Standout Papers
Citation Impact
Citing Papers
Piezo1 and Piezo2 Are Essential Components of Distinct Mechanically Activated Cation Channels
2010 StandoutScienceNobel
Gain-of-function Na v 1.8 mutations in painful neuropathy
2012
Regulated import and degradation of a cytosolic protein in the yeast vacuole
1991 StandoutNatureNobel
Structure of the signal recognition particle interacting with the elongation-arrested ribosome
2004 StandoutNatureNobel
cAMP‐dependent phosphorylation of the tetrodotoxin‐resistant voltage‐dependent sodium channel SNS
1999
ΔμH+ and ATP function at different steps of the catalytic cycle of preprotein translocase
1991
Peptide-binding specificity of the molecular chaperone BiP
1991 StandoutNatureNobel
Voltage‐gated sodium channels in nociceptive versus non‐nociceptive nodose vagal sensory neurons innervating guinea pig lungs
2008
SecB functions as a cytosolic signal recognition factor for protein export in E. coli
1989 StandoutNobel
Folding of nascent polypeptide chains in a high molecular mass assembly with molecular chaperones
1994 Nature
Inhibition of the ω-conotoxin-sensitive calcium current by distinct G proteins
1992 StandoutNobel
Unity in Function in the Absence of Consensus in Sequence: Role of Leader Peptides in Export
1989 Science
A yeast mitochondrial outer membrane protein essential for protein import and cell viability
1990 Nature
The Dissociation of ATP from hsp70 of Saccharomyces cerevisiae Is Stimulated by Both Ydj1p and Peptide Substrates
1995
GroE prevents the accumulation of early folding intermediates of pre-.beta.-lactamase without changing the folding pathway
1992
Destabilization of the complete protein secondary structure on binding to the chaperone GroEL
1994 StandoutNatureNobel
Control of type-D GABAergic neuron differentiation by C. elegans UNC-30 homeodomain protein
1994 StandoutNatureNobel
Protein targeting to and translocation across the membrane of the endoplasmic reticulum
1992
Molecular mechanisms of nociception
2001 StandoutNatureNobel
Successive action of DnaK, DnaJ and GroEL along the pathway of chaperone-mediated protein folding
1992 Nature
Selective spider toxins reveal a role for the Nav1.1 channel in mechanical pain
2016 StandoutNatureNobel
The signal recognition particle in S. cerevisiae
1991
Model for signal sequence recognition from amino-acid sequence of 54K subunit of signal recognition particle
1989 StandoutNatureNobel
The signal recognition particle receptor mediates the GTP-dependent displacement of SRP from the signal sequence of the nascent polypeptide
1989
Calmodulin Regulates Current Density and Frequency-Dependent Inhibition of Sodium Channel Nav1.8 in DRG Neurons
2006
KAR2, a karyogamy gene, is the yeast homolog of the mammalian BiP/GRP78 gene
1989
Piezo proteins are pore-forming subunits of mechanically activated channels
2012 StandoutNatureNobel
Protein folding in mitochondria requires complex formation with hsp60 and ATP hydrolysis
1989 Nature
The NaV1.7 sodium channel: from molecule to man
2012
Three-dimensional structure of the ATPase fragment of a 70K heat-shock cognate protein
1990 Nature
Changes in the expression of tetrodotoxin-sensitive sodium channels within dorsal root ganglia neurons in inflammatory pain
2004
YDJ1p facilitates polypeptide translocation across different intracellular membranes by a conserved mechanism
1992
Characterization of the yeast HSP60 gene coding for a mitochondrial assembly factor
1989 Nature
SEC mutants and the secretory apparatus
2002 StandoutNobel
The E. coli dnaK gene product, the hsp70 homolog, can reactivate heat-inactivated RNA polymerase in an ATP hydrolysis-dependent manner
1990
Gain-of-function mutation in Nav1.7 in familial erythromelalgia induces bursting of sensory neurons
2005
Nav1.7 Mutant A863P in Erythromelalgia: Effects of Altered Activation and Steady-State Inactivation on Excitability of Nociceptive Dorsal Root Ganglion Neurons
2006
An SCN9A channelopathy causes congenital inability to experience pain
2006 StandoutNature
How do polypeptides cross the mitochondrial membranes?
