Standout Papers
- Architecture of RNA Polymerase II and Implications for the Transcription Mechanism (2000)
- Yeast RNA Polymerase II at 5 Å Resolution (1999)
- Evidence for a mediator cycle at the initiation of transcription (1997)
- Formation and Crystallization of Yeast RNA Polymerase II Elongation Complexes (1997)
- Repeated tertiary fold of RNA polymerase II and implications for DNA binding (1998)
- Electron Crystal Structure of an RNA Polymerase II Transcription Elongation Complex (1999)
- Structural Basis of Transcription: An RNA Polymerase II Elongation Complex at 3.3 Å Resolution (2001)
Citation Impact
Citing Papers
Role of Mitochondrial RNA Polymerase in the Toxicity of Nucleotide Inhibitors of Hepatitis C Virus
2015
Structures of Cas9 Endonucleases Reveal RNA-Mediated Conformational Activation
2014 StandoutScienceNobel
Protein characterization of Saccharomyces cerevisiae RNA polymerase II after in vivo cross-linking
2007 StandoutNobel
Structures of a CRISPR-Cas9 R-loop complex primed for DNA cleavage
2016 StandoutScienceNobel
Structural Basis of Transcription Initiation: RNA Polymerase Holoenzyme at 4 Å Resolution
2002 Science
Structural Basis of Transcription: Backtracked RNA Polymerase II at 3.4 Angstrom Resolution
2009 StandoutScienceNobel
Schizosacharomyces pombe RNA polymerase II at 3.6-Å resolution
2009 Nobel
RNA polymerase II trigger loop residues stabilize and position the incoming nucleotide triphosphate in transcription
2010 StandoutNobel
Mouse models of acute and chronic hepacivirus infection
2017 StandoutScienceNobel
AID Enzyme-Induced Hypermutation in an Actively Transcribed Gene in Fibroblasts
2002 StandoutScienceNobel
Donation of catalytic residues to RNA polymerase active center by transcription factor Gre
2003
Hierarchical design of pseudosymmetric protein nanocages
2024 StandoutNatureNobel
Structures of the RNA-guided surveillance complex from a bacterial immune system
2011 StandoutNatureNobel
Structural insight into the TFIIE–TFIIH interaction: TFIIE and p53 share the binding region on TFIIH
2008
Discrimination against Deoxyribonucleotide Substrates by Bacterial RNA Polymerase
2004
Tuning in to Interference: R-Loops and Cascade Complexes in CRISPR Immunity
2012
Structural Basis of Transcription
2004 StandoutNobel
The role of TFIIB-RNA polymerase II interaction in start site selection in yeast cells
2002
Architecture of the RNA Polymerase II-TFIIS Complex and Implications for mRNA Cleavage
2003
Deletion of the RNA Polymerase Subunit RPB4 Acts as a Global, Not Stress-specific, Shut-off Switch for RNA Polymerase II Transcription at High Temperatures
2001
The Med proteins of yeast and their function through the RNA polymerase II carboxy-terminal domain
1998 StandoutNobel
Structural Basis of Transcription: Role of the Trigger Loop in Substrate Specificity and Catalysis
2006 StandoutNobel
SEC14L2 enables pan-genotype HCV replication in cell culture
2015 StandoutNatureNobel
Forward Translocation Is the Natural Pathway of RNA Release at an Intrinsic Terminator
2004
Structures of Complete RNA Polymerase II and Its Subcomplex, Rpb4/7
2005
Functional Interplay between the Jaw Domain of Bacterial RNA Polymerase and Allele-specific Residues in the Product RNA-binding Pocket
2005
Structural basis for substrate loading in bacterial RNA polymerase
2007 Nature
Unravelling hepatitis C virus replication from genome to function
2005 StandoutNatureNobel
Crystal structure of a bacterial RNA polymerase holoenzyme at 2.6 Å resolution
2002 Nature
Visualizing polynucleotide polymerase machines at work
2006 StandoutNobel
