Standout Papers
Citation Impact
Citing Papers
Targeting of Diacylglycerol Degradation to M1 Muscarinic Receptors by ß-Arrestins
2007 StandoutScienceNobel
Piezo1 and Piezo2 Are Essential Components of Distinct Mechanically Activated Cation Channels
2010 StandoutScienceNobel
The coupling of α 6 β 4 integrin to Ras-MAP kinase pathways mediated by Shc controls keratinocyte proliferation
1997
Regulation and composition of activator protein 1 (AP-1) transcription factors controlling collagenase and c-Jun promoter activities
2001
Structural basis for the interaction of Ras with RaIGDS
1998
MAPKs: new JNK expands the group
1994
Parallel signal processing among mammalian MAPKs
1995
Rac1 Activity Is Required for the Activation of Hypoxia-inducible Factor 1
2001 StandoutNobel
Cloning and Characterization of a Human STE20-like Protein Kinase with Unusual Cofactor Requirements
1997
AP-1 function and regulation
1997 Standout
Activation of Jun Kinase/Stress-activated Protein Kinase by GTPase-deficient Mutants of Gα12 and Gα13
1995
PD 098059 Is a Specific Inhibitor of the Activation of Mitogen-activated Protein Kinase Kinase in Vitro and in Vivo
1995 Standout
Membrane targeting of the nucleotide exchange factor Sos is sufficient for activating the Ras signaling pathway
1994
Dissection of TNF Receptor 1 Effector Functions: JNK Activation Is Not Linked to Apoptosis While NF-κB Activation Prevents Cell Death
1996 Standout
Signaling by proinflammatory cytokines: oligomerization of TRAF2 and TRAF6 is sufficient for JNK and IKK activation and target gene induction via an amino-terminal effector domain
1999
Protection from reoxygenation injury by inhibition of rac1.
1998
Sphingosine 1-Phosphate Rapidly Activates the Mitogen-activated Protein Kinase Pathway by a G Protein-dependent Mechanism
1995
Ternary complex factors: growth factor regulated transcriptional activators
1994
Stress-signalling kinase Sek1 protects thymocytes from apoptosis mediated by CD95 and CD3
1997 Nature
Regulation of transcription by MAP kinase cascades
1996
Signal Transduction by the JNK Group of MAP Kinases
2000 Standout
Calcium's Role in Mechanotransduction during Muscle Development
2014 Standout
Role of ERas in promoting tumour-like properties in mouse embryonic stem cells
2003 StandoutNatureNobel
M-Ras/R-Ras3, a Transforming Ras Protein Regulated by Sos1, GRF1, and p120 Ras GTPase-activating Protein, Interacts with the Putative Ras Effector AF6
1999
Specificity of receptor tyrosine kinase signaling: Transient versus sustained extracellular signal-regulated kinase activation
1995 Standout
Sounding the Alarm: Protein Kinase Cascades Activated by Stress and Inflammation
1996
Unravelling hepatitis C virus replication from genome to function
2005 StandoutNatureNobel
MAP kinase- and Rho-dependent signals interact to regulate gene expression but not actin morphology in cardiac muscle cells
1997
c-Jun regulates cell cycle progression and apoptosis by distinct mechanisms
1999
Cdc42 and Rac1 induce integrin-mediated cell motility and invasiveness through PI(3)K
1997 Nature
Role of MEKK1 in Cell Survival and Activation of JNK and ERK Pathways Defined by Targeted Gene Disruption
1998
Structure at 1.65 Å of RhoA and its GTPase-activating protein in complex with a transition-state analogue
1997 Nature
JNK1: A protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain
1994 Standout
The 70 kDa S6 Kinase Complexes with and Is Activated by the Rho Family G Proteins Cdc42 and Rac1
1996
A phosphatidylinositol-3-OH kinase family member regulating longevity and diapause in Caenorhabditis elegans
1996 StandoutNatureNobel
Regulatory T Cells and Immune Tolerance
2008 StandoutNobel
