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Citing Papers
De novo protein synthesis is required for the activation-induced cytidine deaminase function in class-switch recombination
2003 StandoutNobel
Preferential localization of IgG memory B cells adjacent to contracted germinal centers
2010
Activation-induced cytidine deaminase deaminates deoxycytidine on single-stranded DNA but requires the action of RNase
2003
Detection of chromatin-associated single-stranded DNA in regions targeted for somatic hypermutation
2007
Evolution of new nonantibody proteins via iterative somatic hypermutation
2004 StandoutNobel
Uracil DNA Glycosylase Activity Is Dispensable for Immunoglobulin Class Switch
2004 StandoutScienceNobel
Activation-induced cytidine deaminase mediates central tolerance in B cells
2011
MSH2–MSH6 stimulates DNA polymerase η, suggesting a role for A:T mutations in antibody genes
2005
AID Enzyme-Induced Hypermutation in an Actively Transcribed Gene in Fibroblasts
2002 StandoutScienceNobel
Hepatitis C Virus E2-CD81 Interaction Induces Hypermutation of the Immunoglobulin Gene in B Cells
2005
Discovery of Activation‐Induced Cytidine Deaminase, the Engraver of Antibody Memory
2007 StandoutNobel
Cutting Edge: Hypermutation in Ig V Genes from Mice Deficient in the MLH1 Mismatch Repair Protein
1999
Somatic Hypermutation in Muts Homologue (Msh)3-, Msh6-, and Msh3/Msh6-Deficient Mice Reveals a Role for the Msh2–Msh6 Heterodimer in Modulating the Base Substitution Pattern
2000
T Cell-Independent Somatic Hypermutation in Murine B Cells with an Immature Phenotype
2004
Somatic Hypermutation of Immunoglobulin Genes
2002
Linking class-switch recombination with somatic hypermutation
2001 StandoutNobel
Immunity through DNA deamination
2003
Structure of the Histone Acetyltransferase Hat1
1998 StandoutNobel
Emerging links between hypermutation of antibody genes and DNA polymerases
2001
AID and mismatch repair in antibody diversification
2002
Multiple sequences from downstream of the Jκ cluster can combine to recruit somatic hypermutation to a heterologous, upstream mutation domain
1998
Immunoglobulin gene conversion: Insights from bursal B cells and the DT40 cell line
2004
Somatic Hypermutation, Transcription, and DNA Mismatch Repair
1998
Helicobacter pylori infection triggers aberrant expression of activation-induced cytidine deaminase in gastric epithelium
2007 StandoutNobel
De Novo DNA Synthesis by Human DNA Polymerase λ, DNA Polymerase μ and Terminal Deoxyribonucleotidyl Transferase
2004
Memory B and memory plasma cells
2010
The role of the non‐homologous end‐joining pathway in lymphocyte development
2004
Somatic hypermutation of human immunoglobulin heavy chain genes: targeting of RGYW motifs on both DNA strands
1998
Mechanistic flexibility as a conserved theme across 3 billion years of nonhomologous DNA end-joining: Table 1.
