Standout Papers
Citation Impact
Citing Papers
Modulation of immune cell reactivity with cis -binding Siglec agonists
2021 StandoutNobel
Strategy for Dual-Analyte Luciferin Imaging: In Vivo Bioluminescence Detection of Hydrogen Peroxide and Caspase Activity in a Murine Model of Acute Inflammation
2013 StandoutNobel
The Role of Innate and Adaptive Immunity in Parkinson's Disease
2013
Early and Progressive Accumulation of Reactive Microglia in the Huntington Disease Brain
2001
Cyclooxygenase-2 mediates microglial activation and secondary dopaminergic cell death in the mouse MPTP model of Parkinson's disease
2006
Neuroinflammation mediated by IL-1β increases susceptibility of dopamine neurons to degeneration in an animal model of Parkinson's disease
2008
Femtomolar Concentrations of Dynorphins Protect Rat Mesencephalic Dopaminergic Neurons against Inflammatory Damage
2001
Evidence of active microglia in substantia nigra pars compacta of parkinsonian monkeys 1 year after MPTP exposure
2004
Microglial activation‐mediated delayed and progressive degeneration of rat nigral dopaminergic neurons: relevance to Parkinson's disease
2002
Naloxone Protects Rat Dopaminergic Neurons against Inflammatory Damage through Inhibition of Microglia Activation and Superoxide Generation
2000
Bilateral Fetal Mesencephalic Grafting in Two Patients with Parkinsonism Induced by 1-Methyl-4-Phenyl-L,2,3,6-Tetrahydropyridine (MPTP)
1992
Inflammation and Alzheimer's disease
2000 Standout
Neuroinflammation in Parkinson's disease: a target for neuroprotection?
2009 Standout
Structure of the TRPA1 ion channel suggests regulatory mechanisms
2015 StandoutNatureNobel
Inhibition of thrombin‐induced microglial activation and NADPH oxidase by minocycline protects dopaminergic neurons in the substantia nigra in vivo
2005
Inducible Nitric-oxide Synthase and Nitric Oxide Production in Human Fetal Astrocytes and Microglia
1997 StandoutNobel
Mechanisms and Functional Implications of Adult Neurogenesis
2008 Standout
Microglial response to 6-hydroxydopamine-induced substantia nigra lesions
1989
Reactive astrocytes: cellular and molecular cues to biological function
1997 Standout
Selective COX-2 inhibition prevents progressive dopamine neuron degeneration in a rat model of Parkinson's disease.
2004
Nitrated α–Synuclein Immunity Accelerates Degeneration of Nigral Dopaminergic Neurons
2008
Dynamic Covalent Chemistry
2002 StandoutNobel
Channel opening and gating mechanism in AMPA-subtype glutamate receptors
2017 StandoutNatureNobel
Presence of T-cytotoxic suppressor and leucocyte common antigen positive cells in Alzheimer's disease brain tissue
1988
Mechanisms Underlying Inflammation in Neurodegeneration
2010 Standout
Microglia-mediated neurotoxicity: uncovering the molecular mechanisms
2006 Standout
In vivo imaging of microglial activation with [11C](R)-PK11195 PET in idiopathic Parkinson's disease
2005
Interaction of polymorphisms in the genes encoding interleukin‐6 and estrogen receptor beta on the susceptibility to Parkinson's disease
2005
Brain β2-microglobulin levels are elevated in the striatum in Parkinson's diseaselevels are elevated in the striatum in Parkinson's disease
1995
NADPH Oxidase Mediates Lipopolysaccharide-induced Neurotoxicity and Proinflammatory Gene Expression in Activated Microglia
2004
Microglial activation and dopamine terminal loss in early Parkinson's disease
2005
Hydrogen peroxide mediates amyloid β protein toxicity
1994 Standout
Microglia in health and disease
2005
The HHQK Domain of β-Amyloid Provides a Structural Basis for the Immunopathology of Alzheimer's Disease
1998
Valproate pretreatment protects dopaminergic neurons from LPS-induced neurotoxicity in rat primary midbrain cultures: role of microglia
2004
Neuromelanin of the substantia nigra: a neuronal black hole with protective and toxic characteristics