1990
Polypeptide chain binding proteins: Catalysts of protein folding and related processes in cells
1989
A protein conjugation system essential for autophagy
1998 StandoutNatureNobel
Mutations in SCN9A, encoding a sodium channel alpha subunit, in patients with primary erythermalgia
2004
Mdj1p, a novel chaperone of the DnaJ family, is involved in mitochondrial biogenesis and protein folding
1994
Involvement of Na+ channels in pain pathways
2001
Assembly of yeast Sec proteins involved in translocation into the endoplasmic reticulum into a membrane-bound multisubunit complex
1991 StandoutNatureNobel
Differential role of GDNF and NGF in the maintenance of two TTX-resistant sodium channels in adult DRG neurons
1999
Protein folding in the cell
1992 StandoutNature
SNAP receptors implicated in vesicle targeting and fusion
1993 StandoutNatureNobel
ProOmpA is stabilized for membrane translocation by either purified E. coli trigger factor or canine signal recognition particle
1988
The tetrodotoxin-resistant sodium channel SNS has a specialized function in pain pathways
1999
Structure of the E. coli protein-conducting channel bound to a translating ribosome
2005 StandoutNatureNobel
Requirement for hsp70 in the mitochondrial matrix for translocation and folding of precursor proteins
1990 Nature
A movable and regulable inactivation function within the steroid binding domain of the glucocorticoid receptor
1988
Genetic and biochemical analysis of vesicular traffic in yeast
1992 StandoutNobel
The TTX‐Resistant Sodium Channel Nav1.8 (SNS/PN3): Expression and Correlation with Membrane Properties in Rat Nociceptive Primary Afferent Neurons
2003
SCN9A Mutations in Paroxysmal Extreme Pain Disorder: Allelic Variants Underlie Distinct Channel Defects and Phenotypes
2006
Identification of a mitochondrial receptor complex required for recognition and membrane insertion of precursor proteins
1990 Nature
COPII–cargo interactions direct protein sorting into ER-derived transport vesicles
1998 StandoutNatureNobel
Gating and modulation of presumptive NaV1.9 channels in enteric and spinal sensory neurons
2004
SRH1 protein, the yeast homologue of the 54 kDa subunit of signal recognition particle, is involved in ER translocation of secretory proteins
1991
Molecular chaperones in cellular protein folding
1996 StandoutNature
Comparative study of the distribution of the α‐subunits of voltage‐gated sodium channels in normal and axotomized rat dorsal root ganglion neurons
2008
The binding cascade of SecB to SecA to SecYE mediates preprotein targeting to the E. coli plasma membrane
1990
Size Matters: Erythromelalgia Mutation S241T in Nav1.7 Alters Channel Gating
2006
SEC21 is a gene required for ER to Golgi protein transport that encodes a subunit of a yeast coatomer
1992 StandoutNatureNobel
Mitochondrial heat-shock protein hsp60 is essential for assembly of proteins imported into yeast mitochondria
1989 Nature
The β2-adrenergic receptor interacts with the Na+/H+-exchanger regulatory factor to control Na+/H+ exchange
1998 StandoutNatureNobel
Electrophysiological Properties of Mutant Na v 1.7 Sodium Channels in a Painful Inherited Neuropathy
2004
Sporadic onset of erythermalgia: A gain‐of‐function mutation in Nav1.7
2006
Several common variants modulate heart rate, PR interval and QRS duration
2010
Heat-shock proteins DnaK and GroEL facilitate export of LacZ hybrid proteins in E. coli
1990 Nature
International Union of Pharmacology. XLVII. Nomenclature and Structure-Function Relationships of Voltage-Gated Sodium Channels
2005 Standout
The mechanism of protein folding. Implications of in vitro refolding models for de novo protein folding and translocation in the cell
1990
Piezo2 senses airway stretch and mediates lung inflation-induced apnoea
2016 StandoutNatureNobel
Molecular Mechanism of Protein Folding in the Cell
2011 StandoutNobel
A role for the TTX-resistant sodium channel Nav 1.8 in NGF-induced hyperalgesia, but not neuropathic pain
2001
S. cerevisiae encodes an essential protein homologous in sequence and function to mammalian BiP
1989
Expression of Alternatively Spliced Sodium Channel α-Subunit Genes
2004
Signal recognition particle-depencent protein targeting, universal to all kingdoms of life
2002
Sec61p and BiP directly facilitate polypeptide translocation into the ER
1992 StandoutNobel
Chimaeras of Myc oncoprotein and steroid receptors cause hormone-dependent transformation of cells
1989 StandoutNatureNobel
Translocation gets a push
1994 StandoutNobel
Mechanisms of intracellular protein transport
1994 StandoutNatureNobel
Inhibition of the Caenorhabditis elegans cell-death protease CED-3 by a CED-3 cleavage site in baculovirus p35 protein
1995 StandoutNatureNobel
C. elegans phagocytosis and cell-migration protein CED-5 is similar to human DOCK180
1998 StandoutNatureNobel
Eukaryotic homologues of Escherichia coli dnaJ: a diverse protein family that functions with hsp70 stress proteins.
