Citation Impact
Citing Papers
Targeted cell killing by reconstituted caspases
2007 StandoutNobel
Poly(ADP-ribose) Polymerase-2 (PARP-2) Is Required for Efficient Base Excision DNA Repair in Association with PARP-1 and XRCC1
2002
PARP-1 cleavage fragments: signatures of cell-death proteases in neurodegeneration
2010
Glioma stem cells promote radioresistance by preferential activation of the DNA damage response
2006 StandoutNature
Poly(ADP‐ribose) polymerase: Molecular biological aspects
1991
Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase
2005 StandoutNature
Alkylating DNA damage stimulates a regulated form of necrotic cell death
2004
Poly(ADP-ribose) polymerase (PARP-1) has a controlling role in homologous recombination
2003
Global Analysis of Transcriptional Regulation by Poly(ADP-ribose) Polymerase-1 and Poly(ADP-ribose) Glycohydrolase in MCF-7 Human Breast Cancer Cells
2009
Poly(ADP-ribosyl)ation by PARP-1: `PAR-laying' NAD+ into a nuclear signal
2005
NAD+-Dependent Modulation of Chromatin Structure and Transcription by Nucleosome Binding Properties of PARP-1
2004
Influence of Metabolism on Epigenetics and Disease
2013 StandoutNobel
Chromatin Modifications and Their Function
2007 Standout
Poly(ADP-ribose) polymerase-1: what have we learned from the deficient mouse model?
2000
Poly(ADP-ribose)polymerase: a perplexing participant in cellular responses to DNA breakage
1991
An ICE‐like protease is a common mediator of apoptosis induced by diverse stimuli in human monocytic THP.1 cells
1995
Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy
2005 StandoutNature
Telomere states and cell fates
2000 StandoutNatureNobel
A receptor subtype involved in neuropeptide-Y-induced food intake
1996 Nature
Database of mouse strains carrying targeted mutations in genes affecting cellular responses to DNA damage. Version 4
2000
The PARP Side of the Nucleus: Molecular Actions, Physiological Outcomes, and Clinical Targets
2010
Inflammatory and age-related pathologies in mice with ectopic expression of human PARP-1
2010
The large subunit of replication factor C is a substrate for caspase-3 invitro and is cleaved by a caspase-3-like protease during Fas-mediated apoptosis
1997
The biochemistry of apoptosis
2000 StandoutNature
Mammalian Base Excision Repair: the Forgotten Archangel
2013
Transient Poly(ADP-ribosyl)ation of Nuclear Proteins and Role of Poly(ADP-ribose) Polymerase in the Early Stages of Apoptosis
1998
PARP is important for genomic stability but dispensable in apoptosis
1997
Ablation of PARP-1 does not interfere with the repair of DNA double-strand breaks, but compromises the reactivation of stalled replication forks
2004
The C. elegans Protein EGL-1 Is Required for Programmed Cell Death and Interacts with the Bcl-2–like Protein CED-9
1998 StandoutNobel
Death substrates come alive
1997
PARP1 deficiency exacerbates diet-induced obesity in mice
2010
A review of PARP inhibitors: from bench to bedside
2010
Second pathway for completion of human DNA base excision-repair: reconstitution with purified proteins and requirement for DNase IV (FEN1)
1997
Functions of poly(ADP-ribose) polymerase in controlling telomere length and chromosomal stability
1999
Role of poly(ADP-ribose) formation in DNA repair
1992 StandoutNatureNobel
ATM-dependent telomere loss in aging human diploid fibroblasts and DNA damage lead to the post-translational activation of p53 protein involving poly(ADP-ribose) polymerase
1997
A role for ghrelin in the central regulation of feeding
2001 StandoutNature
Poly(ADP-ribose) polymerase gene disruption renders mice resistant to cerebral ischemia
1997
Inhibition of cell proliferation in Saccharomyces cerevisiae by expression of human NAD+ ADP-ribosyltransferase requires the DNA binding domain (“zinc fingers”)
1992
