Standout Papers
Citation Impact
Citing Papers
Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy
2013 Standout
The complex relationship between TFEB transcription factor phosphorylation and subcellular localization
2018
Amyloid Precursor-Like Protein 2 Increases the Endocytosis, Instability, and Turnover of the H2-Kd MHC Class I Molecule
2008
Apolipoprotein E and Alzheimer's disease: the influence of apolipoprotein E on amyloid-β and other amyloidogenic proteins
2017
Temporal gene profiling of the 5XFAD transgenic mouse model highlights the importance of microglial activation in Alzheimer’s disease
2014
Apolipoprotein E Is a Ligand for Triggering Receptor Expressed on Myeloid Cells 2 (TREM2)
2015
Genetic Animal Models of Cerebral Vasculopathies
2011
Potent amyloidogenicity and pathogenicity of Aβ43
2011
Apolipoprotein E and its receptors in Alzheimer's disease: pathways, pathogenesis and therapy
2009
Programmable editing of a target base in genomic DNA without double-stranded DNA cleavage
2016 StandoutNature
A genetic cause of Alzheimer disease: mechanistic insights from Down syndrome
2015
Synapses and Alzheimer's Disease
2012 StandoutNobel
Synaptic organizing complexes
2010
Targeting Aβ and tau in Alzheimer's disease, an early interim report
2009
The amyloid cascade hypothesis for Alzheimer's disease: an appraisal for the development of therapeutics
2011 Standout
Alzheimer Mechanisms and Therapeutic Strategies
2012
The link between altered cholesterol metabolism and Alzheimer's disease
2012
Intraneuronal amyloid β and reduced brain volume in a novel APP T714I mouse model for Alzheimer's disease
2006
Mechanisms Underlying Inflammation in Neurodegeneration
2010 Standout
Neuronal LRP1 Knockout in Adult Mice Leads to Impaired Brain Lipid Metabolism and Progressive, Age-Dependent Synapse Loss and Neurodegeneration
2010
Oxidative stress, dysfunctional glucose metabolism and Alzheimer disease
2019 Standout
Lysosomes as dynamic regulators of cell and organismal homeostasis
2019
Mechanisms of action of hydroxychloroquine and chloroquine: implications for rheumatology
2020 Standout
Modeling familial Alzheimer's disease with induced pluripotent stem cells
2011 StandoutNobel
The Neurovascular Unit Coming of Age: A Journey through Neurovascular Coupling in Health and Disease
2017 Standout
Low-Density Lipoprotein Receptor-Related Protein-1 Mediates Endocytic Clearance of Tissue Inhibitor of Metalloproteinases-1 and Promotes Its Cytokine-Like Activities
2014 StandoutNobel
Amyloid-β–induced neuronal dysfunction in Alzheimer's disease: from synapses toward neural networks
2010
Oxidative stress and the amyloid beta peptide in Alzheimer’s disease
2017 Standout
The secretases: enzymes with therapeutic potential in Alzheimer disease
2010
Direct binding of cholesterol to the amyloid precursor protein: An important interaction in lipid–Alzheimer's disease relationships?
2010
Amyloid Precursor Protein Trafficking, Processing, and Function
2008
A general framework for estimating the relative pathogenicity of human genetic variants
2014 Standout
Biology and pathophysiology of the amyloid precursor protein
2011
Biological Functions of Autophagy Genes: A Disease Perspective
2019 Standout
TREM2 Lipid Sensing Sustains the Microglial Response in an Alzheimer’s Disease Model
2015 Standout
Immune attack: the role of inflammation in Alzheimer disease
2015 Standout
Alzheimer Disease: An Update on Pathobiology and Treatment Strategies
2019 Standout
Anticoagulant treatment is associated with decreased mortality in severe coronavirus disease 2019 patients with coagulopathy
2020 Standout
Overexpression of Low-Density Lipoprotein Receptor in the Brain Markedly Inhibits Amyloid Deposition and Increases Extracellular Aβ Clearance
2009
Red meat consumption and risk of type 2 diabetes: 3 cohorts of US adults and an updated meta-analysis
2011 Standout
Pharmaceutical and medicinal significance of sulfur (SVI)-Containing motifs for drug discovery: A critical review
2018 Standout
Mechanism for Amyloid Precursor-like Protein 2 Enhancement of Major Histocompatibility Complex Class I Molecule Degradation
2009
ApoE and Aβ in Alzheimer’s Disease: Accidental Encounters or Partners?
