Standout Papers
Citation Impact
Citing Papers
p53: puzzle and paradigm.
1996 Standout
Bone Density Ligand, Sclerostin, Directly Interacts With LRP5 but Not LRP5G171V to Modulate Wnt Activity
2006
PtdIns(3,4,5) P 3-Dependent Activation of the mTORC2 Kinase Complex
2015
Loss of cryptochrome reduces cancer risk in p53 mutant mice
2009 StandoutNobel
Structural Basis of Wnt Recognition by Frizzled
2012 Science
Tumor Induction and Tissue Atrophy in Mice Lacking E2F-1
1996
Development of rhabdomyosarcoma in HER-2/neu transgenic p53 mutant mice.
2003
Mitotic and mitogenic Wnt signalling
2012
Porcupine inhibitor suppresses paracrine Wnt-driven growth of Rnf43;Znrf3 -mutant neoplasia
2015
mTOR Regulation and Therapeutic Rejuvenation of Aging Hematopoietic Stem Cells
2009
Hallmarks of Cancer: The Next Generation
2011 Standout
Reversal of Senescence in Mouse Fibroblasts through Lentiviral Suppression of p53
2003
Atm-Deficient Mice: A Paradigm of Ataxia Telangiectasia
1996
AML1, the Target of Multiple Chromosomal Translocations in Human Leukemia, Is Essential for Normal Fetal Liver Hematopoiesis
1996 Standout
Rb targets histone H3 methylation and HP1 to promoters
2001 Nature
Probing p53 biological functions through the use of genetically engineered mouse models
2005
Tumour suppressors, kinases and clamps: How p53 regulates the cell cycle in response to DNA damage
1995
Wide spectrum of tumors in knock-in mice carrying a Cdk4 protein insensitive to INK4 inhibitors
2001
CDK inhibitors: positive and negative regulators of G1-phase progression
1999 Standout
Essential role of mouse telomerase in highly proliferative organs
1998 StandoutNatureNobel
mTOR Signaling in Growth Control and Disease
2012 Standout
The retinoblastoma gene family in differentiation and development
1999
The RB and p53 pathways in cancer
2002 Standout
Can we safely target the WNT pathway?
2014
A novel function of adenovirus E1A is required to overcome growth arrest by the CDK2 inhibitor p27Kip1
1998
Structural basis for the recognition of hydroxyproline in HIF-1α by pVHL
2002 StandoutNatureNobel
Tumor formation and inactivation of RIZ1, an Rb-binding member of a nuclear protein–methyltransferase superfamily
2001
Role for the p53 homologue p73 in E2F-1-induced apoptosis
2000 StandoutNatureNobel
The Petinoblastoma Tumor Suppressor Protein
1994
Synergistic tumor suppressor activity of BRCA2 and p53 in a conditional mouse model for breast cancer
2001
The complex world of WNT receptor signalling
2012
p53, the Cellular Gatekeeper for Growth and Division
1997 Standout
Cyclin A Is a Functional Target of Retinoblastoma Tumor Suppressor Protein-mediated Cell Cycle Arrest
1999
Stable binding to E2F is not required for the retinoblastoma protein to activate transcription, promote differentiation, and suppress tumor cell growth
1998 StandoutNobel
Induction of Pluripotent Stem Cells from Mouse Embryonic and Adult Fibroblast Cultures by Defined Factors
2006 StandoutNobel
p73-deficient mice have neurological, pheromonal and inflammatory defects but lack spontaneous tumours
2000 Nature
Foxp3 controls regulatory T-cell function by interacting with AML1/Runx1
2007 StandoutNatureNobel
Ablation of the Retinoblastoma gene family deregulates G1 control causing immortalization and increased cell turnover under growth-restricting conditions
2000
Tumor surveillance via the ARF–p53 pathway
1998
Role of HIF-1α in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis
1998 StandoutNatureNobel
Secreted and Transmembrane Wnt Inhibitors and Activators
2012
Endogenous oncogenic K-rasG12D stimulates proliferation and widespread neoplastic and developmental defects
2004
Gpr124 Controls CNS Angiogenesis and Blood-Brain Barrier Integrity by Promoting Ligand-Specific Canonical Wnt Signaling
2014
Myc pathways provoking cell suicide and cancer
2003
Telomere states and cell fates
2000 StandoutNatureNobel
Telomeres and telomerase in cancer
2009
Lgr5-Expressing Cells Are Sufficient and Necessary for Postnatal Mammary Gland Organogenesis
2013
Modeling Disease in Human ESCs Using an Efficient BAC-Based Homologous Recombination System
2010
Reduced Apoptosis and Cytochrome c–Mediated Caspase Activation in Mice Lacking Caspase 9
1998
The role of p53 in tumour suppression: lessons from mouse models
1999
Cloning and chromosomal mapping of the human p53-related KET gene to Chromosome 3q27 and its murine homolog Ket to mouse Chromosome 16
1998
Neural-Tube Defects
1999 Standout
