Standout Papers
Citation Impact
Citing Papers
A monomeric G protein-coupled receptor isolated in a high-density lipoprotein particle efficiently activates its G protein
2007 StandoutNobel
High-Resolution Crystal Structure of an Engineered Human β 2 -Adrenergic G Protein–Coupled Receptor
2007 StandoutScienceNobel
GPCR Engineering Yields High-Resolution Structural Insights into β 2 -Adrenergic Receptor Function
2007 StandoutScienceNobel
Mammalian Transient Receptor Potential TRPA1 Channels: From Structure to Disease
2019
A fluorescent probe designed for studying protein conformational change
2005 StandoutNobel
A unique mechanism of β-blocker action: Carvedilol stimulates β-arrestin signaling
2007 StandoutNobel
The 2.6 Angstrom Crystal Structure of a Human A 2A Adenosine Receptor Bound to an Antagonist
2008 StandoutScience
Cannabinoids Cause Central Sympathoexcitation and Bradycardia in Rabbits
2000
Structure of the TRPA1 ion channel suggests regulatory mechanisms
2015 StandoutNatureNobel
Hemodynamic effects of cannabinoids: coronary and cerebral vasodilation mediated by cannabinoid CB1 receptors
2001
Pharmacological Onomastics: What's in a name?
2007
In Vino Veritas: Alcohol and Heart Disease
2005
G-protein-coupled Receptor Kinase Specificity for β-Arrestin Recruitment to the β2-Adrenergic Receptor Revealed by Fluorescence Resonance Energy Transfer
2006 StandoutNobel
Presynaptic cannabinoid CB1 receptors are involved in the inhibition of the neurogenic vasopressor response during septic shock in pithed rats
2004
Ibuprofen-like activity in extra-virgin olive oil
2005 StandoutNature
Endocannabinoid-Mediated Long-Term Plasticity Requires cAMP/PKA Signaling and RIM1α
2007 StandoutNobel
Cardiovascular Pharmacology of Cannabinoids
2005
Cellular assays as portals to seven-transmembrane receptor-based drug discovery
2009
Crystal structure of the human β2 adrenergic G-protein-coupled receptor
2007 StandoutNatureNobel
Structure and Conformational Changes in the C-terminal Domain of the β2-Adrenoceptor
2007 StandoutNobel
Probing the β2 Adrenoceptor Binding Site with Catechol Reveals Differences in Binding and Activation by Agonists and Partial Agonists
2005 StandoutNobel
Vanilloid receptors on sensory nerves mediate the vasodilator action of anandamide
1999 StandoutNatureNobel
Irritant-evoked activation and calcium modulation of the TRPA1 receptor
2020 StandoutNatureNobel
Ligand-regulated oligomerization of β2-adrenoceptors in a model lipid bilayer
2009 StandoutNobel
Functional Selectivity through Protean and Biased Agonism: Who Steers the Ship?
2007
Blood pressure regulation by endocannabinoids and their receptors
2005
Olive Oil Isochromans Inhibit Human Platelet Reactivity
2003
Agonist Binding: A Multistep Process
2004 StandoutNobel
Endocannabinoids as cardiovascular modulators
2000
Anandamide and methanandamide induce both vanilloid VR1- and cannabinoid CB1 receptor-mediated changes in heart rate and blood pressure in anaesthetized rats
2001
Ligand-specific regulation of the extracellular surface of a G-protein-coupled receptor
2010 StandoutNatureNobel
Kinetic Analysis of G Protein–Coupled Receptor Signaling Using Fluorescence Resonance Energy Transfer in Living Cells
2007
Structure of the human M2 muscarinic acetylcholine receptor bound to an antagonist
2012 StandoutNatureNobel
The Endocannabinoid System as an Emerging Target of Pharmacotherapy
2006 Standout
The structure and function of G-protein-coupled receptors
2009 StandoutNatureNobel
Structure and function of cGMP-dependent protein kinases
2005
Evaluation of the Pichia pastoris expression system for the production of GPCRs for structural analysis
2011
Central effects of the cannabinoid receptor agonist WIN55212‐2 on respiratory and cardiovascular regulation in anaesthetised rats
2004
Detection of an Endogenous Cannabimimetic Molecule, 2-Arachidonoylglycerol, and Cannabinoid CB1 Receptor mRNA in Human Vascular Cells: Is 2-Arachidonoylglycerol a Possible Vasomodulator?