JAK2, Ras, and Raf Are Required for Activation of Extracellular Signal-regulated Kinase/Mitogen-activated Protein Kinase by Growth Hormone
1995
Inhibition of hypoxia/reoxygenation-induced apoptosis by an antisense oligonucleotide targeted to JNK1 in human kidney cells
2000
Transforming G Protein-coupled Receptors Potently Activate JNK (SAPK)
1995
Mitogen-activated protein kinase pathways
1997 Standout
Protein phosphatase 2Calpha inhibits the human stress-responsive p38 and JNK MAPK pathways
1998
Oncoprotein Networks
1997
Signal transduction by the c-Jun N-terminal kinase (JNK) — from inflammation to development
1998
Ras - a versatile cellular switch
1998
Synergistic activation of SAPK1/JNK1 by two MAP kinase kinases in vitro
1998
Dishevelled Activates JNK and Discriminates between JNK Pathways in Planar Polarity and wingless Signaling
1998
The small GTP-binding proteins Rac1 and Cdc42regulate the activity of the JNK/SAPK signaling pathway
1995 Standout
From JNK to Pay Dirt: Jun Kinases, their Biochemistry, Physiology and Clinical Importance
2005
The Hallmarks of Cancer
2000 Standout
Defective neural tube morphogenesis and altered apoptosis in the absence of both JNK1 and JNK2
1999
Transcriptional Regulation by Extracellular signals: Mechanisms and Specificity
1995
Activation of Yeast Protein Kinase C by Rho1 GTPase
1996
Pro-inflammatory Cytokines and Environmental Stress Cause p38 Mitogen-activated Protein Kinase Activation by Dual Phosphorylation on Tyrosine and Threonine
1995 Standout
A c-jun dominant negative mutant protects sympathetic neurons against programmed cell death
1995
Bcl-2 Undergoes Phosphorylation by c-Jun N-terminal Kinase/Stress-activated Protein Kinases in the Presence of the Constitutively Active GTP-binding Protein Rac1
1997
The Rho family GTPases RhoA, Racl , and CDC42Hsregulate transcriptional activation by SRF
1995
How MAP Kinases Are Regulated
1995 Standout
Visualizing the mechanical activation of Src
2005 StandoutNatureNobel
c-Fos transcriptional activity stimulated by H-Ras-activated protein kinase distinct from JNK and ERK
1994 Nature
JNKK1 organizes a MAP kinase module through specific and sequential interactions with upstream and downstream components mediated by its amino-terminal extension
1998
Crystal structure of JNK3: a kinase implicated in neuronal apoptosis
1998
p53 Is Phosphorylated in Vitro and in Vivo by an Ultraviolet Radiation-induced Protein Kinase Characteristic of the c-Jun Kinase, JNK1
1995
Requirement for ceramide-initiated SAPK/JNK signalling in stress-induced apoptosis
1996 StandoutNature
Acute hypertension activates mitogen-activated protein kinases in arterial wall.
1996
C-terminal Mutation of G Protein β Subunit Affects Differentially Extracellular Signal-regulated Kinase and c-Jun N-terminal Kinase Pathways in Human Embryonal Kidney 293 Cells
1997
The stress-activated protein kinase subfamily of c-Jun kinases
1994 StandoutNature
A protein conjugation system essential for autophagy
1998 StandoutNatureNobel
Ectopic Expression of Nonliganded Retinoic Acid Receptor β Abrogates AP-1 Activity by Selective Degradation of c-Jun in Cervical Carcinoma Cells
2004 StandoutNobel
Actin-biding Protein-280 Binds the Stress-activated Protein Kinase (SAPK) Activator SEK-1 and Is Required for Tumor Necrosis Factor-α Activation of SAPK in Melanoma Cells
1997
Altered thymic T-cell selection due to a mutation of the ZAP-70 gene causes autoimmune arthritis in mice
2003 StandoutNatureNobel
c-Jun Can Recruit JNK to Phosphorylate Dimerization Partners via Specific Docking Interactions
1996
Independent Human MAP-Kinase Signal Transduction Pathways Defined by MEK and MKK Isoforms
1995 Science
