Standout Papers
Citation Impact
Citing Papers
Brain monoglyceride lipase participating in endocannabinoid inactivation
2002
Humanized Foxp2 accelerates learning by enhancing transitions from declarative to procedural performance
2014 StandoutNobel
Cross-talk between Akkermansia muciniphila and intestinal epithelium controls diet-induced obesity
2013 Standout
Catalysis by dihydrofolate reductase and other enzymes arises from electrostatic preorganization, not conformational motions
2011 StandoutNobel
The endocannabinoid nervous system
2001
Effect of the enzyme inhibitor, phenylmethylsulfonyl fluoride, on the IOP profiles of topical anandamides.
2002
Pharmacology of Cannabinoid CB 1 and CB 2 Receptors
1997
Cannabinoids Protect Astrocytes from Ceramide-induced Apoptosis through the Phosphatidylinositol 3-Kinase/Protein Kinase B Pathway
2002
The endocannabinoid system as a target for therapeutic drugs
2000
The stress-regulated protein p8 mediates cannabinoid-induced apoptosis of tumor cells
2006
Cannabinoids Induce Apoptosis of Pancreatic Tumor Cells via Endoplasmic Reticulum Stress–Related Genes
2006
Actions of Cannabinoids on Membrane Properties and Synaptic Transmission in Rat Periaqueductal Gray Neurons In Vitro
2000
Evidence for a New G Protein-Coupled Cannabinoid Receptor in Mouse Brain
2001
Cannabinoid Transmission and Pain Perception
1998
The peripheral cannabinoid receptor: adenylate cyclase inhibition and G protein coupling
1995
The general anesthetic propofol increases brain N‐arachidonylethanolamine (anandamide) content and inhibits fatty acid amide hydrolase
2003
Cannabinoid pharmacology in the cardiovascular system: potential protective mechanisms through lipid signalling
2004
SR 141716A Acts as an Inverse Agonist to Increase Neuronal Voltage-Dependent Ca2+ Currents by Reversal of Tonic CB1 Cannabinoid Receptor Activity
1998
Cannabinoids and the immune system: Potential for the treatment of inflammatory diseases?
2005
Structure, expression and regulation of the cannabinoid receptor gene (CB1) in Huntington's disease transgenic mice
2004
Biosynthesis and inactivation of endocannabinoids: Relevance to their proposed role as neuromodulators
1999
International Union of Pharmacology. XXVII. Classification of Cannabinoid Receptors
2002 Standout
Supply and demand for endocannabinoids
2011
ω-6 Polyunsaturated fatty acids extend life span through the activation of autophagy
2013 StandoutNobel
The Endogenous Cannabinoid System Regulates Seizure Frequency and Duration in a Model of Temporal Lobe Epilepsy
2003
Understanding Synapses: Past, Present, and Future
2008 StandoutNobel
Cannabinoid CB1‐receptor mediated regulation of gastrointestinal motility in mice in a model of intestinal inflammation
2001
The movement of N-arachidonoylethanolamine (anandamide) across cellular membranes
2000
Modulation of anxiety through blockade of anandamide hydrolysis
2002 Standout
Cannabinoid physiology and pharmacology: 30 years of progress
2004
Simultaneous Measurement of Anandamide and 2-Arachidonoylglycerol by Polymyxin B-Selective Adsorption and Subsequent High-Performance Liquid Chromatography Analysis: Increase in Endogenous Cannabinoids in the Sera of Patients with Endotoxic Shock
2001
Endocannabinoid levels in rat limbic forebrain and hypothalamus in relation to fasting, feeding and satiation: stimulation of eating by 2‐arachidonoyl glycerol
2002
Molecular Characterization of N-Acylethanolamine-hydrolyzing Acid Amidase, a Novel Member of the Choloylglycine Hydrolase Family with Structural and Functional Similarity to Acid Ceramidase
2005
Massive accumulation of N‐acylethanolamines after stroke. Cell signalling in acute cerebral ischemia?
