Citation Impact
Citing Papers
Selective targeting of engineered T cells using orthogonal IL-2 cytokine-receptor complexes
2018 StandoutScienceNobel
Confirmation of intersubunit connectivity and topology of designed protein complexes by native MS
2018 StandoutNobel
Nature of the protein universe
2009 StandoutNobel
High-throughput characterization of protein–protein interactions by reprogramming yeast mating
2017 StandoutNobel
Removing T-cell epitopes with computational protein design
2014 StandoutNobel
Topological control of cytokine receptor signaling induces differential effects in hematopoiesis
2019 StandoutScienceNobel
The use of mRNA display to select high-affinity protein-binding peptides
2001 StandoutNobel
Structure of the Quaternary Complex of Interleukin-2 with Its α, ß, and γ c Receptors
2005 Science
Hierarchical design of pseudosymmetric protein nanocages
2024 StandoutNatureNobel
De novo design of allosterically switchable protein assemblies
2024 StandoutNatureNobel
Subtilases: The superfamily of subtilisin-like serine proteases
1997
Inhibition of human α-thrombin by a phosphonate tripeptide proceeds via a metastable pentacoordinated phosphorus intermediate 1 1Edited by R. Huber
2001
Peptide-binding specificity of the molecular chaperone BiP
1991 StandoutNatureNobel
Furin is a subtilisin-like proprotein processing enzyme in higher eukaryotes
1990
Crystal Structure of lac Repressor Core Tetramer and Its Implications for DNA Looping
1995 StandoutScienceNobel
Scoring noncovalent protein-ligand interactions: A continuous differentiable function tuned to compute binding affinities
1996
Selection and evolution of enzymes from a partially randomized non-catalytic scaffold
2007 StandoutNatureNobel
High-resolution cryo-electron microscopy structure of the Trypanosoma brucei ribosome
2013 StandoutNatureNobel
Strategies for the inhibition of serine proteases
2001
An engineered disulfide cross-link accelerates the refolding rate of calcium-free subtilisin by 850-fold
1993
Functional proteins from a random-sequence library
2001 StandoutNatureNobel
Multifarious Determinants of Cytokine Receptor Signaling Specificity
2014
Hydrophobic stabilization in T4 lysozyme determined directly by multiple substitutions of Ile 3
1988 Nature
Design and Synthesis of a Homogeneous Erythropoietin Analogue with Two Human Complex‐Type Sialyloligosaccharides: Combined Use of Chemical and Bacterial Protein Expression Methods
2009 StandoutNobel
Head‐to‐Tail Peptide Cyclodimerization by Copper‐Catalyzed Azide–Alkyne Cycloaddition
2005
Structure of the protein subunits in the photosynthetic reaction centre of Rhodopseudomonas viridis at 3Å resolution
1985 StandoutNatureNobel
[43] Purification of vicinal dithiol-containing proteins by arsenical-based affinity chromatography
1994
The role of internal packing interactions in determining the structure and stability of a protein
1991
Localization of Rat Cathepsin K in Osteoclasts and Resorption Pits: Inhibition of Bone Resorption and Cathepsin K-Activity by Peptidyl Vinyl Sulfones
1999
An agonist-induced conformational change in the growth hormone receptor determines the choice of signalling pathway
2008
High resolution functional analysis of antibody-antigen interactions
1992
Oncogenic Mutations Counteract Intrinsic Disorder in the EGFR Kinase and Promote Receptor Dimerization
2012 StandoutNobel
The Erythropoietin Receptor Transmembrane Domain Mediates Complex Formation with Viral Anemic and Polycythemic gp55 Proteins
2003
Tuning Cytokine Receptor Signaling by Re-orienting Dimer Geometry with Surrogate Ligands
2015
Inactivation of Subtilisin Carlsberg by N-((tert-Butoxycarbonyl)alanylprolylphenylalanyl)-O-benzoyl Hydroxylamine: Formation of a Covalent Enzyme-Inhibitor Linkage in the Form of a Carbamate Derivative
1994
Improved affinity of engineered streptavidin for the Strep‐tag II peptide is due to a fixed open conformation of the lid‐like loop at the binding site
2002
Selective in vitro glycosylation of recombinant proteins: semi-synthesis of novel homogeneous glycoforms of human erythropoietin
2001 StandoutNobel
Surrogate Wnt agonists that phenocopy canonical Wnt and β-catenin signalling
2017 StandoutNatureNobel
Structure of the zinc-binding domain of an essential component of the hepatitis C virus replicase