2003
Protective action of the peroxisome proliferator‐activated receptor‐γ agonist pioglitazone in a mouse model of Parkinson's disease
2002
Transforming growth factor-β1 levels are elevated in the striatum and in ventricular cerebrospinal fluid in Parkinson's disease
1995
Cyclooxygenase-2-deficient mice are resistant to 1-methyl-4-phenyl1, 2, 3, 6-tetrahydropyridine-induced damage of dopaminergic neurons in the substantia nigra
2002
Functional neurogenesis in the adult hippocampus
2002 StandoutNature
Microglial activation with atypical proinflammatory cytokine expression in a rat model of Parkinson's disease
2003
Tumor necrosis factor-alpha receptor ablation in a chronic MPTP mouse model of Parkinson's disease
2004
Human neuromelanin induces neuroinflammation and neurodegeneration in the rat substantia nigra: implications for Parkinson's disease
2008
Inhibition of the cyclooxygenase isoenzymes COX-1 and COX-2 provide neuroprotection in the MPTP-mouse model of Parkinson's disease
2000
Advances in LC–MS/MS-based glycoproteomics: Getting closer to system-wide site-specific mapping of the N- and O-glycoproteome
2014
Microglial response is poorly correlated with neurodegeneration following chronic, low-dose MPTP administration in monkeys
2003
Increase in Peripheral CD4 Bright+ CD8 Dull+ T Cells in Parkinson Disease
2001
Role of the Toll-Like Receptor 4 in Neuroinflammation in Alzheimer’s Disease
2007
γδ+ T cells are increased in patients with Parkinson's disease
1994
Activation of murine microglial cell lines by lipopolysaccharide and interferon‐γ causes NO‐mediated decreases in mitochondrial and cellular function
2001
Evidence of active nerve cell degeneration in the substantia nigra of humans years after 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine exposure
1999
Simple screening method for improving membrane protein thermostability
2011
Local distribution of microglia in the normal adult human central nervous system differs by up to one order of magnitude
2001
Glial reactions in Parkinson's disease
2007
Microglia and inflammation-mediated neurodegeneration: Multiple triggers with a common mechanism
2005
Transplantation of Embryonic Dopamine Neurons for Severe Parkinson's Disease
2001 Standout
Inflammation induces mitochondrial dysfunction and dopaminergic neurodegeneration in the nigrostriatal system
2006
Air pollution: mechanisms of neuroinflammation and CNS disease
2009 Standout
NLRP3 is activated in Alzheimer’s disease and contributes to pathology in APP/PS1 mice
2012 StandoutNature
Structural and functional features of central nervous system lymphatic vessels
2015 StandoutNature
Neuroinflammation of the nigrostriatal pathway during progressive 6‐OHDA dopamine degeneration in rats monitored by immunohistochemistry and PET imaging
2002
Molecular Mechanisms of Depression: Perspectives on New Treatment Strategies
2013 Standout
Slow Degradation of Aggregates of the Alzheimer's Disease Amyloid β-Protein by Microglial Cells
1997
Gut Microbiota Regulate Motor Deficits and Neuroinflammation in a Model of Parkinson’s Disease
2016 Standout
Alzheimer Disease: An Update on Pathobiology and Treatment Strategies
2019 Standout
Synuclein activates microglia in a model of Parkinson's disease
2007
Running increases cell proliferation and neurogenesis in the adult mouse dentate gyrus
1999 Standout
mTOR Signaling in Growth, Metabolism, and Disease
2017 Standout
Microglia, major player in the brain inflammation: their roles in the pathogenesis of Parkinson's disease
2006
Association of interleukin-1β polymorphisms with idiopathic Parkinson's disease
2002
Macrophage/microglial-mediated primary demyelination and motor disease induced by the central nervous system production of interleukin-3 in transgenic mice.