2008
AID-Dependent Generation of Resected Double-Strand DNA Breaks and Recruitment of Rad52/Rad51 in Somatic Hypermutation
2003
Class-switch recombination: interplay of transcription, DNA deamination and DNA repair
2004
Hypermutation targets a green fluorescent protein-encoding transgene in the presence of immunoglobulin enhancers
1999
Role of AID in Tumorigenesis
2007 StandoutNobel
Down-regulation of DNA polymerase β accompanies somatic hypermutation in human BL2 cell lines
2006
Histone Modifications Associated with Somatic Hypermutation
2005
Deficiency in Msh2 affects the efficiency and local sequence specificity of immunoglobulin class-switch recombination: parallels with somatic hypermutation
1999
A specific loop in human DNA polymerase mu allows switching between creative and DNA-instructed synthesis
2006
PMS2-deficiency diminishes hypermutation of a λ1 transgene in young but not older mice
1999
AID Is Required for c-myc/IgH Chromosome Translocations In Vivo
2004 StandoutNobel
Somatic hypermutation of VκJκ rearrangements: targeting of RGYW motifs on both DNA strands and preferential selection of mutated codons within RGYW motifs
1999
The AID enzyme induces class switch recombination in fibroblasts
2002 StandoutNatureNobel
Endonucleolytic Function of MutLα in Human Mismatch Repair
2006 StandoutNobel
Critical test of hot spot motifs for immunoglobulin hypermutation
1997
MDM2 can interact with the C-terminus of AID but it is inessential for antibody diversification in DT40 B cells
2005
Transcription-targeted DNA deamination by the AID antibody diversification enzyme
2003 Nature
TdT-Accessible Breaks Are Scattered over the Immunoglobulin V Domain in a Constitutively Hypermutating B Cell Line
1998
Activation-induced Cytosine Deaminase (AID) Is Actively Exported out of the Nucleus but Retained by the Induction of DNA Breaks
2004
Mammalian Base Excision Repair: the Forgotten Archangel
2013
The generation of antibody diversity through somatic hypermutation and class switch recombination
2004
The regulation of somatic hypermutation
2004
The X family portrait: Structural insights into biological functions of X family polymerases
2007
The mechanisms of immune diversification and their disorders
2003
Towards an understanding of somatic hypermutation
2001
T Follicular Helper Cells Have Distinct Modes of Migration and Molecular Signatures in Naive and Memory Immune Responses
2015
What role for AID: mutator, or assembler of the immunoglobulin mutasome?
2003
A coming-of-age story: activation-induced cytidine deaminase turns 10
2009
Retroviral restriction by APOBEC proteins
2004
The role of activation-induced cytidine deaminase in antibody diversification, immunodeficiency, and B-cell malignancies
2004
Activation-induced cytidine deaminase turns on somatic hypermutation in hybridomas
2002 Nature
XRCC4:DNA ligase IV can ligate incompatible DNA ends and can ligate across gaps
2007
The c-MYC allele that is translocated into the IgH locus undergoes constitutive hypermutation in a Burkitt's lymphoma line
2000
In situ class switching and differentiation to IgA-producing cells in the gut lamina propria
2001 StandoutNatureNobel
The influence of transcriptional orientation on endogenous switch region function
2003
Somatic hypermutation at A·T pairs: polymerase error versus dUTP incorporation
2005
Activation-Induced Cytidine Deaminase Expression in CD4+ T Cells is Associated with a Unique IL-10-Producing Subset that Increases with Age
2011 StandoutNobel
Altered somatic hypermutation and reduced class-switch recombination in exonuclease 1–mutant mice
2004
The Frameshift Infidelity of Human DNA Polymerase λ
2003
Clonal selection and learning in the antibody system
1996 StandoutNature
Sequence of the human immunoglobulin diversity (D) segment locus: a systematic analysis provides no evidence for the use of DIR segments, inverted D segments, “minor” D segments or D-D recombination 1 1Edited By J. Karn
