Standout Papers
Citation Impact
Citing Papers
High-Resolution Crystal Structure of an Engineered Human β 2 -Adrenergic G Protein–Coupled Receptor
2007 StandoutScienceNobel
Epidermal Merkel cells are mechanosensory cells that tune mammalian touch receptors
2014 StandoutNatureNobel
Radioimmunoassays for α-endorphin and β-endorphin
1977 StandoutNobel
Piezo2 is required for Merkel-cell mechanotransduction
2014 StandoutNatureNobel
Molecular biology of the opioid receptors: structures, functions and distributions
1995
Involvement of the hypothalamus in opiate-stimulated prolactin secretion
1988
Recent advances in molecular recognition and signal transduction of active peptides: Receptors for opioid peptides
1995
Crystal structure of the µ-opioid receptor bound to a morphinan antagonist
2012 StandoutNatureNobel
Binding of the opiate-like pentapeptide methionine-enkephalin to a particulate fraction from rat brain
1976
Immunohistochemical studies using antibodies to leucine-enkephalin: Initial observations on the nervous system of the rat
1976
Structure of the δ-opioid receptor bound to naltrindole
2012 StandoutNatureNobel
Endogenous Opioids Mediate the Nocturnal Prolactin Surge in the Pregnant Rat*
1991
Recent advances in selective opioid receptor agonists and antagonists
2003
Neuropeptides in perspective: The last ten years
1991
beta-Lipotropin as a prohormone for the morphinomimetic peptides endorphins and enkephalins.
1976 StandoutNobel
Effects of naloxone, morphine and methionine enkephalin on serum prolactin, luteinizing hormone, follicle stimulating hormone, thyroid stimulating hormone and growth hormone
1977
Associative Learning in Aplysia : Evidence for Conditioned Fear in an Invertebrate
1981 StandoutScienceNobel
Anatomy of the CNS opioid systems
1985
Enhanced Morphine Analgesia in Mice Lacking β-Arrestin 2
1999 StandoutScienceNobel
Alpha-Adrenergic Receptor Subtypes
1980 StandoutNobel
Acute tolerance to the excitatory effect of enkephalin microinjections into hippocampus
1979
Intraventricular Met5-enkephalin causes unexpected lowering of pain threshold and narcotic withdrawal signs in rats
1976 Nature
Bioorganometallic Chemistry of Ferrocene
2004 Standout
Yeast α factor is processed from a larger precursor polypeptide: The essential role of a membrane-bound dipeptidyl aminopeptidase
1983 StandoutNobel
Two endogenous neuropeptides modulate the gill and siphon withdrawal reflex in Aplysia by presynaptic facilitation involving cAMP-dependent closure of a serotonin-sensitive potassium channel.
1984 StandoutNobel
Opiate receptor binding in primate spinal cord: distribution and changes after dorsal root section
1976
Protein Structure Determination in Solution by Nuclear Magnetic Resonance Spectroscopy
1989 StandoutScienceNobel
Opiate analgesics inhibit substance P release from rat trigeminal nucleus
1977 Nature
Conformational states of enkephalins in solution
1977
Isolation and structure identification of a morphine-like peptide “enkephalin” in bovine brain
1976
Immunocytochemistry with internally labeled monoclonal antibodies.
1982 StandoutNobel
Peptidergic transmission in sympathetic ganglia of the frog.
1982
Elucidation by FAB–MS of the structure of a new cardioactive peptide from Aplysia
1982 Nature
Structure-Activity Relationships of Enkephalin-Like Peptides
1980
Pituitary somatotrophs contain [Met]enkephalin-like immunoreactivity.
1978
Conformation of [Leu5]Enkephalin from X-Ray Diffraction: Features Important for Recognition at Opiate Receptor
1978 Science
A perceptual-defensive-recuperative model of fear and pain
1980
Molecular pharmacology of somatostatin receptor subtypes
1997
β-Endorphin as a potent analgesic by intravenous injection
1976 Nature
beta-endorphin is a potent analgesic agent.
1976
Structural and conformational relationships between the enkephalins and the opiates
1976 Nature
Naloxone-induced reversal of schizophrenic hallucinations
1977
Preferential conformation of the endogenous opiate-like pentapeptide met-enkephalin in DMSO-d6 solution determined by high field 1H NMR
1976
Self-administration of D-Ala2-Met-enkephalinamide at hypothalamic self-stimulation sites
1980
In Situ Hybridization to Study the Origin and Fate of Identified Neurons
1983 StandoutScienceNobel
A cyclic enkephalin analog with high in vitro opiate activity.