Macrophage-derived extracellular vesicle-packaged WNTs rescue intestinal stem cells and enhance survival after radiation injury
2016
Wnt Proteins Are Self-Renewal Factors for Mammary Stem Cells and Promote Their Long-Term Expansion in Culture
2010
Haematopoietic stem cells require a highly regulated protein synthesis rate
2014 Nature
Database of mouse strains carrying targeted mutations in genes affecting cellular responses to DNA damage. Version 4
2000
Oncogene-Induced Cell Senescence — Halting on the Road to Cancer
2006
Rhabdomyosarcoma development in mice lacking Trp53 and Fos
2003
Role of the retinoblastoma protein in the pathogenesis of human cancer.
1997 StandoutNobel
Immunogenicity of induced pluripotent stem cells
2011 StandoutNature
Developmental Stage and Time Dictate the Fate of Wnt/β-Catenin-Responsive Stem Cells in the Mammary Gland
2012
Short Telomeres Limit Tumor Progression In Vivo by Inducing Senescence
2007 StandoutNobel
A mouse model of ATR-Seckel shows embryonic replicative stress and accelerated aging
2009
A protein conjugation system essential for autophagy
1998 StandoutNatureNobel
Early loss of the retinoblastoma gene is associated with impaired growth inhibitory innervation during melanotroph carcinogenesis in Rb+/- mice.
1996
Monoallelically Expressed Gene Related to p53 at 1p36, a Region Frequently Deleted in Neuroblastoma and Other Human Cancers
1997
WNT signaling in bone homeostasis and disease: from human mutations to treatments
2013 Standout
p53-Dependent apoptosis suppresses tumor growth and progression in vivo
1994
mTOR Signaling in Growth, Metabolism, and Disease
2017 Standout
Alveolar rhabdomyosarcomas in conditional Pax3:Fkhr mice: cooperativity of Ink4a/ARF and Trp53 loss of function
2004 StandoutNobel
The regulation of E2F by pRB-family proteins
1998 Standout
Tumor Suppression at the Mouse INK4a Locus Mediated by the Alternative Reading Frame Product p19
1997
Wnt/β-Catenin Signaling and Disease
2012 Standout
Wnt/β-Catenin Signaling: Components, Mechanisms, and Diseases
2009 Standout
Tumor suppression by Ink4a–Arf: progress and puzzles
2003
Integrated genomic characterization of endometrial carcinoma
2013 StandoutNature
Immune infiltration in human tumors: a prognostic factor that should not be ignored
2009
Hypoxia Inhibits G1/S Transition through Regulation of p27 Expression
2001 StandoutNobel
Transgenic mouse model for studying the transcriptional activity of the p53 protein: age- and tissue-dependent changes in radiation-induced activation during embryogenesis
1997
Differential Phosphorylation of DNA-PKcs Regulates the Interplay between End-Processing and End-Ligation during Nonhomologous End-Joining
2015
mTOR: from growth signal integration to cancer, diabetes and ageing
2010 Standout
Prevention of neural tube defects: vitamins, enzymes and genes
1998
The tyrosine kinase c-Abl regulates p73 in apoptotic response to cisplatin-induced DNA damage
1999 StandoutNatureNobel
Biochemical properties and biological effects of p53
1995
Retention of wild-type p53 in tumors from p53 heterozygous mice: reduction of p53 dosage can promote cancer formation
1998
'Super p53' mice exhibit enhanced DNA damage response, are tumor resistant and age normally
2002
Oncogenic ras Provokes Premature Cell Senescence Associated with Accumulation of p53 and p16INK4a
1997 Standout
Premature senescence involving p53 and p16 is activated in response to constitutive MEK/MAPK mitogenic signaling
1998
E1A signaling to p53 involves the p19ARFtumor suppressor
1998
LRP5 Mutations Linked to High Bone Mass Diseases Cause Reduced LRP5 Binding and Inhibition by SOST
2006
Programmed Cell Senescence during Mammalian Embryonic Development
2013 Standout
Cellular mechanisms of tumour suppression by the retinoblastoma gene
2008
A Syndrome of Multiorgan Hyperplasia with Features of Gigantism, Tumorigenesis, and Female Sterility in p27 -Deficient Mice
1996
p73 is a human p53-related protein that can induce apoptosis
1997 StandoutNatureNobel
Mouse models for neural tube closure defects
2000
p53 Deficiency Rescues the Adverse Effects of Telomere Loss and Cooperates with Telomere Dysfunction to Accelerate Carcinogenesis
1999 StandoutNobel
Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53
1995 Nature
Autophagy and Aging
2011 Standout
Ser18 and 23 phosphorylation is required for p53‐dependent apoptosis and tumor suppression
2006
Sibling rivalry in the E2F family
2002
Induction of DNA synthesis and apoptosis are separable functions of E2F-1.