Transcript cleavage factors GreA and GreB act as transient catalytic components of RNA polymerase
2003
Structural basis for transcription elongation by bacterial RNA polymerase
2007 Nature
Mapping the Location of TFIIB within the RNA Polymerase II Transcription Preinitiation Complex
2004
Crystallization and preliminary crystallographic analysis of T7 RNA polymerase elongation complex
2002
Binding of TFIIB to RNA Polymerase II
2003
Crystal Structure of Thermus aquaticus Core RNA Polymerase at 3.3 Å Resolution
1999
RNA Polymerase II Subunit Rpb9 Regulates Transcription Elongation in Vivo
2000
Downstream DNA Selectively Affects a Paused Conformation of Human RNA Polymerase II
2004
Direct Interaction between the Subunit RAP30 of Transcription Factor IIF (TFIIF) and RNA Polymerase Subunit 5, Which Contributes to the Association between TFIIF and RNA Polymerase II
2001
Structure-activity relationship analysis of mitochondrial toxicity caused by antiviral ribonucleoside analogs
2017
Structural visualization of key steps in human transcription initiation
2013 Nature
The Role of the Transcription Bubble and TFIIB in Promoter Clearance by RNA Polymerase II
2005
A transcription reinitiation intermediate that is stabilized by activator
2000 Nature
Mechanism and Regulation of Yeast RNA Polymerase II Transcription
1998 StandoutNobel
Transcriptional activation independent of TFIIH kinase and the RNA polymerase II mediator in vivo
1998 Nature
The RNA Polymerase II Machinery
2002
The AID enzyme induces class switch recombination in fibroblasts
2002 StandoutNatureNobel
RNA polymerase II–TFIIB structure and mechanism of transcription initiation
2009 Nature
Structure and activity of the Cas3 HD nuclease MJ0384, an effector enzyme of the CRISPR interference
2011
Unified two-metal mechanism of RNA synthesis and degradation by RNA polymerase
2003
Bacterial RNA polymerase
2001
The CRISPR-associated DNA-cleaving enzyme Cpf1 also processes precursor CRISPR RNA
2016 StandoutNatureNobel
The 8-Nucleotide-long RNA:DNA Hybrid Is a Primary Stability Determinant of the RNA Polymerase II Elongation Complex
2000
Crystal Structure of the Processivity Clamp Loader Gamma (γ) Complex of E. coli DNA Polymerase III
2001
The structural basis of the transition from initiation to elongation phases of transcription, as well as translocation and strand separation, by T7 RNA polymerase
2004 StandoutNobel
Promoting elongation with transcript cleavage stimulatory factors
2002
Common structural features of nucleic acid polymerases
2002
Structures of phi29 DNA polymerase complexed with substrate: the mechanism of translocation in B‐family polymerases
2007 StandoutNobel
Structure of the Yeast RNA Polymerase II Holoenzyme
2002 StandoutNobel
Structure and mechanism of the RNA polymerase II transcription machinery
2004
Major Conformational Changes Occur during the Transition from an Initiation Complex to an Elongation Complex by T7 RNA Polymerase
2002
Electron Crystal Structure of the Transcription Factor and DNA Repair Complex, Core TFIIH
2000 StandoutNobel
Structure of Yeast RNA Polymerase II in Solution
2002
Complete RNA Polymerase II Elongation Complex Structure and Its Interactions with NTP and TFIIS
2004
RNA-guided genetic silencing systems in bacteria and archaea
2012 StandoutNatureNobel
RNA Polymerase II/TFIIF Structure and Conserved Organization of the Initiation Complex
2003 StandoutNobel
Inhibition of Bacterial RNA Polymerase by Streptolydigin: Stabilization of a Straight-Bridge-Helix Active-Center Conformation
2005
Suppression of inflammation by a synthetic histone mimic
2010 StandoutNatureNobel
