Standout Papers
Citation Impact
Citing Papers
HCV Persistence and Immune Evasion in the Absence of Memory T Cell Help
2003 StandoutScienceNobel
Differential Antigen Processing by Dendritic Cell Subsets in Vivo
2007 StandoutScienceNobel
Tumor-reactive CD4+ T cells develop cytotoxic activity and eradicate large established melanoma after transfer into lymphopenic hosts
2010 StandoutNobel
Control of Regulatory T Cell Development by the Transcription Factor Foxp3
2003 StandoutScienceNobel
Conserved N-terminal cysteine dioxygenases transduce responses to hypoxia in animals and plants
2019 StandoutScienceNobel
The microbiota regulates type 2 immunity through RORγt + T cells
2015 StandoutScienceNobel
Hallmarks of Cancer: The Next Generation
2011 Standout
Pattern of nucleotide substitution at major histocompatibility complex class I loci reveals overdominant selection
1988 StandoutNature
Exogenous and endogenous glycolipid antigens activate NKT cells during microbial infections
2005 StandoutNatureNobel
Establishment of tissue‐specific tolerance is driven by regulatory T cells selected by thymic epithelium
1996
Extracellular vesicle-mediated transfer of functional RNA in the tumor microenvironment
2015
A community effect in animal development
1988 StandoutNatureNobel
NONDEPLETING ANTI-CD4 MONOCLONAL ANTIBODY ENHANCES THE ABILITY OF ORAL ALLOANTIGEN DELIVERY TO INDUCE INDEFINITE SURVIVAL OF CARDIAC ALLOGRAFTS: ORAL TOLERANCE TO ALLOANTIGEN1
2000
Adoptive T cell therapy for cancer in the clinic
2007
CD22 blockade restores homeostatic microglial phagocytosis in ageing brains
2019 StandoutNatureNobel
Sensitization to self (virus) antigen by in situ expression of murine interferon-gamma.
1995
Unravelling hepatitis C virus replication from genome to function
2005 StandoutNatureNobel
Peripheral-antigen-expressing cells in thymic medulla: factors in self-tolerance and autoimmunity
1998
Foxp3 controls regulatory T-cell function by interacting with AML1/Runx1
2007 StandoutNatureNobel
Microbial translocation augments the function of adoptively transferred self/tumor-specific CD8+ T cells via TLR4 signaling
2007
Involvement of endothelial progenitor cells in tumor vascularization
2010
Virus persistence in acutely infected immunocompetent mice by exhaustion of antiviral cytotoxic effector T cells
1993 StandoutNature
Mechanisms in CD4 antibody‐mediated transplantation tolerance: kinetics of induction, antigen dependency and role of regulatory T cells
1994
Influence of tumour micro-environment heterogeneity on therapeutic response
2013 StandoutNature
Tumor endothelium FasL establishes a selective immune barrier promoting tolerance in tumors
2014
Phagocytosis of apoptotic cells in homeostasis
2015
Developmental regulation of MHC class II transport in mouse dendritic cells
1997 StandoutNatureNobel
Tolerance to solid organ transplants through transfer of MHC class II genes
2001
Hallmarks of cancer: Interactions with the tumor stroma
2010
Could endogenous self-peptides presented by dendritic cells initiate rheumatoid arthritis?
1996
Self‐Ignorance in the Peripheral T‐Cell Pool
1993
PRETRANSPLANT ADMINISTRATION OF A SINGLE DONOR CLASS I MAJOR HISTOCOMPATABILITY COMPLEX MOLECULE IS SUFFICIENT FOR THE INDEFINITE SURVIVAL OF FULLY ALLOGENEIC CARDIAC ALLOGRAFTS
1997
Transformation of the microvascular system during multistage tumorigenesis
2002
Altered thymic T-cell selection due to a mutation of the ZAP-70 gene causes autoimmune arthritis in mice
2003 StandoutNatureNobel
What is the role of regulatory T cells in transplantation tolerance?
1999
Immunologic self-tolerance maintained by CD25+CD4+ naturally anergic and suppressive T cells: induction of autoimmune disease by breaking their anergic/suppressive state.
