Citation Impact
Citing Papers
Double-Stranded RNA Is Produced by Positive-Strand RNA Viruses and DNA Viruses but Not in Detectable Amounts by Negative-Strand RNA Viruses
2006
Modulation of immune cell reactivity with cis -binding Siglec agonists
2021 StandoutNobel
Induction of interferon-stimulated gene expression and antiviral responses require protein deacetylase activity
2004 StandoutNobel
The TAR RNA-binding Protein, TRBP, Stimulates the Expression of TAR-containing RNAs in Vitro and in VivoIndependently of Its Ability to Inhibit the dsRNA-dependent Kinase PKR
2003
To Interfere and to Anti-interfere: The Interplay Between Hepatitis C Virus and Interferon
2002
Activation of Double-stranded RNA-activated Protein Kinase (PKR) by Interferon-stimulated Gene 15 (ISG15) Modification Down-regulates Protein Translation
2012
Activation of the Double-stranded RNA-regulated Protein Kinase by Depletion of Endoplasmic Reticular Calcium Stores
1995
PKR is activated by cellular dsRNAs during mitosis and acts as a mitotic regulator
2014
Characterization of the Solution Complex between the Interferon-induced, Double-stranded RNA-activated Protein Kinase and HIV-I Trans-activating Region RNA
1997
Recognition of double-stranded RNA and activation of NF-κB by Toll-like receptor 3
2001 StandoutNature
Stress-induced Apoptosis Associated with Null Mutation of ADAR1 RNA Editing Deaminase Gene
2004
Calcium Depletion from the Endoplasmic Reticulum Activates the Double-stranded RNA-dependent Protein Kinase (PKR) to Inhibit Protein Synthesis
1995
Oncogenic potential of TAR RNA binding protein TRBP and its regulatory interaction with RNA-dependent protein kinase PKR
1997
Inflammation and metabolic disorders
2006 StandoutNature
Interferon-induced Mx proteins in antiviral host defense
2007
Double-stranded RNA-dependent Protein Kinase Mediates c-Myc Suppression Induced by Type I Interferons
1996
Completion of the entire hepatitis C virus life cycle in genetically humanized mice
2013 StandoutNatureNobel
TICAM-1, an adaptor molecule that participates in Toll-like receptor 3–mediated interferon-β induction
2003
Activation of the IκBα Kinase Complex by MEKK1, a Kinase of the JNK Pathway
1997
The Interferon-inducible Protein Kinase PKR Modulates the Transcriptional Activation of Immunoglobulin κ Gene
1995
Human ADAR1 Prevents Endogenous RNA from Triggering Translational Shutdown
2018 StandoutNobel
Differential viral induction of distinct interferon-alpha genes by positive feedback through interferon regulatory factor-7
1998
Unravelling hepatitis C virus replication from genome to function
2005 StandoutNatureNobel
RANKL maintains bone homeostasis through c-Fos-dependent induction of interferon-β
2002 Nature
Cell Type-Specific Involvement of RIG-I in Antiviral Response
2005
Physical association between STAT1 and the interferon-inducible protein kinase PKR and implications for interferon and double-stranded RNA signaling pathways
1997
Interferon action and apoptosis are defective in mice devoid of 2',5'-oligoadenylate-dependent RNase L
1997
Nonspecific, concentration-dependent stimulation and repression of mammalian gene expression by small interfering RNAs (siRNAs)
2003
Activation of the Double‐Stranded‐RNA‐Activated Protein Kinase and Induction of Vascular Cell Adhesion Molecule‐1 by Poly (I) · Poly (C) in Endothelial Cells
1995
Regulation of IFN‐α/β genes: evidence for a dual function of the transcription factor complex ISGF3 in the production and action of IFN‐α/β
1996
Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells
2001 StandoutNature
Characterization of Transgenic Mice with Targeted Disruption of the Catalytic Domain of the Double-stranded RNA-dependent Protein Kinase, PKR
1999
Characterization of a Mutant Pancreatic eIF-2α Kinase, PEK, and Co-localization with Somatostatin in Islet Delta Cells
1999
Staufen protein associates with the 3′UTR of bicoid mRNA to form particles that move in a microtubule-dependent manner
1994 StandoutNobel
Translational control in cancer
2010
The Double-Stranded RNA-Dependent Protein Kinase PKR: Structure and Function
1997
Ikappa Balpha is a target for the mitogen-activated 90kDa ribosomal S6 kinase
1997
Intrinsic Immunity Shapes Viral Resistance of Stem Cells
2017 StandoutNobel
Poly(dI·dC)-induced Toll-like Receptor 3 (TLR3)-mediated Activation of NFκB and MAP Kinase Is through an Interleukin-1 Receptor-associated Kinase (IRAK)-independent Pathway Employing the Signaling Components TLR3-TRAF6-TAK1-TAB2-PKR
2003
MX2 is an interferon-induced inhibitor of HIV-1 infection
2013 StandoutNatureNobel
Direct triggering of the type I interferon system by virus infection: activation of a transcription factor complex containing IRF-3 and CBP/p300
1998
Phosphorylation of Eukaryotic Translation Initiation Factor 2 Mediates Apoptosis in Response to Activation of the Double-stranded RNA-dependent Protein Kinase
1998
The peptide repeat domain of nucleoporin Nup98 functions as a docking site in transport across the nuclear pore complex
