Standout Papers
Citation Impact
Citing Papers
Phosphorylation of ULK1 (hATG1) by AMP-Activated Protein Kinase Connects Energy Sensing to Mitophagy
2010 StandoutScience
ATP-Citrate Lyase Links Cellular Metabolism to Histone Acetylation
2009 StandoutScience
ER Tubules Mark Sites of Mitochondrial Division
2011 StandoutScience
Caloric Restriction Delays Disease Onset and Mortality in Rhesus Monkeys
2009 StandoutScience
AMP-Activated Protein Kinase–Deficient Mice Are Resistant to the Metabolic Effects of Resveratrol
2009
Haematological rather than skeletal muscle adaptations contribute to the increase in peak oxygen uptake induced by moderate endurance training
2015
Sirtuins as regulators of metabolism and healthspan
2012 Standout
PARP-1 Inhibition Increases Mitochondrial Metabolism through SIRT1 Activation
2011
AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity
2009 StandoutNature
The NAD+-Dependent Deacetylase SIRT1 Modulates CLOCK-Mediated Chromatin Remodeling and Circadian Control
2008
Specific SIRT1 Activation Mimics Low Energy Levels and Protects against Diet-Induced Metabolic Disorders by Enhancing Fat Oxidation
2008
The secretory function of adipocytes in the physiology of white adipose tissue
2008
Superior mitochondrial adaptations in human skeletal muscle after interval compared to continuous single‐leg cycling matched for total work
2016
High-intensity interval training in patients with lifestyle-induced cardiometabolic disease: a systematic review and meta-analysis
2013
Intramolecular Control of Protein Stability, Subnuclear Compartmentalization, and Coactivator Function of Peroxisome Proliferator-activated Receptor γ Coactivator 1α
2007
Resveratrol alleviates alcoholic fatty liver in mice
2008
SIRT6 protects against pathological damage caused by diet‐induced obesity
2009
Short-Term Effects of Nose-Only Cigarette Smoke Exposure on Glutathione Redox Homeostasis, Cytochrome P450 1A1/2 and Respiratory Enzyme Activities in Mice Tissues
2013 Standout
The Histone Deacetylase Sirt6 Regulates Glucose Homeostasis via Hif1α
2010
Adipose tissue browning and metabolic health
2013
Diabetic Foot Ulcers and Their Recurrence
2017 Standout
Deleted in breast cancer–1 regulates SIRT1 activity and contributes to high-fat diet–induced liver steatosis in mice
2010
Influence of Metabolism on Epigenetics and Disease
2013 StandoutNobel
What is Best Practice for Training Intensity and Duration Distribution in Endurance Athletes?
2010
Sirtuin 1 in lipid metabolism and obesity
2011
Sirtuin-7 Inhibits the Activity of Hypoxia-inducible Factors
2013 StandoutNobel
The Failing Heart — An Engine Out of Fuel
2007 Standout
The genetics of ageing
2010 StandoutNature
Endocrine regulation of ageing
2007
Slowing ageing by design: the rise of NAD+ and sirtuin-activating compounds
2016
The AMPK signalling pathway coordinates cell growth, autophagy and metabolism
2011 Standout
Obesity-induced gut microbial metabolite promotes liver cancer through senescence secretome
2013 StandoutNature
Development of protein kinase activators: AMPK as a target in metabolic disorders and cancer
2009
Fast/Glycolytic Muscle Fiber Growth Reduces Fat Mass and Improves Metabolic Parameters in Obese Mice
2008
Is mitochondrial dysfunction a cause of insulin resistance?