2005 StandoutNatureNobel
Structure of a β1-adrenergic G-protein-coupled receptor
2008 StandoutNatureNobel
Mechanism of folding chamber closure in a group II chaperonin
2010 StandoutNatureNobel
Crystal Structure of the Complex of Human Epidermal Growth Factor and Receptor Extracellular Domains
2002
Computational design of ligand-binding proteins with high affinity and selectivity
2013 StandoutNatureNobel
Accurate prediction of the stability and activity effects of site-directed mutagenesis on a protein core
1991 StandoutNatureNobel
Dissection of the structure and activity of the tyrosyl-tRNA synthetase by site-directed mutagenesis
1987
AutoDock Vina: Improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading
2009 Standout
Structure‐based redesign of proteins for minimal T‐cell epitope content
2013
The protein-conducting channel SecYEG
2004
Complete switch from Mdm2 to human papillomavirus E6-mediated degradation of p53 in cervical cancer cells
2001 StandoutNobel
JAK2 activation by growth hormone and other cytokines
2015
Computation-Guided Backbone Grafting of a Discontinuous Motif onto a Protein Scaffold
2011 StandoutScienceNobel
Computational method to reduce the search space for directed protein evolution
2001 StandoutNobel
The SWISS-MODEL workspace: a web-based environment for protein structure homology modelling
2005 Standout
Structural Studies of Mutants of T4 Lysozyme That Alter Hydrophobic Stabilization
1989
Contribution of long-range electrostatic interactions to the stabilization of the catalytic transition state of the serine protease subtilisin BPN'
1993
Rationally Engineered Therapeutic Proteins with Reduced Immunogenicity
2005
Ligand-Binding Proteins: Their Potential for Application in Systems for Controlled Delivery and Uptake of Ligands
2000
A Method to Identify Protein Sequences That Fold into a Known Three-Dimensional Structure
1991 StandoutScience
Azapeptides Structurally Based upon Inhibitory Sites of Cystatins as Potent and Selective Inhibitors of Cysteine Proteases
2002
Crystal structure of muconate lactonizing enzyme at 3 Å resolution
1987 StandoutNobel
Induction of apoptosis in human papillomaviruspositive cancer cells by peptide aptamers targeting the viral E6 oncoprotein
2000
Insights into Cytokine–Receptor Interactions from Cytokine Engineering
2014
Long-range order in the src SH3 folding transition state
2000 StandoutNobel
The NMR–Rosetta capsid model of M13 bacteriophage reveals a quadrupled hydrophobic packing epitope
2015 StandoutNobel
Mechanistic Diversity of Cytokine Receptor Signaling Across Cell Membranes
2004
Reversible Photocontrol of Biological Systems by the Incorporation of Molecular Photoswitches
2013 StandoutNobel
Distortion Pathways of Transition Metal Coordination Polyhedra Induced by Chelating Topology
2015
Receptor-mediated dimerization of JAK2 FERM domains is required for JAK2 activation
2018
Conversion of agonist site to metal-ion chelator site in the β 2 -adrenergic receptor
1999
An x-ray absorption study of the iron site in bacterial photosynthetic reaction centers
1982
Structural homology of reaction centers from Rhodopseudomonas sphaeroides and Rhodopseudomonas viridis as determined by x-ray diffraction.
1986 StandoutNobel
Protease Inhibitors: Current Status and Future Prospects
2000
Structures of Metal–Organic Frameworks with Rod Secondary Building Units
2016 StandoutNobel
Mapping the Protein Universe
1996 Science
Electrostatic Basis for Enzyme Catalysis
2006 StandoutNobel
De Novo Design of an Allosteric Metalloprotein Assembly with Strained Disulfide Bonds
2016
Transition metal complexes with sulfur ligands CIV. Protonation and alkylation of thiolate donors of [Fe(CO)2(‘S4’)] and [Fe(CO)(‘S5’)]: syntheses and properties of Fe(II) complexes with open-chain thioether ligands (‘S4’2−=1,2-bis(2-mercaptophenylthio)ethane(2−); ‘S5’2−=2,2′-bis(2-mercapto-phenylthio)diethylsulfide(2−))
1994
The 3D profile method for identifying fibril-forming segments of proteins
2006 StandoutNobel
Computational Design of Proteins Targeting the Conserved Stem Region of Influenza Hemagglutinin
2011 StandoutScienceNobel
Prohormone processing in Xenopus oocytes: characterization of cleavage signals and cleavage enzymes.
