Standout Papers
Citation Impact
Citing Papers
Self‐processing of ribozyme‐flanked RNAs into guide RNAs in vitro and in vivo for CRISPR‐mediated genome editing
2013
Potent CRISPR-Cas9 inhibitors from Staphylococcus genomes
2020 StandoutNobel
C2c2 is a single-component programmable RNA-guided RNA-targeting CRISPR effector
2016 StandoutScience
Genome-wide CRISPR screens reveal a specific ligand for the glycan-binding immune checkpoint receptor Siglec-7
2021 StandoutNobel
Nucleic acid detection with CRISPR-Cas13a/C2c2
2017 StandoutScience
CRISPR/Cas9 in Genome Editing and Beyond
2016
High-throughput biochemical profiling reveals sequence determinants of dCas9 off-target binding and unbinding
2017 StandoutNobel
The H3K27me3 Demethylase dUTX Is a Suppressor of Notch- and Rb-Dependent Tumors in Drosophila
2010
PIEZO ion channel is required for root mechanotransduction in Arabidopsis thaliana
2021 StandoutNobel
CRISPR-Cas12a target binding unleashes indiscriminate single-stranded DNase activity
2018 StandoutScienceNobel
Engineered receptors for soluble cellular communication and disease sensing
2024 StandoutNatureNobel
Plug-and-Play Genetic Access to Drosophila Cell Types using Exchangeable Exon Cassettes
2015
dCas9 fusion to computer-designed PRC2 inhibitor reveals functional TATA box in distal promoter region
2022 StandoutNobel
The promise and challenge of therapeutic genome editing
2020 StandoutNatureNobel
Human pluripotent reprogramming with CRISPR activators
2018
Enhancing extracellular vesicle cargo loading and functional delivery by engineering protein-lipid interactions
2024 StandoutNobel
Programmable editing of a target base in genomic DNA without double-stranded DNA cleavage
2016 StandoutNature
Discoveries in structure and physiology of mechanically activated ion channels
2020 StandoutNatureNobel
Highly specific epigenome editing by CRISPR-Cas9 repressors for silencing of distal regulatory elements
2015
Editing the epigenome: technologies for programmable transcription and epigenetic modulation
2016
In Vivo Target Gene Activation via CRISPR/Cas9-Mediated Trans-epigenetic Modulation
2017
Multi-input chemical control of protein dimerization for programming graded cellular responses
2019 StandoutNobel
Genome-wide specificity of DNA binding, gene regulation, and chromatin remodeling by TALE- and CRISPR/Cas9-based transcriptional activators
2015
A CRISPR–dCas Toolbox for Genetic Engineering and Synthetic Biology
2018
Inducible and multiplex gene regulation using CRISPR–Cpf1-based transcription factors
2017
New CRISPR–Cas systems from uncultivated microbes
2016 StandoutNatureNobel
Aptazyme-embedded guide RNAs enable ligand-responsive genome editing and transcriptional activation
2017
Evolved Cas9 variants with broad PAM compatibility and high DNA specificity
2018 Nature
Large-scale design of robust genetic circuits with multiple inputs and outputs for mammalian cells
2017
Multiplexable, locus-specific targeting of long RNAs with CRISPR-Display
2015
CRISPR-Cas9 Circular Permutants as Programmable Scaffolds for Genome Modification
2019 StandoutNobel
A selectable, plasmid-based system to generate CRISPR/Cas9 gene edited and knock-in mosquito cell lines
2021 Nobel
Enabling functional genomics with genome engineering
2015
Epigenome editing by a CRISPR-Cas9-based acetyltransferase activates genes from promoters and enhancers
2015
Engineering cell sensing and responses using a GPCR-coupled CRISPR-Cas system
2017
Programmable base editing of A•T to G•C in genomic DNA without DNA cleavage
2017 StandoutNature
Evaluation of off-target and on-target scoring algorithms and integration into the guide RNA selection tool CRISPOR
2016
sgRNAcas9: A Software Package for Designing CRISPR sgRNA and Evaluating Potential Off-Target Cleavage Sites
2014
mTOR at the nexus of nutrition, growth, ageing and disease
2020 Standout
Diversity and evolution of class 2 CRISPR–Cas systems
2017
Hypoxia drives glucose transporter 3 expression through hypoxia-inducible transcription factor (HIF)–mediated induction of the long noncoding RNA NICI
2019 StandoutNobel
Cas9 gRNA engineering for genome editing, activation and repression
2015
A Broad-Spectrum Inhibitor of CRISPR-Cas9
2017 StandoutNobel
Enhanced Specificity and Efficiency of the CRISPR/Cas9 System with Optimized sgRNA Parameters in Drosophila
2014
CRISPR/Cas9-Based Engineering of the Epigenome
2017
Genome-scale CRISPR-Cas9 knockout and transcriptional activation screening
2017