1998
Physiology and Pathophysiology of Purinergic Neurotransmission
2007 Standout
Plant Polyphenols: Chemical Properties, Biological Activities, and Synthesis
2011 Standout
Teaching old receptors new tricks: biasing seven-transmembrane receptors
2010 StandoutNobel
Conformational complexity of G-protein-coupled receptors
2007 StandoutNobel
β-Arrestin1 mediates nicotinic acid–induced flushing, but not its antilipolytic effect, in mice
2009 StandoutNobel
Analysis of the respiratory effects of cannabinoids in rats
2003
Sequential Binding of Agonists to the β2 Adrenoceptor
2003 StandoutNobel
TRPA1 as a drug target—promise and challenges
2015
A FlAsH-based FRET approach to determine G protein–coupled receptor activation in living cells
2005 StandoutNobel
The peripheral sympathetic nervous system is the major target of cannabinoids in eliciting cardiovascular depression
2003
Effects of Cannabinoids on Neurotransmission
2005
Engineered Nanoparticles for Drug Delivery in Cancer Therapy
2014 Standout
GRAIL
2003
Synergies and Coincidence Requirements between NO, cGMP, and Ca2+ in the Induction of Cerebellar Long-Term Depression
1997 StandoutNobel
β-arrestin-mediated receptor trafficking and signal transduction
2011 StandoutNobel
Dosage‐dependent switch from G protein‐coupled to G protein‐independent signaling by a GPCR
2006 StandoutNobel
Collateral efficacy in drug discovery: taking advantage of the good (allosteric) nature of 7TM receptors
2007
The quest for a vascular endothelial cannabinoid receptor
2002
Mass Spectrometric Analysis of Agonist Effects on Posttranslational Modifications of the β-2 Adrenoceptor in Mammalian Cells
2005 StandoutNobel
Distinct conformational changes in β-arrestin report biased agonism at seven-transmembrane receptors
2008 StandoutNobel
Detection of self-reactive CD8 + T cells with an anergic phenotype in healthy individuals
2014 StandoutScienceNobel
A new form of cerebellar long-term potentiation is postsynaptic and depends on nitric oxide but not cAMP
2002 StandoutNobel
Plasmon-Waveguide Resonance Studies of Ligand Binding to the Human β2-Adrenergic Receptor
2004 StandoutNobel
Systemic and portal hemodynamic effects of anandamide
2001
Cholesterol increases kinetic, energetic, and mechanical stability of the human β2-adrenergic receptor
2012 StandoutNobel
Fluorescent Pirenzepine Derivatives as Potential Bitopic Ligands of the Human M1 Muscarinic Receptor
2004
Mesenteric Vasodilation Mediated by Endothelial Anandamide Receptors
1999
β-arrestin- but not G protein-mediated signaling by the “decoy” receptor CXCR7
2009 StandoutNobel
Probing Single Biomolecules in Solution Using the Anti-Brownian Electrokinetic (ABEL) Trap
2012 StandoutNobel
Platelet‐ and macrophage‐derived endogenous cannabinoids are involved in endotoxin‐induced hypotension
1998
BODIPY Dyes and Their Derivatives: Syntheses and Spectroscopic Properties
2007 Standout
Cannabinoid-induced mesenteric vasodilation through an endothelial site distinct from CB1 or CB2 receptors
1999
Functional CB1 cannabinoid receptors in human vascular endothelial cells
2000
Phosphodiesterase 4D is required for β 2 adrenoceptor subtype-specific signaling in cardiac myocytes
2005 StandoutNobel
Spatiotemporal dynamics of guanosine 3′,5′-cyclic monophosphate revealed by a genetically encoded, fluorescent indicator
2001 StandoutNobel
Conformational Dynamics of Single G Protein-Coupled Receptors in Solution
2011 StandoutNobel
Reduction ofNω-hydroxy-L -arginine by the mitochondrial amidoxime reducing component (mARC)
2010
The Mononuclear Molybdenum Enzymes
2014 Standout
Anandamide-induced vasorelaxation in rabbit aortic rings has two components: G protein dependent and independent
2002
Selective engagement of G protein coupled receptor kinases (GRKs) encodes distinct functions of biased ligands
2009 StandoutNobel
The effect of ligand efficacy on the formation and stability of a GPCR-G protein complex
2009 StandoutNobel
Section Review: Cardiovascular & Renal: Cyclic nucleotide phosphodiesterases as therapeutic targets in cardiovascular diseases
1995
Reversing cerebellar long-term depression
2003 StandoutNobel
Cannabinoid antagonist SR-141716 inhibits endotoxic hypotension by a cardiac mechanism not involving CB1 or CB2 receptors
2004
Rapid endo‐lysosomal escape of poly(DL‐lactide‐ co glycolide) nanoparticles: implications for drug and gene delivery
2002
NG-hydroxy-l -arginine and nitric oxide inhibit Caco-2 tumor cell proliferation by distinct mechanisms
1998 StandoutNobel
Identification of the role of endogenous cannabinoids in pain modulation: strategies and pitfalls
2000
Human TRPA1 is intrinsically cold- and chemosensitive with and without its N-terminal ankyrin repeat domain
2014
Works of Bernard Bucher being referenced
TRPA1 mediates spinal antinociception induced by acetaminophen and the cannabinoid Δ9-tetrahydrocannabiorcol
2011 Standout
Cannabinoid CB1 receptor-mediated inhibition of the neurogenic vasopressor response in the pithed rat
1997
Expression of EGFP-amino-tagged human mu opioid receptor in Drosophila Schneider 2 cells: a potential expression system for large-scale production of G-protein coupled receptors
2003
Distinct Motifs of Neuropeptide Y Receptors Differentially Regulate Trafficking and Desensitization
2007
Subsensitivity of presynaptic adenosine A1-receptors in caudal arteries of spontaneously hypertensive rats
1989
Inhibition of cyclic GMP‐dependent protein kinase‐mediated effects by (Rp)‐8‐bromo‐PET‐cyclic GMPS
1995
Rapid Internalization and Recycling of the Human Neuropeptide Y Y1 Receptor
2002
Mutations in the Extracellular Amino-terminal Domain of the NK2 Neurokinin Receptor Abolish cAMP Signaling but Preserve Intracellular Calcium Responses
2002
Effects of cyclic AMP and analogues on neurogenic transmission in the rat tail artery
1994
The Neurokinin A Receptor Activates Calcium and cAMP Responses through Distinct Conformational States
2001
Effects of cyclic GMP and analogues on neurogenic transmission in the rat tail artery
1994
Increase in serum NG-hydroxy-l-arginine in rats treated with bacterial lipopolysaccharide
1995
A novel, conformation‐specific allosteric inhibitor of the tachykinin NK2 receptor (NK2R) with functionally selective properties
2007
Wine Polyphenols Decrease Blood Pressure, Improve NO Vasodilatation, and Induce Gene Expression
2001