2014
Autophagy in Human Health and Disease
2013 Standout
Amyloid Precursor Protein Protects Neuronal Network Function after Hypoxia via Control of Voltage-Gated Calcium Channels
2016
Critical review: involvement of endoplasmic reticulum stress in the aetiology of Alzheimer's disease
2018
Flotillin-Dependent Clustering of the Amyloid Precursor Protein Regulates Its Endocytosis and Amyloidogenic Processing in Neurons
2008 StandoutNobel
Tracking pathophysiological processes in Alzheimer's disease: an updated hypothetical model of dynamic biomarkers
2013 Standout
LRAD3, A Novel Low-Density Lipoprotein Receptor Family Member That Modulates Amyloid Precursor Protein Trafficking
2011
The Glymphatic System: A Beginner’s Guide
2015 Standout
Alzheimer's disease
2016 Standout
Alzheimer’s disease: pathological mechanisms and the beneficial role of melatonin
2011
Leucine-Rich Repeat Transmembrane Proteins Are Essential for Maintenance of Long-Term Potentiation
2013 StandoutNobel
GxxxG motifs within the amyloid precursor protein transmembrane sequence are critical for the etiology of Aβ42
2007
The Role of Apolipoprotein E in Alzheimer's Disease
2009
Secretome protein enrichment identifies physiological BACE1 protease substrates in neurons
2012
Lipoprotein receptors and cholesterol in APP trafficking and proteolytic processing, implications for Alzheimer's disease
2008
Basic mechanisms of neurodegeneration: a critical update
2010
<p>Alzheimer’s disease: pathogenesis, diagnostics, and therapeutics</p>
2019 Standout
Oxidative modification to LDL receptor-related protein 1 in hippocampus from subjects with Alzheimer disease: Implications for Aβ accumulation in AD brain
2010
The Amyloid State of Proteins in Human Diseases
2012 Standout
Alzheimer's disease: Targeting the Cholinergic System
2016
HumanAPOEIsoform-Dependent Effects on Brain β-Amyloid Levels in PDAPP Transgenic Mice
2009
Reactive Astrocytes: Production, Function, and Therapeutic Potential
2017 Standout
Lymphatics in Neurological Disorders: A Neuro-Lympho-Vascular Component of Multiple Sclerosis and Alzheimer’s Disease?
2016
Heparan Sulphate Proteoglycan and the Low-Density Lipoprotein Receptor-Related Protein 1 Constitute Major Pathways for Neuronal Amyloid-β Uptake
2011
LDL Receptor-Related Protein 1: Unique Tissue-Specific Functions Revealed by Selective Gene Knockout Studies
2008
The Pathobiology of Vascular Dementia
2013 Standout
Astrocyte-Microglia Cross Talk through Complement Activation Modulates Amyloid Pathology in Mouse Models of Alzheimer's Disease
2016
The toxic Aβ oligomer and Alzheimer's disease: an emperor in need of clothes
2012 Standout
Down syndrome
2020 Standout
Intracellular amyloid-β in Alzheimer's disease
2007 Standout
Insights on the pathophysiology of Alzheimer's disease: The crosstalk between amyloid pathology, neuroinflammation and the peripheral immune system
2016
Neurotoxicity of Alzheimer's disease Aβ peptides is induced by small changes in the Aβ42 to Aβ40 ratio
2010
Endocytosis of nanomedicines
2010 Standout
The ubiquitin kinase PINK1 recruits autophagy receptors to induce mitophagy
2015 StandoutNature
A Unique Microglia Type Associated with Restricting Development of Alzheimer’s Disease
2017 Standout
NFκB-Activated Astroglial Release of Complement C3 Compromises Neuronal Morphology and Function Associated with Alzheimer’s Disease
2014
The amyloid state and its association with protein misfolding diseases
2014 Standout
Aspirin-Triggered Lipoxin A4 Stimulates Alternative Activation of Microglia and Reduces Alzheimer Disease–Like Pathology in Mice
2013
Neuroinflammation and microglial activation in Alzheimer disease: where do we go from here?