1995 StandoutNobel
Osteoclast differentiation and activation
2003 StandoutNature
Activation of the interferon system by short-interfering RNAs
2003
Viral infection switches non-plasmacytoid dendritic cells into high interferon producers
2003 Nature
A diverse range of gene products are effectors of the type I interferon antiviral response
2011 StandoutNatureNobel
Deficient cytokine signaling in mouse embryo fibroblasts with a targeted deletion in the PKR gene: role of IRF-1 and NF-kappa B
1997
Revealing the world of RNA interference
2004 StandoutNatureNobel
Identification of Lps2 as a key transducer of MyD88-independent TIR signalling
2003 StandoutNatureNobel
Initiation of Protein Synthesis in Eukaryotic Cells
1996
Signaling to NF-κB
2004 Standout
Platelet-derived Growth Factor Signal Transduction through the Interferon-inducible Kinase PKR
1995
PKR Transduces MDA5-Dependent Signals for Type I IFN Induction
2016
Stress signaling from the lumen of the endoplasmic reticulum: coordination of gene transcriptional and translational controls
1999 Standout
Site-Specific Phosphorylation of IκBα by a Novel Ubiquitination-Dependent Protein Kinase Activity
1996
Induction of IRF‐3/‐7 kinase and NF‐κB in response to double‐stranded RNA and virus infection: common and unique pathways
2001
Nasal Immunization with Anthrax Protective Antigen Protein Adjuvanted with Polyriboinosinic–Polyribocytidylic Acid Induced Strong Mucosal and Systemic Immunities
2006
Type I Interferon Induction Pathway, but Not Released Interferon, Participates in the Maturation of Dendritic Cells Induced by Negative‐Strand RNA Viruses
2003
TLR4, but not TLR2, mediates IFN-β–induced STAT1α/β-dependent gene expression in macrophages
2002
Endoplasmic Reticulum Stress Signaling in Disease
2006
Inferences, questions and possibilities in Toll-like receptor signalling
2004 StandoutNatureNobel
Interferon-inducible antiviral effectors
2008 Standout
Interferon Action in Triply Deficient Mice Reveals the Existence of Alternative Antiviral Pathways
1999
Malignant transformation by a mutant of the IFN-inducible dsRNA-dependent protein kinase
1992 Science
Toll-Like Receptors
2003 Standout
β-Arrestin inhibits NF-κB activity by means of its interaction with the NF-κB inhibitor IκBα
2004 StandoutNobel
Phosphorylation of IκBα in the C-Terminal PEST Domain by Casein Kinase II Affects Intrinsic Protein Stability
1996
The dsRNA binding protein family: critical roles, diverse cellular functions
2003
Functional classification of interferon-stimulated genes identified using microarrays
2001
A double-stranded RNA-activated protein kinase-dependent pathway mediating stress-induced apoptosis
1997
HOW CELLS RESPOND TO INTERFERONS
1998 Standout
Control of PKR Protein Kinase by Hepatitis C Virus Nonstructural 5A Protein: Molecular Mechanisms of Kinase Regulation
1998
Blockage of NF-κB Signaling by Selective Ablation of an mRNA target by 2-5A Antisense Chimeras
1994 Science
Constitutive Activation of Toll-Mediated Antifungal Defense in Serpin-Deficient Drosophila
1999 StandoutScienceNobel
A conserved double-stranded RNA-binding domain.
1992
NF-κB and Rel Proteins in Innate Immunity
1995
Double-Stranded RNA-Activated Protein Kinase (PKR) Is Negatively Regulated by 60S Ribosomal Subunit Protein L18
1999
Possible involvement of double-stranded RNA-activated protein kinase in cell death by influenza virus infection
1996
N- and C-Terminal Sequences Control Degradation of MAD3/IκBα in Response to Inducers of NF-κB Activity
1995
Posttranslational hydroxylation of ankyrin repeats in IκB proteins by the hypoxia-inducible factor (HIF) asparaginyl hydroxylase, factor inhibiting HIF (FIH)
2006 StandoutNobel
Maturation, Activation, and Protection of Dendritic Cells Induced by Double-stranded RNA
1999
Constitutive expression of human double-stranded RNA-activated p68 kinase in murine cells mediates phosphorylation of eukaryotic initiation factor 2 and partial resistance to encephalomyocarditis virus growth
1992
ATP-independent diffusion of double-stranded RNA binding proteins
2012 StandoutNobel
Targeted disruption of IRF-1 or IRF-2 results in abnormal type I IFN gene induction and aberrant lymphocyte development
1993
mRNA binding protein mrnp 41 localizes to both nucleus and cytoplasm
1997 StandoutNobel
Specific inhibition of gene expression by small double-stranded RNAs in invertebrate and vertebrate systems
2001 StandoutNobel
Translational Repression Mediates Activation of Nuclear Factor Kappa B by Phosphorylated Translation Initiation Factor 2
2004
In vitro reconstitution of the human RISC-loading complex
2008 StandoutNobel
RNAi-mediated immunity provides strong protection against the negative-strand RNA vesicular stomatitis virus in Drosophila
2010 StandoutNobel
An essential role for the interferon-inducible, double-stranded RNA-activated protein kinase PKR in the tumor necrosis factor-induced apoptosis in U937 cells.