1991 StandoutNobel
A structural census of the current population of protein sequences
1997 StandoutNobel
A unified statistical framework for sequence comparison and structure comparison
1998 StandoutNobel
Mechanistic Studies on Synthetic Fe−S-Based Clusters and Their Relevance to the Action of Nitrogenases
2005 StandoutNobel
Cu-Catalyzed Azide−Alkyne Cycloaddition
2008 StandoutNobel
Structure of E. coli Glutaminyl-tRNA Synthetase Complexed with tRNA Gln and ATP at 2.8 Å Resolution
1989 StandoutScienceNobel
Specific Covalent Labeling of Recombinant Protein Molecules Inside Live Cells
1998 StandoutScienceNobel
Irreversible Inhibitors of Serine, Cysteine, and Threonine Proteases
2002 Standout
Synthesis of bioactive protein hydrogels by genetically encoded SpyTag-SpyCatcher chemistry
2014 StandoutNobel
Nonnatural protein–protein interaction-pair design by key residues grafting
2007
Filamentous Phage Display in the New Millennium
2005
Directed evolution of a far-red fluorescent rhodopsin
2014 StandoutNobel
Recombinant immunotoxin for cancer treatment with low immunogenicity by identification and silencing of human T-cell epitopes
2014 StandoutNobel
Directed evolution of the epidermal growth factor receptor extracellular domain for expression in yeast
2005
Works of B.A. Katz being referenced
Design of potent selective zinc-mediated serine protease inhibitors
1998 Nature
Crystal structure of muconolactone isomerase at 3.3 Å resolution
1989
The Structure of the Extracellular Region of Human Hepsin Reveals a Serine Protease Domain and a Novel Scavenger Receptor Cysteine-Rich (SRCR) Domain
2003
Binding to Protein Targets of Peptidic Leads Discovered by Phage Display: Crystal Structures of Streptavidin-Bound Linear and Cyclic Peptide Ligands Containing the HPQ Sequence
1995
Streptavidin-binding and -dimerizing ligands discovered by phage display, topochemistry, and structure-based design
1999
Expression of human cathepsin K in Pichia pastoris and preliminary crystallographic studies of an inhibitor complex
1997
Crystal structure of subtilisin BPN′ variants containing disulfide bonds and cavities: Concerted structural rearrangements induced by mutagenesis
1990
Episelection: Novel Ki .apprx. Nanomolar Inhibitors of Serine Proteases Selected by Binding or Chemistry on an Enzyme Surface
1995
Engineering a soluble extracellular erythropoietin receptor (EPObp) in Pichia pastoris to eliminate microheterogeneity, and its complex with erythropoietin
1999
Binding of biotin to streptavidin stabilizes intersubunit salt bridges between Asp61 and His87 at low pH
1997
Efficiency of signalling through cytokine receptors depends critically on receptor orientation
1998 Nature
Low resolution crystal structure of muconolactone isomerase
1985
Spin-state isomerism of tris(2-picolylamine)iron(II). The diiodide and the hydrated dichloride
1980
A Novel Approach to Serine Protease Inhibition: Kinetic Characterization of Inhibitors Whose Potencies and Selectivities Are Dramatically Enhanced by Zinc(II)
2000
Low-spin ferric porphyrin complexes: analysis of the electronic structure based on single-crystal electron spin resonance measurements
1983
STRUCTURAL AND MECHANISTIC DETERMINANTS OF AFFINITY AND SPECIFICITY OF LIGANDS DISCOVERED OR ENGINEERED BY PHAGE DISPLAY
1997
The three-dimensional structure of Bacillus amyloliquefaciens subtilisin at 1.8 A and an analysis of the structural consequences of peroxide inactivation.
1988
Molecular transformations in the solid state. Crystallographic resolution of the spin isomers of tris(2-picolylamine)iron(II) dichloride and the structural relationship between the methanol and ethanol solvates
1979
The crystallographically determined structures of atypical strained disulfides engineered into subtilisin.
1986