Standout Papers
Citation Impact
Citing Papers
Precise and Heritable Genome Editing in Evolutionarily Diverse Nematodes Using TALENs and CRISPR/Cas9 to Engineer Insertions and Deletions
2013 StandoutNobel
A myocardium tropic adeno-associated virus (AAV) evolved by DNA shuffling and in vivo selection
2009
Structural Basis of Transcription: Backtracked RNA Polymerase II at 3.4 Angstrom Resolution
2009 StandoutScienceNobel
A Neural Circuit for Memory Specificity and Generalization
2013 StandoutScienceNobel
Production of amorphadiene in yeast, and its conversion to dihydroartemisinic acid, precursor to the antimalarial agent artemisinin
2012 Standout
Intravenous Administration of Self-complementary AAV9 Enables Transgene Delivery to Adult Motor Neurons
2009
Oligonucleotide conjugated multi-functional adeno-associated viruses
2018
Bump-and-Hole Engineering Identifies Specific Substrates of Glycosyltransferases in Living Cells
2020 StandoutNobel
CD8+ T Cell Recognition of Epitopes Within the Capsid of Adeno-associated Virus 8–based Gene Transfer Vectors Depends on Vectors’ Genome
2013
Engineering adeno-associated viruses for clinical gene therapy
2014
Universal Method for the Purification of Recombinant AAV Vectors of Differing Serotypes
2017
Convection-enhanced delivery and systemic mannitol increase gene product distribution of AAV vectors 5, 8, and 9 and increase gene product in the adult mouse brain
2010
Programmable editing of a target base in genomic DNA without double-stranded DNA cleavage
2016 StandoutNature
Superior In vivo Transduction of Human Hepatocytes Using Engineered AAV3 Capsid
2016 StandoutNobel
In Vivo Selection Yields AAV-B1 Capsid for Central Nervous System and Muscle Gene Therapy
2016
Molecular evolution of a novel hyperactive Sleeping Beauty transposase enables robust stable gene transfer in vertebrates
2009
Young blood reverses age-related impairments in cognitive function and synaptic plasticity in mice
2014
AAV Capsid Structure and Cell Interactions
2011
Selection and evaluation of clinically relevant AAV variants in a xenograft liver model
2013 Nature
Immune genes are primed for robust transcription by proximal long noncoding RNAs located in nuclear compartments
2018
Gene therapy for neurological disorders: progress and prospects
2018
Cre-dependent selection yields AAV variants for widespread gene transfer to the adult brain
2016
Correction of Neurological Disease of Mucopolysaccharidosis IIIB in Adult Mice by rAAV9 Trans-Blood–Brain Barrier Gene Delivery
2011
An optogenetic toolbox designed for primates
2011
Tropism-modified AAV Vectors Overcome Barriers to Successful Cutaneous Therapy
2014
Synaptotagmin-1 and Synaptotagmin-7 Trigger Synchronous and Asynchronous Phases of Neurotransmitter Release
2013 StandoutNobel
Directed Evolution of a Novel Adeno-associated Virus (AAV) Vector That Crosses the Seizure-compromised Blood–Brain Barrier (BBB)
2009
Amyloid Oligomers Exacerbate Tau Pathology in a Mouse Model of Tauopathy
2012 Standout
Efficient and Targeted Transduction of Nonhuman Primate Liver With Systemically Delivered Optimized AAV3B Vectors
2015
Intracellular transport of recombinant adeno-associated virus vectors
2012
Presynaptic Neurexin-3 Alternative Splicing trans-Synaptically Controls Postsynaptic AMPA Receptor Trafficking
2013 StandoutNobel
Multiplex pairwise assembly of array-derived DNA oligonucleotides
2015 StandoutNobel
Modular system for the construction of zinc-finger libraries and proteins
2010
Production of the antimalarial drug precursor artemisinic acid in engineered yeast
2006 StandoutNature
State-of-the-art gene-based therapies: the road ahead
2011
Neurotransmitter Release: The Last Millisecond in the Life of a Synaptic Vesicle
2013 StandoutNobel
ZFN, TALEN, and CRISPR/Cas-based methods for genome engineering
2013 Standout
Genome-Scale CRISPR-Mediated Control of Gene Repression and Activation
2014 Standout
Regulation of hypoxia adaptation: an overlooked virulence attribute of pathogenic fungi?