2008
Hallmarks of aging: An expanding universe
2023 Standout
Energy metabolism in heart failure
2003
Abdominal aortic aneurysm
2005 Standout
Autophagy and senescence, converging roles in pathophysiology as seen through mouse models
2021
NCoR1 Is a Conserved Physiological Modulator of Muscle Mass and Oxidative Function
2011
NAD+ as a Signaling Molecule Modulating Metabolism
2011
Conserved Metabolic Regulatory Functions of Sirtuins
2008
Cancer Epigenetics: From Mechanism to Therapy
2012 Standout
Sirtuins, Aging, and Medicine
2011
Mitochondrial diseases
2012
Tipping the metabolic scales towards increased longevity in mammals
2015
Sirtuins, Aging, and Metabolism
2011
Regulation of nucleotide excision repair activity by transcriptional and post-transcriptional control of the XPA protein
2010 StandoutNobel
Impaired DNA Damage Response, Genome Instability, and Tumorigenesis in SIRT1 Mutant Mice
2008
The multifaceted functions of sirtuins in cancer
2015
Roles of SIRT1 in the Acute and Restorative Phases following Induction of Inflammation
2010
Glucose Restriction Inhibits Skeletal Myoblast Differentiation by Activating SIRT1 through AMPK-Mediated Regulation of Nampt
2008
Transcriptional targets of sirtuins in the coordination of mammalian physiology
2008
A Mitochondrial Superoxide Signal Triggers Increased Longevity in Caenorhabditis elegans
2010
Tissue-specific regulation of SIRT1 by calorie restriction
2008
Biological Functions of Autophagy Genes: A Disease Perspective
2019 Standout
Organization and Evolution of Brain Lipidome Revealed by Large-Scale Analysis of Human, Chimpanzee, Macaque, and Mouse Tissues
2015 StandoutNobel
Human nutrition, the gut microbiome and the immune system
2011 StandoutNature
The Potential for High-Intensity Interval Training to Reduce Cardiometabolic Disease Risk
2012
Mitochondria: In Sickness and in Health
2012 Standout
Exposure to resveratrol triggers pharmacological correction of fatty acid utilization in human fatty acid oxidation-deficient fibroblasts
2011
PARP-2 Regulates SIRT1 Expression and Whole-Body Energy Expenditure
2011
High-Intensity Interval Training, Solutions to the Programming Puzzle
2013
Resveratrol is Not a Direct Activator of SIRT1 Enzyme Activity
2009
In Vivo Correction of COX Deficiency by Activation of the AMPK/PGC-1α Axis
2011
Resveratrol Ameliorates Aging-Related Metabolic Phenotypes by Inhibiting cAMP Phosphodiesterases
2012
Phosphorylation Regulates SIRT1 Function
2008
The different shades of fat
2014 Nature
Increased vascular contractility in isolated vessels from cigarette smoking rats is mediated by basal endothelin release
2006
Endurance Training and V˙O2max
2015
Role of exercise duration on metabolic adaptations in working muscle to short-term moderate-to-heavy aerobic-based cycle training
2013
SIRT1: recent lessons from mouse models
2010
The NAD+/Sirtuin Pathway Modulates Longevity through Activation of Mitochondrial UPR and FOXO Signaling
2013
Brown adipose tissue thermogenic adaptation requires Nrf1-mediated proteasomal activity
2018 StandoutNobel
From Dietary Fiber to Host Physiology: Short-Chain Fatty Acids as Key Bacterial Metabolites
2016 Standout
Recent progress in the biology and physiology of sirtuins
2009 Nature
Fibre-Specific Responses to Endurance and Low Volume High Intensity Interval Training: Striking Similarities in Acute and Chronic Adaptation
2014
The NAD+ Precursor Nicotinamide Riboside Enhances Oxidative Metabolism and Protects against High-Fat Diet-Induced Obesity
2012
Hepatocyte-Specific Deletion of SIRT1 Alters Fatty Acid Metabolism and Results in Hepatic Steatosis and Inflammation
2009
AMP-activated protein kinase and its downstream transcriptional pathways
2010
Autophagy and Aging
2011 Standout
Calcineurin Co-regulates Contractile and Metabolic Components of Slow Muscle Phenotype
2000
Biochemical Analysis of the Canonical Model for the Mammalian Circadian Clock
2011 StandoutNobel
Run Sprint Interval Training Improves Aerobic Performance but Not Maximal Cardiac Output
2010
Sprint Interval Training Effects on Aerobic Capacity: A Systematic Review and Meta-Analysis
2013
Exercise Metabolism and the Molecular Regulation of Skeletal Muscle Adaptation
2013
Metabolic Networks of Longevity
2010
Calorie Restriction-like Effects of 30 Days of Resveratrol Supplementation on Energy Metabolism and Metabolic Profile in Obese Humans
2011
SRT1720, SRT2183, SRT1460, and Resveratrol Are Not Direct Activators of SIRT1
2010
Transcriptional co-activator PGC-1α drives the formation of slow-twitch muscle fibres
2002 StandoutNature
What We Talk About When We Talk About Fat
2014 Standout
Structural and Functional Alteration of Blood Vessels Caused by Cigarette Smoking: An Overview of Molecular Mechanisms
2007
Negative regulation of the deacetylase SIRT1 by DBC1
2008 Nature
AKT/PKB Signaling: Navigating the Network
2017 Standout
Effectiveness of High-Intensity Interval Training (HIT) and Continuous Endurance Training for VO2max Improvements: A Systematic Review and Meta-Analysis of Controlled Trials
2015
Repertoires of Autophagy in the Pathogenesis of Ocular Diseases
2015 Standout
The role of senescent cells in ageing
2014 StandoutNature
Caloric restriction mimetics: towards a molecular definition
2014
Brown Remodeling of White Adipose Tissue by SirT1-Dependent Deacetylation of Pparγ
2012
Geroscience: Linking Aging to Chronic Disease
2014 Standout
Metabolic Control of Autophagy
2014
The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis
2019 StandoutNature
Targeting Sirtuin 1 to Improve Metabolism: All You Need Is NAD+?
