Standout Papers
Citation Impact
Citing Papers
Role of LBPA and Alix in Multivesicular Liposome Formation and Endosome Organization
2004 StandoutScienceNobel
Targeting of Diacylglycerol Degradation to M1 Muscarinic Receptors by ß-Arrestins
2007 StandoutScienceNobel
Differential Antigen Processing by Dendritic Cell Subsets in Vivo
2007 StandoutScienceNobel
Aire-Dependent Thymic Development of Tumor-Associated Regulatory T Cells
2013 StandoutScienceNobel
Small assemblies of unmodified amyloid β-protein are the proximate neurotoxin in Alzheimer’s disease
2004
Structural Classification of Toxic Amyloid Oligomers
2008
Alzheimer's disease: synaptic dysfunction and Aβ
2009
CD3/CD28 Costimulation-Induced NF-κB Activation Is Mediated by Recruitment of Protein Kinase C-θ, Bcl10, and IκB Kinase β to the Immunological Synapse through CARMA1
2003
Amyloid β-Protein Assembly and Alzheimer Disease
2008
Impaired synaptic plasticity and learning in aged amyloid precursor protein transgenic mice
1999
Lipids revert inert Aβ amyloid fibrils to neurotoxic protofibrils that affect learning in mice
2007
Targeting small Aβ oligomers: the solution to an Alzheimer's disease conundrum?
2001
The 'Arctic' APP mutation (E693G) causes Alzheimer's disease by enhanced Aβ protofibril formation
2001
Pathway Complexity of Prion Protein Assembly into Amyloid
2002 Nobel
Copper Binding to the Amyloid-β (Aβ) Peptide Associated with Alzheimer's Disease
2004
Presenilins are essential for regulating neurotransmitter release
2009 StandoutNatureNobel
The Highly Cooperative Folding of Small Naturally Occurring Proteins Is Likely the Result of Natural Selection
2007 StandoutNobel
Dimeric Amyloid β Protein Rapidly Accumulates in Lipid Rafts followed by Apolipoprotein E and Phosphorylated Tau Accumulation in the Tg2576 Mouse Model of Alzheimer's Disease
2004
Review: Immunoglobulin Light Chain Amyloidosis—The Archetype of Structural and Pathogenic Variability
2000
ICOS co-stimulatory receptor is essential for T-cell activation and function
2001 StandoutNatureNobel
Temporal Profile of Amyloid-β (Aβ) Oligomerization in an in Vivo Model of Alzheimer Disease
2005
In Vitro Characterization of Conditions for Amyloid-β Peptide Oligomerization and Fibrillogenesis
2003
Inherent toxicity of aggregates implies a common mechanism for protein misfolding diseases
2002 StandoutNature
Deciphering the Molecular Basis of Memory Failure in Alzheimer's Disease
2004
Synaptic Targeting by Alzheimer's-Related Amyloid β Oligomers
2004
Aβ Oligomers Induce Neuronal Oxidative Stress through an N-Methyl-D-aspartate Receptor-dependent Mechanism That Is Blocked by the Alzheimer Drug Memantine
2007
CD22 blockade restores homeostatic microglial phagocytosis in ageing brains
2019 StandoutNatureNobel
Natural Oligomers of the Alzheimer Amyloid-β Protein Induce Reversible Synapse Loss by Modulating an NMDA-Type Glutamate Receptor-Dependent Signaling Pathway
2007
Amyloid Oligomers Exacerbate Tau Pathology in a Mouse Model of Tauopathy
2012 Standout
Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid β-peptide
2007 Standout
Amyloid β-Protein Fibrillogenesis
1999
Protein aggregation and aggregate toxicity: new insights into protein folding, misfolding diseases and biological evolution
2003
Pathogenic protein seeding in alzheimer disease and other neurodegenerative disorders
2011
The receptor DEC-205 expressed by dendritic cells and thymic epithelial cells is involved in antigen processing
1995 StandoutNatureNobel
The Nonfibrillar Amyloid β‐Peptide Induces Apoptotic Neuronal Cell Death
1999
Multiple Assembly Pathways Underlie Amyloid-β Fibril Polymorphisms
2005
Integrins Form an Expanding Diffusional Barrier that Coordinates Phagocytosis
2016 StandoutNobel
Regulatory T Cells and Immune Tolerance
2008 StandoutNobel
PGH2‐derived levuglandin adducts increase the neurotoxicity of amyloid β1–42
2006
Probing the Initial Stage of Aggregation of the Aβ10-35-protein: Assessing the Propensity for Peptide Dimerization
2004
Contribution of two conserved glycine residues to fibrillogenesis of the 106–126 prion protein fragment. Evidence that a soluble variant of the 106–126 peptide is neurotoxic
2003
Cellular prion protein mediates impairment of synaptic plasticity by amyloid-β oligomers
2009 Nature
The level of CD8 expression can determine the outcome of thymic selection
1992 StandoutNobel
Developmental Regulation of Invariant Chain Proteolysis Controls MHC Class II Trafficking in Mouse Dendritic Cells