1996
The executioners sing a new song: killer caspases activate microglia
2011
Genetics of human prefrontal function
2003
Contributory mechanisms in the causation of neurodegenerative disorders
1993
Lipopolysaccharide Intranigral Injection Induces Inflammatory Reaction and Damage in Nigrostriatal Dopaminergic System
1998
Nitric oxide synthase and neuronal vulnerability in parkinson's disease
1996
Glial pathology but absence of apoptotic nigral neurons in long‐standing Parkinson's disease
1998
Neurotoxic Effects of Lipopolysaccharide on Nigral Dopaminergic Neurons Are Mediated by Microglial Activation, Interleukin-1β, and Expression of Caspase-11 in Mice
2004
Cytotoxicity of microglia
1993
Blocking Soluble Tumor Necrosis Factor Signaling with Dominant-Negative Tumor Necrosis Factor Inhibitor Attenuates Loss of Dopaminergic Neurons in Models of Parkinson's Disease
2006
A Progressive Mouse Model of Parkinson's Disease: The Thy1-aSyn (“Line 61”) Mice
2012
Alterations of T-lymphocyte populations in Parkinson disease
2005
P2X4 receptors induced in spinal microglia gate tactile allodynia after nerve injury
2003 StandoutNature
Behavioral and morphological effects of minocycline in the 6-hydroxydopamine rat model of Parkinson's disease
2006
Immunological features of α‐synuclein in Parkinson's disease
2008
Molecular consequences of activated microglia in the brain: overactivation induces apoptosis
2001
Synergistic neurotoxic effects of combined treatments with cytokines in murine primary mixed neuron/glia cultures
1998
From endoplasmic-reticulum stress to the inflammatory response
2008 StandoutNature
Glial degeneration and reactive gliosis in alpha-synucleinopathies: the emerging concept of primary gliodegeneration
2006
Circulating interleukin-15 and RANTES chemokine in Parkinson’s disease
2007
Genetic ablation of tumor necrosis factor‐alpha (TNF‐α) and pharmacological inhibition of TNF‐synthesis attenuates MPTP toxicity in mouse striatum
2004
Caspase-11 Mediates Inflammatory Dopaminergic Cell Death in the 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine Mouse Model of Parkinson's Disease
2004
Inflammatory Cytokine Gene Polymorphisms and Increased Risk of Parkinson Disease
2007
β-Amyloid stimulates glial cells in vitro to produce growth factors that accumulate in senile plaques in Alzheimer's disease
1992
The PPARγ agonist pioglitazone is effective in the MPTP mouse model of Parkinson's disease through inhibition of monoamine oxidase B
2008
The Single Intranigral Injection of LPS as a New Model for Studying the Selective Effects of Inflammatory Reactions on Dopaminergic System
2000
Alzheimer's Disease
2010 Standout
Progressive dopamine neuron loss following supra-nigral lipopolysaccharide (LPS) infusion into rats exposed to LPS prenatally
2006
Role of Nitric Oxide in Inflammation‐Mediated Neurodegeneration
2002
Matrix Metalloproteinase-3: A Novel Signaling Proteinase from Apoptotic Neuronal Cells That Activates Microglia
2005
Neuroinflammatory mechanisms in Parkinson's disease: Potential environmental triggers, pathways, and targets for early therapeutic intervention
2007
A CD14 monocyte receptor polymorphism and genetic susceptibility to Parkinson's disease for females
2005
Functional roles of microglia in the brain
1993
The Role of Glial Reaction and Inflammation in Parkinson's Disease
2003
Brain injury and tumor necrosis factors induce calbindin D‐28K in astrocytes: Evidence for a cytoprotective response
1995
The role of iron in brain ageing and neurodegenerative disorders
2014 Standout
Association of circulating TNF-α and IL-6 with ageing and parkinsonism
1999
Mechanisms and Functions of Inflammasomes
2014 Standout
Microglia in the aging brain: relevance to neurodegeneration
2010
Age-related microglial activation in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced dopaminergic neurodegeneration in C57BL/6 mice
2003
Presence of reactive microglia in monkey substantia nigra years after 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine administration