1997 StandoutNobel
I. VH gene transcription creates stabilized secondary structures for coordinated mutagenesis during somatic hypermutation
2008
A Gradient of Template Dependence Defines Distinct Biological Roles for Family X Polymerases in Nonhomologous End Joining
2005
The PU.1 and NF-EM5 binding motifs in the Igκ 3′ enhancer are responsible for directing somatic hypermutations to the intrinsic hotspots in the transgenic Vκ gene
2001
Aid
2004 StandoutNobel
A Biochemically Defined System for Coding Joint Formation in V(D)J Recombination
2008
Effects of Sequence and Structure on the Hypermutability of Immunoglobulin Genes
2002
Mechanism and Control of V(D)J Recombination versus Class Switch Recombination: Similarities and Differences
2005
DNA-PKcs has KU-dependent function in rRNA processing and haematopoiesis
2020 StandoutNatureNobel
Bacterial DNA repair by non-homologous end joining
2007
C-Terminal Deletion of AID Uncouples Class Switch Recombination from Somatic Hypermutation and Gene Conversion
2003
AID mutant analyses indicate requirement for class-switch-specific cofactors
2003 StandoutNobel
Somatic immunoglobulin hypermutation
2002
End-bridging is required for pol μ to efficiently promote repair of noncomplementary ends by nonhomologous end joining
2008
Chromatin remodeller SMARCA4 recruits topoisomerase 1 and suppresses transcription-associated genomic instability
2016 StandoutNobel
A Biochemically Defined System for Mammalian Nonhomologous DNA End Joining
2004
The AID Dilemma
2012 StandoutNobel
To Slip or Skip, Visualizing Frameshift Mutation Dynamics for Error-prone DNA Polymerases
2004
The Structural Mechanism of Translocation and Helicase Activity in T7 RNA Polymerase
2004 StandoutNobel
Activation-induced deaminase: controversies and open questions
2004
DNA polymerase mu (Pol micro), homologous to TdT, could act as a DNA mutator in eukaryotic cells
2000
Implication of DNA Polymerase λ in Alignment-based Gap Filling for Nonhomologous DNA End Joining in Human Nuclear Extracts
2003
The Mechanism of Human Nonhomologous DNA End Joining
2007
Class Switch Recombination and Hypermutation Require Activation-Induced Cytidine Deaminase (AID), a Potential RNA Editing Enzyme
2000 StandoutNobel
Mismatch Recognition and Uracil Excision Provide Complementary Paths to Both Ig Switching and the A/T-Focused Phase of Somatic Mutation
2004
Human DNA Polymerase λ Possesses Terminal Deoxyribonucleotidyl Transferase Activity And Can Elongate RNA Primers: Implications for Novel Functions
2003
The Translesion DNA Polymerase ζ Plays a Major Role in Ig and bcl-6 Somatic Hypermutation
2001
AID is required to initiate Nbs1/γ-H2AX focus formation and mutations at sites of class switching
2001 StandoutNatureNobel
Structural insight into the substrate specificity of DNA Polymerase μ
2006
DNA Double-Strand Breaks in Immunoglobulin Genes Undergoing Somatic Hypermutation
2000
Induction of Somatic Hypermutation Is Associated with Modifications in Immunoglobulin Variable Region Chromatin
2003
Trex1 Exonuclease Degrades ssDNA to Prevent Chronic Checkpoint Activation and Autoimmune Disease
2007 StandoutNobel
PCNA function in the activation and strand direction of MutLα endonuclease in mismatch repair
2010 StandoutNobel
Carboxy-terminal domain of AID required for its mRNA complex formation in vivo
2009 StandoutNobel
Mammalian DNA Mismatch Repair
1999
Repair of ionizing radiation-induced DNA double-strand breaks by non-homologous end-joining
2009
DNA Polymerase η Is Involved in Hypermutation Occurring during Immunoglobulin Class Switch Recombination
2004
Reduced Isotype Switching in Splenic B Cells from Mice Deficient in Mismatch Repair Enzymes
1999
DNA MISMATCH REPAIR AND GENETIC INSTABILITY
2000
