Citation Impact
Citing Papers
Improvement of comparative model accuracy by free-energy optimization along principal components of natural structural variation
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Principles for designing proteins with cavities formed by curved β sheets
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In vivo imaging of hydrogen peroxide production in a murine tumor model with a chemoselective bioluminescent reporter
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Emergence of symmetry in homooligomeric biological assemblies
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Conversion of monomeric protein L to an obligate dimer by computational protein design
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Oligomer Formation By 3D Domain Swapping: A Model For Protein Assembly And Misassembly
1997
Crystal structure of a laccase from Melanocarpus albomyces with an intact trinuclear copper site
2002
Spectral and Kinetic Properties of the Fet3 Protein fromSaccharomyces cerevisiae, a Multinuclear Copper Ferroxidase Enzyme
1998
Identification, classification, and analysis of beta‐bulges in proteins
1993
A Primer on Vesicle Budding
1999 StandoutNobel
The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans
1997 StandoutNatureNobel
Channel opening and gating mechanism in AMPA-subtype glutamate receptors
2017 StandoutNatureNobel
Intramolecular electron transfer in laccases
2011
Role of ERas in promoting tumour-like properties in mouse embryonic stem cells
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Intrinsic disorder in scaffold proteins: Getting more from less
2008
Requirement of Phosphatidylinositol 3-Kinase Activity for Bradykinin Stimulation of NF-κB Activation in Cultured Human Epithelial Cells
1999
Substrate and Dioxygen Binding to the Endospore Coat Laccase from Bacillus subtilis
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Crystal structure of the type-2 Cu depleted laccase from Coprinus dnereus at 2.2 Å resolution
1998
A phosphatidylinositol-3-OH kinase family member regulating longevity and diapause in Caenorhabditis elegans
1996 StandoutNatureNobel
Snapshots of ARF1
1999
Mutations at Asp112 adjacent to the trinuclear Cu center in CueO as the proton donor in the four‐electron reduction of dioxygen
2006
Different Domains of Mammalian ADP-ribosylation Factor 1 Mediate Interaction with Selected Target Proteins
1997
Single-Site Mutations Induce 3D Domain Swapping in the B1 Domain of Protein L from Peptostreptococcus magnus
2001 StandoutNobel
3D domain swapping: A mechanism for oligomer assembly
1995
Structural Basis of Inward Rectification
2002 StandoutNobel
Interaction Sites of the G Protein β Subunit with Brain G Protein-coupled Inward Rectifier K+ Channel
2001
Crystal Structure of Intact Elongation Factor EF-Tu from Escherichia coli in GDP Conformation at 2.05Å Resolution
1999
Colorectal carcinomas in mice lacking the catalytic subunit of PI(3)Kγ
2000 StandoutNatureNobel
Conformational changes in the G protein Gs induced by the β2 adrenergic receptor
2011 StandoutNatureNobel
Negative Regulation of PKB/Akt-Dependent Cell Survival by the Tumor Suppressor PTEN
1998 StandoutNobel
Crystal structure of the β2 adrenergic receptor–Gs protein complex
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Structural Basis for Activation of ARF GTPase
1998
Role of Phosphoinositide 3-OH Kinase in Cell Transformation and Control of the Actin Cytoskeleton by Ras
1997
Oncogenic Mutations Counteract Intrinsic Disorder in the EGFR Kinase and Promote Receptor Dimerization
2012 StandoutNobel
Structure of a Ran-binding domain complexed with Ran bound to a GTP analogue: implications for nuclear transport
1999 Nature
An α to β conformational switch in EF-Tu
1996
De novo design of a fluorescence-activating β-barrel
2018 StandoutNatureNobel
Sar1p N-Terminal Helix Initiates Membrane Curvature and Completes the Fission of a COPII Vesicle
2005 StandoutNobel
Constitutively active and G-protein coupled inward rectifier K+ channels: Kir2.0 and Kir3.0
2007
RF3 Induces Ribosomal Conformational Changes Responsible for Dissociation of Class I Release Factors
2007 StandoutNobel
Helix unwinding in the effector region of elongation factor EF-Tu–GDP
1996
O2 Reduction to H2O by the multicopper oxidases
2008
Reactive oxygen species have a causal role in multiple forms of insulin resistance
2006 StandoutNature
Oxygen Binding, Activation, and Reduction to Water by Copper Proteins
2001
The WD repeat: a common architecture for diverse functions
1999
Structure-Function Analysis of the Cuprous Oxidase Activity in Fet3p from Saccharomyces cerevisiae
2007
CASK Functions as a Mg2+-Independent Neurexin Kinase
2008 StandoutNobel
Seven-transmembrane-spanning receptors and heart function
2002 StandoutNatureNobel
Structure of the nuclear transport complex karyopherin-β2–Ran˙GppNHp
1999 StandoutNatureNobel
Crystal Structure of a Laccase from the FungusTrametes versicolor at 1.90-Å Resolution Containing a Full Complement of Coppers
2002
Analysis of the human hephaestin gene and protein: comparative modelling of the N-terminus ecto-domain based upon ceruloplasmin
2002
Targeted suppression of the ferroxidase and iron trafficking activities of the multicopper oxidase Fet3p from Saccharomyces cerevisiae