1993
Sodium Channel β Subunits: Anything but Auxiliary
2001
Reconstitution of protein translocation from solubilized yeast membranes reveals topologically distinct roles for BiP and cytosolic Hsc70.
1993 StandoutNobel
Protein translocation mutants defective in the insertion of integral membrane proteins into the endoplasmic reticulum.
1992 StandoutNobel
Purification and characterization of BiP/Kar2 protein from Saccharomyces cerevisiae.
1992
The Escherichia coli heat shock proteins GroEL and GroES modulate the folding of the beta-lactamase precursor.
1990
Transport of Proteins Across the Endoplasmic Reticulum Membrane
1992 Science
DnaK and DnaJ heat shock proteins participate in protein export in Escherichia coli.
1992
Specialized Nucleoprotein Structures at the Origin of Replication of Bacteriophage λ
1989
Nonlethal sec71-1 and sec72-1 mutations eliminate proteins associated with the Sec63p-BiP complex from S. cerevisiae.
1994
Initiation of lambda DNA replication with purified host- and bacteriophage-encoded proteins: the role of the dnaK, dnaJ and grpE heat shock proteins.
1989
Structural and functional dissection of Sec62p, a membrane-bound component of the yeast endoplasmic reticulum protein import machinery.
1990 StandoutNobel
A member of the Hsp70 family is localized in mitochondria and resembles Escherichia coli DnaK.
1989
Identification, characterization, and purification of two mammalian stress proteins present in mitochondria, grp 75, a member of the hsp 70 family and hsp 58, a homolog of the bacterial groEL protein
1989
Mutation of the mouse klotho gene leads to a syndrome resembling ageing.
1997 Standout
Polypeptide translocation across the endoplasmic reticulum membrane.
1992 StandoutNobel
Immunoglobulin heavy chain and binding protein complexes are dissociated in vivo by light chain addition.
1990
Purification of the Escherichia coli secB gene product and demonstration of its activity in an in vitro protein translocation system
1989
Prevention of Protein Denaturation Under Heat Stress by the Chaperonin Hsp60
1992 Science
A dual role for mitochondrial heat shock protein 70 in membrane translocation of preproteins.
1993
Slow Closed-State Inactivation: A Novel Mechanism Underlying Ramp Currents in Cells Expressing the hNE/PN1 Sodium Channel
1998
Topology and functional domains of Sec63p, an endoplasmic reticulum membrane protein required for secretory protein translocation.
1992 StandoutNobel
An essential member of the HSP70 gene family of Saccharomyces cerevisiae is homologous to immunoglobulin heavy chain binding protein.
1990
β-Adrenergic and Somatostatin Receptors Regulate Na-H Exchange Independent of cAMP
1989
SSC1, an Essential Member of the Yeast HSP70 Multigene Family, Encodes a Mitochondrial Protein
1989
A single sodium channel mutation produces hyper- or hypoexcitability in different types of neurons
2006
Translocation of ProOmpA possessing an intramolecular disulfide bridge into membrane vesicles of Escherichia coli. Effect of membrane energization.
1990
Hsp70 proteins, similar to Escherichia coli DnaK, in chloroplasts and mitochondria of Euglena gracilis.
1990
Sec59 Encodes a Membrane Protein Required for Core Glycosylation in Saccharomyces cerevisiae
1989 StandoutNobel
Sodium Channels in Normal and Pathological Pain
2010
Antibodies against 70-kD heat shock cognate protein inhibit mediated nuclear import of karyophilic proteins.
1992
Genetic dissection of the early stages of protein secretion in yeast
1989
Neuropathic Pain Develops Normally in Mice Lacking both Nav1.7 and Nav1.8
2005
Protein Translocation Across Membranes
1988 Science
Impaired Nociception and Pain Sensation in Mice Lacking the Capsaicin Receptor
2000 StandoutScienceNobel
Three pure chaperone proteins of Escherichia coli--SecB, trigger factor and GroEL--form soluble complexes with precursor proteins in vitro.
