Senescence in Cancer and Aging
2007 Standout
Increased p53 activity does not accelerate telomere‐driven ageing
2006
On the cellular basis of immunological T cell memory
1995
Human lymphoblast and erythrocyte multicatalytic proteases: differential peptidase activities and responses to the 11S regulator
1995
Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders
2011 StandoutNature
Tissue regenerative delays and synthetic lethality in adult mice after combined deletion of Atr and Trp53
2009
A theoretical approach towards the identification of cleavage-determining amino acid motifs of the 20s proteasome 1 1Edited by R. Huber
1999
p53: link to the past, bridge to the future
2005
Global heterochromatin loss
2012
A soma-to-germline transformation in long-lived Caenorhabditis elegans mutants
2009 StandoutNatureNobel
Senescent Cells, Tumor Suppression, and Organismal Aging: Good Citizens, Bad Neighbors
2005 Standout
Accelerated ageing in mice deficient in Zmpste24 protease is linked to p53 signalling activation
2005 Nature
DNA Repair, Genome Stability, and Aging
2005
A new progeroid syndrome reveals that genotoxic stress suppresses the somatotroph axis
2006 Nature
Lactacystin and clasto-Lactacystin β-Lactone Modify Multiple Proteasome β-Subunits and Inhibit Intracellular Protein Degradation and Major Histocompatibility Complex Class I Antigen Presentation
1997
Cellular senescence and DNA repair
2006
How stem cells age and why this makes us grow old
2007
MHC ligands and peptide motifs: first listing
1995
Mycobacteria‐reactive Lyt‐2+ T cell lines
1988
Age to survive: DNA damage and aging
2008
Antigen processing by the proteasome
2001
Epigenetic phenomena linked to diabetic complications
2010
Epitope affinity for MHC class I determines helper requirement for CTL priming
2000 StandoutNobel
Host factors in the pathogenesis of HIV disease
1997
Mechanisms of Exogenous Antigen Presentation by MHC Class I Molecules in Vitro and in Vivo: Implications for Generating CD8+ T Cell Responses to Infectious Agents, Tumors, Transplants, and Vaccines
1999
Immunity, Inflammation, and Cancer
2010 Standout
Altered senescence, apoptosis, and DNA damage response in a mutant p53 model of accelerated aging
2009
Metabolic Regulation by p53 Family Members
2013
Anti‐aging activity of the Ink4/Arf locus
2009
p63 deficiency activates a program of cellular senescence and leads to accelerated aging
2005
p53 isoforms can regulate p53 transcriptional activity
2005
Epigenetics and aging: the targets and the marks
2007
Glycemic control in diabetes is restored by therapeutic manipulation of cytokines that regulate beta cell stress
2014
Effects of Major‐Histocompatibility‐Complex‐Encoded Subunits on the Peptidase and Proteolytic Activities of Human 20S Proteasomes
1996
Stems Cells and the Pathways to Aging and Cancer
2008
p53 in health and disease
2007 Standout
The common biology of cancer and ageing
2007 Nature
Increased gene dosage of Ink4a/Arf results in cancer resistance and normal aging
2004
The Human 26 S and 20 S Proteasomes Generate Overlapping but Different Sets of Peptide Fragments from a Model Protein Substrate
2000
p53/p63/p73 isoforms: an orchestra of isoforms to harmonise cell differentiation and response to stress
2006
Two faces of p53: aging and tumor suppression
2007
Thioredoxin-Interacting Protein Mediates ER Stress-Induced β Cell Death through Initiation of the Inflammasome
2012
Emerging models and paradigms for stem cell ageing
2011
Deconstructing p53 transcriptional networks in tumor suppression
2011
Perturbation of CD4+ and CD8+ T-cell repertoires during progression to AIDS and regulation of the CD4+ repertoire during antiviral therapy
1998
Peptide selection for presentation by HLA class I: A role for the human transporter associated with antigen processing?
1996
Structure of 20S proteasome from yeast at 2.4Å resolution
1997 StandoutNatureNobel
An algorithm for the prediction of proteasomal cleavages
2000
New use of BCG for recombinant vaccines
1991 StandoutNature
DYRK1A and DYRK3 Promote Cell Survival through Phosphorylation and Activation of SIRT1
2010
Semaphorin3E-Induced Inflammation Contributes to Insulin Resistance in Dietary Obesity
2013
All the peptides that fit: the beginning, the middle, and the end of the MHC class I antigen‐processing pathway
2005
Delayed ageing through damage protection by the Arf/p53 pathway
2007 Nature
The role of senescent cells in ageing
2014 StandoutNature
Targeting Sirtuin 1 to Improve Metabolism: All You Need Is NAD+?