1998
The secreted factors responsible for pre-metastatic niche formation: Old sayings and new thoughts
2011
The tyrosine kinase c-Abl regulates p73 in apoptotic response to cisplatin-induced DNA damage
1999 StandoutNatureNobel
How virus induces a rapid or slow onset insulin-dependent diabetes mellitus in a transgenic model
1994
Taking dendritic cells into medicine
2007 StandoutNatureNobel
Antitumor applications of stimulating toll-like receptor 9 with CpG oligodeoxynucleotides
2004
B-cell apoptosis induced by antigen receptor crosslinking is blocked by a T-cell signal through CD40
1993 StandoutNatureNobel
Peripheral deletion of self-reactive B cells
1991 Nature
Regulatory T cells in transplantation tolerance
2003 StandoutNobel
Activation-induced cell death (apoptosis) of mature peripheral T lymphocytes
1993
Restoring function in exhausted CD8 T cells during chronic viral infection
2005 StandoutNatureNobel
Cross‐presentation, dendritic cell subsets, and the generation of immunity to cellular antigens
2004
Self-Tolerance Checkpoints in B Lymphocyte Development
1995
Communication by Extracellular Vesicles: Where We Are and Where We Need to Go
2016 Standout
Antigen-induced apoptotic death of Ly-1 B cells responsible for autoimmune disease in transgenic mice
1992 StandoutNatureNobel
Focal expression of interleukin-2 does not break unresponsiveness to "self" (viral) antigen expressed in beta cells but enhances development of autoimmune disease (diabetes) after initiation of an anti-self immune response.
1995 StandoutNobel
Anergic T cells actively suppress T cell responses via the antigen-presenting cell
1998
Cancer exome analysis reveals a T-cell-dependent mechanism of cancer immunoediting
2012 StandoutNatureNobel
Evidence for a Thymus‐Dependent Form of Tolerance that is Not Based on Elimination or Anergy of Reactive T cells
1996
Why isn't the fetus rejected?
2001
Removing the Vertebrate-Specific TBP N Terminus Disrupts Placental β2m-Dependent Interactions with the Maternal Immune System
2002 StandoutNobel
Tie2-expressing monocytes: regulation of tumor angiogenesis and therapeutic implications
2007
A common E2F-1 and p73 pathway mediates cell death induced by TCR activation
2000 StandoutNatureNobel
Dendritic cells and the control of immunity
1998 StandoutNatureNobel
Transgenic Mice and Analysis of B-Cell Tolerance
1992
Organ-specific autoimmunity
1995
Elimination from peripheral lymphoid tissues of self-reactive B lymphocytes recognizing membrane-bound antigens
1991 Nature
Transcriptional regulation by the phosphorylation-dependent factor CREB
2001 Standout
Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease
2011 StandoutNature
The role of pericytes in blood-vessel formation and maintenance
2005
Tumor Angiogenesis
2008 Standout
Thymic selection of CD4+CD25+ regulatory T cells induced by an agonist self-peptide
2001
Insulin disrupts β-adrenergic signalling to protein kinase A in adipocytes
2005 StandoutNatureNobel
Inferences, questions and possibilities in Toll-like receptor signalling
2004 StandoutNatureNobel
Dominant transplantation tolerance impairs CD8+ T cell function but not expansion
2002
Peripheral tolerance of CD4 T cells following local activation in adolescent mice
1996
Virus-specific CD8+ T-cell memory determined by clonal burst size
1994 StandoutNatureNobel
The bcl-2 gene product inhibits clonal deletion of self-reactive B lymphocytes in the periphery but not in the bone marrow.
1993 StandoutNobel
Identification of Regulatory T Cells in Tolerated Allografts
2002
Developmental failure of chimeric embryos expressing high levels of H-2Dd transplantation antigens.
1992
Naturally Arising CD4+Regulatory T Cells for Immunologic Self -Tolerance and Negative Control of Immune Responses
2003 StandoutNobel
PD-1 Inhibits Antiviral Immunity at the Effector Phase in the Liver
2003 StandoutNobel
Targeting of drugs and nanoparticles to tumors
2010
Endothelial-Mural Cell Signaling in Vascular Development and Angiogenesis
2009
Vascular normalizing doses of antiangiogenic treatment reprogram the immunosuppressive tumor microenvironment and enhance immunotherapy
2012
Regulatory T Cells Overexpress a Subset of Th2 Gene Transcripts
2002
Differentiation of Monocytes into Dendritic Cells in a Model of Transendothelial Trafficking
1998 StandoutScienceNobel
Mutation of the mouse klotho gene leads to a syndrome resembling ageing.
1997 Standout
Receptor editing: an approach by autoreactive B cells to escape tolerance.
1993
Costimulator B7-1 confers antigen-presenting-cell function to parenchymal tissue and in conjunction with tumor necrosis factor alpha leads to autoimmunity in transgenic mice.
1994
Viral and immunological determinants of hepatitis C virus clearance, persistence, and disease
2002
Tolerance induction by thymic medullary epithelium.
