Standout Papers
Citation Impact
Citing Papers
p53: puzzle and paradigm.
1996 Standout
Bax-Deficient Mice with Lymphoid Hyperplasia and Male Germ Cell Death
1995 Science
Induced Pluripotent Stem Cell Lines Derived from Human Somatic Cells
2007 StandoutScience
Loss of cryptochrome reduces cancer risk in p53 mutant mice
2009 StandoutNobel
Critical Role of Smads and AP-1 Complex in Transforming Growth Factor-β-dependent Apoptosis
2000
Transcriptional regulator of programmed cell death encoded by Caenorhabditis elegans gene ces-2
1996 StandoutNatureNobel
The genetic regulation of apoptosis
1995
Targeting HIF-1 for cancer therapy
2003 StandoutNobel
TGF-β signaling in tumor suppression and cancer progression
2001 Standout
Induction of Pluripotent Stem Cells from Mouse Embryonic and Adult Fibroblast Cultures by Defined Factors
2006 StandoutNobel
TGF-beta receptor-activated p38 MAP kinase mediates Smad-independent TGF-beta responses
2002
Induction of Pluripotent Stem Cells from Adult Human Fibroblasts by Defined Factors
2007 StandoutNobel
Role of HIF-1α in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis
1998 StandoutNatureNobel
Transformation by the (R)-enantiomer of 2-hydroxyglutarate linked to EGLN activation
2012 StandoutNatureNobel
The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis
1999 StandoutNatureNobel
Smad-dependent and Smad-independent pathways in TGF-β family signalling
2003 StandoutNature
Angiogenesis in cancer and other diseases
2000 StandoutNature
The Hallmarks of Cancer
2000 Standout
An Alternatively Spliced C. elegans ced-4 RNA Encodes a Novel Cell Death Inhibitor
1996 StandoutNobel
Proliferating cell nuclear antigen: More than a clamp for DNA polymerases
1997
Analyzing real-time PCR data by the comparative CT method
2008 Standout
Coupling endoplasmic reticulum stress to the cell death program
2004
Interaction of the p53-Regulated Protein Gadd45 with Proliferating Cell Nuclear Antigen
1994 Science
p53 modulation of TFIIH–associated nucleotide excision repair activity
1995
COMMENTARY: p53 Tumor suppressor gene: from the basic research laboratory to the clinic—an abridged historical perspective
1996
CHOP is implicated in programmed cell death in response to impaired function of the endoplasmic reticulum
1998 Standout
Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death
2012 Standout
Distinct mRNA microarray profiles of tolerogenic dendritic cells
2001
Transient activation of NF-κB through a TAK1/IKK kinase pathway by TGF-β1 inhibits AP-1/SMAD signaling and apoptosis: implications in liver tumor formation
2003
Foundations in Cancer Research p53 and ATM: Cell Cycle, Cell Death, and Cancer
1997
Inhibition of p53 Transcriptional Activity by Bcl-2 Requires Its Membrane-anchoring Domain
1999
Biochemical properties and biological effects of p53
1995
Generation of germline-competent induced pluripotent stem cells
2007 StandoutNatureNobel
DNA Repair: Enzymatic Mechanisms and Relevance to Drug Response
1996
Apoptosis and differentiation of human embryonic stem cells induced by sustained activation of c-Myc
2007
limma powers differential expression analyses for RNA-sequencing and microarray studies
2015 Standout
p73 is a human p53-related protein that can induce apoptosis
1997 StandoutNatureNobel
A novel effector domain from the RNA-binding protein TLS or EWS is required for oncogenic transformation by CHOP.
1994
GADD34 induces p53 phosphorylation and p21/WAF1 transcription
2003
AID Produces DNA Double-Strand Breaks in Non-Ig Genes and Mature B Cell Lymphomas with Reciprocal Chromosome Translocations
2009
CHOP induces death by promoting protein synthesis and oxidation in the stressed endoplasmic reticulum
2004 Standout
DNA-PKcs has KU-dependent function in rRNA processing and haematopoiesis
2020 StandoutNatureNobel
Stress signaling from the lumen of the endoplasmic reticulum: coordination of gene transcriptional and translational controls
1999 Standout
Exploring complex networks
2001 StandoutNature
Viruses and apoptosis
1995
Inferences, questions and possibilities in Toll-like receptor signalling
2004 StandoutNatureNobel
The Homeoprotein Nanog Is Required for Maintenance of Pluripotency in Mouse Epiblast and ES Cells
2003 StandoutNobel
Identification of novel stress-induced genes downstream of chop
1998
Complete switch from Mdm2 to human papillomavirus E6-mediated degradation of p53 in cervical cancer cells
2001 StandoutNobel
Accumulation of the FACT complex, as well as histone H3.3, serves as a target marker for somatic hypermutation
2013 StandoutNobel
A specific subdomain in φ29 DNA polymerase confers both processivity and strand-displacement capacity
2005 StandoutNobel
Replication of a Cytopathic Strain of Bovine Viral Diarrhea Virus Activates PERK and Induces Endoplasmic Reticulum Stress-Mediated Apoptosis of MDBK Cells
2002
In vitro repair of oxidative DNA damage by human nucleotide excision repair system: Possible explanation for neurodegeneration in Xeroderma pigmentosum patients
1997 StandoutNobel
Molecular Interaction Map of the Mammalian Cell Cycle Control and DNA Repair Systems
1999 Nobel
Feedback Inhibition of the Unfolded Protein Response by GADD34-Mediated Dephosphorylation of eIF2α
2001
Opposing Effects of ERK and JNK-p38 MAP Kinases on Apoptosis
1995 StandoutScience
Hypoxia-inducible factor 1α protein expression is controlled by oxygen-regulated ubiquitination that is disrupted by deletions and missense mutations
2000 StandoutNobel
Consistent loss of functional transforming growth factor β receptor expression in murine plasmacytomas
1998
Physiology meets biophysics: Visualizing the interaction of hypoxia-inducible factor 1α with p300 and CBP
2002 StandoutNobel
Induction of apoptosis in HeLa cells by trans-activation-deficient p53.
