Standout Papers
Citation Impact
Citing Papers
Confirmation of intersubunit connectivity and topology of designed protein complexes by native MS
2018 StandoutNobel
Generation of ordered protein assemblies using rigid three-body fusion
2021 StandoutNobel
Clinical Features and Outcome of Patients With Non–Small-Cell Lung Cancer Who Harbor EML4-ALK
2009
DNA capture by a CRISPR-Cas9–guided adenine base editor
2020 StandoutScienceNobel
Inhibition of vascular endothelial growth factor with a sequence-specific hypoxia response element antagonist
2004 StandoutNobel
Response to MET Inhibitors in Patients with Stage IV Lung Adenocarcinomas Harboring MET Mutations Causing Exon 14 Skipping
2015
Structures of the CRISPR genome integration complex
2017 StandoutScienceNobel
Hallucinating symmetric protein assemblies
2022 StandoutScienceNobel
Accurate computational design of multipass transmembrane proteins
2018 StandoutScienceNobel
De novo design of picomolar SARS-CoV-2 miniprotein inhibitors
2020 StandoutScienceNobel
Near-atomic cryo-EM imaging of a small protein displayed on a designed scaffolding system
2018
Structural basis for the recognition of SARS-CoV-2 by full-length human ACE2
2020 StandoutScience
Rapid and automated design of two-component protein nanomaterials using ProteinMPNN
2024 StandoutNobel
Hierarchical design of pseudosymmetric protein nanocages
2024 StandoutNatureNobel
The gene encoding human annexin V has a TATA-less promoter with a high G + C content
1994
De novo design of allosterically switchable protein assemblies
2024 StandoutNatureNobel
Annexin I is a stress protein induced by heat, oxidative stress and a sulfhydryl‐reactive agent
2000
Recognition of double-stranded RNA and activation of NF-κB by Toll-like receptor 3
2001 StandoutNature
Unravelling biological macromolecules with cryo-electron microscopy
2016 Nature
cryoSPARC: algorithms for rapid unsupervised cryo-EM structure determination
2017 Standout
MAP kinase activation during heat shock in quiescent and exponentially growing mammalian cells
1993
Anaplastic lymphoma kinase: role in cancer pathogenesis and small-molecule inhibitor development for therapy
2009
The annexin family of calcium-binding proteins
1989
Identification and characterization of phospholipase A2 inhibitory proteins in human mononuclear cells
1990
The annexins: Specific markers of midline structures and sensory neurons in the developing murine central nervous system
1995
Oncogenic kinase signalling
2001 StandoutNature
Cancer nanotechnology: The impact of passive and active targeting in the era of modern cancer biology
2013 Standout
The biology and management of non-small cell lung cancer
2018 StandoutNature
Lipocortins as Antiphospholipase A2 and Anti-Inflammatory Proteins
1990
First-Line Crizotinib versus Chemotherapy in ALK-Positive Lung Cancer
2014 Standout
Participation of annexins in protein phosphorylation
1997
Purification and characterization of phospholipase A2 inhibitory proteins from pig thyroid gland
1988
Irritant-evoked activation and calcium modulation of the TRPA1 receptor
2020 StandoutNatureNobel
Annexin II tetramer: structure and function
1995
Crizotinib inALK-Rearranged Inflammatory Myofibroblastic Tumor
2010 Standout
The F-actin capping proteins of Physarum polycephalum: cap42(a) is very similar, if not identical, to fragmin and is structurally and functionally very homologous to gelsolin; cap42(b) is Physarum actin.
1987
A novel kinase cascade triggered by stress and heat shock that stimulates MAPKAP kinase-2 and phosphorylation of the small heat shock proteins
1994 StandoutNobel
Structural snapshots of TRPV1 reveal mechanism of polymodal functionality
2021 StandoutNobel
CASK Functions as a Mg2+-Independent Neurexin Kinase
2008 StandoutNobel
How Chemoproteomics Can Enable Drug Discovery and Development
2012
Exosomes facilitate therapeutic targeting of oncogenic KRAS in pancreatic cancer
2017 StandoutNature
Structure of the Tie2 RTK Domain
2000
Pancreatic cancer biology and genetics
2002
Glypican-1 identifies cancer exosomes and detects early pancreatic cancer
2015 StandoutNature
The mec-4 gene is a member of a family of Caenorhabditis elegans genes that can mutate to induce neuronal degeneration
1991 StandoutNatureNobel
Three-dimensional segregation of supramolecular activation clusters in T cells
1998 StandoutNature
Perspectives on Oxygen Sensing
1999 StandoutNobel
TGFα deficiency results in hair follicle and eye abnormalities in targeted and waved-1 mice
1993 StandoutNobel
CasX enzymes comprise a distinct family of RNA-guided genome editors
2019 StandoutNatureNobel
Annexin VI is required for budding of clathrin-coated pits
1992 StandoutNobel
Annexins: the problem of assessing the biological role for a gene family of multifunctional calcium- and phospholipid-binding proteins
1994
Genetics and biology of pancreatic ductal adenocarcinoma
2006
Regulation of Protein Kinases
2004
Human insulin receptor and its relationship to the tyrosine kinase family of oncogenes
1985 StandoutNature
Functional implications of nitric oxide produced by mitochondria in mitochondrial metabolism
1998
Identification and characterization of a hormonally regulated form of phospholipase A2 in rat renal mesangial cells.
