Standout Papers
Citation Impact
Citing Papers
Plasma membrane-associated proteins are clustered into islands attached to the cytoskeleton
2006
Partitioning of Lipid-Modified Monomeric GFPs into Membrane Microdomains of Live Cells
2002 StandoutScienceNobel
Genome-Wide Analysis in Vivo of Translation with Nucleotide Resolution Using Ribosome Profiling
2009 StandoutScience
Role of Sec61p in the ER-associated degradation of short-lived transmembrane proteins
2008 StandoutNobel
Recognition of Cognate Transfer RNA by the 30 S Ribosomal Subunit
2001 StandoutScienceNobel
Structure of the 70 S Ribosome Complexed with mRNA and tRNA
2006 StandoutScienceNobel
α-Synuclein Promotes SNARE-Complex Assembly in Vivo and in Vitro
2010 StandoutScienceNobel
Cotranslational structure acquisition of nascent polypeptides monitored by NMR spectroscopy
2010
Structure of the signal recognition particle interacting with the elongation-arrested ribosome
2004 StandoutNatureNobel
tRNA selection and kinetic proofreading in translation
2004 Nobel
SecB functions as a cytosolic signal recognition factor for protein export in E. coli
1989 StandoutNobel
The Preprotein Translocation Channel of the Outer Membrane of Mitochondria
1998
Folding of nascent polypeptide chains in a high molecular mass assembly with molecular chaperones
1994 Nature
Incorporation of aminoacyl-tRNA into the ribosome as seen by cryo-electron microscopy
2003 StandoutNobel
Ribosome Function: Governing the Fate of a Nascent Polypeptide
2004
Arrangement of tRNAs in Pre- and Posttranslocational Ribosomes Revealed by Electron Cryomicroscopy
1997
Phosphatidylinositol Phosphates as Co-activators of Ca2+ Binding to C2 Domains of Synaptotagmin 1
2006 StandoutNobel
GTP binding and hydrolysis by the signal recognition particle during initiation of protein translocation
1993 Nature
Unraveling the mechanisms of synaptotagmin and SNARE function in neurotransmitter release
2006
A mammalian homolog of SEC61p and SECYp is associated with ribosomes and nascent polypeptides during translocation
1992
The Polypeptide Tunnel System in the Ribosome and Its Gating in Erythromycin Resistance Mutants of L4 and L22
2001
Functional insights from the structure of the 30S ribosomal subunit and its interactions with antibiotics
2000 StandoutNatureNobel
Three-dimensional structure of the yeast ribosome
1998 StandoutNobel
Molecular Mechanism of Drug-Dependent Ribosome Stalling
2008
The signal recognition particle in S. cerevisiae
1991
Model for signal sequence recognition from amino-acid sequence of 54K subunit of signal recognition particle
1989 StandoutNatureNobel
ER protein quality control and proteasome-mediated protein degradation
1999
Distinct Machinery Is Required in Saccharomyces cerevisiae for the Endoplasmic Reticulum-associated Degradation of a Multispanning Membrane Protein and a Soluble Luminal Protein
2004
The signal recognition particle receptor mediates the GTP-dependent displacement of SRP from the signal sequence of the nascent polypeptide
1989
Endoplasmic Reticulum Degradation of a Mutated ATP-binding Cassette Transporter Pdr5 Proceeds in a Concerted Action of Sec61 and the Proteasome
1998
A protein-conducting channel in the endoplasmic reticulum
1991 StandoutNobel
Molecular Mechanism of Membrane Protein Integration into the Endoplasmic Reticulum
1997
Multi-protein assemblies underlie the mesoscale organization of the plasma membrane
2014 StandoutNobel
Architecture of the Protein-Conducting Channel Associated with the Translating 80S Ribosome
2001 StandoutNobel
More than just a channel: Provocative new features of protein traffic across the ER membrane
1991
Protein Unfolding Is Not a Prerequisite for Endoplasmic Reticulum-to-Cytosol Dislocation
2003
The crystal structure of elongation factor EF-Tu from Thermus aquaticus in the GTP conformation
1993
Structural insight into the role of the ribosomal tunnel in cellular regulation
2003 StandoutNobel
The glycan code of the endoplasmic reticulum: asparagine-linked carbohydrates as protein maturation and quality-control tags
2005
What recent ribosome structures have revealed about the mechanism of translation
2009 StandoutNatureNobel
The Plasticity of a Translation Arrest Motif Yields Insights into Nascent Polypeptide Recognition inside the Ribosome Tunnel
2009
Protein Translocation
1999 StandoutNobel
Oligomeric complexes involved in translocation of proteins across the membrane of the endoplasmic reticulum
1999
Cellular mechanisms of membrane protein folding
2009
Sequence-Specific Alteration of the Ribosome–Membrane Junction Exposes Nascent Secretory Proteins to the Cytosol
1996
Protein Translocation Is Mediated by Oligomers of the SecY Complex with One SecY Copy Forming the Channel
2007