1998
Soluble Amyloid β Peptide Concentration as a Predictor of Synaptic Change in Alzheimer's Disease
1999
Enhanced Toxicity and Cellular Binding of a Modified Amyloid β Peptide with a Methionine to Valine Substitution
2004
Unfolding the role of protein misfolding in neurodegenerative diseases
2003
Amyloid-β protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory
2008 Standout
Naturally secreted oligomers of amyloid β protein potently inhibit hippocampal long-term potentiation in vivo
2002 StandoutNature
Appearance of Sodium Dodecyl Sulfate-Stable Amyloid β-Protein (Aβ) Dimer in the Cortex During Aging
1999
Developmental regulation of MHC class II transport in mouse dendritic cells
1997 StandoutNatureNobel
Phenolic anti-inflammatory antioxidant reversal of Aβ-induced cognitive deficits and neuropathology
2001
Peptides Naturally Presented by MHC Class I Molecules
1993
Monoclonal antibodies that target pathological assemblies of Aβ
2006
Biology of Amyloid: Structure, Function, and Regulation
2010
Myasthenia Gravis
1994 Standout
Presenilins and APP in Neuritic and Synaptic Plasticity: Implications for the Pathogenesis of Alzheimer's Disease
2002
Selection of Foxp3+ regulatory T cells specific for self antigen expressed and presented by Aire+ medullary thymic epithelial cells
2007
The Sixth International Conference on Alzheimer's Disease, Amsterdam, The Netherlands, July 1998. The amyloid cascade hypothesis debate: Emerging consensus on the role of Aβ and amyloid in Alzheimer's disease
1998
Predominant naturally processed peptides bound to HLA-DR1 are derived from MHC-related molecules and are heterogeneous in size
1992 Nature
Only amyloidogenic intermediates of transthyretin induce apoptosis
2002
Review: Alzheimer's Amyloid β-Peptide-Associated Free Radical Oxidative Stress and Neurotoxicity
2000
Apolipoprotein E4 Potentiates Amyloid β Peptide-induced Lysosomal Leakage and Apoptosis in Neuronal Cells
2002
Three-dimensional structure of the human class II histocompatibility antigen HLA-DR1
1993 StandoutNature
Protein aggregation and neurodegenerative disease
2004 Standout
β-Amyloid Is Different in Normal Aging and in Alzheimer Disease
2005
A de novo designed helix-turn-helix peptide forms nontoxic amyloid fibrils.
2000
Curcumin Inhibits Formation of Amyloid β Oligomers and Fibrils, Binds Plaques, and Reduces Amyloid in Vivo
2004 Standout
Residues 17–20 and 30–35 of beta‐amyloid play critical roles in aggregation
2003
Bacterial Inclusion Bodies Contain Amyloid-Like Structure
2008
A sensitive method to detect defined peptide among those eluted from murine MHC class II molecules
1993
Localization, Quantitation, and In Situ Detection of Specific Peptide–MHC Class I Complexes Using a Monoclonal Antibody
1997
Dynamics of Diacylglycerol Kinase ζ Translocation in Living T-cells
2002
Certain Inhibitors of Synthetic Amyloid β-Peptide (Aβ) Fibrillogenesis Block Oligomerization of Natural Aβ and Thereby Rescue Long-Term Potentiation
2005
The human class II MHC protein HLA-DR1 assembles as empty αβ heterodimers in the absence of antigenic peptide
1992
Amyloid β-Protein Toxicity and the Pathogenesis of Alzheimer Disease
2008
Taking dendritic cells into medicine
2007 StandoutNatureNobel
Ibuprofen effects on Alzheimer pathology and open field activity in APPsw transgenic mice
2001
Amyloid pores from pathogenic mutations
2002 Nature
Live Cell Fluorescence Imaging of T Cell MEKK2
1999
Aβ Oligomer-Induced Aberrations in Synapse Composition, Shape, and Density Provide a Molecular Basis for Loss of Connectivity in Alzheimer's Disease
2007
Neprilysin-sensitive Synapse-associated Amyloid-β Peptide Oligomers Impair Neuronal Plasticity and Cognitive Function
2006
The set of naturally processed peptides displayed by DR molecules is tuned by polymorphism of residue 86
1993
APP Processing and Synaptic Function
2003
Leukocyte polarization in cell migration and immune interactions
1999
Aβ42 Neurotoxicity Is Mediated by Ongoing Nucleated Polymerization Process Rather than by Discrete Aβ42 Species
2010
Soluble oligomers of β amyloid (1-42) inhibit long-term potentiation but not long-term depression in rat dentate gyrus
2002
Roles of amyloid precursor protein and its fragments in regulating neural activity, plasticity and memory
2003
Presence of Sodium Dodecyl Sulfate-Stable Amyloid β-Protein Dimers in the Hippocampus CA1 Not Exhibiting Neurofibrillary Tangle Formation