Activation of the Raf/MAP kinase cascade by the Ras-related protein TC21 is required for the TC21-mediated transformation of NIH 3T3 cells
1999
A central role for JNK in obesity and insulin resistance
2002 StandoutNature
MEKK2 gene disruption causes loss of cytokine production in response to IgE and c-Kit ligand stimulation of ES cell-derived mast cells
2000
Suppression of Integrin Activation: A Novel Function of a Ras/Raf-Initiated MAP Kinase Pathway
1997
The Regulation of AP-1 Activity by Mitogen-activated Protein Kinases
1995 Standout
Maximal activation of transcription by statl and stat3 requires both tyrosine and serine phosphorylation
1995 Standout
Regulation of c-Myc through Phosphorylation at Ser-62 and Ser-71 by c-Jun N-Terminal Kinase
1999
Extracellular Signal-Regulated Kinase and c-Jun NH2-Terminal Kinase Activities Are Continuously and Differentially Increased in Aorta of Hypertensive Rats
1997 StandoutNobel
Rho GTPases and signaling networks
1997 Standout
c-Jun N-terminal kinase is required for metalloproteinase expression and joint destruction in inflammatory arthritis
2001
Role of Phosphoinositide 3-OH Kinase in Cell Transformation and Control of the Actin Cytoskeleton by Ras
1997
Defective IL-12 production in mitogen-activated protein (MAP) kinase kinase 3(Mkk3)-deficient mice
1999
Mitogen and stress response pathways: MAP kinase cascades and phosphatase regulation in mammals and yeast
1995
The tyrosine kinase c-Abl regulates p73 in apoptotic response to cisplatin-induced DNA damage
1999 StandoutNatureNobel
Contractile Activity Stimulates the c-Jun NH2-terminal Kinase Pathway in Rat Skeletal Muscle
1997
SEK1/MKK4 Is Required for Maintenance of a Normal Peripheral Lymphoid Compartment but Not for Lymphocyte Development
1998
The 2.2 Å crystal structure of the Ras-binding domain of the serine/threonine kinase c-Raf1 in complex with RaplA and a GTP analogue
1995 Nature
Regulation of the protein kinase Raf-1 by oncogenic Ras through phosphatidylinositol 3-kinase, Cdc42/Rac and Pak
2000
Activation of the JNK pathway is important for cardiomyocyte death in response to simulated ischemia
1999
The UV response involving the ras signaling pathway and AP-1 transcription factors is conserved between yeast and mammals
1994
Tumor necrosis factor alpha -induced activation of c-jun N-terminal kinase is mediated by TRAF2
1997
Suppression of c-Myc-induced apoptosis by Ras signalling through PI(3)K and PKB
1997 Nature
Mitogenic Signaling via G Protein-Coupled Receptors
1996 StandoutNobel
Involvement of the Small GTPase Rho in Integrin-mediated Activation of Mitogen-activated Protein Kinase
1996
AP-1: One Switch for Many Signals
1999
Alternative Antigen Receptor (TCR) Signaling in T Cells Derived from ZAP-70-deficient Patients Expressing High Levels of Syk
2000
Three distinct signalling responses by murine fibroblasts to genotoxic stress
1996 Nature
Thrombin Induces Activation of p38 MAP Kinase in Human Platelets
1995
Ceramide Activates the Stress-activated Protein Kinases
1995
The Evi-1 oncoprotein inhibits c-Jun N-terminal kinase and prevents stress-induced cell death
2000
The Jnk1 and Jnk2 Protein Kinases Are Required for Regional Specific Apoptosis during Early Brain Development
1999
c-Jun NH2-terminal Kinases Target the Ubiquitination of Their Associated Transcription Factors
1997
The Mammalian UV Response
2000
Interaction between c-Rel and the Mitogen-activated Protein Kinase Kinase Kinase 1 Signaling Cascade in Mediating B Enhancer Activation
1996
Mammalian MAP kinase signalling cascades
2001 StandoutNature
The PtdIns(3,4)P2 phosphatase INPP4A is a suppressor of excitotoxic neuronal death
2010 StandoutNatureNobel
JNK2 is required for efficient T-cell activation and apoptosis but not for normal lymphocyte development