1996
Regulation of apoptosis by the circadian clock through NF-κB signaling
2011 StandoutNobel
Interactions between double-stranded RNA regulators and the protein kinase DAI.
1992
Avoiding horror autotoxicus: The importance of dendritic cells in peripheral T cell tolerance
2002 StandoutNobel
PD-L1 and PD-L2 are differentially regulated by Th1 and Th2 cells
2003 StandoutNobel
REL/NF-κB/IκB Story
1995
Interactions between Double-Stranded RNA Regulators and the Protein Kinase DAI
1992
NF-κB AND REL PROTEINS: Evolutionarily Conserved Mediators of Immune Responses
1998 Standout
CELLULAR RESPONSES TO INTERFERON-γ
1997 Standout
Double-stranded-RNA-dependent protein kinase and TAR RNA-binding protein form homo- and heterodimers in vivo.
1995
Essential role of mda-5 in type I IFN responses to polyriboinosinic:polyribocytidylic acid and encephalomyocarditis picornavirus
2006 StandoutNobel
The Murine PKR Tumor Suppressor Gene Is Rearranged in a Lymphocytic Leukemia
1998
Involvement of the double-stranded-RNA-dependent kinase PKR in interferon expression and interferon-mediated antiviral activity.
1995
Details of Toll-like receptor:adapter interaction revealed by germ-line mutagenesis
2006 StandoutNobel
Clearance of replicating hepatitis C virus replicon RNAs in cell culture by small interfering RNAs
2002 StandoutNobel
Increased Susceptibility to DNA Virus Infection in Mice with a GCN2 Mutation
2011 StandoutNobel
Toll-like receptors 9 and 3 as essential components of innate immune defense against mouse cytomegalovirus infection
2004 StandoutNobel
Tumor suppressor function of the interferon-induced double-stranded RNA-activated protein kinase.
1993
Impact of Protein Kinase PKR in Cell Biology: from Antiviral to Antiproliferative Action
2006
PKR-Dependent and -Independent Mechanisms Are Involved in Translational Shutoff during Sindbis Virus Infection
2004 StandoutNobel
Abrogation of translation initiation factor eIF-2 phosphorylation causes malignant transformation of NIH 3T3 cells.
1995
Identification and Characterization of Pancreatic Eukaryotic Initiation Factor 2 α-Subunit Kinase, PEK, Involved in Translational Control
1998
Mutants of the RNA-Dependent Protein Kinase (PKR) Lacking Double-Stranded RNA Binding Domain I Can Act as Transdominant Inhibitors and Induce Malignant Transformation
1995
TLR3 Is Essential for the Induction of Protective Immunity against Punta Toro Virus Infection by the Double-Stranded RNA (dsRNA), Poly(I:C12U), but not Poly(I:C): Differential Recognition of Synthetic dsRNA Molecules
2007
Mapping of the Inducible IκB Phosphorylation Sites That Signal Its Ubiquitination and Degradation†
1996
Selective contribution of IFN-α/β signaling to the maturation of dendritic cells induced by double-stranded RNA or viral infection
2003
Functional reconstitution of human eukaryotic translation initiation factor 3 (eIF3)
2011 StandoutNobel
IKK-1 and IKK-2: Cytokine-Activated IκB Kinases Essential for NF-κB Activation
1997 StandoutScience
HIV-1-infected monocyte-derived dendritic cells do not undergo maturation but can elicit IL-10 production and T cell regulation
2004 StandoutNobel
THE NF-κB AND IκB PROTEINS: New Discoveries and Insights
1996 Standout
THE UBIQUITIN SYSTEM
1998 StandoutNobel
Conserved Structures and Diversity of Functions of RNA-Binding Proteins
1994 StandoutScience
The Apoptosis Pathway Triggered by the Interferon-Induced Protein Kinase PKR Requires the Third Basic Domain, Initiates Upstream of Bcl-2, and Involves ICE-like Proteases1
1997
The microbial mimic poly IC induces durable and protective CD4+T cell immunity together with a dendritic cell targeted vaccine
2008 StandoutNobel
Phosphorylation of hepatitis C virus nonstructural protein 5A modulates its protein interactions and viral RNA replication
2004 StandoutNobel
ATP-sensitive potassium channel (K ATP )–dependent regulation of cardiotropic viral infections
2011 StandoutNobel
Works of Ashutosh Kumar being referenced
Double-stranded RNA-dependent protein kinase activates transcription factor NF-kappa B by phosphorylating I kappa B.
1994
Identification of double-stranded RNA-binding domains in the interferon-induced double-stranded RNA-activated p68 kinase.
1992
Deficient signaling in mice devoid of double-stranded RNA-dependent protein kinase.
1995