Citation Impact
Citing Papers
ShinyGO: a graphical gene-set enrichment tool for animals and plants
2019 Standout
C2c2 is a single-component programmable RNA-guided RNA-targeting CRISPR effector
2016 StandoutScience
Measuring error rates in genomic perturbation screens: gold standards for human functional genomics
2014
Crippling life support for SARS-CoV-2 and other viruses through synthetic lethality
2020 StandoutNobel
Co-incidence of RCC-susceptibility polymorphisms with HIF cis-acting sequences supports a pathway tuning model of cancer
2019 StandoutNobel
Itraconazole and Arsenic Trioxide Inhibit Hedgehog Pathway Activation and Tumor Growth Associated with Acquired Resistance to Smoothened Antagonists
2013
Regulation of Cellular Senescence by Polycomb Chromatin Modifiers through Distinct DNA Damage- and Histone Methylation-Dependent Pathways
2018
Pan-cancer patterns of somatic copy number alteration
2013
The promise and challenge of therapeutic genome editing
2020 StandoutNatureNobel
TP53 loss creates therapeutic vulnerability in colorectal cancer
2015 Nature
High-Resolution CRISPR Screens Reveal Fitness Genes and Genotype-Specific Cancer Liabilities
2015
Viral Packaging and Cell Culture for CRISPR-Based Screens
2016
A view on drug resistance in cancer
2019 StandoutNature
Genetic effects on gene expression across human tissues
2017 StandoutNature
Medulloblastomics: the end of the beginning
2012
Cell cycle proteins as promising targets in cancer therapy
2017 Standout
RIG-I-like receptors: their regulation and roles in RNA sensing
2020
Molecular subgroups of medulloblastoma
2012
Mutant p53 induces a hypoxia transcriptional program in gastric and esophageal adenocarcinoma
2019 StandoutNobel
Regulation and Functions of the ER-Associated Nrf1 Transcription Factor
2022 StandoutNobel
Am I ready for CRISPR? A user's guide to genetic screens
2017
The evolving landscape of biomarkers for checkpoint inhibitor immunotherapy
2019 Standout
Genetic interaction networks in cancer cells
2019
A CRISPR–dCas Toolbox for Genetic Engineering and Synthetic Biology
2018
The Many Roles of BAF (mSWI/SNF) and PBAF Complexes in Cancer
2016
Clonal Heterogeneity and Tumor Evolution: Past, Present, and the Future
2017 Standout
A genome-wide CRISPR screen identifies a restricted set of HIV host dependency factors
2016
The Molecular Signatures Database Hallmark Gene Set Collection
2015 Standout
Functional Genomic Landscape of Human Breast Cancer Drivers, Vulnerabilities, and Resistance
2016
CRISPR–Cas9 genome engineering of primary CD4+ T cells for the interrogation of HIV–host factor interactions
2018 StandoutNobel
The mini-driver model of polygenic cancer evolution
2015 StandoutNobel
The Human Transcription Factors
2018 Standout
Hepatocellular carcinoma
2021 Standout
Global Genetic Networks and the Genotype-to-Phenotype Relationship
2019
Hacking the Cancer Genome: Profiling Therapeutically Actionable Long Non-coding RNAs Using CRISPR-Cas9 Screening
2019
The Cancer Genome Atlas Pan-Cancer analysis project
2013 Standout
Genetic screens in isogenic mammalian cell lines without single cell cloning
2020
In vivo CRISPR screening identifies Ptpn2 as a cancer immunotherapy target
2017 Nature
Identification of Druggable Cancer Driver Genes Amplified across TCGA Datasets
2014
Local and systemic mechanisms linking periodontal disease and inflammatory comorbidities
2021 Standout
The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary
2016 Standout
Molecular subgroups of medulloblastoma: the current consensus
2011
Medulloblastomics revisited: biological and clinical insights from thousands of patients
2019
Cellular senescence in ageing: from mechanisms to therapeutic opportunities
2020 Standout
Mechanisms of NAFLD development and therapeutic strategies
2018 Standout
From Krebs to clinic: glutamine metabolism to cancer therapy
2016 Standout
Optimized sgRNA design to maximize activity and minimize off-target effects of CRISPR-Cas9
2016 Standout
Synthetic lethality as an engine for cancer drug target discovery
2019
Immune Checkpoint Targeting in Cancer Therapy: Toward Combination Strategies with Curative Potential
2015 StandoutNobel
High-Throughput Approaches to Pinpoint Function within the Noncoding Genome
2017
Using Big Data to Discover Diagnostics and Therapeutics for Gastrointestinal and Liver Diseases
2016
Functional interrogation of a SARS-CoV-2 host protein interactome identifies unique and shared coronavirus host factors
2020 StandoutNobel
Implementing Genome-Driven Oncology
2017
Stable RNA interference rules for silencing
2013
The Cancer Cell Map Initiative: Defining the Hallmark Networks of Cancer
2015
On the Dependency of Cellular Protein Levels on mRNA Abundance
2016 Standout
Unraveling the therapeutic potential of the Hedgehog pathway in cancer
2013 Standout
Histological variants of medulloblastoma are the most powerful clinical prognostic indicators
2012
Regulation and Function of the PD-L1 Checkpoint
2018 Standout
Genome-Wide CRISPR/Cas9 Screening for Identification of Cancer Genes in Cell Lines
2018
Genome editing with CRISPR–Cas nucleases, base editors, transposases and prime editors
2020 Standout
Single-cell landscape of bronchoalveolar immune cells in patients with COVID-19
2020 Standout
PROTAC targeted protein degraders: the past is prologue
2022 Standout
Applications of CRISPR technologies in research and beyond
2016 StandoutNobel
Strategies and challenges for the next generation of antibody–drug conjugates
2017 Standout
Novel molecular subgroups for clinical classification and outcome prediction in childhood medulloblastoma: a cohort study
2017
Myeloid cell contributions to cardiovascular health and disease
2018
Synthetic lethal therapies for cancer: what’s next after PARP inhibitors?