Accessing the Phenotype Gap: Enabling Systematic Investigation of Paralog Functional Complexity with CRISPR
2017
Functional genetics for all: engineered nucleases, CRISPR and the gene editing revolution
2014
Pooled Knockin Targeting for Genome Engineering of Cellular Immunotherapies
2020
Applications of CRISPR technologies in research and beyond
2016 StandoutNobel
Genome-Scale Identification of SARS-CoV-2 and Pan-coronavirus Host Factor Networks
2020 StandoutNobel
The next generation of CRISPR–Cas technologies and applications
2019
Transcription factors: from enhancer binding to developmental control
2012 Standout
The Biology of CRISPR-Cas: Backward and Forward
2018 StandoutNobel
The Canonical Notch Signaling Pathway: Unfolding the Activation Mechanism
2009 Standout
CRISPR-Based Technologies for the Manipulation of Eukaryotic Genomes
2016 Standout
Cornerstones of CRISPR–Cas in drug discovery and therapy
2016 StandoutNobel
CasX enzymes comprise a distinct family of RNA-guided genome editors
2019 StandoutNatureNobel
Mechanical regulation of stem-cell differentiation by the stretch-activated Piezo channel
2018 Nature
Lysosome-targeting chimaeras for degradation of extracellular proteins
2020 StandoutNatureNobel
Refined sgRNA efficacy prediction improves large- and small-scale CRISPR–Cas9 applications
2017 StandoutNobel
TMEM41B Is a Pan-flavivirus Host Factor
2020 StandoutNobel
CRISPR/Cas9-Mediated Genome Editing of Epigenetic Factors for Cancer Therapy
2015
Performance of the Cas9 Nickase System inDrosophila melanogaster
2014
A Cas9–guide RNA complex preorganized for target DNA recognition
2015 StandoutScienceNobel
Multiplexed and portable nucleic acid detection platform with Cas13, Cas12a, and Csm6
2018 StandoutScience
CRISPRi and CRISPRa Screens in Mammalian Cells for Precision Biology and Medicine
2017
Systematic discovery of natural CRISPR-Cas12a inhibitors
2018 StandoutScienceNobel
CRISPR Correction of Duchenne Muscular Dystrophy
2018
Biochemical purification and pharmacological inhibition of a mammalian prolyl hydroxylase acting on hypoxia-inducible factor
2002 StandoutNobel
The new frontier of genome engineering with CRISPR-Cas9
2014 StandoutScienceNobel
CRISPR-CasΦ from huge phages is a hypercompact genome editor
2020 StandoutScienceNobel
Programmed DNA destruction by miniature CRISPR-Cas14 enzymes
2018 StandoutScienceNobel
The von Hippel-Lindau Tumor Suppressor Gene
2020
Efficient CRISPR/Cas9 Plasmids for Rapid and Versatile Genome Editing inDrosophila
2014
Modular repeat protein sculpting using rigid helical junctions
2020 StandoutNobel
Metabolic reprogramming and cancer progression
2020 StandoutScience
Cas9 interrogates DNA in discrete steps modulated by mismatches and supercoiling
2020 StandoutNobel
Sudestada1, a Drosophila ribosomal prolyl-hydroxylase required for mRNA translation, cell homeostasis, and organ growth
2014 StandoutNobel
De novo design of protein homodimers containing tunable symmetric protein pockets
2022 StandoutNobel
CRISPR-Cas guides the future of genetic engineering
2018 StandoutScienceNobel
Growth Factors, Matrices, and Forces Combine and Control Stem Cells
2009 StandoutScience
E3 ubiquitin ligase Mindbomb 1 facilitates nuclear delivery of adenovirus genomes
2020 StandoutNobel
Circadian neuron feedback controls the Drosophila sleep–activity profile
2016 StandoutNatureNobel
De novo design of protein logic gates
2020 StandoutScienceNobel
Compact and highly active next-generation libraries for CRISPR-mediated gene repression and activation
2016
Nontoxic nanopore electroporation for effective intracellular delivery of biological macromolecules
2019 StandoutNobel
Works of Benjamin E. Housden being referenced
Direct Response to Notch Activation: Signaling Crosstalk and Incoherent Logic
2009
HIF-independent synthetic lethality between CDK4/6 inhibition and VHL loss across species
2019 StandoutNobel
Comparison of Cas9 activators in multiple species
2016
Design and Generation of Drosophila Single Guide RNA Expression Constructs
2016
Highly efficient Cas9-mediated transcriptional programming
2015
mTORC1 Couples Nucleotide Synthesis to Nucleotide Demand Resulting in a Targetable Metabolic Vulnerability
2017
Cas9-Based Genome Editing in Drosophila
2014
Identification of potential drug targets for tuberous sclerosis complex by synthetic screens combining CRISPR-based knockouts with RNAi
2015
In Vivo Transcriptional Activation Using CRISPR/Cas9 in Drosophila
2015
Optimized gene editing technology for Drosophila melanogaster using germ line-specific Cas9
2013