2004
Charge recombination from the P+Q−A state in reaction centers from Rhodopseudomonas viridis
1987
Endocannabinoids: endogenous cannabinoid receptor ligands with neuromodulatory action
1998
The role of Cannabinoids in neurodegenerative diseases
2001
Brain Cannabinoid Systems as Targets for the Therapy of Neurological Disorders
1998
The N-acylation-phosphodiesterase pathway and cell signalling
1996
Potentiation of the action of anandamide on hippocampal slices by the fatty acid amide hydrolase inhibitor, palmitylsulphonyl fluoride (AM 374)
1999
Pharmacological Actions of Cannabinoids
2005
Structural Requirements for Cannabinoid Receptor Probes
2005
Structure—Activity Relationships Among N‐Arachidonylethanolamine (Anandamide) Head Group Analogues for the Anandamide Transporter
2000
Nature of biological electron transfer
1992 StandoutNature
Endocannabinoids Mediate Presynaptic Inhibition of Glutamatergic Transmission in Rat Ventral Tegmental Area Dopamine Neurons through Activation of CB1 Receptors
2004
Cannabinoid analgesia
2002
Anandamide Amidohydrolase Activity in Rat Brain Microsomes
1995
Cannabinoids inhibit neurodegeneration in models of multiple sclerosis
2003
Enzymes of porcine brain hydrolyzing 2-arachidonoylglycerol, an endogenous ligand of cannabinoid receptors
1999
Adverse Health Effects of Marijuana Use
2014 Standout
Natural engineering principles of electron tunnelling in biological oxidation–reduction
1999 StandoutNature
2-Arachidonoylglycerol and Anandamide Oppositely Modulate Norepinephrine Release from the Rat Heart Sympathetic Nerves
2001
Generation of 2-Arachidonoylglycerol, an Endogenous Cannabinoid Receptor Ligand, in Picrotoxinin-Administered Rat Brain
2000
Involvement of cannabinoid receptors in inflammatory hypersensitivity to colonic distension in rats
2006
Emerging properties of cannabinoid medicines in management of multiple sclerosis
2005
Endocannabinoid-Mediated Long-Term Plasticity Requires cAMP/PKA Signaling and RIM1α
2007 StandoutNobel
New Perspectives in the Studies on Endocannabinoid and Cannabis: Cannabinoid Receptors and Schizophrenia
2004
Control of pain initiation by endogenous cannabinoids
1998 StandoutNature
Pharmacophores for Ligand Recognition and Activation / Inactivation of the Cannabinoid Receptors
2003
Cannabinoids and brain injury: therapeutic implications
2002
Changes in cannabinoid CB1 receptors in striatal and cortical regions of rats with experimental allergic encephalomyelitis, an animal model of multiple sclerosis
2001
The endocannabinoid system in the physiology and pathophysiology of the gastrointestinal tract
2005
Endocannabinoid signaling as a synaptic circuit breaker in neurological disease
2008
Endocannabinoids as physiological regulators of colonic propulsion in mice
2002
Effect of cannabinoids on neural transmission in rat gastric fundus
2002
Endocannabinoids
1998
Endocannabinoids Modulate N-Type Calcium Channels and G-Protein-Coupled Inwardly Rectifying Potassium Channels via CB1 Cannabinoid Receptors Heterologously Expressed in Mammalian Neurons
2004
Biphasic modulation of voltage-dependent currents of retinal cones by cannabinoid CB1 receptor agonist WIN 55212-2
2003
Localization of Diacylglycerol Lipase-α around Postsynaptic Spine Suggests Close Proximity between Production Site of an Endocannabinoid, 2-Arachidonoyl-glycerol, and Presynaptic Cannabinoid CB1 Receptor
2006
Cannabinoid signaling in glial cells
2004
Down-regulation of cannabinoid-1 (CB-1) receptors in specific extrahypothalamic regions of rats with dietary obesity: a role for endogenous cannabinoids in driving appetite for palatable food?
2002
Hydroxypropyl-β-cyclodextrin increases aqueous solubility and stability of anandamide
1996
Contribution of endocannabinoids in the endothelial protection afforded by ischemic preconditioning in the isolated rat heart
2003
Biosynthesis and Inactivation of N-Arachidonoylethanolamine (Anandamide) and N-Docosahexaenoylethanolamine in Bovine Retina
1999
Inhibition of skin tumor growth and angiogenesis in vivo by activation of cannabinoid receptors
2003
Identification of the CB1 Cannabinoid Receptor and Fatty Acid Amide Hydrolase (FAAH) in the Human Placenta
2003
ETHANOL INDUCES HIGHER BEC IN CB1 CANNABINOID RECEPTOR KNOCKOUT MICE WHILE DECREASING ETHANOL PREFERENCE
2004
Vanilloid receptors on sensory nerves mediate the vasodilator action of anandamide
1999 StandoutNatureNobel
Molecular characterization of an enzyme that degrades neuromodulatory fatty-acid amides
1996 StandoutNature
Molecular Neurobiology of The Cannabinoid Receptor
1996
Coronary Vasodilator Effects of Endogenous Cannabinoids in Vasopressin-Preconstricted Unpaced Rat Isolated Hearts
2005
Endocannabinoid‐mediated short‐term synaptic plasticity: depolarization‐induced suppression of inhibition (DSI) and depolarization‐induced suppression of excitation (DSE)
2004
The gastrointestinal pharmacology of cannabinoids
2001
Endocannabinoids and the control of energy balance
2006
Cannabinoids for gastrointestinal diseases: potential therapeutic applications
2003