1997
DNA-PKcs has KU-dependent function in rRNA processing and haematopoiesis
2020 StandoutNatureNobel
p63 is essential for regenerative proliferation in limb, craniofacial and epithelial development
1999 StandoutNature
Interplay of p53 and DNA-repair protein XRCC4 in tumorigenesis, genomic stability and development
2000 Nature
Visualization of a short-range Wnt gradient in the intestinal stem-cell niche
2016 Nature
Inhibitors of mammalian G1 cyclin-dependent kinases.
1995 Standout
The Folliculin Tumor Suppressor Is a GAP for the RagC/D GTPases That Signal Amino Acid Levels to mTORC1
2013
Cancer exome analysis reveals a T-cell-dependent mechanism of cancer immunoediting
2012 StandoutNatureNobel
The Hallmarks of Aging
2013 Standout
WLS Retrograde Transport to the Endoplasmic Reticulum during Wnt Secretion
2014
Cyclins and cancer II: Cyclin D and CDK inhibitors come of age
1994 Standout
Macrophage biology in development, homeostasis and disease
2013 StandoutNature
CDC25 Phosphatases as Potential Human Oncogenes
1995 Science
The role of the bcl-2/ced-9 gene family in cancer and general implications of defects in cell death control for tumourigenesis and resistance to chemotherapy
1997
The Ink4a Tumor Suppressor Gene Product, p19Arf, Interacts with MDM2 and Neutralizes MDM2's Inhibition of p53
1998
The restriction point and control of cell proliferation
1997
DNA Ligase IV Deficiency in Mice Leads to Defective Neurogenesis and Embryonic Lethality via the p53 Pathway
2000
A teratologic suppressor role for p53 in benzo(a)pyrene–treated transgenic p53-deficient mice
1995
Loss-of-Function Mutations in the WNT Co-receptor LRP6 Cause Autosomal-Dominant Oligodontia
2015
Regulating protein degradation by ubiquitination
1997
A conserved siRNA-degrading RNase negatively regulates RNA interference in C. elegans
2004 StandoutNatureNobel
Telomere shortening in mTR-/- embryos is associated with failure to close the neural tube
1999
Small-molecule inhibition of Wnt signaling through activation of casein kinase 1α
2010
A ubiquitin-like system mediates protein lipidation
2000 StandoutNatureNobel
Mice Lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control
1995 Standout
Ataxia-Telangiectasia:Closer to Unraveling the Mystery
1995
MLL3 Is a Haploinsufficient 7q Tumor Suppressor in Acute Myeloid Leukemia
2014
Update on Wnt signaling in bone cell biology and bone disease
2011
Wnt/β-Catenin Signaling, Disease, and Emerging Therapeutic Modalities
2017 Standout
Metchnikoff's policemen: macrophages in development, homeostasis and regeneration
2011
Heterogeneous expression of Wnt/β‐catenin target genes within colorectal cancer
2007
Suppression of induced pluripotent stem cell generation by the p53–p21 pathway
2009 StandoutNatureNobel
bax -deficiency promotes drug resistance and oncogenic transformation by attenuating p53-dependent apoptosis
1997
p21 Is a Critical CDK2 Regulator Essential for Proliferation Control in Rb-deficient Cells
1998
Selective induction of p53 and chemosensitivity in RB-deficient cells by E1A mutants unable to bind the RB-related proteins
1997
Mutant p53 rescues human diploid cells from senescence without inhibiting the induction of SDI1/WAF1.