1999
A novel SAPK/JNK kinase, MKK7, stimulated by TNFalpha and cellular stresses
1997
Seven-transmembrane-spanning receptors and heart function
2002 StandoutNatureNobel
Structure of the nuclear transport complex karyopherin-β2–Ran˙GppNHp
1999 StandoutNatureNobel
Arachidonic acid induces the activation of the stress‐activated protein kinase, membrane ruffling and H2O2 production via a small GTPase Rac1
1999
New Insights into the Control of MAP Kinase Pathways
1999
Involvement of growth factor receptors in the mammalian UVC response
1994
Mixed-lineage kinase control of JNK and p38 MAPK pathways
2002
Joint damage and inflammation in c‐Jun N‐terminal kinase 2 knockout mice with passive murine collagen‐induced arthritis
2002
JNK, cytoskeletal regulator and stress response kinase? A Drosophila perspective
1999
The stress-activated protein kinase pathways
1999
The stress-activated protein kinase pathway mediates cell death following injury induced by cis-platinum, UV irradiation or heat
1996
JNK is involved in signal integration during costimulation of T lymphocytes
1994
Identification of IQGAP as a Putative Target for the Small GTPases, Cdc42 and Rac1
1996
Activation of cAMP and mitogen responsive genes relies on a common nuclear factor
1994 Nature
The MEKK-JNK Pathway Is Stimulated by α1-Adrenergic Receptor and Ras Activation and Is Associated with in Vitro and in Vivo Cardiac Hypertrophy
1997
Inferences, questions and possibilities in Toll-like receptor signalling
2004 StandoutNatureNobel
Stretch Activates Jun N-terminal Kinase/Stress-activated Protein Kinase in Vascular Smooth Muscle Cells through Mechanisms Involving Autocrine ATP Stimulation of Purinoceptors
1998
Regulation of JNK signaling by GSTp
1999
All-trans-Retinoic Acid Inhibits Jun N-terminal Kinase-dependent Signaling Pathways
1998
The c-Jun N-terminal protein kinase family of mitogen-activated protein kinases (JNK MAPKs)
2001
T Lymphocyte Activation Signals for Interleukin-2 Production Involve Activation of MKK6-p38 and MKK7-SAPK/JNK Signaling Pathways Sensitive to Cyclosporin A
1998
Activation of Stress-activated Protein Kinases/c-Jun N-terminal Protein Kinases (SAPKs/JNKs) by a Novel Mitogen-activated Protein Kinase Kinase (MKK7)
1997
Integrin-mediated Activation of MEK and Mitogen-activated Protein Kinase Is Independent of Ras
1996
DNA Damaging Agents Induce Expression of Fas Ligand and Subsequent Apoptosis in T Lymphocytes via the Activation of NF-κB and AP-1
1998
Jun N-Terminal Kinase in Rheumatoid Arthritis
1999
A JNK signal transduction pathway that mediates morphogenesis and an immune response in Drosophila.
1996
All-trans-Retinoic Acid Inhibits Jun N-Terminal Kinase by Increasing Dual-Specificity Phosphatase Activity
1999
The JNK Pathway Regulates the In Vivo Deletion of Immature CD4+CD8+ Thymocytes
1998
Tumor necrosis factor (TNF)-mediated kinase cascades: Bifurcation of Nuclear Factor-κB and c-jun N-terminal kinase (JNK/SAPK) pathways at TNF receptor-associated factor 2
1997
Integrin function: molecular hierarchies of cytoskeletal and signaling molecules.
1995
Angiotensin II Stimulates c-Jun NH2-Terminal Kinase in Cultured Cardiac Myocytes of Neonatal Rats
1997
Dynamic regulation of c-Jun N-terminal kinase activity in mouse brain by environmental stimuli
1997
The Drosophila Jun-N-terminal kinase is required for cell morphogenesis but not for DJun-dependent cell fate specification in the eye.
1996
The Stress Kinase Mitogen-Activated Protein Kinase Kinase (Mkk)7 Is a Negative Regulator of Antigen Receptor and Growth Factor Receptor–Induced Proliferation in Hematopoietic Cells
2001 StandoutNobel
Selective interaction of JNK protein kinase isoforms with transcription factors.