2020 Standout
Neurovascular pathways to neurodegeneration in Alzheimer's disease and other disorders
2011 Standout
The Biology of Lactoferrin, an Iron-Binding Protein That Can Help Defend Against Viruses and Bacteria
2020
The amyloid hypothesis of Alzheimer's disease at 25 years
2016 Standout
Loss‐of‐function presenilin mutations in Alzheimer disease
2007
Comprehensive Review on Alzheimer’s Disease: Causes and Treatment
2020 Standout
Down Syndrome
2020 Standout
TFEB at a glance
2016
The neuropathological diagnosis of Alzheimer’s disease
2019 Standout
Copper Active Sites in Biology
2014 Standout
Qualitative changes in human γ-secretase underlie familial Alzheimer’s disease
2015
Analysis of 6,515 exomes reveals the recent origin of most human protein-coding variants
2012 Nature
Microglia Function in the Central Nervous System During Health and Neurodegeneration
2017 Standout
A dural lymphatic vascular system that drains brain interstitial fluid and macromolecules
2015 Standout
The commensal microbiome is associated with anti–PD-1 efficacy in metastatic melanoma patients
2018 StandoutScience
Bioinorganic Chemistry of Alzheimer’s Disease
2012
The mechanism of γ-Secretase dysfunction in familial Alzheimer disease
2012
MiT/TFE transcription factors are activated during mitophagy downstream of Parkin and Atg5
2015
Amyloid precursor protein and endosomal‐lysosomal dysfunction in Alzheimer's disease: inseparable partners in a multifactorial disease
2017
Reactive Oxygen Species (ROS)-Based Nanomedicine
2019 Standout
The amyloid precursor protein: A biochemical enigma in brain development, function and disease
2013
Extrapineal melatonin: sources, regulation, and potential functions
2014 Standout
Amyloid precursor protein (APP) traffics from the cell surface via endosomes for amyloid β (Aβ) production in the trans -Golgi network
2012 StandoutNobel
Insulin is a Two-Edged Knife on the Brain
2009
Chemical Glycoproteomics
2016 StandoutNobel
Works of Baiping Wang being referenced
Genetic Dissection of the Amyloid Precursor Protein in Developmental Function and Amyloid Pathogenesis
2010 StandoutNobel
Selective clearance of aberrant tau proteins and rescue of neurotoxicity by transcription factor EB
2014
The Amyloid Precursor Protein Controls Adult Hippocampal Neurogenesis through GABAergic Interneurons
2014
Presynaptic and Postsynaptic Interaction of the Amyloid Precursor Protein Promotes Peripheral and Central Synaptogenesis
2009
Wild-type Presenilin 1 Protects against Alzheimer Disease Mutation-induced Amyloid Pathology
2006
Amyloid Precursor Protein Regulates Ca v 1.2 L-type Calcium Channel Levels and Function to Influence GABAergic Short-Term Plasticity
2009
Amyloid Precursor Protein Regulates Brain Apolipoprotein E and Cholesterol Metabolism through Lipoprotein Receptor LRP1
2007
Soluble amyloid precursor protein (APP) regulates transthyretin and Klotho gene expression without rescuing the essential function of APP
2010 StandoutNobel
Amyolid precursor protein mediates presynaptic localization and activity of the high-affinity choline transporter
2007