2010
Enabling functional genomics with genome engineering
2015
TRANSFAC(R) and its module TRANSCompel(R): transcriptional gene regulation in eukaryotes
2005 Standout
Virus-mediated gene delivery for human gene therapy
2012
Mapping and analysis of chromatin state dynamics in nine human cell types
2011 StandoutNature
Intravascular AAV9 preferentially targets neonatal neurons and adult astrocytes
2008
Easy quantitative assessment of genome editing by sequence trace decomposition
2014 Standout
Generation of Novel AAV Variants by Directed Evolution for Improved CFTR Delivery to Human Ciliated Airway Epithelium
2009
Evolution of a designed protein assembly encapsulating its own RNA genome
2017 StandoutNatureNobel
Alzheimer Disease: An Update on Pathobiology and Treatment Strategies
2019 Standout
Rapid Single-Step Induction of Functional Neurons from Human Pluripotent Stem Cells
2013 StandoutNobel
A Rationally Engineered Capsid Variant of AAV9 for Systemic CNS-Directed and Peripheral Tissue-Detargeted Gene Delivery in Neonates
2018
Neocortical excitation/inhibition balance in information processing and social dysfunction
2011 StandoutNature
DNA Shuffling of Adeno-associated Virus Yields Functionally Diverse Viral Progeny
2008
In vivo genome editing using Staphylococcus aureus Cas9
2015 StandoutNature
Distinct Neuronal Coding Schemes in Memory Revealed by Selective Erasure of Fast Synchronous Synaptic Transmission
2012 StandoutNobel
AAV-8 and AAV-9 Vectors Cooperate with Serum Proteins Differently Than AAV-1 and AAV-6
2018
CRISPR-Cas systems for editing, regulating and targeting genomes
2014 Standout
Hypoxia Rescues Frataxin Loss by Restoring Iron Sulfur Cluster Biogenesis
2019 StandoutNobel
Adeno-associated virus capsid antigen presentation is dependent on endosomal escape
2013
Gene Transfer Properties and Structural Modeling of Human Stem Cell-derived AAV
2014
The AAV Vector Toolkit: Poised at the Clinical Crossroads
2012
Development and Applications of CRISPR-Cas9 for Genome Engineering
2014 Standout
Non-coding RNAs in human disease
2011 Standout
Transcriptional regulatory code of a eukaryotic genome
2004 StandoutNature
Adeno-associated virus vector as a platform for gene therapy delivery
2019 Standout
CRISPR/Cas9‐mediated genome engineering: An adeno‐associated viral (AAV) vector toolbox
2014
Applications of CRISPR technologies in research and beyond
2016 StandoutNobel
Inferring gene regulatory logic from high-throughput measurements of thousands of systematically designed promoters
2012
Defining roles of specific reactive oxygen species (ROS) in cell biology and physiology
2022 Standout
A survey of ex vivo/in vitro transduction efficiency of mammalian primary cells and cell lines with Nine natural adeno-associated virus (AAV1-9) and one engineered adeno-associated virus serotype
2013
Novel Adeno-associated Viruses Derived From Pig Tissues Transduce Most Major Organs in Mice
2014
Directed Evolution of Adeno-associated Virus for Enhanced Gene Delivery and Gene Targeting in Human Pluripotent Stem Cells
2011
Systematic Mutagenesis of α-Synuclein Reveals Distinct Sequence Requirements for Physiological and Pathological Activities
2012 StandoutNobel
Comparative Study of Liver Gene Transfer With AAV Vectors Based on Natural and Engineered AAV Capsids
2015
Optimization of the Capsid of Recombinant Adeno-Associated Virus 2 (AAV2) Vectors: The Final Threshold?