2003
Mutational Analysis of Gβγ and Phospholipid Interaction with G Protein-coupled Receptor Kinase 2
2000
LRRC8 Proteins Form Volume-Regulated Anion Channels that Sense Ionic Strength
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Regulation of Protein Kinases
2004
Axin-mediated CKI phosphorylation of β-catenin at Ser 45: a molecular switch for the Wnt pathway
2002
A trithorax-group complex purified from Saccharomyces cerevisiae is required for methylation of histone H3
2001 StandoutNobel
CERULOPLASMIN METABOLISM AND FUNCTION
2002
Elucidation of AMPA receptor–stargazin complexes by cryo–electron microscopy
2016 StandoutScienceNobel
Fibrosis, not cell size, delineates β-myosin heavy chain reexpression during cardiac hypertrophy and normal aging in vivo
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The kinase Grk2 regulates Nedd4/Nedd4-2-dependent control of epithelial Na + channels
2004 StandoutNobel
Spectroscopic and Electronic Structure Studies of the Trinuclear Cu Cluster Active Site of the Multicopper Oxidase Laccase: Nature of Its Coordination Unsaturation
2005
Dynamical Contributions to Enzyme Catalysis: Critical Tests of A Popular Hypothesis
2006 StandoutNobel
Crystal structures of peptide complexes of the amino-terminal SH2 domain of the Syp tyrosine phosphatase
1994
Spectroscopic Demonstration of a Large Antisymmetric Exchange Contribution to the Spin-Frustrated Ground State of a D3 Symmetric Hydroxy-Bridged Trinuclear Cu(II) Complex: Ground-to-Excited State Superexchange Pathways
2004
The multifaceted subunit interfaces of ionotropic glutamate receptors
2014
Multicopper Oxidases and Oxygenases
1996 Standout
A Tris(μ-hydroxy)tricopper(II) Complex as a Model of the Native Intermediate in Laccase and Its Relationship to a Binuclear Analogue
2005
Copper Active Sites in Biology
2014 Standout
Recombinant Expression and Functional Characterization of Human Hephaestin: A Multicopper Oxidase with Ferroxidase Activity
2005
Ribosome-induced changes in elongation factor Tu conformation control GTP hydrolysis
2009 StandoutNobel
Transduction of interleukin-2 antiapoptotic and proliferative signals via Akt protein kinase
1997
Independent β-arrestin 2 and G protein-mediated pathways for angiotensin II activation of extracellular signal-regulated kinases 1 and 2
2003 StandoutNobel
Regulation of C. elegans Life-Span by Insulinlike Signaling in the Nervous System
2000 StandoutScienceNobel
MODULAR PEPTIDE RECOGNITION DOMAINS IN EUKARYOTIC SIGNALING
1997
ADP-ribosylation factor and phosphatidic acid levels in Golgi membranes during budding of coatomer-coated vesicles
1998 StandoutNobel
Systematic Perturbation of the Trinuclear Copper Cluster in the Multicopper Oxidases: The Role of Active Site Asymmetry in Its Reduction of O2 to H2O
2010
Spectroscopic and Magnetic Studies of Human Ceruloplasmin: Identification of a Redox-Inactive Reduced Type 1 Copper Site
1998
Crystal structure of Sar1-GDP at 1.7 A resolution and the role of the NH2 terminus in ER export
2001
Nature of the Intermediate Formed in the Reduction of O2 to H2O at the Trinuclear Copper Cluster Active Site in Native Laccase
2002
Syk Activation Initiates Downstream Signaling Events During Human Polymorphonuclear Leukocyte Phagocytosis
1999 StandoutNobel
Role of Polo-like kinase in the degradation of early mitotic inhibitor 1, a regulator of the anaphase promoting complex/cyclosome
2004 StandoutNobel
Spectroscopic Analysis of the Trinuclear Cluster in the Fet3 Protein from Yeast, a Multinuclear Copper Oxidase
2000
Inflammation and autoimmunity caused by a SHP1 mutation depend on IL-1, MyD88, and a microbial trigger
2008 StandoutNobel
Crystal Structure of a Four-Copper Laccase Complexed with an Arylamine: Insights into Substrate Recognition and Correlation with Kinetics,
2002
Cytoplasmic Signaling Pathways That Regulate Cardiac Hypertrophy
2001
Cloning and Characterization of a G Protein-Activated Human Phosphoinositide-3 Kinase
1995 Science
PD-L1 and PD-L2 are differentially regulated by Th1 and Th2 cells
2003 StandoutNobel
Decay of the Peroxide Intermediate in Laccase: Reductive Cleavage of the O−O Bond
2001
Structural Basis of the Ferrous Iron Specificity of the Yeast Ferroxidase, Fet3p
2006
Spectroscopy and Reactivity of the Type 1 Copper Site in Fet3p from Saccharomyces cerevisiae: Correlation of Structure with Reactivity in the Multicopper Oxidases
2001
Functional Insights from Glutamate Receptor Ion Channel Structures
2012
Spectroscopic and Kinetic Studies of Perturbed Trinuclear Copper Clusters: The Role of Protons in Reductive Cleavage of the O−O Bond in the Multicopper Oxidase Fet3p
2007
Reaction Mechanisms of the Multicopper Oxidase CueO from Escherichia coli Support Its Functional Role as a Cuprous Oxidase
2010
Electronic structures of exchange coupled trigonal trimeric Cu(II) complexes: Spin frustration, antisymmetric exchange, pseudo-A terms, and their relation to O2 activation in the multicopper oxidases
2006
Electrostatic Basis for Enzyme Catalysis
2006 StandoutNobel
The copper-iron connection in biology: Structure of the metallo-oxidase Fet3p
2005
Visualization of elongation factor G on the Escherichia coli 70S ribosome: The mechanism of translocation
1998 StandoutNobel
Domain swapping: entangling alliances between proteins.