2011
The Hallmarks of Aging
2013 Standout
Rapid degradation of a large fraction of newly synthesized proteins by proteasomes
2000 StandoutNature
Removing the Vertebrate-Specific TBP N Terminus Disrupts Placental β2m-Dependent Interactions with the Maternal Immune System
2002 StandoutNobel
The epigenetics of aging and neurodegeneration
2015
Naturally occurring p16Ink4a-positive cells shorten healthy lifespan
2016 StandoutNature
DNA damage response and cellular senescence in tissues of aging mice
2009
Disruption of the circadian clock due to theClockmutation has discrete effects on aging and carcinogenesis
2008
Sirtuin Catalysis and Regulation
2012
JNK1 Phosphorylates SIRT1 and Promotes Its Enzymatic Activity
2009
The Aging Stress Response
2010
Inflammation, metaflammation and immunometabolic disorders
2017 StandoutNature
Coordinated Dual Cleavages Induced by the Proteasome Regulator PA28 Lead to Dominant MHC Ligands
1996
26 S Proteasome-mediated Production of an Authentic Major Histocompatibility Class I-restricted Epitope from an Intact Protein Substrate
1999
Sirtuin 1 Modulates Cellular Responses to Hypoxia by Deacetylating Hypoxia-Inducible Factor 1α
2010
Neuronal Expression of p53 Dominant-Negative Proteins in Adult Drosophila melanogaster Extends Life Span
2005
SIRT1 is regulated by a PPARγ–SIRT1 negative feedback loop associated with senescence
2010
Peptide antigen production by the proteasome: complexity provides efficiency
1996
Inflammation in obesity, diabetes, and related disorders
2022 Standout
Changes in thymic function with age and during the treatment of HIV infection
1998 StandoutNature
p21 Both Attenuates and Drives Senescence and Aging in BubR1 Progeroid Mice
2013
Inhibition of ubiquitin/proteasome-dependent protein degradation by the Gly-Ala repeat domain of the Epstein–Barr virus nuclear antigen 1
1997 StandoutNobel
The proteasome activator 11 S REG (PA28) and Class I antigen presentation
1999
Impaired resistance to Mycobacterium tuberculosis infection after selective in vivo depletion of L3T4+ and Lyt-2+ T cells
1987
Circadian clock disruption improves the efficacy of chemotherapy through p73-mediated apoptosis
2011 StandoutNobel
Immunization with HIV Gag targeted to dendritic cells followed by recombinant New York vaccinia virus induces robust T-cell immunity in nonhuman primates
2011 StandoutNobel
Quantification of CD4, CCR5, and CXCR4 levels on lymphocyte subsets, dendritic cells, and differentially conditioned monocyte-derived macrophages
1999 StandoutNobel
DEC-205 receptor on dendritic cells mediates presentation of HIV gag protein to CD8 + T cells in a spectrum of human MHC I haplotypes
2007 StandoutNobel
Potentiation of Simian Immunodeficiency Virus (SIV)-Specific CD4+ and CD8+ T Cell Responses by a DNA-SIV and NYVAC-SIV Prime/Boost Regimen
2001
Cytotoxic T Lymphocyte Epitopes of HIV-1 Nef
2000
The Senescence-Associated Secretory Phenotype: The Dark Side of Tumor Suppression
2010 Standout
Telomere length is paternally inherited and is associated with parental lifespan
2007 StandoutNobel
Phenotypic Analysis of Antigen-Specific T Lymphocytes
1996 StandoutScience
Potential Immunocompetence of Proteolytic Fragments Produced by Proteasomes before Evolution of the Vertebrate Immune System
1997 StandoutNobel
Induction of AIDS Virus-Specific CTL Activity in Fresh, Unstimulated Peripheral Blood Lymphocytes from Rhesus Macaques Vaccinated with a DNA Prime/Modified Vaccinia Virus Ankara Boost Regimen
2000
The proteolytic fragments generated by vertebrate proteasomes: structural relationships to major histocompatibility complex class I binding peptides.