The endocannabinoid system in the basal ganglia and in the mesolimbic reward system: implications for neurological and psychiatric disorders
2003
Discovery and characterization of endogenous cannabinoids
1999
Cannabinoid Transmission and Reward-Related Events
1998
Inhibition by cannabinoid receptor agonists of acetylcholine release from the guinea‐pig myenteric plexus
1997
Pharmacological modulation of the endocannabinoid system in a viral model of multiple sclerosis
2005
The synthetic cannabinoid WIN55,212‐2 attenuates hyperalgesia and allodynia in a rat model of neuropathic pain
2001
Cannabinoid-based drugs as anti-inflammatory therapeutics
2005
A historical overview of chemical research on cannabinoids
2000
Activation of G-proteins in brain by endogenous and exogenous cannabinoids
2006
Review article: endocannabinoids and their receptors in the enteric nervous system
2005
Dopamine activation of endogenous cannabinoid signaling in dorsal striatum
1999
Inhibition by 2-Arachidonoylglycerol, a Novel Type of Possible Neuromodulator, of the Depolarization-Induced Increase in Intracellular Free Calcium in Neuroblastoma × Glioma Hybrid NG108-15 Cells
1997
Influence of the Redox Potential of the Primary Quinone Electron Acceptor on Photoinhibition in Photosystem II
2007
Elevation of Endocannabinoid Levels in the Ventrolateral Periaqueductal Grey through Inhibition of Fatty Acid Amide Hydrolase Affects Descending Nociceptive Pathways via Both Cannabinoid Receptor Type 1 and Transient Receptor Potential Vanilloid Type-1 Receptors
2006
Neurophysiological investigation of the basis of the fMRI signal
2001 StandoutNature
Molecular biology of cannabinoid receptors
2002
Aberrant cannabinoid signaling impairs oviductal transport of embryos
2004
Receptor-dependent formation of endogenous cannabinoids in cortical neurons
2001
The endocannabinoid system and its therapeutic exploitation
2004
Characterization of a Novel Endocannabinoid, Virodhamine, with Antagonist Activity at the CB1 Receptor
2002
In vivo pharmacological actions of two novel inhibitors of anandamide cellular uptake
2003
Towards a Cannabinoid Hypothesis of Schizophrenia: Cognitive Impairments Due to Dysregulation of the Endogenous Cannabinoid System
1997
Comparison of novel cannabinoid partial agonists and SR141716A in the guinea‐pig small intestine
2000
Electrogenic steps in the redox reactions catalyzed by photosynthetic reaction‐centre complex fromRhodopseudomonas viridis
1988
Endocannabinoids as cardiovascular modulators
2000
Targeting the cannabinoid system for pain relief?
2013
Novel selective and metabolically stable inhibitors of anandamide cellular uptake
2003
New potent and selective inhibitors of anandamide reuptake with antispastic activity in a mouse model of multiple sclerosis
2005
Inhibition of exocytotic noradrenaline release by presynaptic cannabinoid CB1receptors on peripheral sympathetic nerves
1996
Despite substantial degradation, 2‐arachidonoylglycerol is a potent full efficacy agonist mediating CB1 receptor‐dependent G‐protein activation in rat cerebellar membranes
2001
Gut microbiome and health: mechanistic insights
2022 Standout
Evidence of a novel site mediating anandamide‐induced negative inotropic and coronary vasodilatator responses in rat isolated hearts
2002
The endocannabinoid-CB1 receptor system in pre- and postnatal life
2004
Fatty Acid Sulfonyl Fluorides Inhibit Anandamide Metabolism and Bind to the Cannabinoid Receptor
1997
The endocannabinoid arachidonyl ethanolamide (anandamide) increases pulmonary arterial pressure via cyclooxygenase-2 products in isolated rabbit lungs
2005
Evidence That the Cannabinoid CB1 Receptor Is a 2-Arachidonoylglycerol Receptor
1999
Postsynaptic endocannabinoid release is critical to long-term depression in the striatum
2002
The Endocannabinoid System as an Emerging Target of Pharmacotherapy
2006 Standout
A second endogenous cannabinoid that modulates long-term potentiation
1997 Nature
Autism-Associated Neuroligin-3 Mutations Commonly Disrupt Tonic Endocannabinoid Signaling
2013 StandoutNobel
Occurrence and postmortem generation of anandamide and other long‐chain N‐acylethanolamines in mammalian brain
1995
Microscopic simulation of quantum dynamics and nuclear tunneling in bacterial reaction centers
1989 StandoutNobel
Time-course of the effects of anandamide, the putative endogenous cannabinoid receptor ligand, on extrapyramidal function
1995
In vivo 13C NMR studies of compartmentalized cerebral carbohydrate metabolism
2002
Cannabinoid Inhibition of Adenylate Cyclase-mediated Signal Transduction and Interleukin 2 (IL-2) Expression in the Murine T-cell Line, EL4.IL-2
1996
Stereochemical Selectivity of Methanandamides for the CB1 and CB2 Cannabinoid Receptors and Their Metabolic Stability
2001
Pharmacology of Cannabinoid Receptors
1995
Structure-activity relationships of anandamide, an endogenous cannabinoid ligand
1999
Endogenous Cannabinoids Mediate Retrograde Signals from Depolarized Postsynaptic Neurons to Presynaptic Terminals
2001
Modulation of the cannabinoid CB2 receptor in microglial cells in response to inflammatory stimuli