2003
Amyloid β protein (Aβ) removal by neuroglial cells in culture
1995
AKT/PKB Signaling: Navigating the Network
2017 Standout
Neuroinflammation and Oxidation/Nitration of α-Synuclein Linked to Dopaminergic Neurodegeneration
2008
Distribution of major histocompatibility complex class II-positive microglia and cytokine profile of Parkinson's disease brains
2003
Parkin Deficiency Increases Vulnerability to Inflammation-Related Nigral Degeneration
2008
Induction of Inflammatory Mediators and Microglial Activation in Mice Transgenic for Mutant Human P301S Tau Protein
2004
Inflammatory Regulators in Parkinson's Disease: iNOS, Lipocortin-1, and Cyclooxygenases-1 and -2
2000
Complement and cytokine gene expression in cultured microglia derived from postmortem human brains
1995
Pathological dynamics of activated microglia following medial forebrain bundle transection
2005
Relationship of microglia and astrocytes to amyloid deposits of Alzheimer disease
1989
Structural Bases of Desensitization in AMPA Receptor-Auxiliary Subunit Complexes
2017 StandoutNobel
The Inflammatory Reaction Following 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine Intoxication in Mouse
1999
Microglial activation induced by factor(s) contained in sera from Alzheimer-related ApoE genotypes
1998
Colonic inflammation in Parkinson's disease
2012
Pathogenic role of glial cells in Parkinson's disease
2002
The molecular neurobiology of depression
2008 StandoutNature
Heterogeneity of CNS myeloid cells and their roles in neurodegeneration
2011
Peripheral Inflammatory Biomarkers and Risk of Parkinson's Disease
2007
Role of reactive oxygen species in LPS‐induced production of prostaglandin E2in microglia
2004
Lymphocyte populations in Parkinson's disease and in rat models of parkinsonism
2001
Bilateral fetal nigral transplantation into the postcommissural putamen in Parkinson's disease
1995
Frailty in elderly people
2013 Standout
Fluorescence-Detection Size-Exclusion Chromatography for Precrystallization Screening of Integral Membrane Proteins
2006
Minocycline inhibits microglial activation and protects nigral cells after 6-hydroxydopamine injection into mouse striatum
2001
Nitrated Alpha-Synuclein and Microglial Neuroregulatory Activities
2008
Involvement of Interferon-γ in Microglial-Mediated Loss of Dopaminergic Neurons
2007
Reciprocal Interactions Between Microglia and Neurons: From Survival to Neuropathology
2002
Nonsteroidal Anti-inflammatory Drugs and the Risk of Parkinson Disease
2003
Increased S100β neurotrophic activity in Alzheimer's disease temporal lobe
1992
Activation of innate immunity in the CNS triggers neurodegeneration through a Toll-like receptor 4-dependent pathway
2003
Elucidation of AMPA receptor–stargazin complexes by cryo–electron microscopy
2016 StandoutScienceNobel
Epidermal Growth Factor and Fibroblast Growth Factor-2 Have Different Effects on Neural Progenitors in the Adult Rat Brain
1997
Neuroinflammation and α-Synuclein Dysfunction Potentiate Each Other, Driving Chronic Progression of Neurodegeneration in a Mouse Model of Parkinson’s Disease
2011
Mammalian Neural Stem Cells
2000 StandoutScience
Structure of the STRA6 receptor for retinol uptake
2016 StandoutScienceNobel
Regional Difference in Susceptibility to Lipopolysaccharide-Induced Neurotoxicity in the Rat Brain: Role of Microglia
2000
Neuroimmunological Processes in Parkinson’s Disease and their Relation to α-Synuclein: Microglia as the Referee between Neuronal Processes and Peripheral Immunity
2013
Agonism of Peroxisome Proliferator Receptor-Gamma may have Therapeutic Potential for Neuroinflammation and Parkinsons Disease
2007
FcεRII/CD23 Is Expressed in Parkinson’s Disease and Induces,In Vitro,Production of Nitric Oxide and Tumor Necrosis Factor-α in Glial Cells
1999
INFLAMMATION AND ALZHEIMERS DISEASE
2000
Cloning and functional expression of cDNAs encoding human and rat pancreatic polypeptide receptors.