1980
Comparative study on analgesic effect of Met5-enkephalin and related lipotropin fragments
1976 Nature
β-endorphin induced akinesia in rats: Effect of apomorphine and α-methyl-p-tyrosine and related modifications of dopamine turnover in the basal ganglia
1977
Primary structure of the human Met- and Leu-enkephalin precursor and its mRNA
1982 Nature
A single gene encodes multiple neuropeptides mediating a stereotyped behavior
1983 StandoutNobel
Physical Dependence of Opiate-Like Peptides
1976 Science
ENDORPHIN LEVELS IN OPIOID‐DEPENDENT HUMAN SUBJECTS: A LONGITUDINAL STUDY*
1982
Porcine pituitary peptides with opiate-like activity: Partial purification and effects in the rat after intraventricular injection
1976
Structure and Biosynthesis of Pro-Adrenocorticotropin/Endorphin and Related Peptides*
1980
Neuropharmacological actions of enkephalin after systemic administration
1976 StandoutNobel
Immunohistochemical localization of enkephalins in median eminence and adenohypophysis
1979
Beta-endorphin: stimulation of growth hormone release in vivo.
1977
Opiate Receptors in the Brain
1977
Morphinomimetic activity of synthetic fragments of beta-lipotropin and analogs.
1976 StandoutNobel
Identification of a Peptide Specific for Aplysia Sensory Neurons by PCR-based Differential Screening
1991 StandoutScienceNobel
Endorphins: Profound Behavioral Effects in Rats Suggest New Etiological Factors in Mental Illness
1976 StandoutScienceNobel
Effects of methionine-enkephalin and leucine-enkephalin compared with those of morphine on brainstem neurones in cat
1976 Nature
Isolation and structure of an untriakontapeptide with opiate activity from camel pituitary glands.
1976
Protein folding
1977
Regulation of noradrenaline release by presynaptic receptor systems
1977
Effects of microiontophoretically applied methionine-enkephalin on single neurones in rat brainstem
1976 Nature
THE ENDORPHINS, NOVEL PEPTIDES OF BRAIN AND HYPOPHYSIAL ORIGIN, WITH OPIATE‐LIKE ACTIVITY: BIOCHEMICAL AND BIOLOGIC STUDIES
1977 StandoutNobel
Chemical Anatomy of the Brain
1984 Science
Effects of methionine-enkephalin on prolactin release and catecholamine levels and turnover in the median eminence
1977
[D-Ala 2 ]-Met-Enkephalinamide: A Potent, Long-Lasting Synthetic Pentapeptide Analgesic
1976 Science
Fine Structural Analysis of the Synaptic Junction of Merkel Cell-Axon-Complexes
1980
Synthesis and conformational studies of a Leu-enkephalin amide analogue containing a ferrocene substructure
2002
Opioid peptide enkephalin: immunohistochemical mapping in rat central nervous system.
1977
Potent prolactin and growth hormone releasing activity of more analogues of Met-enkephalin
1977 StandoutNatureNobel
β-Endorphin: Endogenous Opiate or Neuroleptic?
1977 StandoutScienceNobel
Agonist-induced conformational changes in the G-protein-coupling domain of the β 2 adrenergic receptor
2001 StandoutNobel
Neural Science
2000 StandoutNobel
Localisation of gastrins to neuro- and adenohypophysis
1978 Nature
Robust excitons inhabit soft supramolecular nanotubes
2014 StandoutNobel
Regional dissociation of beta-endorphin and enkephalin contents in rat brain and pituitary.
1977 StandoutNobel
Foot-shock induced stress increases β-endorphin levels in blood but not brain
1977 StandoutNatureNobel
The excitatory response of in vitro hippocampal pyramidal cells to normorphine and methionine-enkephalin may be mediated by different receptor populations
1982
On the role of endogenous opioid peptides: Failure of naloxone to influence shock escape threshold in the rat
1976
Theoretical conformational analysis of met‐enkephalin
1977
Effects of enkephalin and morphine on Renshaw cells in feline spinal cord
1976 Nature
Uncovering Molecular Mechanisms Involved in Activation of G Protein-Coupled Receptors
2000
Cellular and Molecular Mechanisms of Drug Dependence
1988 StandoutScience
Stimulation of prolactin release in the rat by intraventricular injection of β-end orphin and methionine-enkephalin
1977
Analgesia induced in vivo by central administration of enkephalin in rat
1976 Nature
Enkephalin: conformational analysis by means of empirical energy calculations.
1977
Cloning of a Delta Opioid Receptor by Functional Expression
1992 Science
Lack of effect of naloxone on pain perception in humans
1976 Nature
Endorphins are located in the intermediate and anterior lobes of the pituitary gland, not in the neurohypophysis
1977 StandoutNobel
Common precursor to corticotropins and endorphins
1977
Enkephalin-stimulated prolactin release
1976
Opioid activity of a peptide, beta-lipotropin-(61-91), derived from beta-lipotropin.
1976
Prolactin: Structure, Function, and Regulation of Secretion
2000 Standout
Specific receptor for the opioid peptide dynorphin: structure--activity relationships.
1981
Tail shock produces inhibition as well as sensitization of the siphon-withdrawal reflex of Aplysia: possible behavioral role for presynaptic inhibition mediated by the peptide Phe-Met-Arg-Phe-NH2.