2005
Involvement of the cAMP/protein kinase A pathway and of mitogen‐activated protein kinase in the anti‐proliferative effects of anandamide in human breast cancer cells
1999
Anandamide, but not 2‐arachidonoylglycerol, accumulates during in vivo neurodegeneration
2001
The Endocannabinoid Anandamide Protects Neurons during CNS Inflammation by Induction of MKP-1 in Microglial Cells
2006
2-Oleoyl Glycerol Is a GPR119 Agonist and Signals GLP-1 Release in Humans
2011
Conformational requirements for endocannabinoid interaction with the cannabinoid receptors, the anandamide transporter and fatty acid amidohydrolase
2000
Cellular signal transduction by anandamide and 2-arachidonoylglycerol
2000
UCM707, a potent and selective inhibitor of endocannabinoid uptake, potentiates hypokinetic and antinociceptive effects of anandamide
2002
Presynaptic Inhibition Caused by Retrograde Signal from Metabotropic Glutamate to Cannabinoid Receptors
2001
Evidence That 2-Arachidonoylglycerol but Not N-Palmitoylethanolamine or Anandamide Is the Physiological Ligand for the Cannabinoid CB2 Receptor
2000
Cannabinoids Acting on CB1 Receptors Decrease Contractile Performance in Human Atrial Muscle
2003
Marijuana: Respiratory Tract Effects
2013
Identification of the CB1 Cannabinoid Receptor and Fatty Acid Amide Hydrolase (FAAH) in the Human Placenta
2003
Enhanced levels of endogenous cannabinoids in the globus pallidus are associated with a reduction in movement in an animal model of Parkinson's disease
2000
Cannabinoid Receptors and Their Relationships with Neuropsychiatric Disorders
2005
Two novel classes of neuroactive fatty acid amides are substrates for mouse neuroblastoma ‘anandamide amidohydrolase’
1995
Ether‐linked analogue of 2‐arachidonoylglycerol (noladin ether) was not detected in the brains of various mammalian species
2003
Cannabinoid receptors and pain
2001
2-Arachidonoylglycerol Increases in Ischemia–Reperfusion Injury of the Rat Liver
2005
Role of the Endogenous Cannabinoid System in the Regulation of Motor Activity
1998
Relationships Between Ligand Affinities for the Cerebellar Cannabinoid Receptor CB1 and the Induction of GDP/GTP Exchange
1999
Presynaptic Modulation by Endocannabinoids
2007
Neurobehavioral activity in mice of N-vanillyl-arachidonyl-amide
2000
p38 MAPK is involved in CB2 receptor‐induced apoptosis of human leukaemia cells
2005
The endogenous cannabinoid system and the basal ganglia
2002
Preferential effects of the cannabinoid CB1 receptor antagonist, SR 141716, on food intake and body weight gain of obese (fa/fa) compared to lean Zucker rats
2003
Analogues and homologues of N-palmitoylethanolamide, a putative endogenous CB2 cannabinoid, as potential ligands for the cannabinoid receptors
1999
Effects of levodopa on endocannabinoid levels in rat basal ganglia: implications for the treatment of levodopa‐induced dyskinesias
2003
Cannabinoids: potential anticancer agents
2003
Pumping capacity of bacterial reaction centers and backpressure regulation of energy transduction
2001
Levels, Metabolism, and Pharmacological Activity of Anandamide in CB1 Cannabinoid Receptor Knockout Mice
2000
Characterization of the Diarylether Sulfonylester (−)-(R)-3-(2-Hydroxymethylindanyl-4-oxy)phenyl-4,4,4-trifluoro-1-sulfonate (BAY 38-7271) as a Potent Cannabinoid Receptor Agonist with Neuroprotective Properties
2002
An entourage effect: inactive endogenous fatty acid glycerol esters enhance 2-arachidonoyl-glycerol cannabinoid activity
1998
The endocannabinoid system: function in survival of the embryo, the newborn and the neuron
2002
Synergistic efects of opioid and cannabinoid antagonists on food intake
2001
Detection of an Endogenous Cannabimimetic Molecule, 2-Arachidonoylglycerol, and Cannabinoid CB1 Receptor mRNA in Human Vascular Cells: Is 2-Arachidonoylglycerol a Possible Vasomodulator?
1998
The Central Cannabinoid Receptor Inactivation Suppresses Endocrine Reproductive Functions
2001
Cannabinoid receptor systems: therapeutic targets for tumour intervention
2003
The diverse CB1and CB2receptor pharmacology of three plant cannabinoids: Δ9‐tetrahydrocannabinol, cannabidiol and Δ9‐tetrahydrocannabivarin
2007 Standout
Mutational analysis and molecular modelling of the antagonist SR 144528 binding site on the human cannabinoid CB2 receptor
2000
Milk intake and survival in newborn cannabinoid CB1 receptor knockout mice: evidence for a “CB3” receptor
2003
Cannabinoid CB1 receptors are localized primarily on cholecystokinin-containing GABAergic interneurons in the rat hippocampal formation
1999
Rapid Glucocorticoid-Mediated Endocannabinoid Release and Opposing Regulation of Glutamate and γ-Aminobutyric Acid Inputs to Hypothalamic Magnocellular Neurons
2005
Modulation of peristalsis by cannabinoid CB1 ligands in the isolated guinea‐pig ileum
2000
Cannabinoids: a real prospect for pain relief
2002
Fatty-Acid Amide Hydrolase Is Expressed in the Mouse Uterus and Embryo during the Periimplantation Period1
1999
Hypothesis: cannabinoid therapy for the treatment of gliomas?