Structure and Function of Lineage-specific Sequence Insertions in the Bacterial RNA Polymerase β′ Subunit
2005
A diverse range of gene products are effectors of the type I interferon antiviral response
2011 StandoutNatureNobel
Head Module Control of Mediator Interactions
2006 StandoutNobel
Structural Organization of Bacterial RNA Polymerase Holoenzyme and the RNA Polymerase-Promoter Open Complex
2002
Structural basis for CRISPR RNA-guided DNA recognition by Cascade
2011 StandoutNobel
Structure of a (Cys3His) zinc ribbon, a ubiquitous motif in archaeal and eucaryal transcription
2000
Transcriptional fidelity and proofreading in Archaea and implications for the mechanism of TFS‐induced RNA cleavage
2004
Structure of human mitochondrial RNA polymerase elongation complex
2013
Structure of a T7 RNA polymerase elongation complex at 2.9 Å resolution
2002 Nature
A Central Role of the RNA Polymerase Trigger Loop in Active-Site Rearrangement during Transcriptional Pausing
2007
A computational approach for predicting off-target toxicity of antiviral ribonucleoside analogues to mitochondrial RNA polymerase
2018 StandoutNobel
The HCV Life Cycle: In vitro Tissue Culture Systems and Therapeutic Targets
2014 Standout
Bacterial RNA polymerases: the wholo story
2003
Mediator complexes and transcription
2001
A Multiprotein Complex That Interacts with RNA Polymerase II Elongator
2001 StandoutNobel
Elongation by RNA polymerase II: the short and long of it
2004
Structure of an Archaeal Homolog of the Eukaryotic RNA Polymerase II RPB4/RPB7 Complex
2001
A Ratchet Mechanism of Transcription Elongation and Its Control
2005
Understanding the hepatitis C virus life cycle paves the way for highly effective therapies
2013 StandoutNobel
Dissociable Rpb4-Rpb7 Subassembly of RNA Polymerase II Binds to Single-strand Nucleic Acid and Mediates a Post-recruitment Step in Transcription Initiation
2001
Antibacterial Peptide Microcin J25 Inhibits Transcription by Binding within and Obstructing the RNA Polymerase Secondary Channel
2004
The Structural Mechanism of Translocation and Helicase Activity in T7 RNA Polymerase
2004 StandoutNobel
Structural Basis for Substrate Selection by T7 RNA Polymerase
2004
Structure and Function of the Transcription Elongation Factor GreB Bound to Bacterial RNA Polymerase
2003
The RNA Polymerase II Trigger Loop Functions in Substrate Selection and Is Directly Targeted by α-Amanitin
2008 Nobel
Selenomethionine Incorporation in Saccharomyces cerevisiae RNA Polymerase II
2001 StandoutNobel
Swing-Gate Model of Nucleotide Entry into the RNA Polymerase Active Center
2002
A movie of the RNA polymerase nucleotide addition cycle
2009
The Med1 subunit of the yeast mediator complex is involved in both transcriptional activation and repression
1999
Architecture of an RNA Polymerase II Transcription Pre-Initiation Complex
2013 StandoutScienceNobel
Initiation of viral RNA-dependent RNA polymerization
2004
The Structure of a Transcribing T7 RNA Polymerase in Transition from Initiation to Elongation
2008 StandoutScienceNobel
Activation mutants in yeast RNA polymerase II subunit RPB3 provide evidence for a structurally conserved surface required for activation in eukaryotes and bacteria
2000
Diffusion of nucleoside triphosphates and role of the entry site to the RNA polymerase II active center
2004 StandoutNobel
Structural basis of transcription: α-Amanitin–RNA polymerase II cocrystal at 2.8 Å resolution
2002 StandoutNobel
Engines of gene expression
2000
Structural Basis of Transcription: Separation of RNA from DNA by RNA Polymerase II
2004 StandoutScienceNobel
Structures of the CRISPR-Cmr complex reveal mode of RNA target positioning