1995
Correction of factor IX deficiency in mice by embryonic stem cells differentiated in vitro
2005 StandoutNobel
p53- and ATM-Dependent Apoptosis Induced by Telomeres Lacking TRF2
1999 Science
Induction of apoptosis in HeLa cells by trans-activation-deficient p53.
1995
The Caenorhabditis elegans gene lin-1 encodes an ETS-domain protein and defines a branch of the vulval induction pathway.
1995 StandoutNobel
Cancer Cell Cycles
1996 StandoutScience
E2F-1 Cooperates with Topoisomerase II Inhibition and DNA Damage To Selectively Augment p53-Independent Apoptosis
1997
The new frontier of genome engineering with CRISPR-Cas9
2014 StandoutScienceNobel
Rb-Mediated Heterochromatin Formation and Silencing of E2F Target Genes during Cellular Senescence
2003 Standout
Cell Cycle Control and Cancer
1994 StandoutScienceNobel
A p53-Dependent Mouse Spindle Checkpoint
1995 Science
CDC25A Phosphatase Is a Target of E2F and Is Required for Efficient E2F-Induced S Phase
1999
Targeted point mutations of p53 lead to dominant-negative inhibition of wild-type p53 function
2002
Deficiency of p53 accelerates mammary tumorigenesis in Wnt-1 transgenic mice and promotes chromosomal instability.
1995
Mutations in the p53 and SCID genes cooperate in tumorigenesis.
1996
Kinase-dependent structural role of DNA-PKcs during immunoglobulin class switch recombination
2018
p53-dependent and independent expression of p21 during cell growth, differentiation, and DNA damage.
1995
LDL receptor-related proteins 5 and 6 in Wnt/β-catenin signaling:Arrows point the way
2004
Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization
1998
Towards an integrated view of Wnt signaling in development
2009
Tissue-specific inactivation of p53 tumor suppression in the mouse.
1996
Targeted Disruption of the Wnt Regulator Kremen Induces Limb Defects and High Bone Density
2008
Wnt proteins synergize to activate β-catenin signaling
2017
Regulation of Immune Responses by mTOR
2012
The retinoblastoma protein and cell cycle control
1995 Standout
Structure and functional properties of Norrin mimic Wnt for signalling with Frizzled4, Lrp5/6, and proteoglycan
2015
Recruitment of folliculin to lysosomes supports the amino acid–dependent activation of Rag GTPases
2013
Growth factor modulation of p53-mediated growth arrest versus apoptosis.
1995
Frizzled 2 and frizzled 7 function redundantly in convergent extension and closure of the ventricular septum and palate: evidence for a network of interacting genes
2012
The TSC1–TSC2 complex: a molecular switchboard controlling cell growth
2008 Standout
R-spondin 2 is required for normal laryngeal-tracheal, lung and limb morphogenesis
2008
E2f3 is critical for normal cellular proliferation
2000
Constitutive Expression of AID Leads to Tumorigenesis
2003 StandoutNobel
Animal models of neural tube defects
1998
Human DNA Repair Genes
2001 StandoutScienceNobel
pRb controls proliferation, differentiation, and death of skeletal muscle cells and other lineages during embryogenesis.
1996
V(D)J recombination activates a p53-dependent DNA damage checkpoint in scid lymphocyte precursors.
1996
The retinoblastoma protein-associated cell cycle arrest in S-phase under moderate hypoxia is disrupted in cells expressing HPV18 E7 oncoprotein
1998
Integrating Genetic Approaches into the Discovery of Anticancer Drugs
1997 StandoutScienceNobel
Developmental Control of Cell Cycle Regulators: A Fly's Perspective
1996 Science
THE UBIQUITIN SYSTEM
1998 StandoutNobel
Skeletal muscle cells lacking the retinoblastoma protein display defects in muscle gene expression and accumulate in S and G2 phases of the cell cycle.