2004
Pharmacology of cannabinoid CB1 and CB2 receptors
1997
Endocannabinoid Signaling Dynamics Probed with Optical Tools
2005
Cannabinoids in Multiple Sclerosis
2004
Cannabinoid receptors and the regulation of immune response
2000
Endocannabinoids at the synapse a decade after the dies mirabilis (29 March 2001): what we still do not know
2012
Effects on the Immune System
2005
Transacylase‐Mediated and Phosphodiesterase‐Mediated Synthesis ofN‐Arachidonoylethanolamine, an Endogenous Cannabinoid‐Receptor Ligand, in Rat Brain Microsomes
1996
GPR55: a new member of the cannabinoid receptor clan?
2007
Ceramide: a new second messenger of cannabinoid action
2001
Cannabinoids reduce hyperalgesia and inflammation via interaction with peripheral CB1 receptors
1998
Disruption of CB1 receptor signaling impairs extinction of spatial memory in mice
2004
The endocannabinoid 2-AG protects the blood–brain barrier after closed head injury and inhibits mRNA expression of proinflammatory cytokines
2005
An endocannabinoid mechanism for stress-induced analgesia
2005 Nature
The molecular logic of endocannabinoid signalling
2003 Standout
The CB2 cannabinoid receptor signals apoptosis via ceramide-dependent activation of the mitochondrial intrinsic pathway
2006
Biosynthesis, Uptake, and Degradation of Anandamide and Palmitoylethanolamide in Leukocytes
1997
Ophthalmic arachidonylethanolamide decreases intraocular pressure in normotensive rabbits
1995
Cannabinoids in the treatment of glaucoma
2002
Increased ethanol consumption and preference and decreased ethanol sensitivity in female FAAH knockout mice
2006
An endogenous cannabinoid tone attenuates cholera toxin-induced fluid accumulation in mice
2003
Retrograde signaling by endocannabinoids
2002
Evaluation of CB1 Receptor Knockout Mice in the Morris Water Maze
2002
Role of the endogenous cannabinoid system as a modulator of dopamine transmission: Implications for Parkinson’s disease and schizophrenia
2001
Effects of topical anandamides on intraocular pressure in normotensive rabbits
1996
Anandamide: some like it hot
2001
De novo-synthesized ceramide is involved in cannabinoid-induced apoptosis
2002
An endogenous cannabinoid (2-AG) is neuroprotective after brain injury
2001 Nature
Δ9-Tetrahydrocannabinol antagonizes endocannabinoid modulation of synaptic transmission between hippocampal neurons in culture
2004
Endocannabinoids and related fatty acid derivatives in pain modulation
2002
Mustard oils and cannabinoids excite sensory nerve fibres through the TRP channel ANKTM1
2004 StandoutNatureNobel
Localisation of cannabinoid CB1 receptor immunoreactivity in the guinea pig and rat myenteric plexus
2002
Further evidence for the presence of cannabinoid CB1 receptors in guinea‐pig small intestine
1996
The Biosynthesis, Fate and Pharmacological Properties of Endocannabinoids
2005
Endocannabinoid-Mediated Control of Synaptic Transmission
2009
Monoglyceride lipase-like enzymatic activity is responsible for hydrolysis of 2-arachidonoylglycerol in rat cerebellar membranes
2004
Neuromodulatory role of the endocannabinoid signaling system in alcoholism: an overview
2002
Role of endocannabinoid system in mental diseases
2004
Reversal of Δ9-THC hyperphagia by SR141716 and naloxone but not dexfenfluramine
2002
The effects of cannabinoids on the brain
1999
Fatty acid amide hydrolase: an emerging therapeutic target in the endocannabinoid system
2003
The endocannabinoid signalling system: Biochemical aspects
2005
Systemic or intrahippocampal cannabinoid administration impairs spatial memory in rats
1995
Cannabinoid receptor ligands: clinical and neuropharmacological considerations, relevant to future drug discovery and development
2000
Endocannabinoids and liver disease – review
2005
Endocannabinoids in the regulation of appetite and body weight
2005
The CB1 Cannabinoid Receptor of Astrocytes Is Coupled to Sphingomyelin Hydrolysis through the Adaptor Protein Fan
2001
Sulfur(VI) Fluoride Exchange (SuFEx): Another Good Reaction for Click Chemistry
2014 StandoutNobel
Effects of cannabinoids on lithium-induced conditioned rejection reactions in a rat model of nausea
2003