1996
Small GTP-Binding Proteins
2001 Standout
Defective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in Tlr4 Gene
1998 StandoutScienceNobel
Signaling in Myocardial Hypertrophy
1999
Synthesis and Function of 3-Phosphorylated Inositol Lipids
2001 Standout
Mitogen-activated protein kinase kinase 7 is an activator of the c-Jun NH 2 -terminal kinase
1997
FOCAL ADHESIONS, CONTRACTILITY, AND SIGNALING
1996 Standout
Angiotensin Blockade Inhibits Activation of Mitogen-Activated Protein Kinases in Rat Balloon-Injured Artery
1998 StandoutNobel
eIF3d is an mRNA cap-binding protein that is required for specialized translation initiation
2016 StandoutNatureNobel
Oncogenic Ras activates c-Jun via a separate pathway from the activation of extracellular signal-regulated kinases.
1994
Opposing Effects of ERK and JNK-p38 MAP Kinases on Apoptosis
1995 StandoutScience
MEK Kinase 1 (MEKK1) Transduces c-Jun NH2-terminal Kinase Activation in Response to Changes in the Microtubule Cytoskeleton
1999
Receptor-tyrosine-kinase- and Gβγ-mediated MAP kinase activation by a common signalling pathway
1995 StandoutNatureNobel
A Role for the p38 Mitogen-activated Protein Kinase Pathway in Myocardial Cell Growth, Sarcomeric Organization, and Cardiac-specific Gene Expression
1997
ATF-2 is preferentially activated by stress-activated protein kinases to mediate c-jun induction in response to genotoxic agents.
1995
Defective liver formation and liver cell apoptosis in mice lacking the stress signaling kinase SEK1/MKK4
1999
Signal transduction by tumor necrosis factor mediated by JNK protein kinases.
1994
An Essential Role for Rho, Rac, and Cdc42 GTPases in Cell Cycle Progression Through G 1
1995 Science
Mixed-Lineage Kinase 3 Delivers CD3/CD28-Derived Signals into the IκB Kinase Complex
2000
Activation of glomerular mitogen-activated protein kinases in angiotensin II-mediated hypertension.
1998 StandoutNobel
Mitogen-Activated Protein (MAP) Kinase Pathways: Regulation and Physiological Functions*
2001 Standout
Differential Activation of Cardiac c-Jun Amino-Terminal Kinase and Extracellular Signal-Regulated Kinase in Angiotensin II–Mediated Hypertension
1998 StandoutNobel
Mechanisms of DNA Excision Repair
1994 StandoutScienceNobel
Integration of MAP Kinase Signal Transduction Pathways at the Serum Response Element
1995 Science
Synergistic Interaction of MEK Kinase 2, c-Jun N-Terminal Kinase (JNK) Kinase 2, and JNK1 Results in Efficient and Specific JNK1 Activation
2000
GTPase-Deficient Gα16 and Gαq Induce PC12 Cell Differentiation and Persistent Activation of cJun NH2-Terminal Kinases
1996
Blocked Signal Transduction to the ERK and JNK Protein Kinases in Anergic CD4 + T Cells
1996 Science
Altering the specificity of signal transduction cascades: positive regulation of c-Jun transcriptional activity by protein kinase A.
1994
Ligand-Activated Retinoic Acid Receptor Inhibits AP-1 Transactivation by Disrupting c-Jun/c-Fos Dimerization
1999
The future of cloning
1999 StandoutNatureNobel
Stress-Induced Fas Ligand Expression in T Cells Is Mediated through a MEK Kinase 1-Regulated Response Element in the Fas Ligand Promoter
1998
SIGNALING TO THE ACTIN CYTOSKELETON
1998
Cellular Transformation and Malignancy Induced by ras Require c-jun
1996
Stress-Activated Protein Kinases in Cardiovascular Disease
1996
Mitogen-Activated Protein Kinases: Specific Messages from Ubiquitous Messengers
1999 Standout
β-Arrestin 2: A Receptor-Regulated MAPK Scaffold for the Activation of JNK3
2000 StandoutScienceNobel
Uses for JNK: the Many and Varied Substrates of the c-Jun N-Terminal Kinases
2006
Lack of a Role for Jun Kinase and AP-1 in Fas-Induced Apoptosis
1997
The PRK2 Kinase Is a Potential Effector Target of both Rho and Rac GTPases and Regulates Actin Cytoskeletal Organization
1997
Coupling of Stress in the ER to Activation of JNK Protein Kinases by Transmembrane Protein Kinase IRE1
2000 StandoutScience
Lipopolysaccharide Signals Activation of Tumor Necrosis Factor Biosynthesis Through the Ras/Raf-1/MEK/MAPK Pathway
1994 StandoutNobel
Induction of c-fos expression through JNK-mediated TCF/Elk-1 phosphorylation.