1996 StandoutNobel
Protein Analysis by Shotgun/Bottom-up Proteomics
2013
Distinct Role for Microglia in Rotenone-Induced Degeneration of Dopaminergic Neurons
2002 Standout
Chronic microglial activation and progressive dopaminergic neurotoxicity
2007
Circulating Insulin-Like Growth Factor I Mediates Exercise-Induced Increases in the Number of New Neurons in the Adult Hippocampus
2001
Experience-Induced Neurogenesis in the Senescent Dentate Gyrus
1998
Synergistic dopaminergic neurotoxicity of MPTP and inflammogen lipopolysaccharide: relevance to the etiology of Parkinson's disease
2003
Structure, sequence and expression of the hepatitis delta (δ) viral genome
1986 StandoutNatureNobel
Potent regulation of microglia‐derived oxidative stress and dopaminergic neuron survival: substance P vs. dynorphin
2006
Microglial NADPH oxidase is a novel target for femtomolar neuroprotection against oxidative stress
2005
Marked decrease of neuropeptide Y Y2 receptor binding sites in the hippocampus in murine prion disease
1997 StandoutNobel
Immunologic diseases, anti-inflammatory drugs, and Parkinson disease: A case-control study
2006
How neuroinflammation contributes to neurodegeneration
2016 StandoutScience
Aggregated α‐synuclein activates microglia: a process leading to disease progression in Parkinson's disease
2005
MPP + ‐induced COX‐2 activation and subsequent dopaminergic neurodegeneration
2005
Neuroprotective activities of CD4+CD25+ regulatory T cells in an animal model of Parkinson’s disease
2007
FcepsilonRII/CD23 is expressed in Parkinson's disease and induces, in vitro, production of nitric oxide and tumor necrosis factor-alpha in glial cells.
1999
The biology , function , and biomedical applications of exosomes
2020 StandoutScience
Brain interleukin 1 and S-100 immunoreactivity are elevated in Down syndrome and Alzheimer disease.
1989 Standout
CLINICAL SIGNIFICANCE OF ANTIBODY TO THE HEPATITIS DELTA VIRUS IN SYMPTOMLESS HBsAg CARRIERS
1985
New directions in single-molecule imaging and analysis
2007 StandoutNobel
Microbiome–microglia connections via the gut–brain axis
2018
Rapid metabolic evolution in human prefrontal cortex
2011 StandoutNobel
Exosomes as drug delivery vehicles for Parkinson's disease therapy
2015 Standout
DYNAMICS OF SINGLE BIOMOLECULES IN FREE SOLUTION
2004
Critical Role for Microglial NADPH Oxidase in Rotenone-Induced Degeneration of Dopaminergic Neurons
2003
RAGE and amyloid-β peptide neurotoxicity in Alzheimer's disease
1996 StandoutNature
Synergistic Dopaminergic Neurotoxicity of the Pesticide Rotenone and Inflammogen Lipopolysaccharide: Relevance to the Etiology of Parkinson's Disease
2003
The absence of reactive astrocytosis is indicative of a unique inflammatory process in Parkinson's disease
1999
Therapeutic immunization protects dopaminergic neurons in a mouse model of Parkinson's disease
2004
Peroxynitrite generated by inducible nitric oxide synthase and NADPH oxidase mediates microglial toxicity to oligodendrocytes
2005
Structural insights into TRPM8 inhibition and desensitization
2019 StandoutScienceNobel
Regulation of Neurogenesis in Adult Mouse Hippocampus by cAMP and the cAMP Response Element-Binding Protein
2002
Self-Assembling Dendrimers
1996 Science
Chemical Glycoproteomics
2016 StandoutNobel
Human Plasma N-Glycoproteome Analysis by Immunoaffinity Subtraction, Hydrazide Chemistry, and Mass Spectrometry
2005
LEF-1 is crucial for neutrophil granulocytopoiesis and its expression is severely reduced in congenital neutropenia
2006 Standout
Air Pollution and Brain Damage
2002
Works of Barry E. Boyes being referenced
Differences among techniques for high‐abundant protein depletion
2005
The Use of Ammonium Formate as a Mobile-Phase Modifier for LC-MS/MS Analysis of Tryptic Digests
2013
Fast high performance liquid chromatography separations for proteomic applications using Fused-Core? silica particles
2011
Size Exclusion Chromatography
1994
Immunohistochemical co-localization of S-100b and the glial fibrillary acidic protein in rat brain
1986
Asymptomatic liver disease in hepatitis B antigen carriers
1974
Determination of plasma [18F]-6-fluorodopa during positron emission tomography: Elimination and metabolism in carbidopa treated subjects
1986
Separation of large DNA restriction fragments on a size-exclusion column by a nonideal mechanism
1988
Wider Pore Superficially Porous Particles for Peptide Separations by HPLC
2010
Gene expression changes by amyloid β peptide-stimulated human postmortem brain microglia identify activation of multiple inflammatory processes
2005
Reactive microglia are positive for HLA‐DR in the substantia nigra of Parkinson's and Alzheimer's disease brains
1988 Standout
Acetylcholine and aromatic amine systems in postmortem brain of an infant with Down's syndrome
1985