A hallmark of active class switch recombination: Transcripts directed by I promoters on looped-out circular DNAs
2001 StandoutNobel
The Role of Polymerase η in Somatic Hypermutation Determined by Analysis of Mutations in a Patient with Xeroderma Pigmentosum Variant
2002
Nonimmunoglobulin target loci of activation-induced cytidine deaminase (AID) share unique features with immunoglobulin genes
2012 StandoutNobel
Error-Prone Repair DNA Polymerases in Prokaryotes and Eukaryotes
2002
Identification of DNA cleavage- and recombination-specific hnRNP cofactors for activation-induced cytidine deaminase
2015 StandoutNobel
Critical Roles of Activation-Induced Cytidine Deaminase in the Homeostasis of Gut Flora
2002 StandoutScienceNobel
Decrease in topoisomerase I is responsible for activation-induced cytidine deaminase (AID)-dependent somatic hypermutation
2011 StandoutNobel
Normal Somatic Hypermutation of Ig Genes in the Absence of 8-Hydroxyguanine-DNA Glycosylase
2003 StandoutNobel
Hypermutation of Immunoglobulin Genes in Memory B Cells of DNA Repair–deficient Mice
1998
Somatic Hypermutation Is Limited by CRM1-dependent Nuclear Export of Activation-induced Deaminase
2004
Molecular Mechanism of Class Switch Recombination: Linkage with Somatic Hypermutation
2002 StandoutNobel
Expression of the AID protein in normal and neoplastic B cells
2004
A Critical Role for REV1 in Regulating the Induction of C:G Transitions and A:T Mutations during Ig Gene Hypermutation
2009
DNA polymerase ζ generates tandem mutations in immunoglobulin variable regions
2012
Aberrant expansion of segmented filamentous bacteria in IgA-deficient gut
2004 StandoutNobel
DNA Mismatch Repair: Functions and Mechanisms
2005 StandoutNobel
Mismatch Repair Co-opted by Hypermutation
1998 Science
The Mechanism of Double-Strand DNA Break Repair by the Nonhomologous DNA End-Joining Pathway
2010 Standout
The Block in Immunoglobulin Class Switch Recombination Caused by Activation-Induced Cytidine Deaminase Deficiency Occurs Prior to the Generation of DNA Double Strand Breaks in Switch μ Region
2003
Computer simulations of protein functions: Searching for the molecular origin of the replication fidelity of DNA polymerases
2005 StandoutNobel
The Targeting of Somatic Hypermutation Closely Resembles That of Meiotic Mutation
2001
In vivoandin vitrostudies of immunoglobulin gene somatic hypermutation
2001 Nobel
The Biochemistry of Somatic Hypermutation
2008
T-Independent Immune Response: New Aspects of B Cell Biology
2000 StandoutScienceNobel
Molecular Mechanisms of Antibody Somatic Hypermutation
2007
Differential regulation of S-region hypermutation and class-switch recombination by noncanonical functions of uracil DNA glycosylase
2014 StandoutNobel
Follicular lymphomas' BCL-2/IgH junctions contain templated nucleotide insertions: novel insights into the mechanism of t(14;18) translocation
2000
Separation of Function between Isotype Switching and Affinity Maturation In Vivo during Acute Immune Responses and Circulating Autoantibodies in UNG-Deficient Mice
2013
Chronic lymphocytic leukemia B cells expressing AID display dissociation between class switch recombination and somatic hypermutation
2003
AID Mediates Hypermutation by Deaminating Single Stranded DNA
2003
Memory B cells contribute to rapid Bcl6 expression by memory follicular helper T cells
2014
The Ig mutator is dependent on the presence, position, and orientation of the large intron enhancer
1998
Increased Transcription Levels Induce Higher Mutation Rates in a Hypermutating Cell Line
2001
DNA Double-Strand Breaks
2002 StandoutNobel
DNA cleavage in immunoglobulin somatic hypermutation depends onde novoprotein synthesis but not on uracil DNA glycosylase
2005 StandoutNobel
Activation of naïve B lymphocytes via CD81, a pathogenetic mechanism for hepatitis C virus-associated B lymphocyte disorders
2005 StandoutNobel