1995
ASK1 Is Essential for JNK/SAPK Activation by TRAF2
1998
JSAP1, a Novel Jun N-Terminal Protein Kinase (JNK)-Binding Protein That Functions as a Scaffold Factor in the JNK Signaling Pathway
1999
Transcription Factor ATF2 Regulation by the JNK Signal Transduction Pathway
1995 Science
An Osmosensing Signal Transduction Pathway in Mammalian Cells
1994 Science
The Jun Kinase 2 Isoform Is Preferentially Required for Epidermal Growth Factor-Induced Transformation of Human A549 Lung Carcinoma Cells
1999
X-CHROMOSOME INACTIVATION IN MAMMALS
1997
Structure of the VHL-ElonginC-ElonginB Complex: Implications for VHL Tumor Suppressor Function
1999 StandoutScienceNobel
Proteolytic Inactivation of MAP-Kinase-Kinase by Anthrax Lethal Factor
1998 Science
Targeted disruption of the MKK4 gene causes embryonic death, inhibition of c-Jun NH 2 -terminal kinase activation, and defects in AP-1 transcriptional activity
1997
The MKK7 Gene Encodes a Group of c-Jun NH2-Terminal Kinase Kinases
1999
Effects of exercise and insulin on mitogen-activated protein kinase signaling pathways in rat skeletal muscle
1996
Membrane Localization of Phosphatidylinositol 3-Kinase Is Sufficient To Activate Multiple Signal-Transducing Kinase Pathways
1996
Embryonic morphogenesis signaling pathway mediated by JNK targets the transcription factor JUN and the TGF-β homologuedecapentaplegic
1997
Cross-linking CD40 on B cells preferentially induces stress-activated protein kinases rather than mitogen-activated protein kinases.
1996
Regulation of c-Jun NH2-terminal Kinase ( Jnk) Gene Expression during T Cell Activation
2000
Multiple Signaling Pathways for the Activation of JNK in Mast Cells: Involvement of Bruton’s Tyrosine Kinase, Protein Kinase C, and JNK Kinases, SEK1 and MKK7
1998
TRANSCRIPTION FACTORS OF THE NFAT FAMILY:Regulation and Function
1997 Standout
Ubiquitination and Degradation of ATF2 Are Dimerization Dependent
1999
Angiotensin II Stimulates Calcium-Dependent Activation of c-Jun N-Terminal Kinase
1995
Regulation of Mitogen-Activated Protein Kinase Signaling Networks by G Protein-Coupled Receptors
2000
Identification of the Major Phosphorylation Site of the Hepatitis C Virus H Strain NS5A Protein as Serine 2321
1999 StandoutNobel
The Kaposi's sarcoma-associated herpes virus G protein-coupled receptor up-regulates vascular endothelial growth factor expression and secretion through mitogen-activated protein kinase and p38 pathways acting on hypoxia-inducible factor 1alpha.
2000
MEK kinase 1 is critically required for c-Jun N-terminal kinase activation by proinflammatory stimuli and growth factor-induced cell migration
2000
BCL-2 Is Phosphorylated and Inactivated by an ASK1/Jun N-Terminal Protein Kinase Pathway Normally Activated at G2/M
1999
Activation of phosphoinositide 3-kinase by interaction with Ras and by point mutation.
1996
Differential calcium dependence in the activation of c-Jun kinase and mitogen-activated protein kinase by muscarinic acetylcholine receptors in rat 1a cells
1995
MEKK1/JNK signaling stabilizes and activates p53
1998
Mitogenic Signaling Mediated by Oxidants in Ras-Transformed Fibroblasts
1997 Science
Mechanical stretch activates the stress‐activated protein kinase in cardiac myocytes
1996
Activation of Stress-activated Protein Kinase/c-Jun N-terminal Kinase, but Not NF-κB, by the Tumor Necrosis Factor (TNF) Receptor 1 through a TNF Receptor-associated Factor 2- and Germinal Center Kinase Related-dependent Pathway
1997
Activated MEK Stimulates Expression of AP-1 Components Independently of Phosphatidylinositol 3-Kinase (PI3-Kinase) but Requires a PI3-Kinase Signal To Stimulate DNA Synthesis
1999
Regulation of Cell Motility by Mitogen-activated Protein Kinase
1997
ATF-2 contains a phosphorylation-dependent transcriptional activation domain.