Mice lacking fatty acid amide hydrolase exhibit a cannabinoid receptor-mediated phenotypic hypoalgesia
2004
Endogenous cannabinoids mediate hypotension after experimental myocardial infarction
2001
Identification and characterisation of a novel splice variant of the human CB1 receptor
2004
Endocannabinoids affect neurological and cognitive function in thioacetamide-induced hepatic encephalopathy in mice
2005
Cannabinoid receptors in atherosclerosis
2006
Inhibition of the cAMP signaling cascade via cannabinoid receptors: a putative mechanism of immune modulation by cannabinoid compounds
1998
The fatty acid amide hydrolase (FAAH)
2000
Appetite suppression and weight loss after the cannabinoid antagonist SR 141716
1998
Striatal Cannabinoid CB1 Receptor mRNA Expression Is Decreased in the Reserpine-Treated Rat Model of Parkinson's Disease
2001
Endocannabinoids May Mediate the Ability of (n-3) Fatty Acids to Reduce Ectopic Fat and Inflammatory Mediators in Obese Zucker Rats
2009
Evidence for novel cannabinoid receptors
2005
Formation and inactivation of endogenous cannabinoid anandamide in central neurons
1994 StandoutNature
Endocannabinoids and the gut
2002
Marijuana, immunity and infection
1998
Arachidonoylserotonin and Other Novel Inhibitors of Fatty Acid Amide Hydrolase
1998
Cannabis, cannabinoids and reproduction
2003
Anandamide amidohydrolase reacting with 2‐arachidonoylglycerol, another cannabinoid receptor ligand
1998
2-arachidonyl-glycerol stimulates nitric oxide release from human immune and vascular tissues and invertebrate immunocytes by cannabinoid receptor 1
2000
Neuropharmacology and therapeutic potential of cannabinoids
2000
Cannabinoids and neuroinflammation
2004
The quest for a vascular endothelial cannabinoid receptor
2002
Therapeutic Potential of Cannabinoids in CNS Disease
2003
Endocannabinoid control of food intake and energy balance
2005
The endocannabinoid system links gut microbiota to adipogenesis
2010
Targeting CB2 cannabinoid receptors as a novel therapy to treat malignant lymphoblastic disease
2002
The endocannabinoid system drives neural progenitor proliferation
2005
Biosynthesis of an Endogenous Cannabinoid Precursor in Neurons and its Control by Calcium and cAMP
1996
CANNABINOID RECEPTORS AND THEIR ENDOGENOUS AGONISTS
1998
Investigation of the free energy functions for electron transfer reactions
1990 StandoutNobel
Beyond aerobic glycolysis: Transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis
2007 Standout
Comparison of the enzymatic stability and intraocular pressure effects of 2-arachidonylglycerol and noladin ether, a novel putative endocannabinoid.
2002
Cannabis: pharmacology and toxicology in animals and humans
1996
Inhibition of skin tumor growth and angiogenesis in vivo by activation of cannabinoid receptors
2003
The Cannabinoid System and Cytokine Network
2000
Cannabis: pharmacology and toxicology in animals and humans
1996
Endogenous cannabinoids and appetite.
2001
The Emerging Role of the Endocannabinoid System in Endocrine Regulation and Energy Balance
2005
Enhanced levels of endogenous cannabinoids in the globus pallidus are associated with a reduction in movement in an animal model of Parkinson's disease
2000
CB1 cannabinoid receptor antagonism promotes remodeling and cannabinoid treatment prevents endothelial dysfunction and hypotension in rats with myocardial infarction
2003
The neurobiology and evolution of cannabinoid signalling
2001
Unresponsiveness to Cannabinoids and Reduced Addictive Effects of Opiates in CB 1 Receptor Knockout Mice
1999 StandoutScience
In vivo nuclear magnetic resonance spectroscopy studies of the relationship between the glutamate--glutamine neurotransmitter cycle and functional neuroenergetics
1999
In Vitro and in Vivo Pharmacological Characterization of JTE-907, a Novel Selective Ligand for Cannabinoid CB2 Receptor
2001
Modulation by divalent metal ions of the autocatalytic reactivity of adenosine triphosphatase from chloroplasts
1981
Chemical requirements for inhibition of gap junction communication by the biologically active lipid oleamide
1998
Mast cells express a peripheral cannabinoid receptor with differential sensitivity to anandamide and palmitoylethanolamide.