1999
The Amyloid State of Proteins in Human Diseases
2012 Standout
Antiamyloidogenic and Neuroprotective Functions of Cathepsin B: Implications for Alzheimer's Disease
2006
Dendritic Function of Tau Mediates Amyloid-β Toxicity in Alzheimer's Disease Mouse Models
2010
Quantitative reactivity profiling predicts functional cysteines in proteomes
2010 StandoutNatureNobel
Non-fibrillar oligomeric species of the amyloid ABri peptide, implicated in familial British dementia, are more potent at inducing apoptotic cell death than protofibrils or mature fibrils11Edited by J. Karn
2001
Amyloid β-Protein Fibrillogenesis
1997
The Transthyretin Amyloidoses: From Delineating the Molecular Mechanism of Aggregation Linked to Pathology to a Regulatory-Agency-Approved Drug
2012
Extensive trafficking of MHC class II-invariant chain complexes in the endocytic pathway and appearance of peptide-loaded class II in multiple compartments
1995
Functional Proteomics Reveals the Biochemical Niche of C. elegans DCR-1 in Multiple Small-RNA-Mediated Pathways
2006 StandoutNobel
Oligomeric and Fibrillar Species of Amyloid-β Peptides Differentially Affect Neuronal Viability
2002 Standout
Structure-based design of non-natural amino-acid inhibitors of amyloid fibril formation
2011 StandoutNatureNobel
Amyloid-β forms fibrils by nucleated conformational conversion of oligomers
2011
Mice Lacking H2-M Complexes, Enigmatic Elements of the MHC Class II Peptide-Loading Pathway
1996
Identification and characterization of key kinetic intermediates in amyloid β-protein fibrillogenesis11Edited by F. Cohen
2001
Three-dimensional segregation of supramolecular activation clusters in T cells
1998 StandoutNature
Vaccination with soluble Aβ oligomers generates toxicity‐neutralizing antibodies
2001
Polyglutamine aggregation behavior in vitro supports a recruitment mechanism of cytotoxicity
2001
Costimulatory regulation of T cell function
1999 StandoutNobel
Dendritic cells and the control of immunity
1998 StandoutNatureNobel
Solution structures of micelle-bound amyloid β-(1-40) and β-(1-42) peptides of Alzheimer’s disease 1 1Edited by P. E. Wright
1999
Cytotoxic T Lymphocyte Antigen-4 Accumulation in the Immunological Synapse Is Regulated by TCR Signal Strength
2002 StandoutNobel
MHC-dependent antigen processing and peptide presentation: Providing ligands for T lymphocyte activation
1994
Neurotoxicity of Alzheimer's disease Aβ peptides is induced by small changes in the Aβ42 to Aβ40 ratio
2010
Docosahexaenoic Acid Protects from Dendritic Pathology in an Alzheimer's Disease Mouse Model
2004
Small Molecule Inhibitors of Aggregation Indicate That Amyloid β Oligomerization and Fibrillization Pathways Are Independent and Distinct
2007
Aβ Oligomers Cause Localized Ca 2+ Elevation, Missorting of Endogenous Tau into Dendrites, Tau Phosphorylation, and Destruction of Microtubules and Spines
2010
Transient accumulation of new class II MHC molecules in a novel endocytic compartment in B lymphocytes
1994 Nature
Inferences, questions and possibilities in Toll-like receptor signalling
2004 StandoutNatureNobel
Pathways towards and away from Alzheimer's disease
2004 StandoutNature
Endosomal proteolysis and MHC class II function
1998
Molecular Mechanisms of Amyloidosis
2003 Standout
A novelβ‐sheet breaker, RS‐0406, reverses amyloidβ‐induced cytotoxicity and impairment of long‐term potentiationin vitro
2002
Elucidation of Primary Structure Elements Controlling Early Amyloid β-Protein Oligomerization
2003
Alzheimer's disease-type neuronal tau hyperphosphorylation induced by Aβ oligomers
2007
Photoconductance and inverse photoconductance in films of functionalized metal nanoparticles
2009 StandoutNatureNobel
Translating cell biology into therapeutic advances in Alzheimer's disease
1999 Nature
Amyloid-β/Fyn–Induced Synaptic, Network, and Cognitive Impairments Depend on Tau Levels in Multiple Mouse Models of Alzheimer's Disease
2011
Effects of secreted oligomers of amyloid β‐protein on hippocampal synaptic plasticity: a potent role for trimers
2006
Protofibrillar Intermediates of Amyloid β-Protein Induce Acute Electrophysiological Changes and Progressive Neurotoxicity in Cortical Neurons
1999
Fractionation and characterization of oligomeric, protofibrillar and fibrillar forms of β-amyloid peptide
2000
Protofibrillar intermediates of amyloid beta-protein induce acute electrophysiological changes and progressive neurotoxicity in cortical neurons.