1995
Mapping of the Inducible IκB Phosphorylation Sites That Signal Its Ubiquitination and Degradation†
1996
Regulation of MAP Kinase Signaling Modules by Scaffold Proteins in Mammals
2003
Characterization of a Rac1- and RhoGDI-Associated Lipid Kinase Signaling Complex
1998
Integrating Genetic Approaches into the Discovery of Anticancer Drugs
1997 StandoutScienceNobel
Inhibition of c-Jun N-Terminal Kinase 2 Expression Suppresses Growth and Induces Apoptosis of Human Tumor Cells in a p53-Dependent Manner
2000
Function of PI3Kγ in Thymocyte Development, T Cell Activation, and Neutrophil Migration
2000 StandoutScienceNobel
Molecular Basis for Interactions of G Protein βγ Subunits with Effectors
1998 StandoutScienceNobel
Induction of Vascular Endothelial Growth Factor by Hypoxia Is Modulated by a Phosphatidylinositol 3-Kinase/Akt Signaling Pathway in Ha-ras-Transformed Cells Through a Hypoxia Inducible Factor-1 Transcriptional Element
1997
Signal Transduction and Signal Modulation by Cell Adhesion Receptors: The Role of Integrins, Cadherins, Immunoglobulin-Cell Adhesion Molecules, and Selectins
1998
Withdrawal of Survival Factors Results in Activation of the JNK Pathway in Neuronal Cells Leading to Fas Ligand Induction and Cell Death
1999
SB 203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin‐1
1995 Standout
JNK2 contains a specificity-determining region responsible for efficient c-Jun binding and phosphorylation.
1994
Interaction of a Mitogen-Activated Protein Kinase Signaling Module with the Neuronal Protein JIP3
2000
JNK1 controls mast cell degranulation and IL-1β production in inflammatory arthritis
2010 StandoutNobel
Impaired CD28-mediated Interleukin 2 Production and Proliferation in Stress Kinase SAPK/ERK1 Kinase (SEK1)/Mitogen-activated Protein Kinase Kinase 4 (MKK4)-deficient T Lymphocytes
1997
Transduction of Receptor Signals by ß-Arrestins
2005 StandoutScienceNobel
Nuclear localization of NF-ATc by a calcineurin-dependent, cyclosporin-sensitive intramolecular interaction.
1997
Works of Audrey Minden being referenced
Signal Transduction Pathways Regulated by Mitogen-activated/Extracellular Response Kinase Kinase Kinase Induce Cell Death
1996
Identification of an oncoprotein- and UV-responsive protein kinase that binds and potentiates the c-Jun activation domain.
1993 Standout
Selective activation of the JNK signaling cascadeand c-Jun transcriptional activity by the small GTPases Rac and Cdc42Hs
1995
Regulation and function of the JNK subgroup of MAP kinases
1997
Gα12 Stimulates c-Jun NH2-terminal Kinase through the Small G Proteins Ras and Rac
1996
Multiple ras functions can contribute to mammalian cell transformation
1995
c-Jun N-Terminal Phosphorylation Correlates with Activation of the JNK Subgroup but Not the ERK Subgroup of Mitogen-Activated Protein Kinases
1994
Identification of a Dual Specificity Kinase That Activates the Jun Kinases and p38-Mpk2
1995 Science
Differential Activation of ERK and JNK Mitogen-Activated Protein Kinases by Raf-1 and MEKK
1994 Science
c-Jun N-terminal phosphorylation correlates with activation of the JNK subgroup but not the ERK subgroup of mitogen-activated protein kinases.
1994
Tumor necrosis factor alpha stimulates AP-1 activity through prolonged activation of the c-Jun kinase
1994
Epidermal Growth Factor Induction of the c-jun Promoter by a Rac Pathway
1998
The minimal self-sufficient element in a murine G+C-rich promoter is a large element with imperfect dyad symmetry.
1993