1995
Solute Solvent Dynamics and Energetics in Enzyme Catalysis: The SN2 Reaction of Dehalogenase as a General Benchmark
2004 StandoutNobel
Charge recombination kinetics as a probe of protonation of the primary acceptor in photosynthetic reaction centers
1985
Cannabinoid Suppression of Noxious Heat-Evoked Activity in Wide Dynamic Range Neurons in the Lumbar Dorsal Horn of the Rat
1999
Δ-9-Tetrahydrocannabinol Enhances Breast Cancer Growth and Metastasis by Suppression of the Antitumor Immune Response
2005
Presynaptic Cannabinoid Sensitivity Is a Major Determinant of Depolarization-Induced Retrograde Suppression at Hippocampal Synapses
2002
The CB1 Cannabinoid Receptor of Astrocytes Is Coupled to Sphingomyelin Hydrolysis through the Adaptor Protein Fan
2001
Anandamide transport is independent of fatty-acid amide hydrolase activity and is blocked by the hydrolysis-resistant inhibitor AM1172
2004
N-acyl-dopamines: novel synthetic CB1 cannabinoid-receptor ligands and inhibitors of anandamide inactivation with cannabimimetic activity in vitro and in vivo
2000
Membrane growth can generate a transmembrane pH gradient in fatty acid vesicles
2004 StandoutNobel
In vivo NMR Studies of the Glutamate Neurotransmitter Flux and Neuroenergetics: Implications for Brain Function
2003
Role of Endogenous Cannabinoids in Synaptic Signaling
2003
Intensely pleasurable responses to music correlate with activity in brain regions implicated in reward and emotion
2001 Standout
Architecture and Function of Membrane Proteins in Planar Supported Bilayers: A Study with Photosynthetic Reaction Centers
1996
Structural Requirements for Binding of Anandamide-Type Compounds to the Brain Cannabinoid Receptor
1997
The characteristics and effect on catalysis of nucleotide binding to noncatalytic sites of chloroplast F1-ATPase
1991 StandoutNobel
Mesenteric Vasodilation Mediated by Endothelial Anandamide Receptors
1999
Cannabinoid Analgesia as a Potential New Therapeutic Option in the Treatment of Chronic Pain
2006
Central and Peripheral Signaling Mechanisms Involved in Endocannabinoid Regulation of Feeding: A Perspective on the Munchies
2005
Molecular Dynamics Simulations of Biological Reactions
2002 StandoutNobel
Electric field effect on absorption spectra of reaction centers of Rb. sphaeroides and Rps. viridis
1987 StandoutNobel
Suppression of Nerve Growth Factor Trk Receptors and Prolactin Receptors by Endocannabinoids Leads to Inhibition of Human Breast and Prostate Cancer Cell Proliferation1
2000
Cyclodextrin Drug Carrier Systems
1998 Standout
Cannabinoid receptors as novel targets for the treatment of melanoma
2006
Novel Analogues of Arachidonylethanolamide (Anandamide): Affinities for the CB1 and CB2 Cannabinoid Receptors and Metabolic Stability
1998
2-Arachidonyl glyceryl ether, an endogenous agonist of the cannabinoid CB 1 receptor
2001
Increased Seizure Susceptibility and Proconvulsant Activity of Anandamide in Mice Lacking Fatty Acid Amide Hydrolase
2003
LY320135, a Novel Cannabinoid CB1 Receptor Antagonist, Unmasks Coupling of the CB1 Receptor to Stimulation of cAMP Accumulation
1998
Cloning and Pharmacological Characterization of the Rat CB2 Cannabinoid Receptor
2000
Platelet‐ and macrophage‐derived endogenous cannabinoids are involved in endotoxin‐induced hypotension
1998
Substrate Specificity and Stereoselectivity of Rat Brain Microsomal Anandamide Amidohydrolase
1999
Inhibitory effects of cannabinoid CB 1 receptor stimulation on tumor growth and metastatic spreading: actions on signals involved in angiogenesis and metastasis
2003
Simulations of the Large Kinetic Isotope Effect and the Temperature Dependence of the Hydrogen Atom Transfer in Lipoxygenase
2004 StandoutNobel
Therapeutic Action of Cannabinoids in a Murine Model of Multiple Sclerosis
2003
Active/Inactive state transitions of the chloroplast F1 ATPase are induced by a slow binding and release of Mg2+. Relationship to catalysis and control of F1 ATPases.
1990 StandoutNobel
CB1 cannabinoid receptors are involved in neuroprotection via NF-κB inhibition
2005
The endogenous cannabinoid anandamide inhibits human breast cancer cell proliferation
1998
Endocannabinoid 2-Arachidonyl Glycerol Is a Full Agonist through Human Type 2 Cannabinoid Receptor: Antagonism by Anandamide
2000
Inhibition of tumor angiogenesis by cannabinoids
2003
Functional CB1 cannabinoid receptors in human vascular endothelial cells
2000
Cannabinoid receptor agonists and antagonists
1998
Functional Interaction between Opioid and Cannabinoid Receptors in Drug Self-Administration
2001
Cannabinol Derivatives: Binding to Cannabinoid Receptors and Inhibition of Adenylylcyclase
1997
Brain Regional Distribution of Endocannabinoids: Implications for Their Biosynthesis and Biological Function
1999
Increase in aqueous solubility, stability and in vitro corneal permeability of anandamide by hydroxypropyl-β-cyclodextrin
1996
Cannabinoid CB1 receptor knockout mice exhibit markedly reduced voluntary alcohol consumption and lack alcohol‐induced dopamine release in the nucleus accumbens
2003
HU-308: A specific agonist for CB 2 , a peripheral cannabinoid receptor
1999
Radical-pair energetics and decay mechanisms in reaction centers containing anthraquinones, naphthoquinones or benzoquinones in place of ubiquinone
1986
Cannabinoids and the gastrointestinal tract
2001
Endocannabinoids and Neuroprotection
2002
Frontiers, Opportunities, and Challenges in Biochemical and Chemical Catalysis of CO2 Fixation
2013 Standout
Rab3B protein is required for long-term depression of hippocampal inhibitory synapses and for normal reversal learning
2011 StandoutNobel
The Cannabinoid 1 Receptor Antagonist, AM251, Prolongs the Survival of Rats with Severe Acute Pancreatitis
2005
Inhibition of glioma growth in vivo by selective activation of the CB(2) cannabinoid receptor.
2001
Inhibitors of arachidonoyl ethanolamide hydrolysis.
1994
Pharmacology of cannabinoids.