1999
Dendritic cell progenitors phagocytose particulates, including bacillus Calmette-Guerin organisms, and sensitize mice to mycobacterial antigens in vivo.
1993
Alzheimer's disease-affected brain: Presence of oligomeric Aβ ligands (ADDLs) suggests a molecular basis for reversible memory loss
2003
Exogenous Induction of Cerebral ß-Amyloidogenesis Is Governed by Agent and Host
2006 Science
Alzheimer Disease: Mechanistic Understanding Predicts Novel Therapies
2004
The Amyloid Hypothesis of Alzheimer's Disease: Progress and Problems on the Road to Therapeutics
2002 StandoutScience
PROTOFIBRILS , PORES , FIBRILS, AND NEURODEGENERATION : Separating the Responsible Protein Aggregates from The Innocent Bystanders
2003
Reorganization of multivesicular bodies regulates MHC class II antigen presentation by dendritic cells
2001
Rbx1, a Component of the VHL Tumor Suppressor Complex and SCF Ubiquitin Ligase
1999 StandoutScienceNobel
Rapid Tyrosine Phosphorylation of Neuronal Proteins Including Tau and Focal Adhesion Kinase in Response to Amyloid-β Peptide Exposure: Involvement of Src Family Protein Kinases
2002
Viral Superantigen Drives Extrafollicular and Follicular B Cell Differentiation Leading to Virus-specific Antibody Production
1997
3D structure of Alzheimer's amyloid-β(1–42) fibrils
2005 Standout
Use-Dependent Effects of Amyloidogenic Fragments of β-Amyloid Precursor Protein on Synaptic Plasticity in Rat HippocampusIn Vivo
2001
Spherical aggregates of β-amyloid (amylospheroid) show high neurotoxicity and activate tau protein kinase I/glycogen synthase kinase-3β
2003
Copper Homeostasis and Neurodegenerative Disorders (Alzheimer's, Prion, and Parkinson's Diseases and Amyotrophic Lateral Sclerosis)
2006 Standout
Identification of a motif for HLA-DR1 binding peptides using M13 display libraries.
1992
De novo design of protein homo-oligomers with modular hydrogen-bond network–mediated specificity
2016 StandoutScienceNobel
Large Protein Fragments as Substrates for Endocytic Antigen Capture by MHC Class II Molecules
1998
Specificity and promiscuity among naturally processed peptides bound to HLA-DR alleles.
1993
Localized Surface Plasmon Resonance Spectroscopy and Sensing
2006 Standout
Major Histocompatibility Complex Class II Compartments in Human and Mouse B Lymphoblasts Represent Conventional Endocytic Compartments
1997
Characterization of Chemical Exchange between Soluble and Aggregated States of β-Amyloid by Solution-State NMR upon Variation of Salt Conditions
2005
Alzheimer's Disease: Genes, Proteins, and Therapy
2001 Standout
Identification of the naturally processed form of hen egg white lysozyme bound to the murine major histocompatibility complex class II molecule I-Ak.