1989
Binding of a soluble factor of Escherichia coli to preproteins does not require ATP and appears to be the first step in protein export.
1989
Protein Sorting to Mitochondria: Evolutionary Conservations of Folding and Assembly
1990 Science
Nociceptor-specific gene deletion reveals a major role for Nav1.7 (PN1) in acute and inflammatory pain
2004
Multiple genes are required for proper insertion of secretory proteins into the endoplasmic reticulum in yeast.
1989 StandoutNobel
Characterization of YDJ1: a yeast homologue of the bacterial dnaJ protein.
1991
BiP and Sec63p are required for both co- and posttranslational protein translocation into the yeast endoplasmic reticulum.
1995 StandoutNobel
The role of cytosolic and membrane factors in processing of the human beta-2 adrenergic receptor following translocation and glycosylation in a cell-free system.
1990 StandoutNobel
Effects of mutations in heat-shock genes groES and groEL on protein export in Escherichia coli.
1989
Two sodium channels contribute to the TTX-R sodium current in primary sensory neurons
1998
Aminopeptidase I of Saccharomyces cerevisiae is localized to the vacuole independent of the secretory pathway.
1992
Pharmacological Dissection and Distribution of NaN/Nav1.9, T-type Ca2+ Currents, and Mechanically Activated Cation Currents in Different Populations of DRG Neurons
2006
The transport of proteins into the nucleus requires the 70-kilodalton heat shock protein or its cytosolic cognate.
1992
Several proteins imported into chloroplasts form stable complexes with the GroEL-related chloroplast molecular chaperone.
1989
A yeast DnaJ homologue, Scj1p, can function in the endoplasmic reticulum with BiP/Kar2p via a conserved domain that specifies interactions with Hsp70s.
1995
Temporal and spatial expression patterns of the small heat shock (hsp16) genes in transgenic Caenorhabditis elegans.
1992
Seventy-kilodalton heat shock proteins and an additional component from reticulocyte lysate stimulate import of M13 procoat protein into microsomes.
1988
NaN, a novel voltage-gated Na channel, is expressed preferentially in peripheral sensory neurons and down-regulated after axotomy
1998
Peptide Binding and Release by Proteins Implicated as Catalysts of Protein Assembly
1989 StandoutScienceNobel
What drives the translocation of proteins?
1992
Sec72p contributes to the selective recognition of signal peptides by the secretory polypeptide translocation complex.
1994 StandoutNobel
The GTP-binding protein Ran/TC4 is required for protein import into the nucleus
1993 StandoutNatureNobel
Unusual Topogenic Sequence Directs Prion Protein Biogenesis
1990 StandoutScienceNobel
Structural and Functional Dissection of Sec62p, a Membrane-Bound Component of the Yeast Endoplasmic Reticulum Protein Import Machinery
1990 StandoutNobel
Purified secB protein of Escherichia coli retards folding and promotes membrane translocation of the maltose-binding protein in vitro.
1988
Genetic interactions between KAR2 and SEC63, encoding eukaryotic homologues of DnaK and DnaJ in the endoplasmic reticulum.
1993
An ATP transporter is required for protein translocation into the yeast endoplasmic reticulum.
1993
Mutational analysis of the human HSP70 protein: distinct domains for nucleolar localization and adenosine triphosphate binding.
1989
Heat Shock Protein-mediated Disassembly of Nucleoprotein Structures Is Required for the Initiation of Bacteriophage λ DNA Replication
1989
A precursor protein partly translocated into yeast mitochondria is bound to a 70 kd mitochondrial stress protein.
1990
ION CHANNELS OF NOCICEPTION
1999
Multiple receptors coupled to adenylate cyclase regulate Na-H exchange independent of cAMP.
1990
SSS1 encodes a stabilizing component of the Sec61 subcomplex of the yeast protein translocation apparatus.
1994 StandoutNobel
Regulation of Hsp70 function by a eukaryotic DnaJ homolog.
1992
Molecular cloning of mtp70, a mitochondrial member of the hsp70 family.
1989
Loss of BiP/GRP78 function blocks translocation of secretory proteins in yeast.
1990
SEC62 encodes a putative membrane protein required for protein translocation into the yeast endoplasmic reticulum.