2011
The Hallmarks of Aging
2013 Standout
A Pathway Involving Farnesoid X Receptor and Small Heterodimer Partner Positively Regulates Hepatic Sirtuin 1 Levels via MicroRNA-34a Inhibition
2010
Overexpression of Atg5 in mice activates autophagy and extends lifespan
2013
Transcriptional control of mitochondrial biogenesis: the central role of PGC-1
2008
The Search for Antiaging Interventions: From Elixirs to Fasting Regimens
2014
Chemical probes for histone-modifying enzymes
2008
SIRT1 Deacetylates and Inhibits SREBP-1C Activity in Regulation of Hepatic Lipid Metabolism*
2010
The Aging Stress Response
2010
Mitochondria—A Nexus for Aging, Calorie Restriction, and Sirtuins?
2008
Inflammation, metaflammation and immunometabolic disorders
2017 StandoutNature
PGC-1α, SIRT1 and AMPK, an energy sensing network that controls energy expenditure
2009
Resveratrol Supplementation Does Not Improve Metabolic Function in Nonobese Women with Normal Glucose Tolerance
2012
Adaptations in muscle metabolic regulation require only a small dose of aerobic-based exercise
2012
AMPK and PPARδ Agonists Are Exercise Mimetics
2008
SIRT1 transgenic mice show phenotypes resembling calorie restriction
2007
Screening for Active Small Molecules in Mitochondrial Complex I Deficient Patient's Fibroblasts, Reveals AICAR as the Most Beneficial Compound
2011
Sirt1 improves healthy ageing and protects from metabolic syndrome-associated cancer
2010
PPARγ in human and mouse physiology
2007
Similar Expression of Oxidative Genes after Interval and Continuous Exercise
2009
High-Intensity Interval Training, Solutions to the Programming Puzzle
2013
Mitochondrial Dynamics in Diabetes
2010
A Fluorogenic Aryl Fluorosulfate for Intraorganellar Transthyretin Imaging in Living Cells and in Caenorhabditis elegans
2015 StandoutNobel
The Aging Brain
2008
Hepatic overexpression of SIRT1 in mice attenuates endoplasmic reticulum stress and insulin resistance in the liver
2011
Effectiveness of revascularisation of the ulcerated foot in patients with diabetes and peripheral artery disease: A systematic review
2020
SIRT1 mRNA Expression May Be Associated With Energy Expenditure and Insulin Sensitivity
2010
Training intensity modulates changes in PGC‐1α and p53 protein content and mitochondrial respiration, but not markers of mitochondrial content in human skeletal muscle
2015
Dietary, Metabolic, and Potentially Environmental Modulation of the Lysine Acetylation Machinery
2010
Sirtuin 1 and Sirtuin 3: Physiological Modulators of Metabolism
2012
Effectiveness of revascularization of the ulcerated foot in patients with diabetes and peripheral artery disease: a systematic review
2015
Spermidine coupled with exercise rescues skeletal muscle atrophy from D-gal-induced aging rats through enhanced autophagy and reduced apoptosis via AMPK-FOXO3a signal pathway
2017
Dialogue between E. coli free radical pathways and the mitochondria of C. elegans
2015 StandoutNobel
Resveratrol Regulates the Expression of Genes Involved in CoQ Synthesis in Liver in Mice Fed with High Fat Diet
2020
Transcriptional Control of Energy Homeostasis by the Estrogen-Related Receptors
2008
Can we optimise the exercise training prescription to maximise improvements in mitochondria function and content?
2013
Sirt1 protects against high-fat diet-induced metabolic damage
2008
The genetic ablation of SRC-3 protects against obesity and improves insulin sensitivity by reducing the acetylation of PGC-1α
2008
Mitochondria express enhanced quality as well as quantity in association with aerobic fitness across recreationally active individuals up to elite athletes
2012
Aggregation-Induced Emission: Together We Shine, United We Soar!