PARP-1 Determines Specificity in a Retinoid Signaling Pathway via Direct Modulation of Mediator
2005
Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis
1995 StandoutNature
Genome maintenance mechanisms for preventing cancer
2001 StandoutNature
Structural and functional diversity in the leucine-rich repeat family of proteins
1996
Interactive effects of inhibitors of poly(ADP-ribose) polymerase and DNA-dependent protein kinase on cellular responses to DNA damage
1999
Heteronuclear Ribonucleoproteins C1 and C2, Components of the Spliceosome, Are Specific Targets of Interleukin 1β-converting Enzyme-like Proteases in Apoptosis
1996
Origin and physiological roles of inflammation
2008 StandoutNature
The DNA damage response: putting checkpoints in perspective
2000 StandoutNature
Biochemistry and molecular cell biology of diabetic complications
2001 StandoutNature
Genetic interaction between PARP and DNA-PK in V(D)J recombination and tumorigenesis
1997
DFF, a Heterodimeric Protein That Functions Downstream of Caspase-3 to Trigger DNA Fragmentation during Apoptosis
1997 Standout
Involvement of poly(ADP-ribose) polymerase in base excision repair
1999
c-Jun N-terminal kinase mediates hydrogen peroxide-induced cell death via sustained poly(ADP-ribose) polymerase-1 activation
2007
Molecular characterization of mitochondrial apoptosis-inducing factor
1999 StandoutNature
Cellular Responses to DNA Damage in the Absence of Poly(ADP-ribose) Polymerase
1998
A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD
1998 StandoutNature
Post-translational modification of poly(ADP-ribose) polymerase induced by DNA strand breaks
1995 StandoutNobel
Transcriptional control by PARP-1: chromatin modulation, enhancer-binding, coregulation, and insulation
2008
Leptin and the regulation of body weight in mammals
1998 StandoutNature
Poly(ADP-Ribose) Polymerase 1 Participates in the Phase Entrainment of Circadian Clocks to Feeding
2010
Isolation of the functional human excision repair gene ERCC5 by intercosmid recombination
1990
PARP inhibition: PARP1 and beyond
2010
Activation of the apoptotic protease CPP32 by cytotoxic T-cell-derived granzyme B
1995 Nature
Nuclear ADP-Ribosylation Reactions in Mammalian Cells: Where Are We Today and Where Are We Going?
2006
Life, death, and the pursuit of apoptosis.
1996
The Bcl-2 Protein Family: Arbiters of Cell Survival
1998 StandoutScience
DNA excision-repair defect of xeroderma pigmentosum prevents removal of a class of oxygen free radical-induced base lesions.
1993 StandoutNobel
Purification and characterization of human DNA damage checkpoint Rad complexes
2001 StandoutNobel
An α-syntrophin-dependent pool of AQP4 in astroglial end-feet confers bidirectional water flow between blood and brain
2003 StandoutNobel
Requirement for d(GATC) sequences in Escherichia coli mutHLS mismatch correction.
1987 StandoutNobel
Diabetic endothelial dysfunction: the role of poly(ADP-ribose) polymerase activation
2001
Neurexin III alpha: extensive alternative splicing generates membrane-bound and soluble forms.
1993 StandoutNobel
Asymmetric repair of bacteriophage T7 heteroduplex DNA
1981
Characterization of anArabidopsis thaliana cDNA homologue to animal poly(ADP‐ribose) polymerase
1995
Quality Control by DNA Repair
1999 StandoutScienceNobel
Mechanisms of DNA Excision Repair
1994 StandoutScienceNobel
Prevention of Apoptosis by Bcl-2: Release of Cytochrome c from Mitochondria Blocked
1997 StandoutScience
DNA-dependent protein kinase catalytic subunit: a target for an ICE-like protease in apoptosis.
1996
Lamin proteolysis facilitates nuclear events during apoptosis.
1996
Cancer Cell Cycles
1996 StandoutScience
Human ERCC5 cDNA-cosmid complementation for excision repair and bipartite amino acid domains conserved with RAD proteins of Saccharomyces cerevisiae and Schizosaccharomyces pombe.