1992 StandoutNobel
Natural Innate and Adaptive Immunity to Cancer
2011 Standout
The role of the graft in establishing tolerance
2002
Chemokine nitration prevents intratumoral infiltration of antigen-specific T cells
2011
The Biochemistry, Biology, and Role of Interleukin 2 in the Induction of Cytotoxic T Cell and Antibody‐Forming B Cell Responses
1982
Pain regulation by non-neuronal cells and inflammation
2016 StandoutScience
Expression of two alpha chains on the surface of T cells in T cell receptor transgenic mice.
1993
The bone marrow constitutes a reservoir of pericyte progenitors
2006
Vascular Normalization as an Emerging Strategy to Enhance Cancer Immunotherapy
2013
Constitutive Presentation of a Natural Tissue Autoantigen Exclusively by Dendritic Cells in the Draining Lymph Node
2002
Limited tumor infiltration by activated T effector cells restricts the therapeutic activity of regulatory T cell depletion against established melanoma
2008 StandoutNobel
Identification and Functional Characterization of Human Cd4+Cd25+ T Cells with Regulatory Properties Isolated from Peripheral Blood
2001
Prevention of Allogeneic Fetal Rejection by Tryptophan Catabolism
1998 StandoutScience
The Linkage of Innate to Adaptive Immunity via Maturing Dendritic Cells In Vivo Requires CD40 Ligation in Addition to Antigen Presentation and CD80/86 Costimulation
2004 StandoutNobel
Cutting Edge: Regulation of Uterine NKT Cells by a Fetal Class I Molecule Other Than CD1
2001
Glucose-Induced Reactive Oxygen Species Cause Apoptosis of Podocytes and Podocyte Depletion at the Onset of Diabetic Nephropathy
2006
The Roles of Therapy-Induced Autophagy and Necrosis in Cancer Treatment
2007
Tumor-targeted TNFα stabilizes tumor vessels and enhances active immunotherapy
2012
Avoiding horror autotoxicus: The importance of dendritic cells in peripheral T cell tolerance
2002 StandoutNobel
The biology , function , and biomedical applications of exosomes
2020 StandoutScience
The Thymus Contains a High Frequency of Cells that Prevent Autoimmune Diabetes on Transfer into Prediabetic Recipients
1996
Induced sensitization of tumor stroma leads to eradication of established cancer by T cells
2007
Cell-surface expression of H-2Db requires N-linked glycans
1987
Extrathymic Development of Vα11 T Cells in Placenta During Pregnancy and Their Possible Physiological Role
2001
Alloantigen–induced specific immunological unresponsiveness
2001
Anergic T Cells as Suppressor Cells in Vitro
1994 Science
CD4 cells can be more efficient at tumor rejection than CD8 cells
2007
The role of the T cell costimulator B7-1 in autoimmunity and the induction and maintenance of tolerance to peripheral antigen
1994
T cell exclusion, immune privilege, and the tumor microenvironment
2015 StandoutScience
Itk Negatively Regulates Induction of T Cell Proliferation by CD28 Costimulation
1997 StandoutNobel
Class I–restricted Cross-Presentation of Exogenous Self-Antigens Leads to Deletion of Autoreactive CD8+ T Cells
1997
Cell Survival Promoted by the Ras-MAPK Signaling Pathway by Transcription-Dependent and -Independent Mechanisms
1999 StandoutScience
Antigen Presentation and T Cell Stimulation by Dendritic Cells
2002
Local Radiation Therapy of B16 Melanoma Tumors Increases the Generation of Tumor Antigen-Specific Effector Cells That Traffic to the Tumor
2005
Thymus and Autoimmunity: Production of CD25+CD4+ Naturally Anergic and Suppressive T Cells as a Key Function of the Thymus in Maintaining Immunologic Self-Tolerance
1999 StandoutNobel
Programmed cell death by bcl-2-dependent and independent mechanisms in B lymphoma cells.
1993
Exon shuffling in vivo can generate novel HLA class I molecules.
1985
Medullary Thymic Epithelium: A Mosaic of Epithelial “Self”?
1998
Defective TCR expression in transgenic mice constructed using cDNA‐based α‐ and β‐chain genes under the control of heterologous regulatory elements
1998
Mechanisms of tolerance induction in major histocompatibility complex class II-restricted T cells specific for a blood-borne self-antigen.