2015 Standout
ROS-based lethality of Caenorhabditis elegans mitochondrial electron transport mutants grown on Escherichia coli siderophore iron release mutants
2019 StandoutNobel
Sirtuins, a key regulator of ageing and age-related neurodegenerative diseases
2022
Mammalian Sirtuins: Biological Insights and Disease Relevance
2010 Standout
The Caenorhabditis elegans ARIP-4 DNA helicase couples mitochondrial surveillance to immune, detoxification, and antiviral pathways
2022 StandoutNobel
Spermidine in health and disease
2018 StandoutScience
Exercise-induced metabolic fluctuations influence AMPK, p38-MAPK and CaMKII phosphorylation in human skeletal muscle
2015
SIRT6, a Mammalian Deacylase with Multitasking Abilities
2019
Moderation of mitochondrial respiration mitigates metabolic syndrome of aging
2020
Sir2 mediates apoptosis through JNK-dependent pathways in Drosophila
2008
Mitochondrial adaptations to high‐volume exercise training are rapidly reversed after a reduction in training volume in human skeletal muscle
2016
Mammalian Sir2 Homolog SIRT3 Regulates Global Mitochondrial Lysine Acetylation
2007
Physiological adaptations to interval training and the role of exercise intensity
2016 Standout
Liver Fibrosis: Mechanistic Concepts and Therapeutic Perspectives
2020
The enzyme CD38 (a NAD glycohydrolase, EC 3.2.2.5) is necessary for the development of diet‐induced obesity
2007
Mitochondrial gene expression in elite cyclists: effects of high-intensity interval exercise
2010
Lack of SIRT1 (Mammalian Sirtuin 1) Activity Leads to Liver Steatosis in the SIRT1+/− Mice: A Role of Lipid Mobilization and Inflammation
2010
Mitochondrial and metabolic dysfunction in ageing and age-related diseases
2022
Sirtuins — novel therapeutic targets to treat age-associated diseases
2008
Butyrate Improves Insulin Sensitivity and Increases Energy Expenditure in Mice
2009 Standout
Multiple Click-Selective tRNA Synthetases Expand Mammalian Cell-Specific Proteomics
2018 StandoutNobel
Mitochondrial activation chemicals synergize with surface receptor PD-1 blockade for T cell-dependent antitumor activity
2017 StandoutNobel
A role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy
2008
Extending Healthy Life Span—From Yeast to Humans
2010 StandoutScience
Fast detection of liver fibrosis with collagen-binding single-nanometer iron oxide nanoparticles via T 1 -weighted MRI
2023 StandoutNobel
The Secret Life of NAD+: An Old Metabolite Controlling New Metabolic Signaling Pathways
2010
Exploring the therapeutic space around NAD+
2012
Dose translation from animal to human studies revisited
2007 Standout
Aging and Survival: The Genetics of Life Span Extension by Dietary Restriction
2008
Works of Bernard Gény being referenced
A new impedance cardiograph device for the non-invasive evaluation of cardiac output at rest and during exercise: comparison with the "direct" Fick method
2000
Improving exercise capacity, 6 wk training tends to reduce circulating endothelin after heart transplantation
2004
Persistent Exercise Intolerance Following Cardiac Transplantation Despite Normal Oxygen Transport
1996
Improvement of $$\dot{V}\hbox{O}_{2 \max},$$ by cardiac output and oxygen extraction adaptation during intermittent versus continuous endurance training
2007
ACE inhibition prevents myocardial infarction-induced skeletal muscle mitochondrial dysfunction
2006
Current Outcome of Elective Open Repair for Infrarenal Abdominal Aortic Aneurysm
2004
Effect of interval versus continuous training on cardiorespiratory and mitochondrial functions: relationship to aerobic performance improvements in sedentary subjects
2008
Health benefits of aerobic training programs in adults aged 70 and over: a systematic review
2016
Resveratrol Improves Mitochondrial Function and Protects against Metabolic Disease by Activating SIRT1 and PGC-1α
2006 Standout
Long-Term Outcomes of Direct and Indirect Below-The-Knee Open Revascularization Based on the Angiosome Concept in Diabetic Patients with Critical Limb Ischemia
2013
Physical activity changes the regulation of mitochondrial respiration in human skeletal muscle
2002
Non-invasive cardiac output evaluation during a maximal progressive exercise test, using a new impedance cardiograph device
2001
Exercise training in normobaric hypoxia in endurance runners. II. Improvement of mitochondrial properties in skeletal muscle
2005
Training at high exercise intensity promotes qualitative adaptations of mitochondrial function in human skeletal muscle
2008