1995
Mechanisms of DNA Excision Repair
1994 StandoutScienceNobel
Apoptosis in the Pathogenesis and Treatment of Disease
1995 StandoutScience
Growth Arrest and DNA Damage-Inducible Protein GADD34 Targets Protein Phosphatase 1α to the Endoplasmic Reticulum and Promotes Dephosphorylation of the α Subunit of Eukaryotic Translation Initiation Factor 2
2003
Death Receptors: Signaling and Modulation
1998 StandoutScience
Bcl-2-mediated alterations in endoplasmic reticulum Ca 2+ analyzed with an improved genetically encoded fluorescent sensor
2004 StandoutNobel
Mutations in the p53 and SCID genes cooperate in tumorigenesis.
1996
Complexes containing activating transcription factor (ATF)/cAMP-responsive-element-binding protein (CREB) interact with the CCAAT/enhancer-binding protein (C/EBP)–ATF composite site to regulate Gadd153 expression during the stress response
1999
The Caenorhabditis elegans mucolipin-like gene cup-5 is essential for viability and regulates lysosomes in multiple cell types
2002 StandoutNobel
Tumor suppressor p53 is a direct transcriptional activator of the human bax gene
1995 Standout
Molecular thanatopsis: a discourse on the BCL2 family and cell death
1996
Avoiding horror autotoxicus: The importance of dendritic cells in peripheral T cell tolerance
2002 StandoutNobel
The Yin and Yang of T Cell Costimulation
1995 StandoutScienceNobel
Growth factor modulation of p53-mediated growth arrest versus apoptosis.
1995
The C-terminal domain of p53 recognizes DNA damaged by ionizing radiation.
1995
Abnormal B lymphocyte development and autoimmunity in hypoxia-inducible factor 1α-deficient chimeric mice
2002 StandoutNobel
Alternative RNA Splicing Produces Multiple Forms of c-Myb with Unique Transcriptional Activities
2008
Two Domains of p53 Interact with the TATA-Binding Protein, and the Adenovirus 13S E1A Protein Disrupts the Association, Relieving p53-Mediated Transcriptional Repression
1995
Peptide blockade of HIFα degradation modulates cellular metabolism and angiogenesis
2002 StandoutNobel
Signals from the Stressed Endoplasmic Reticulum Induce C/EBP-Homologous Protein (CHOP/GADD153)
1996
Japanese Encephalitis Virus Infection Initiates Endoplasmic Reticulum Stress and an Unfolded Protein Response
2002
HdmX stimulates Hdm2-mediated ubiquitination and degradation of p53
2003 StandoutNobel
A central role for Stat3 in IL-6-induced regulation of growth and differentiation in M1 leukemia cells.
1996
LIF/STAT3 controls ES cell self-renewal and pluripotency by a Myc-dependent mechanism
2005
The redox/DNA repair protein, Ref-1, is essential for early embryonic development in mice.
1996
Cell type-specific inhibition of p53-mediated apoptosis by mdm2.
1996
Stress-Induced Binding of the Transcription Factor CHOP to a Novel DNA Control Element
1996
A role for transcriptional repression of p21 CIP1 by c-Myc in overcoming transforming growth factor β-induced cell-cycle arrest
2000
Human DNA Repair Genes
2001 StandoutScienceNobel
Circadian control of XPA and excision repair of cisplatin-DNA damage by cryptochrome and HERC2 ubiquitin ligase
2010 StandoutNobel
hMutSα- and hMutLα-dependent phosphorylation of p53 in response to DNA methylator damage
1999 StandoutNobel
APE1 is dispensable for S-region cleavage but required for its repair in class switch recombination
2014 StandoutNobel
Translocation of C. elegans CED-4 to Nuclear Membranes During Programmed Cell Death
2000 StandoutScienceNobel
Identification and functional significance of genes regulated by structurally different histone deacetylase inhibitors
2005
Relief of p53-mediated transcriptional repression by the adenovirus E1B 19-kDa protein or the cellular Bcl-2 protein.
1994
Increased Tumor Proliferation and Genomic Instability without Decreased Apoptosis in MMTV-ras Mice Deficient in p53
1997
Works of B Hoffman being referenced
Apoptotic signaling by c-MYC
2008
Retroviral Insertional Mutagenesis in Murine Promonocytic Leukemias:c-myb and Mm/1
1996
The novel primary response gene MyD118 and the proto-oncogenes myb, myc, and bcl-2 modulate transforming growth factor beta 1-induced apoptosis of myeloid leukemia cells.
1994
Immediate early up-regulation of bax expression by p53 but not TGF beta 1: a paradigm for distinct apoptotic pathways.
1994
The gadd and MyD genes define a novel set of mammalian genes encoding acidic proteins that synergistically suppress cell growth.
1994 StandoutNobel
Molecular controls of growth arrest and apoptosis: p53-dependent and independent pathways.
1995
Progression of the myeloid differentiation program is dominant to transforming growth factor-beta 1-induced apoptosis in M1 myeloid leukemic cells
1994
p53 involvement in control of G2 exit of the cell cycle: role in DNA damage-induced apoptosis.
1995
Molecular controls of apoptosis: differentiation/growth arrest primary response genes, proto-oncogenes, and tumor suppressor genes as positive & negative modulators.
1994
The proto-oncogene c-myc blocks myeloid differentiation independently of its target gene ornithine decarboxylase
1996