1996
Preferential Localization of Effector Memory Cells in Nonlymphoid Tissue
2001 StandoutScience
Intramembrane Proteolysis of Signal Peptides: An Essential Step in the Generation of HLA-E Epitopes
2001
Nutrient Availability Regulates SIRT1 Through a Forkhead-Dependent Pathway
2004 Science
Mammalian Sirtuins: Biological Insights and Disease Relevance
2010 Standout
Inflammatory Bowel Disease
2010 Standout
How neuroinflammation contributes to neurodegeneration
2016 StandoutScience
Four faces of cellular senescence
2011 Standout
ATM and ATR Substrate Analysis Reveals Extensive Protein Networks Responsive to DNA Damage
2007 StandoutScience
Broad, Intense Anti-Human Immunodeficiency Virus (HIV) Ex Vivo CD8+Responses in HIV Type 1-Infected Patients: Comparison with Anti-Epstein-Barr Virus Responses and Changes during Antiretroviral Therapy
1999
DEGRADATION OF CELL PROTEINS AND THE GENERATION OF MHC CLASS I-PRESENTED PEPTIDES
1999
Histone demethylase JMJD2C is a coactivator for hypoxia-inducible factor 1 that is required for breast cancer progression
2012 StandoutNobel
Receptor-Mediated Uptake of Antigen/Heat Shock Protein Complexes Results in Major Histocompatibility Complex Class I Antigen Presentation via Two Distinct Processing Pathways
1999 StandoutNobel
Visualizing the dynamics of p21 Waf1/Cip1 cyclin-dependent kinase inhibitor expression in living animals
2007
MECHANISMS OF MHC CLASS I–RESTRICTED ANTIGEN PROCESSING
1998
The Caenorhabditis elegans IMPAS gene, imp-2, is essential for development and is functionally distinct from related presenilins
2004 StandoutNobel
Senescence-Associated Secretory Phenotypes Reveal Cell-Nonautonomous Functions of Oncogenic RAS and the p53 Tumor Suppressor
2008 Standout
ANTIGEN PROCESSING AND PRESENTATION BY THE CLASS I MAJOR HISTOCOMPATIBILITY COMPLEX
1996
At the crossroads of cell biology and immunology: DRiPs and other sources of peptide ligands for MHC class I molecules
2001
The Ubiquitin-Proteasome Proteolytic Pathway: Destruction for the Sake of Construction
2002 StandoutNobel
Normal development is an integral part of tumorigenesis in T cell-specific PTEN-deficient mice
2008 StandoutNobel
THE UBIQUITIN SYSTEM
1998 StandoutNobel
Works of Bernhard Maier being referenced
Proteasomes Can Either Generate or Destroy MHC Class I Epitopes: Evidence for Nonproteasomal Epitope Generation in the Cytosol
1998
Islet β-Cell Endoplasmic Reticulum Stress Precedes the Onset of Type 1 Diabetes in the Nonobese Diabetic Mouse Model
2012
Structural constraints of HIV-1 Nef may curtail escape from HLA-B7-restricted CTL recognition
1997
Contribution of proteasome-mediated proteolysis to the hierarchy of epitopes presented by major histocompatibility complex class I molecules
1995
Human immune response to HIV-1-Nef. I. CD45RO− T lymphocytes of non-infected donors contain cytotoxic T lymphocyte precursors at high frequency
1994
Progressive loss of SIRT1 with cell cycle withdrawal
2006
Human immune response to HIV-1 Nef. II. Induction of HIV-1/HIV-2 Nef cross-reactive cytotoxic T lymphocytes in peripheral blood lymphocytes of non-infected healthy individuals
1996
Phosphorylation Regulates SIRT1 Function
2008
Peptide motifs of HLA-A3, -A24, and -B7 molecules as determined by pool sequencing
1994
Beta cell extracellular vesicle miR-21-5p cargo is increased in response to inflammatory cytokines and serves as a biomarker of type 1 diabetes
2018
Modulation of mammalian life span by the short isoform of p53
2004
Methyltransferase Set7/9 Maintains Transcription and Euchromatin Structure at Islet-Enriched Genes
2008
Peroxisome Proliferator-Activated Receptor γ Activation Restores Islet Function in Diabetic Mice through Reduction of Endoplasmic Reticulum Stress and Maintenance of Euchromatin Structure
2009
Sequence constraints and recognition by CTL of an HLA-B27-restricted HIV-1 gag epitope.
1995
Limiting dilution analysis of proliferating and helper T cells in the in vivo immune response to KLH: derepression of helper T cells at moderately increased frequencies.
1986
Δ40 Isoform of p53 Controls β-Cell Proliferation and Glucose Homeostasis in Mice
2011
Autoreactive T Cell Clones from Mice Infected with Mycobacterium Bovis, Strain Bacillus Calmette-Guérin (BCG) I. Phenotype, Specificity and in vitro Function
1986
Dynamics of viral variants in HIV-1 Nef and specific cytotoxic T lymphocytes in vivo.
1996