1987 StandoutNobel
Regulation of prolactin release by endogenous opiates
1977 Nature
The regional distribution of a morphine-like factor enkephalin in monkey brain
1976
Regional distribution of leu and met enkephalin in rat brain
1977
Crystal structure of leucine-enkephalin
1983 StandoutNatureNobel
Naloxone blockade of acupuncture analgesia: Endorphin implicated
1976
Opiate receptor subclasses differ in their conformational requirements
1982 Nature
Tolerance and dependence induced by morphine-like pituitary peptides in rats
1976
An iontophoretic survey of opioid peptide actions in the rat limbic system: in search of opiate epileptogenic mechanisms
1980
Cloning and sequence analysis of cDNA for porcine β-neo-endorphin/dynorphin precursor
1982 Nature
Biosynthetic origin and receptor conformation of methionine enkephalin
1976 Nature
360 MHz proton NMR spectra of active and inactive derivatives of methionine-enkephalin. Assignments, derived parameters, conformational implications
1977
Enkephalin-Induced Depression of Single Neurons in Brain Areas with Opiate Receptors—Antagonism by Naloxone
1976 Science
Radioimmunoassay and characterization of enkephalins in rat tissues.
1978
β-Endorphin and Adrenocorticotropin Are Selected Concomitantly by the Pituitary Gland
1977 StandoutScienceNobel
Isolation, primary structure, and synthesis of α-endorphin and γ-endorphin, two peptides of hypothalamic-hypophysial origin with morphinomimetic activity
1976 StandoutNobel
Central nervous system mechanisms of analgesia
1976
C fragment of lipotropin has a high affinity for brain opiate receptors
1976 Nature
Solid phase synthesis of porcine α-endorphin and γ-endorphin, two hypothalamic-pituitary peptides with opiate activity
1977
Mode of deactivation of the enkephalins by rat and human plasma and rat brain homogenates
1976 Nature
Neuroanatomical focus for morphine and enkaphalin-induced hypermotility
1977 Nature
Opioid Peptides Endorphins in Pituitary and Brain
1976 Science
A family of genes that codes for ELH, a neuropeptide eliciting a stereotyped pattern of behavior in Aplysia
1982 StandoutNobel
Tailoring Porphyrins and Chlorins for Self-Assembly in Biomimetic Artificial Antenna Systems
2005
An Analog of Enkephalin Having Prolonged Opiate-Like Effects in Vivo
1977 StandoutScienceNobel
High-performance liquid chromatography of tyrosine-related peptides with electrochemical detection
1983
Visualization of opiate receptors and opioid peptides in sequential brain sections
1982
Morphine-like peptides in mammalian brain: isolation, structure elucidation, and interactions with the opiate receptor.
1976
Effect of Intraventricular Injection of Neurotensin and Other Various Bioactive Peptides on Plasma Immunoreactive Somatostatin Levels in Rat Hypophysial Portal Blood*
1981
Naloxone inhibition of stress-induced increase in prolactin secretion
1978
Opiate receptor affinities and behavioral effects of enkephalin: Structure-activity relationship of ten synthetic peptide analogues
1976
Peptidergic neurones
1980 Nature
Cholecystokinin and its COOH-terminal octapeptide in the pig brain.
1977 StandoutNobel
β-ferrocenylalanyl peptides
1980
Synthesis and opioid activities of stereoisomers and other D-amino acid analogs of methionine-enkephalin
1976 StandoutNobel
Stress-induced parallel changes in central opioid levels and pain responsiveness in the rat
1977 Nature
Enkephalin-induced inhibition of cortical neurones and the lack of this effect in morphine tolerant/dependent rats
1976
Evidence for analgesic activity of enkephalin in the mouse
1976 Nature
Radioimmunoassay of brain peptides: Evaluation of a methodology for the assay of β-endorphin and enkephalin
1977 StandoutNobel
Conformation of Met5-enkephalin determined by high field PMR spectroscopy
1976 Nature
Opioid and Nonopioid Mechanisms of Stress Analgesia
1980 StandoutScience
Neuronal actions of endorphins and enkephalins among brain regions: a comparative microiontophoretic study.
1977 StandoutNobel
Endogenous opioid peptides: multiple agonists and receptors
1977 StandoutNature
The Hypothalamic Control of the Menstrual Cycle and the Role of Endogenous Opioid Peptides
1984
Opiate receptor affinity of peptides related to Leu-enkephalin
1976
Morphine- and opioid peptide-induced inhibition of the release of dopamine from tuberoinfundibular neurons
1979
Proton magnetic resonance studies of conformation and flexibility of enkephalin peptides
1976 Nature
Works of B.A. Morgan being referenced
Somatostatin receptor subtype specificity in human fetal pituitary cultures. Differential role of SSTR2 and SSTR5 for growth hormone, thyroid-stimulating hormone, and prolactin regulation.
1997
Structure-activity relationships of methionine-enkephalin
1976
Identification of two related pentapeptides from the brain with potent opiate agonist activity
1975 StandoutNature
Pharmacology identification of two related pentapeptides from the brain with potent opiate agonist activity
1976
Opiate analgesics: the effect of agonist-antagonist character on prolactin secretion
1978