1994
daf-2 , an Insulin Receptor-Like Gene That Regulates Longevity and Diapause in Caenorhabditis elegans
1997 StandoutScienceNobel
Redox cycling and kinetic analysis of single molecules of solution-phase nitrite reductase
2011 StandoutNobel
THE IL-4 RECEPTOR: Signaling Mechanisms and Biologic Functions
1999
Genetically encoded fluorescent reporters of protein tyrosine kinase activities in living cells
2001 StandoutNobel
Spectroscopic Characterization and O2 Reactivity of the Trinuclear Cu Cluster of Mutants of the Multicopper Oxidase Fet3p
2002
Electronic Structure of the Peroxy Intermediate and Its Correlation to the Native Intermediate in the Multicopper Oxidases: Insights into the Reductive Cleavage of the O−O Bond
2007
The structure of the inter-SH2 domain of class IA phosphoinositide 3-kinase determined by site-directed spin labeling EPR and homology modeling
2003
Function of PI3Kγ in Thymocyte Development, T Cell Activation, and Neutrophil Migration
2000 StandoutScienceNobel
Structural Basis of Type II Topoisomerase Inhibition by the Anticancer Drug Etoposide
2011 StandoutScience
G PROTEIN MECHANISMS: Insights from Structural Analysis
1997
G proteins, effectors and GAPs: structure and mechanism
1997
Structure–function relationships of copper-containing nitrite reductases
1999
Structural flexibility of the Gαs α-helical domain in the β 2 -adrenoceptor Gs complex
2011 StandoutNobel
Point Mutations at the Type I Cu Ligands, Cys457 and Met467, and at the Putative Proton Donor, Asp105, in Myrothecium verrucaria Bilirubin Oxidase and Reactions with Dioxygen
2005
Ferrous Binding to the Multicopper OxidasesSaccharomyces cerevisiaeFet3p and Human Ceruloplasmin: Contributions to Ferroxidase Activity
2004
Frozen Density Functional Free Energy Simulations of Redox Proteins: Computational Studies of the Reduction Potential of Plastocyanin and Rusticyanin
2003 StandoutNobel
Geometric and electronic structure differences between the type 3 copper sites of the multicopper oxidases and hemocyanin/tyrosinase
2009
Crystal structure and electron transfer kinetics of CueO, a multicopper oxidase required for copper homeostasis in Escherichia coli
2002
Works of B.D. Bax being referenced
The Structure of Phosphorylated GSK-3β Complexed with a Peptide, FRATtide, that Inhibits β-Catenin Phosphorylation
2001
High resolution structure of an oligomeric eye lens β-crystallin
1991
Phosducin induces a structural change in transducin βγ
1998
Challenges for and current status of research into positive modulators of AMPA receptors
2010
X-ray analysis of βB2-crystallin and evolution of oligomeric lens proteins
1990 Nature
The structure of rat ADP-ribosylation factor-1 (ARF-1) complexed to GDP determined from two different crystal forms
1995
Structural basis of quinolone inhibition of type IIA topoisomerases and target-mediated resistance
2010
ADP ribosylation factor 1 mutants identify a phospholipase D effector region and reveal that phospholipase D participates in lysosomal secretion but is not sufficient for recruitment of coatomer I
1999
PI 3-kinase: structural and functional analysis of intersubunit interactions.
1994
Interaction of the p85 subunit of PI 3-kinase and its N-terminal SH2 domain with a PDGF receptor phosphorylation site: structural features and analysis of conformational changes.
1992
The X-ray structure of human serum ceruloplasmin at 3.1 Å: nature of the copper centres
1996
Integration of Lead Optimization with Crystallography for a Membrane-Bound Ion Channel Target: Discovery of a New Class of AMPA Receptor Positive Allosteric Modulators
2010