1996
p53-Independent Expression of p21 Cip1 in Muscle and Other Terminally Differentiating Cells
1995 Science
Shared role of the pRB-related p130 and p107 proteins in limb development.
1996
DNA damage is able to induce senescence in tumor cells in vitro and in vivo.
2002
A Matter of Life and Cell Death
1998 Science
Works of Bart O. Williams being referenced
LRP6 Mediates cAMP Generation by G Protein–Coupled Receptors Through Regulating the Membrane Targeting of Gα s
2011
Where Wnts Went: The Exploding Field of Lrp5 and Lrp6 Signaling in Bone
2008
Prostaglandin E 2 Promotes Colon Cancer Cell Growth Through a G s -Axin-ß-Catenin Signaling Axis
2005 Science
mTOR Mediates Wnt-Induced Epidermal Stem Cell Exhaustion and Aging
2009
A subset of p53-deficient embryos exhibit exencephaly
1995
Tumor spectrum analysis in p53-mutant mice
1994 Standout
Coordinated Induction of the Ubiquitin Conjugation Pathway Accompanies the Developmentally Programmed Death of Insect Skeletal Muscle
1995
The Wnt Co-Receptor Lrp6 Is Required for Normal Mouse Mammary Gland Development
2009
The Wnt Signaling Receptor Lrp5 Is Required for Mammary Ductal Stem Cell Activity and Wnt1-induced Tumorigenesis
2006
Multiple PPPS/TP motifs act in a combinatorial fashion to transduce Wnt signaling through LRP6
2007
Loss of E2F-1 reduces tumorigenesis and extends the lifespan of Rb1(+/−) mice
1998
Mechanisms of carcinogenesis and the mutant mouse
1996
LRP5 and LRP6 in development and disease
2012
Cooperative tumorigenic effects of germline mutations in Rb and p53
1994
The Wnt Receptor, Lrp5, Is Expressed by Mouse Mammary Stem Cells and Is Required to Maintain the Basal Lineage
2009
Targeted disruption of the three Rb-related genes leads to loss of G1 control and immortalization
2000
A Novel Set of Wnt-Frizzled Fusion Proteins Identifies Receptor Components That Activate β-Catenin-dependent Signaling
2002
Lrp5 and Lrp6 redundantly control skeletal development in the mouse embryo
2011
Structure and function of Norrin in assembly and activation of a Frizzled 4–Lrp5/6 complex
2013
Generation of normal lymphocyte populations by Rb-deficient embryonic stem cells
1993
Wnt-independent activation of β-catenin mediated by a Dkk1-Fz5 fusion protein
2005
Surrogate Wnt agonists that phenocopy canonical Wnt and β-catenin signalling
2017 StandoutNatureNobel
Regulation of Wnt Signaling by Sox Proteins
1999
Tumorigenic and Developmental Effects of Combined Germ-line Mutations in Rb and p53
1994
TSC2 Integrates Wnt and Energy Signals via a Coordinated Phosphorylation by AMPK and GSK3 to Regulate Cell Growth
2006 Standout
Deficiency of FLCN in Mouse Kidney Led to Development of Polycystic Kidneys and Renal Neoplasia
2008
Regulation of angiogenesis by a non-canonical Wnt–Flt1 pathway in myeloid cells
2011 Nature
p53-dependent apoptosis produced by Rb-deficiency in the developing mouse lens
1994 Nature
Essential Role of β-Catenin in Postnatal Bone Acquisition
2005
Wntless functions in mature osteoblasts to regulate bone mass
2012
Stroma provides an intestinal stem cell niche in the absence of epithelial Wnts
2014
Reduced Affinity to and Inhibition by DKK1 Form a Common Mechanism by Which High Bone Mass-Associated Missense Mutations in LRP5 Affect Canonical Wnt Signaling
2005
p53-dependent G1 arrest involves pRB-related proteins and is disrupted by the human papillomavirus 16 E7 oncoprotein.
1994
Extensive contribution of Rb-deficient cells to adult chimeric mice with limited histopathological consequences.
1994
Altered Cell Cycle Kinetics, Gene Expression, and G1 Restriction Point Regulation in Rb-Deficient Fibroblasts
1996
Decreased BMD and Limb Deformities in Mice Carrying Mutations in Both Lrp5 and Lrp6
2004
Targeted disruption of p107: functional overlap between p107 and Rb.
1996