1994
Works of Bernd Arnold being referenced
Chemokines direct endothelial progenitors into tumor neovessels
2005
Anergy induced by thymic medullary epithelium
1992
Glucose, Glycation, and RAGE
2003
Mini‐review: Overcoming tumor‐intrinsic resistance to immune effector function
2004
Peripheral T‐cell tolerance: the contribution of permissive T‐cell migration into parenchymal tissues of the neonate
1999
Expression of major histocompatibility complex class I antigens at low levels in the thymus induces T cell tolerance via a non‐deletional mechanism
1992
Down-regulation of T cell receptors on self-reactive T cells as a novel mechanism for extrathymic tolerance induction
1991
Efficient presentation of exogenous antigen by liver endothelial cells to CD8+ T cells results in antigen-specific T-cell tolerance
2000
Autoaggression and tumor rejection: it takes more than self‐specific T‐cell activation
1999
Multiple levels of peripheral tolerance
1993
Long life span of tolerant T cells and the role of antigen in maintenance of peripheral tolerance
1995
A role for Th2 cytokines in the suppression of CD8+ T cell‐mediated graft rejection
1997
Influence of antigen density on degree of clonal deletion in T cell receptor transgenic mice
1992
Receptor for advanced glycation end products (RAGE) regulates sepsis but not the adaptive immune response
2004
Tolerance induction as a multi‐step process
1994
Autoimmune diabetes as a consequence of locally produced interleukin-2
1992 Nature
Lymphatic endothelium‐specific hyaluronan receptor LYVE‐1 is expressed by stabilin‐1+, F4/80+, CD11b+ macrophages in malignant tumours and wound healing tissue in vivo and in bone marrow cultures in vitro: implications for the assessment of lymphangiogenesis
2006
Deficiency of liver sinusoidal scavenger receptors stabilin-1 and -2 in mice causes glomerulofibrotic nephropathy via impaired hepatic clearance of noxious blood factors
2011
Vascular targeting of anti-CD40 antibodies and IL-2 into autochthonous tumors enhances immunotherapy in mice
2008
Extracellular Vesicle-Mediated Transfer of Genetic Information between the Hematopoietic System and the Brain in Response to Inflammation
2014
Clonal Deletion of Autospecific B Lymphocytes
1991
Vascular normalization in Rgs5-deficient tumours promotes immune destruction
2008 Nature
Distinct mechanisms of extrathymic T cell tolerance due to differential expression of self antigen
1992
Levels of Peripheral T Cell Tolerance Induced by Different Doses of Tolerogen
1994 Science
Cytolytic T cells recognize the two amino-terminal domains of H-2 K antigens in tandem in influenza A infected cells
1984
Regulator of G-protein signaling-5 induction in pericytes coincides with active vessel remodeling during neovascularization
2005
Workshop R: Tumor Immunology, Abstract R1 bis R30
2001
RAGE signaling sustains inflammation and promotes tumor development
2008
Release of High Mobility Group Box 1 by Dendritic Cells Controls T Cell Activation via the Receptor for Advanced Glycation End Products
2005
A Con A-stimulated T-cell hybridoma releases factors affecting haematopoietic colony-forming cells and B-cell antibody responses
1980 Nature
Alloreactive immune responses of transgenic mice expressing a foreign transplantation antigen in a soluble form.
1988
CpG Motifs as Proinflammatory Factors Render Autochthonous Tumors Permissive for Infiltration and Destruction
2004
Non‐Deletional Mechanisms of Peripheral and Central Tolerance: Studies with Transgenic Mice with Tissue‐Specific Expression of a Foreign MHC Class I Antigen
1991
Impaired fetal T cell development and perinatal lethality in mice lacking the cAMP response element binding protein
1998
Peripheral Tolerance as a Multi‐Step Mechanism
1993
Control of Neonatal Tolerance to Tissue Antigens by Peripheral T Cell Trafficking
1998 Science
Complete nucleotide sequence of the murine H-2kkgene. Comparison of three H-2K locus alleles
1984
T Cell Awareness of Paternal Alloantigens During Pregnancy
1995 Science
MHC Class-I Transgenic Mice
1991
Receptor for advanced glycation end products (RAGE) regulates sepsis but not the adaptive immune response
2004 Standout
The serine protease inhibitor SerpinA3N attenuates neuropathic pain by inhibiting T cell–derived leukocyte elastase
2015
NK- and CD8+ T Cell-Mediated Eradication of Established Tumors by Peritumoral Injection of CpG-Containing Oligodeoxynucleotides
2001
Transgenic mice expressing a soluble foreign H-2 class I antigen are tolerant to allogeneic fragments presented by self class I but not to the whole membrane-bound alloantigen.
1990