2004
The cannabinoid system and immune modulation
2003
Clinical endocannabinoid deficiency (CECD): can this concept explain therapeutic benefits of cannabis in migraine, fibromyalgia, irritable bowel syndrome and other treatment-resistant conditions?
2004
Catalytic properties of chloroplast F1-ATPase modified at catalytic or noncatalytic sites by 2-azido adenine nucleotides.
1988 StandoutNobel
The role of tightly bound ADP on chloroplast ATPase.
1985 StandoutNobel
Host-Gut Microbiota Metabolic Interactions
2012 StandoutScience
Rapid metabolic evolution in human prefrontal cortex
2011 StandoutNobel
CANNABINOID RECEPTORS AS THERAPEUTIC TARGETS
2005
SR 144528, an Antagonist for the Peripheral Cannabinoid Receptor that Behaves as an Inverse Agonist
1999
Cannabinoids Promote Oligodendrocyte Progenitor Survival: Involvement of Cannabinoid Receptors and Phosphatidylinositol-3 Kinase/Akt Signaling
2002
Converting conformational changes to electrostatic energy in molecular motors: The energetics of ATP synthase
2003 StandoutNobel
Electric-field dependence of the quantum yield in reaction centers of photosynthetic bacteria
1986
Differential Expression of Cannabinoid Receptors in the Human Colon: Cannabinoids Promote Epithelial Wound Healing
2005
Cannabinoids as Novel Anti-Inflammatory Drugs
2009
Simulation of enzyme reactions using valence bond force fields and other hybrid quantum/classical approaches
1993 StandoutNobel
ENDOCANNABINOID-MEDIATED SYNAPTIC PLASTICITY IN THE CNS
2006
Vascular targets for cannabinoids: animal and human studies
2013
Dysregulated Cannabinoid Signaling Disrupts Uterine Receptivity for Embryo Implantation
2001
Arylfluorosulfates Inactivate Intracellular Lipid Binding Protein(s) through Chemoselective SuFEx Reaction with a Binding Site Tyr Residue
2016 StandoutNobel
Plant, Synthetic, and Endogenous Cannabinoids in Medicine
2005
Tetrahydrocannabinol and endocannabinoids in feeding and appetite
2002
Nonpsychotropic Cannabinoid Receptors Regulate Microglial Cell Migration
2003
Evidence for a New G Protein-Coupled Cannabinoid Receptor in Mouse Brain
2001
N-arachidonoyll -serine, an endocannabinoid-like brain constituent with vasodilatory properties
2006
Cloning of the first sn1-DAG lipases points to the spatial and temporal regulation of endocannabinoid signaling in the brain
2003
The Endocannabinoid System and the Brain
2012
Dispersed Polaron Simulations of Electron Transfer in Photosynthetic Reaction Centers
1989 StandoutScienceNobel
Biosynthesis of anandamide and related acylethanolamides in mouse J774 macrophages and N18 neuroblastoma cells
1996
Synthesis of Lipidated Green Fluorescent Protein and Its Incorporation in Supported Lipid Bilayers
2005 StandoutNobel
Endogenous cannabinoids and appetite
2001
Quantum corrections for rate constants of diabatic and adiabatic reactions in solutions
1990 StandoutNobel
Probes of catalytic site cooperativity during catalysis by the chloroplast adenosine triphosphate and the adenosine triphosphate synthase.
1983 StandoutNobel
The cannabinoid agonist WIN55,212-2 increases intracellular calcium via CB1receptor coupling to Gq/11G proteins
2005
Supersensitivity to anandamide and enhanced endogenous cannabinoid signaling in mice lacking fatty acid amide hydrolase
2001
2-Arachidonoylglycerol
2004
Mechanism of action of cannabinoids: how it may lead to treatment of cachexia, emesis, and pain.
2006
Up‐regulation of anandamide levels as an endogenous mechanism and a pharmacological strategy to limit colon inflammation
2006
Proton-Coupled Electron Transfer
2012 Standout
Structure, mechanism and regulation of pyruvate carboxylase
2008
Involvement of Cannabinoid Receptors in the Intraocular Pressure-Lowering Effects of WIN55212-2
2000
Structural determinants for recognition and translocation by the anandamide transporter
1999
Multiple Functions of Endocannabinoid Signaling in the Brain
2012
A new strategy to block tumor growth by inhibiting endocannabinoid inactivation
2004
Enzymatic synthesis of anandamide, an endogenous ligand for the cannabinoid receptor, by brain membranes.
1994
Works of Asher Gopher being referenced
Two new unsaturated fatty acid ethanolamides in brain that bind to the cannabinoid receptor
1993
Identification of an endogenous 2-monoglyceride, present in canine gut, that binds to cannabinoid receptors
1995 Standout
The effect of an applied electric field on the charge recombination kinetics in reaction centers reconstituted in planar lipid bilayers
1985
Cerebral metabolic compartmentation. Estimation of glucose flux via pyruvate carboxylase/pyruvate dehydrogenase by 13C NMR isotopomer analysis of D-[U-13C]glucose metabolites.
1994
Evaluation of partial rate constants of competitive inhibition by analysis of nonlinear kinetics
1978