RNA editing of hepatitis B virus transcripts by activation-induced cytidine deaminase
2013 StandoutNobel
V(D)J Recombination: RAG Proteins, Repair Factors, and Regulation
2002
Different Mismatch Repair Deficiencies All Have the Same Effects on Somatic Hypermutation
1999
Severe Attenuation of the B Cell Immune Response in Msh2-deficient Mice
1999
The relationship between hypothesis and experiment in unveiling the mechanisms of antibody gene diversification
2011
Evolutionary Comparison of the Mechanism of DNA Cleavage with Respect to Immune Diversity and Genomic Instability
2012 StandoutNobel
Advantages and Disadvantages of Cytidine Deamination
2004
Variable deletion and duplication at recombination junction ends: Implication for staggered double-strand cleavage in class-switch recombination
2001 StandoutNobel
Histone3 lysine4 trimethylation regulated by the facilitates chromatin transcription complex is critical for DNA cleavage in class switch recombination
2010 StandoutNobel
Somatic Hypermutation in the Absence of DNA-Dependent Protein Kinase Catalytic Subunit (DNA-Pkcs) or Recombination-Activating Gene (Rag)1 Activity
2000
Somatic hypermutation of the B cell receptor genesB29(Igβ, CD79b) andmb1(Igα, CD79a)
2003
APE1 is dispensable for S-region cleavage but required for its repair in class switch recombination
2014 StandoutNobel
Hypermutation in Ig V genes from mice deficient in the MLH1 mismatch repair protein.
1999
A distinct subpopulation of CD25−T-follicular regulatory cells localizes in the germinal centers
2017 StandoutNobel
A Role for Msh6 But Not Msh3 in Somatic Hypermutation and Class Switch Recombination
2004
Somatic hypermutation of immunoglobulin κ transgenes: Association of mutability with demethylation
2001
Msh2 ATPase Activity Is Essential for Somatic Hypermutation at A-T Basepairs and for Efficient Class Switch Recombination
2003
Cernunnos/XLF promotes the ligation of mismatched and noncohesive DNA ends
2007
Activation-induced cytidine deaminase shuttles between nucleus and cytoplasm like apolipoprotein B mRNA editing catalytic polypeptide 1
2004 StandoutNobel
DNA Breaks in Hypermutating Immunoglobulin Genes: Evidence for a Break-and-Repair Pathway of Somatic Hypermutation
2001
AID-GFP chimeric protein increases hypermutation of Ig genes with no evidence of nuclear localization
2002 Nobel
RNA-editing cytidine deaminase Apobec-1 is unable to induce somatic hypermutation in mammalian cells
2003 StandoutNobel
AID to overcome the limitations of genomic information
2005 StandoutNobel
Works of Barbara Bertocci being referenced
Cutting Edge: DNA Polymerases μ and λ Are Dispensable for Ig Gene Hypermutation
2002
AID-dependent somatic hypermutation occurs as a DNA single-strand event in the BL2 cell line
2002
Nonoverlapping Functions of DNA Polymerases Mu, Lambda, and Terminal Deoxynucleotidyltransferase during Immunoglobulin V(D)J Recombination In Vivo
2006
Mismatch Repair Deficiency Interferes with the Accumulation of Mutations in Chronically Stimulated B Cells and Not with the Hypermutation Process
1998
Probing Immunoglobulin Gene Hypermutation with Microsatellites Suggests a Nonreplicative Short Patch DNA Synthesis Process
1998
Multiple layers of B cell memory with different effector functions
2009
8-oxo-guanine bypass by human DNA polymerases in the presence of auxiliary proteins
2007 Nature
Formation of the Chicken B-Cell Repertoire: Ontogenesis, Regulation of Ig Gene Rearrangement, and Diversification by Gene Conversion
1994
Mismatch repair and immunoglobulin gene hypermutation: did we learn something?
1999
Introduction: What mechanism(s) drive hypermutation?
1996
Ig gene hypermutation: A mechanism is due
2002
Transcription, β–like DNA polymerases and hypermutation
2001
Immunoglobulin κ Light Chain Gene Rearrangement Is Impaired in Mice Deficient for DNA Polymerase Mu
2003