1993
Ku is associated with the telomere in mammals
1999 StandoutNobel
Marked decrease of neuropeptide Y Y2 receptor binding sites in the hippocampus in murine prion disease
1997 StandoutNobel
Poly(ADP-Ribose)Polymerase-1 (PARP1) Controls Adipogenic Gene Expression and Adipocyte Function
2011
On PAR with PARP: cellular stress signaling through poly(ADP-ribose) and PARP-1
2012 Standout
Bipartite substrate discrimination by human nucleotide excision repair
1997
The role of proteases during apoptosis
1996
Poly(ADP-ribose) polymerase is a mediator of necrotic cell death by ATP depletion
1999
The Release of Cytochrome c from Mitochondria: A Primary Site for Bcl-2 Regulation of Apoptosis
1997 StandoutScience
Methyl-directed repair of DNA base-pair mismatches in vitro.
1983 StandoutNobel
Poly(ADP-ribosyl)ation reactions in the regulation of nuclear functions
1999 Standout
Toll-related receptors and the control of antimicrobial peptide expression inDrosophila
2000 StandoutNobel
Requirement of poly(ADP-ribose) polymerase in recovery from DNA damage in mice and in cells
1997
Caspases: the executioners of apoptosis
1997 Standout
Assembly, subunit composition, and footprint of human DNA repair excision nuclease
1998 StandoutNobel
Differential regulation of S-region hypermutation and class-switch recombination by noncanonical functions of uracil DNA glycosylase
2014 StandoutNobel
Cancer Genome Landscapes
2013 StandoutScience
Mitochondria and Apoptosis
1998 StandoutScience
The diverse biological roles of mammalian PARPS, a small but powerful family of poly-ADP-ribose polymerases
2007
Bcl-2 inhibits the mitochondrial release of an apoptogenic protease.
1996
Apopain/CPP32 cleaves proteins that are essential for cellular repair: a fundamental principle of apoptotic death.
1996
Recognition and processing of damaged DNA
1995 StandoutNobel
Enzymatic Processing of Radiation-Induced Free Radical Damage in DNA
1998
Human DNA Repair Genes
2001 StandoutScienceNobel
Neurexins: Synaptic Cell Surface Proteins Related to the α-Latrotoxin Receptor and Laminin
1992 StandoutScienceNobel
The zinc fingers of human poly(ADP-ribose) polymerase are differentially required for the recognition of DNA breaks and nicks and the consequent enzyme activation. Other structures recognize intact DNA.
1990
Specific cleavage of the retinoblastoma protein by an ICE-like protease in apoptosis.
1996
Caspases: Enemies Within
1998 StandoutScience
Preferential binding of ATR protein to UV-damaged DNA
2002 StandoutNobel
Deficiency in Poly(ADP-ribose) Polymerase-1 (PARP-1) Accelerates Aging and Spontaneous Carcinogenesis in Mice
2008
slit: an extracellular protein necessary for development of midline glia and commissural axon pathways contains both EGF and LRR domains.
1990
NAD(+)-dependent repair of damaged DNA by human cell extracts.
1993 StandoutNobel
Molecular cloning of the human nucleotide-excision-repair gene ERCC4.
1994 StandoutNobel
Works of B. Auer being referenced
Mice lacking ADPRT and poly(ADP-ribosyl)ation develop normally but are susceptible to skin disease.
1995
ADP-ribosyltransferase from Helix pomatia. Purification and characterization
1987
ADP-ribosylation in isolated nuclei of Physarum polycephalum
1988
Purification and characterization of NAD+:ADP-ribosyltransferase (polymerizing) from Dictyostelium discoideum
1993
DNA repair dependent NAD+ metabolism is impaired in cells from patients with Fanconi's anemia.
1983
Transient expression of a plasmid gene, a tool to study DNA repair in human cells: defect of DNA repair in Cockayne syndrome; one thymine cyclobutane dimer is sufficient to block transcription.
1986
Human nuclear NAD+ ADP-ribosyltransferase: localization of the gene on chromosome 1q41-q42 and expression of an active human enzyme in Escherichia coli.
1989
Isolation of a cDNA clone for human NAD+: protein ADP-ribosyltransferase.
1987
Poly-ADP-ribosylation is not required for excision of a DNA damage
1983
Genomic organization, localization, and allelic differences in the gene for the human neuropeptide Y Y1 receptor.
1993
The primary structure of human ribonuclease/angiogenin inhibitor (RAI) discloses a novel highly diversified protein superfamily with a common repetitive module.
1988
Is the DNA of Virus T7 Methylated?
1979