2018
Medulloblastoma: clinicopathological correlates of SHH, WNT, and non-SHH/WNT molecular subgroups
2011
Gene Copy-Number Alterations: A Cost-Benefit Analysis
2013
The PI3K Pathway in Human Disease
2017 Standout
Cornerstones of CRISPR–Cas in drug discovery and therapy
2016 StandoutNobel
Discovery and saturation analysis of cancer genes across 21 tumour types
2014 StandoutNature
Proteasome machinery is instrumental in a common gain-of-function program of the p53 missense mutants in cancer
2016
Cancer therapies based on targeted protein degradation — lessons learned with lenalidomide
2021
Gene regulation by long non-coding RNAs and its biological functions
2020 Standout
Biomedical applications of copper ionophores
2020
Emerging Opportunities To Manipulate Metal Trafficking for Therapeutic Benefit
2019
The 2021 WHO Classification of Tumors of the Central Nervous System: a summary
2021 Standout
CBTRUS Statistical Report: Primary Brain and Central Nervous System Tumors Diagnosed in the United States in 2006-2010
2013 Standout
Inhibition of BRD4 attenuates tumor cell self-renewal and suppresses stem cell signaling in MYC driven medulloblastoma
2014
CRISPRi and CRISPRa Screens in Mammalian Cells for Precision Biology and Medicine
2017
Medulloblastoma genomics in the modern molecular era
2019
FIREWORKS: a bottom-up approach to integrative coessentiality network analysis
2020
The Caenorhabditis elegans ARIP-4 DNA helicase couples mitochondrial surveillance to immune, detoxification, and antiviral pathways
2022 StandoutNobel
O-GlcNAcylation Signal Mediates Proteasome Inhibitor Resistance in Cancer Cells by Stabilizing NRF1
2018
Copper induces cell death by targeting lipoylated TCA cycle proteins
2022 StandoutScience
High Frequency of Germline SUFU Mutations in Children With Desmoplastic/Nodular Medulloblastoma Younger Than 3 Years of Age
2012
Cas9 interrogates DNA in discrete steps modulated by mismatches and supercoiling
2020 StandoutNobel
CRISPR-Cas guides the future of genetic engineering
2018 StandoutScienceNobel
UbiHub: a data hub for the explorers of ubiquitination pathways
2018
CRISPOR: intuitive guide selection for CRISPR/Cas9 genome editing experiments and screens
2018 Standout
Cancer immunotherapy using checkpoint blockade
2018 StandoutScience
Accurate proteome-wide missense variant effect prediction with AlphaMissense
2023 StandoutScienceNobel
Works of Aviad Tsherniak being referenced
Identification of an “Exceptional Responder” Cell Line to MEK1 Inhibition: Clinical Implications for MEK-Targeted Therapy
2015
Genome-Wide Interrogation of Human Cancers Identifies EGLN1 Dependency in Clear Cell Ovarian Cancers
2019
Integrated cross-study datasets of genetic dependencies in cancer
2021
Complementary information derived from CRISPR Cas9 mediated gene deletion and suppression
2017
Improved estimation of cancer dependencies from large-scale RNAi screens using model-based normalization and data integration
2018
SWI/SNF-mutant cancers depend on catalytic and non-catalytic activity of EZH2
2015
ATARiS: Computational quantification of gene suppression phenotypes from multisample RNAi screens
2012
Functional Genomic Characterization of Cancer Genomes
2016
Cancer Vulnerabilities Unveiled by Genomic Loss
2012
Identification of ADAR1 adenosine deaminase dependency in a subset of cancer cells
2018
Mitochondrial metabolism promotes adaptation to proteotoxic stress
2019
Multiplex CRISPR/Cas9-Based Genome Editing in Human Hematopoietic Stem Cells Models Clonal Hematopoiesis and Myeloid Neoplasia
2017
Interrogation of Mammalian Protein Complex Structure, Function, and Membership Using Genome-Scale Fitness Screens
2018
Integrative Genomic Analysis of Medulloblastoma Identifies a Molecular Subgroup That Drives Poor Clinical Outcome
2010
Predicting Relapse in Patients With Medulloblastoma by Integrating Evidence From Clinical and Genomic Features
2011
Functional, chemical genomic, and super-enhancer screening identify sensitivity to cyclin D1/CDK4 pathway inhibition in Ewing sarcoma
2015