2015 StandoutScienceNobel
Photo-Cross-Linking of a Purified Preinitiation Complex Reveals Central Roles for the RNA Polymerase II Mobile Clamp and TFIIE in Initiation Mechanisms
2004
Molecular Mechanism of Class Switch Recombination: Linkage with Somatic Hypermutation
2002 StandoutNobel
Architecture of initiation-competent 12-subunit RNA polymerase II
2003
Simulations of RNA base pairs in a nanodroplet reveal solvation-dependent stability
2007 StandoutNobel
The RNA Polymerase II Elongation Complex
2003
Structural Confirmation of a Bent and Open Model for the Initiation Complex of T7 RNA Polymerase
2007
The molecular basis of eukaryotic transcription
2007 Nobel
Conserved Structures of Mediator and RNA Polymerase II Holoenzyme
1999 StandoutScienceNobel
Structural Basis for Transcription Regulation by Alarmone ppGpp
2004
Multiple Mechanisms of Suppression Circumvent Transcription Defects in an RNA Polymerase Mutant
2000
Structural Perspective on Mutations Affecting the Function of Multisubunit RNA Polymerases
2006
Structure of Eukaryotic RNA Polymerases
2008
TRANSCRIPTION OF EUKARYOTIC PROTEIN-CODING GENES
2000
Structural basis of transcription inhibition by α-amanitin and implications for RNA polymerase II translocation
2008
Mediator of Transcriptional Regulation
2000 StandoutNobel
Complete, 12-subunit RNA polymerase II at 4.1-Å resolution: Implications for the initiation of transcription
2003 StandoutNobel
RNA polymerase II subunit Rpb9 is important for transcriptional fidelity in vivo
2006
Opening and Closing of the Bacterial RNA Polymerase Clamp
2012 Science
Structure of an RNA Polymerase II–TFIIB Complex and the Transcription Initiation Mechanism
2009 ScienceNobel
The A14–A43 heterodimer subunit in yeast RNA pol I and their relationship to Rpb4–Rpb7 pol II subunits
2002
Structural Basis for the Transition from Initiation to Elongation Transcription in T7 RNA Polymerase
2002 StandoutScienceNobel
Structural Basis of Transcription: An RNA Polymerase II-TFIIB Cocrystal at 4.5 Angstroms
2004 StandoutScienceNobel
The initiation–elongation transition: Lateral mobility of RNA in RNA polymerase II complexes is greatly reduced at +8/+9 and absent by +23
2003
Structural Basis of Transcription: RNA Polymerase II at 2.8 Ångstrom Resolution
2001 StandoutScienceNobel
Bacterial RNA polymerase subunit ω and eukaryotic RNA polymerase subunit RPB6 are sequence, structural, and functional homologs and promote RNA polymerase assembly
2001
Structure-based analysis of RNA polymerase function: the largest subunit's rudder contributes critically to elongation complex stability and is not involved in the maintenance of RNA-DNA hybrid length
2002
Association of the Mediator complex with enhancers of active genes
2003 StandoutNobel
Works of Averell Gnatt being referenced
Sensitivity of Mitochondrial Transcription and Resistance of RNA Polymerase II Dependent Nuclear Transcription to Antiviral Ribonucleosides
2012
Elongation by RNA polymerase II: structure–function relationship
2002
Yeast RNA Polymerase II at 5 Å Resolution
1999 StandoutNobel
Formation and Crystallization of Yeast RNA Polymerase II Elongation Complexes
1997 StandoutNobel
Electron Crystal Structure of an RNA Polymerase II Transcription Elongation Complex
1999 StandoutNobel
Structural Basis of Transcription: An RNA Polymerase II Elongation Complex at 3.3 Å Resolution
2001 StandoutScienceNobel
Evidence for a mediator cycle at the initiation of transcription
1997 StandoutNobel
Architecture of RNA Polymerase II and Implications for the Transcription Mechanism
2000 StandoutScienceNobel