2013
CRISPR-Based Technologies for the Manipulation of Eukaryotic Genomes
2016 Standout
Promoterless gene targeting without nucleases ameliorates haemophilia B in mice
2014 Nature
Targeted plasmid integration into the human genome by an engineered zinc-finger recombinase
2011
Molecular signatures of disease brain endothelia provide new sites for CNS-directed enzyme therapy
2009
The Human Condition—A Molecular Approach
2014 StandoutNobel
Optogenetics in Neural Systems
2011 Standout
Chimeric piggyBac transposases for genomic targeting in human cells
2012
Gene regulation by long non-coding RNAs and its biological functions
2020 Standout
MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification
2008 Standout
Biochemical analysis of TREX complex recruitment to intronless and intron‐containing yeast genes
2004 StandoutNobel
TRANSFAC(R): transcriptional regulation, from patterns to profiles
2003 Standout
Genome-editing Technologies for Gene and Cell Therapy
2016
Bioengineered AAV Capsids with Combined High Human Liver Transduction In Vivo and Unique Humoral Seroreactivity
2017
Human Hepatocyte Growth Factor Receptor Is a Cellular Coreceptor for Adeno-Associated Virus Serotype 3
2010
Adeno-Associated Virus Gene Therapy for Liver Disease
2016
Adeno-Associated Virus-Based Gene Therapy for CNS Diseases
2016
Ionizable Lipid Nanoparticles for In Vivo mRNA Delivery to the Placenta during Pregnancy
2023 StandoutNobel
Sterol Regulatory Element Binding Proteins in Fungi: Hypoxic Transcription Factors Linked to Pathogenesis
2010
Architecture of an RNA Polymerase II Transcription Pre-Initiation Complex
2013 StandoutScienceNobel
Erratum: Gene therapy for neurological disorders: progress and prospects
2018
Pivoting the Plant Immune System from Dissection to Deployment
2013 StandoutScience
Rds3p Is Required for Stable U2 snRNP Recruitment to the Splicing Apparatus
2003
Dual Activators of the Sterol Biosynthetic Pathway of Saccharomyces cerevisiae: Similar Activation/Regulatory Domains but Different Response Mechanisms
2005
Adeno-Associated Virus Structural Biology as a Tool in Vector Development
2013
Overcoming Preexisting Humoral Immunity to AAV Using Capsid Decoys
2013
The transcription elongation factor TFIIS is a component of RNA polymerase II preinitiation complexes
2007
Engineered AAV vector minimizes in vivo targeting of transduced hepatocytes by capsid-specific CD8+ T cells
2013
Chimeric Antigen Receptor Therapy
2018 Standout
Immune responses to AAV vectors: overcoming barriers to successful gene therapy
2013
Efficient modification of CCR5 in primary human hematopoietic cells using a megaTAL nuclease and AAV donor template
2015
The gut microbiota as an environmental factor that regulates fat storage
2004 Standout
Candidate autism gene screen identifies critical role for cell-adhesion molecule CASPR2 in dendritic arborization and spine development
2012 StandoutNobel
Targeted gene knock-in by homology-directed genome editing using Cas9 ribonucleoprotein and AAV donor delivery
2017 StandoutNobel
Comparative Analysis of Adeno-Associated Virus Capsid Stability and Dynamics
2013
The return of metabolism: biochemistry and physiology of the pentose phosphate pathway
2014 Standout
Multiple Click-Selective tRNA Synthetases Expand Mammalian Cell-Specific Proteomics
2018 StandoutNobel
OGFOD1 catalyzes prolyl hydroxylation of RPS23 and is involved in translation control and stress granule formation
2014 StandoutNobel
Chemogenetic Approaches to Probe Redox Pathways: Implications for Cardiovascular Pharmacology and Toxicology
2021
Works of Bassel Akache being referenced
In Vitro and In Vivo Gene Therapy Vector Evolution via Multispecies Interbreeding and Retargeting of Adeno-Associated Viruses
2008
Site-directed transposon integration in human cells
2007
A Two-hybrid Screen Identifies Cathepsins B and L as Uncoating Factors for Adeno-associated Virus 2 and 8
2007
Phenotypic analysis of genes encoding yeast zinc cluster proteins
2001
New Regulators of Drug Sensitivity in the Family of Yeast Zinc Cluster Proteins
2002
The 37/67-Kilodalton Laminin Receptor Is a Receptor for Adeno-Associated Virus Serotypes 8, 2, 3, and 9
2006
Candida albicans Zinc Cluster Protein Upc2p Confers Resistance to Antifungal Drugs and Is an Activator of Ergosterol Biosynthetic Genes
2005