1992
Emerging Principles for the Recognition of Peptide Antigens by MHC Class I Molecules
1992 Science
A monoclonal antibody against synthetic Aβ dimer assemblies neutralizes brain‐derived synaptic plasticity‐disrupting Aβ
2011
TCR, LFA-1, and CD28 Play Unique and Complementary Roles in Signaling T Cell Cytoskeletal Reorganization
1999
Assembly, Transport, and Function of MHC Class II Molecules
1994
Alzheimer's Disease Is a Synaptic Failure
2002 StandoutScience
Cystatin C reduces thein vitroformation of soluble Aβ1‐42 oligomers and protofibrils
2006
Transport of Peptide-MHC Class II Complexes in Developing Dendritic Cells
2000 StandoutScienceNobel
Small Molecule Microarrays Enable the Discovery of Compounds That Bind the Alzheimer’s Aβ Peptide and Reduce its Cytotoxicity
2010
Alzheimer's Disease: Molecular Understanding Predicts Amyloid-Based Therapeutics
2003
Evolution of amyloid: What normal protein folding may tell us about fibrillogenesis and disease
1999
Laminin inhibits both Aβ40 and Aβ42 fibril formation but does not affect Aβ40 or Aβ42-induced cytotoxicity in PC12 cells
1999
Separation of subcellular compartments containing distinct functional forms of MHC class II.
1994
Plaque-independent disruption of neural circuits in Alzheimer’s disease mouse models
1999
CTLA-4-Mediated Inhibition in Regulation of T Cell Responses: Mechanisms and Manipulation in Tumor Immunotherapy
2001 StandoutNobel
Proteases and Proteolysis in Alzheimer Disease: A Multifactorial View on the Disease Process
2010
Receptor-Mediated Uptake of Antigen/Heat Shock Protein Complexes Results in Major Histocompatibility Complex Class I Antigen Presentation via Two Distinct Processing Pathways
1999 StandoutNobel
High-Level Neuronal Expression of Aβ1–42in Wild-Type Human Amyloid Protein Precursor Transgenic Mice: Synaptotoxicity without Plaque Formation
2000 Standout
N-Methylated Peptide Inhibitors of β-Amyloid Aggregation and Toxicity. Optimization of the Inhibitor Structure
2006
Inositol Stereoisomers Stabilize an Oligomeric Aggregate of Alzheimer Amyloid β Peptide and Inhibit Aβ-induced Toxicity
2000
Common structure and toxic function of amyloid oligomers implies a common mechanism of pathogenesis
2006
An approach to correlate tandem mass spectral data of peptides with amino acid sequences in a protein database
1994 Standout
Acceleration of oligomerization, not fibrillization, is a shared property of both α-synuclein mutations linked to early-onset Parkinson's disease: Implications for pathogenesis and therapy
2000
Imaging Distinct Conformational States of Amyloid-β Fibrils in Alzheimer’s Disease Using Novel Luminescent Probes
2007
Common Structure of Soluble Amyloid Oligomers Implies Common Mechanism of Pathogenesis
2003 StandoutScience
The Development of Amyloid β Protein Deposits in the Aged Brain
2006
Peptides Presented to the Immune System by the Murine Class II Major Histocompatibility Complex Molecule I-A d
1992 Science
Protein Kinase C-θ Participates in NF-κB Activation Induced by CD3-CD28 Costimulation through Selective Activation of IκB Kinase β
2000
THE UBIQUITIN SYSTEM
1998 StandoutNobel
Truncation variants of peptides isolated from MHC class II molecules suggest sequence motifs
1992 Nature
Self-Assembly of β-Amyloid 42 Is Retarded by Small Molecular Ligands at the Stage of Structural Intermediates
2000 StandoutNobel
Nonproliferating Bystander CD4+ T Cells Lacking Activation Markers Support HIV Replication During Immune Activation
2001 StandoutNobel
Amyloid β-protein (Aβ) assembly: Aβ40 and Aβ42 oligomerize through distinct pathways
2002
Efficient loading of identical viral peptide onto class II molecules by antigenized immunoglobulin and influenza virus.
1993 StandoutNobel
Involvement of PD-L1 on tumor cells in the escape from host immune system and tumor immunotherapy by PD-L1 blockade
2002 StandoutNobel
Amyloid β42Activates a G-Protein-Coupled Chemoattractant Receptor, FPR-Like-1
2001
Molecular basis for amyloid-β polymorphism
2011
On the complexity of self
1991 Nature
Invariant chain cleavage and peptide loading in major histocompatibility complex class II vesicles.
1995
CELL BIOLOGY OF ANTIGEN PROCESSING IN VITRO AND IN VIVO
2005
Works of Avlin Barlow being referenced
Direct physical interaction involving CD40 ligand on T cells and CD40 on B cells is required to propagate MMTV
1995
Selective modulation of protein kinase C-Θ during T-cell activation
1997 Nature
On the intrathymic intercellular transfer of self-determinants
1999
Sequence analysis of peptides bound to MHC class II molecules
1991 Nature
Diffusible, nonfibrillar ligands derived from Aβ 1–42 are potent central nervous system neurotoxins
1998 Standout