1989 StandoutNobel
A Sec63p-BiP complex from yeast is required for protein translocation in a reconstituted proteoliposome.
1993 StandoutNobel
In vivo and in vitro analysis of ptl1, a yeast ts mutant with a membrane-associated defect in protein translocation.
1988
Contribution of Nav1.8 Sodium Channels to Action Potential Electrogenesis in DRG Neurons
2001
The ATPase activity of secA is regulated by acidic phospholipids, secY, and the leader and mature domains of precursor proteins
1990
Identification of a groES-like chaperonin in mitochondria that facilitates protein folding.
1990
Identification of PN1, a predominant voltage-dependent sodium channel expressed principally in peripheral neurons
1997
Rufinamide Attenuates Mechanical Allodynia in a Model of Neuropathic Pain in the Mouse and Stabilizes Voltage-gated Sodium Channel Inactivated State
2012
A yeast gene important for protein assembly into the endoplasmic reticulum and the nucleus has homology to DnaJ, an Escherichia coli heat shock protein.
1989
Similarity of the three-dimensional structures of actin and the ATPase fragment of a 70-kDa heat shock cognate protein.
1991
Mutants in three novel complementation groups inhibit membrane protein insertion into and soluble protein translocation across the endoplasmic reticulum membrane of Saccharomyces cerevisiae.
1992
Molecular Biology of Prion Diseases
1991 StandoutScienceNobel
Interaction between BiP and Sec63p is required for the completion of protein translocation into the ER of Saccharomyces cerevisiae.
1995 StandoutNobel
Secretion in yeast: preprotein binding to a membrane receptor and ATP-dependent translocation are sequential and separable events in vitro.
1989
A Role for a 70-Kilodalton Heat Shock Protein in Lysosomal Degradation of Intracellular Proteins
1989 Science
Distribution of the Tetrodotoxin-Resistant Sodium Channel PN3 in Rat Sensory Neurons in Normal and Neuropathic Conditions
1998
Functional Attributes Discriminating Mechano-Insensitive and Mechano-Responsive C Nociceptors in Human Skin
1999
A large presecretory protein translocates both cotranslationally, using signal recognition particle and ribosome, and post-translationally, without these ribonucleoparticles, when synthesized in the presence of mammalian microsomes.
1990
Mitochondrial protein import: biochemical and genetic evidence for interaction of matrix hsp70 and the inner membrane protein MIM44.
1994
Hypermorphic mutation of the voltage-gated sodium channel encoding gene Scn10a causes a dramatic stimulus-dependent neurobehavioral phenotype
2011 StandoutNobel
Sec59 encodes a membrane protein required for core glycosylation in Saccharomyces cerevisiae.
1989 StandoutNobel
Cyclophilin 20 Is Involved in Mitochondrial Protein Folding in Cooperation with Molecular Chaperones Hsp70 and Hsp60
1995
70-kD heat shock-related protein is one of at least two distinct cytosolic factors stimulating protein import into mitochondria.
1988
Signal recognition particle (SRP) stabilizes the translocation-competent conformation of pre-secretory proteins.
1988
SecA protein hydrolyzes ATP and is an essential component of the protein translocation ATPase of Escherichia coli.
1989
Control of folding and membrane translocation by binding of the chaperone DnaJ to nascent polypeptides.
1993
Sequential action of mitochondrial chaperones in protein import into the matrix.
1991
Works of B. Koch being referenced
A subfamily of stress proteins facilitates translocation of secretory and mitochondrial precursor polypeptides
1988 StandoutNatureNobel
A Novel Tetrodotoxin-sensitive, Voltage-gated Sodium Channel Expressed in Rat and Human Dorsal Root Ganglia
1997
A tetrodotoxin-resistant voltage-gated sodium channel from human dorsal root ganglia, hPN3/ SCN10A
1998
Structure and Function of a Novel Voltage-gated, Tetrodotoxin-resistant Sodium Channel Specific to Sensory Neurons
1996
Functional Analysis of a Voltage‐Gated Sodium Channel and Its Splice Variant from Rat Dorsal Root Ganglia
1998
The role of stress proteins in membrane biogenesis
1988 StandoutNobel
Pertussis toxin blocks both cyclic AMP-mediated and cyclic AMP-independent actions of somatostatin. Evidence for coupling of Ni to decreases in intracellular free calcium.
1985