1988
Protein Tyrosine Kinase Structure and Function
2000
Intracellular Signaling by Hydrolysis of Phospholipids and Activation of Protein Kinase C
1992 StandoutScience
Targeting ALK: Precision Medicine Takes on Drug Resistance
2017
Self-Assembling 2D Arrays with de Novo Protein Building Blocks
2019 StandoutNobel
Alkylation of cysteine 82 of p11 abolishes the complex formation with the tyrosine-protein kinase substrate p36 (annexin 2, calpactin 1, lipocortin 2).
1990
Surface location and high affinity for calcium of a 500-kd liver membrane protein closely related to the LDL-receptor suggest a physiological role as lipoprotein receptor.
1988
Identification of chromaffin granule-binding proteins. Relationship of the chromobindins to calelectrin, synhibin, and the tyrosine kinase substrates p35 and p36.
1987
Isolation of intercalator-dependent protein-linked DNA strand cleavage activity from cell nuclei and identification as topoisomerase II
1986 StandoutNobel
Human 67-kDa calelectrin contains a duplication of four repeats found in 35-kDa lipocortins.
1988 StandoutNobel
Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation
2020 StandoutScience
Three-dimensional structure of cyanobacterial photosystem I at 2.5 Å resolution
2001 StandoutNature
gCap39, a Calcium Ion- and Polyphosphoinositide-Regulated Actin Capping Protein
1990 StandoutScienceNobel
Transforming growth factor-alpha. A model for membrane-anchored growth factors.
1990
A strategy for isolation of cDNAs encoding proteins affecting human intestinal epithelial cell growth and differentiation: characterization of a novel gut-specific N-myristoylated annexin.
1992
Computational design of mechanically coupled axle-rotor protein assemblies
2022 StandoutScienceNobel
ATP-dependent incorporation of 20S protease into the 26S complex that degrades proteins conjugated to ubiquitin.
1989 StandoutNobel
DNA Mismatch Correction in a Defined System
1989 StandoutScienceNobel
Annexins: From Structure to Function
2002 Standout
Regulation of calpactin I phospholipid binding by calpactin I light-chain binding and phosphorylation by p60v-src
1987
Prosomes
1986
Antisense RNA: Function and Fate of Duplex RNA in Cells of Higher Eukaryotes
1998
p36, the major cytoplasmic substrate of src tyrosine protein kinase, binds to its p11 regulatory subunit via a short amino-terminal amphiphatic helix.
1988
Kinetic and Catalytic Mechanisms of Protein Kinases
2001
Structural insight into TRPV5 channel function and modulation
2019 StandoutNobel
Design and Structure−Activity Relationship of a New Class of Potent VEGF Receptor Tyrosine Kinase Inhibitors
1999
Annexin I is phosphorylated in the multivesicular body during the processing of the epidermal growth factor receptor.
1993
Insulin-Dependent Tyrosine Protein Kinase: Cellular Distribution and Copurification with the Insulin Receptor
1985
Anaplastic lymphoma kinase: signalling in development and disease
2009
Size classes of products synthesized processively by DNA polymerase III and DNA polymerase III holoenzyme of Escherichia coli.
1981
Intercellular Communication and Cell-Cell Adhesio n
1992 Science
Distinct cellular expression pattern of annexins in Hydra vulgaris.
1992
Complete sequence of the bithorax complex of Drosophila.
1995 StandoutNobel
Top-down design of protein architectures with reinforcement learning
2023 StandoutScienceNobel
The Annexins and Exocytosis
1992 Science
Structural insights into TRPM8 inhibition and desensitization
2019 StandoutScienceNobel
Reconfigurable asymmetric protein assemblies through implicit negative design
2022 StandoutScienceNobel
Functional analysis of the human annexin I and VI gene promoters
1998
Chemical Glycoproteomics
2016 StandoutNobel
Works of Barbara Mroczkowski being referenced
An Orally Available Small-Molecule Inhibitor of c-Met, PF-2341066, Exhibits Cytoreductive Antitumor Efficacy through Antiproliferative and Antiangiogenic Mechanisms
2007
2.3 Å resolution cryo-EM structure of human p97 and mechanism of allosteric inhibition
2016 Science
Cytoreductive antitumor activity of PF-2341066, a novel inhibitor of anaplastic lymphoma kinase and c-Met, in experimental models of anaplastic large-cell lymphoma
2007
Phase 0 Clinical Trials: Conceptions and Misconceptions
2008
Crystal structure of the kinase domain of human vascular endothelial growth factor receptor 2: a key enzyme in angiogenesis
1999
Differentiation of HL‐60 cells is associated with an increase in the 35‐kDa protein lipocortin I
1988
A calcium-dependent 35-kilodalton substrate for epidermal growth factor receptor/kinase isolated from normal tissue.
1986 StandoutNobel
ATP-stimulated interaction between epidermal growth factor receptor and supercoiled DNA
1984 StandoutNatureNobel
Characterization of translational-control ribonucleic acid isolated from embryonic chick muscle
1983
Expression of human epidermal growth factor precursor cDNA in transfected mouse NIH 3T3 cells.
1988 Nobel
Characterization and Kinetic Mechanism of Catalytic Domain of Human Vascular Endothelial Growth Factor Receptor-2 Tyrosine Kinase (VEGFR2 TK), a Key Enzyme in Angiogenesis
1998
Recombinant Human Epidermal Growth Factor Precursor Is a Glycosylated Membrane Protein with Biological Activity
1989 Nobel
Growth factors in the regenerating pancreas of gamma-interferon transgenic mice.
1996