The Tim core complex defines the number of mitochondrial translocation contact sites and can hold arrested preproteins in the absence of matrix Hsp70-Tim44
1997
Structural insight into the protein translocation channel
2004
A model of protein synthesis based on cryo-electron microscopy of the E. coli ribosome
1995 Nature
Snapshots of membrane-translocating proteins
1996
Converging concepts of protein folding in vitro and in vivo
2009
Protein Quality Control in the Cytosol and the Endoplasmic Reticulum: Brothers in Arms
2010
Mechanism of Polypeptide Translocation into the Endoplasmic Reticulum
1996 StandoutNobel
Structures of active conformations of Gi alpha 1 and the mechanism of GTP hydrolysis
1994 StandoutScienceNobel
Peptide bond formation does not involve acid-base catalysis by ribosomal residues
2006
Cotranslocational Degradation Protects the Stressed Endoplasmic Reticulum from Protein Overload
2006
A cradle for new proteins: trigger factor at the ribosome
2005
Binding of the complexin N terminus to the SNARE complex potentiates synaptic-vesicle fusogenicity
2010
Oligomeric Rings of the Sec61p Complex Induced by Ligands Required for Protein Translocation
1996
Enhanced proofreading governs CRISPR–Cas9 targeting accuracy
2017 StandoutNatureNobel
The protein-conducting channel in the membrane of the endoplasmic reticulum is open laterally toward the lipid bilayer
1995
Kinetic Analysis of the Translocation of Fluorescent Precursor Proteins into Escherichia coli Membrane Vesicles
2002
Signal Recognition Particle (SRP), a Ubiquitous Initiator of Protein Translocation
1995
BiP Acts as a Molecular Ratchet during Posttranslational Transport of Prepro-α Factor across the ER Membrane
1999
Complete kinetic mechanism of elongation factor Tu-dependent binding of aminoacyl-tRNA to the A site of the E.coli ribosome
1998
Der1p, a protein required for degradation of malfolded soluble proteins of the endoplasmic reticulum: topology and Der1-like proteins
2004
On peptide bond formation, translocation, nascent protein progression and the regulatory properties of ribosomes
2003 StandoutNobel
Synaptic vesicle fusion
2008
Cryo-EM structure of the ribosome–SecYE complex in the membrane environment
2011
A posttargeting signal sequence recognition event in the endoplasmic reticulum membrane
1995
Induced fit in initial selection and proofreading of aminoacyl-tRNA on the ribosome
1999
The Structure of Ribosome-Channel Complexes Engaged in Protein Translocation
2000
Giant MACPF/CDC pore forming toxins: A class of their own
2015
From peptide‐bond formation to cotranslational folding: dynamic, regulatory and evolutionary aspects
2004 StandoutNobel
SNAP receptors implicated in vesicle targeting and fusion
1993 StandoutNatureNobel
Approaching the mechanism of protein transport across the ER membrane
1996
Ribosomal crystallography: Peptide bond formation and its inhibition
2003 StandoutNobel
Molecular chaperones in protein folding and proteostasis
2011 StandoutNature
Protein translocation into proteoliposomes reconstituted from purified components of the endoplasmic reticulum membrane
1993
Electrostatics in the Ribosomal Tunnel Modulate Chain Elongation Rates
2008
Measurements of Internal Distance Changes of the 30 S Ribosome Using FRET with Multiple Donor–Acceptor Pairs: Quantitative Spectroscopic Methods
2005
The Movement of tRNA Through the Ribosome
1998
Coupled chaperone action in folding and assembly of hexadecameric Rubisco
2010 Nature
Real-time observation of trigger factor function on translating ribosomes
2006 Nature
The Protein Import Motor of Mitochondria
1999
SecYEG assembles into a tetramer to form the active protein translocation channel
2000
Structure and assembly of pore-forming proteins
2010
Mechanisms of membrane fusion: disparate players and common principles
2008
A protein of the endoplasmic reticulum involved early in polypeptide translocation
1992 Nature
SEC65 gene product is a subunit of the yeast signal recognition particle required for its integrity
1992 Nature
TRPV1 structures in nanodiscs reveal mechanisms of ligand and lipid action
2016 StandoutNatureNobel
X-ray structure of a protein-conducting channel
2003 Nature
Conformational control of DNA target cleavage by CRISPR–Cas9
2015 StandoutNatureNobel
Molecular simulations of cotranslational protein folding: fragment stabilities, folding cooperativity and trapping in the ribosome tunnel
2005
Biogenesis of Polytopic Membrane Proteins: Membrane Segments Assemble within Translocation Channels prior to Membrane Integration
1996
Complexin Clamps Asynchronous Release by Blocking a Secondary Ca2+ Sensor via Its Accessory α Helix
2010 StandoutNobel
Synaptotagmin-Mediated Bending of the Target Membrane Is a Critical Step in Ca2+-Regulated Fusion
2009
The Native 3D Organization of Bacterial Polysomes
2009
Protein Folding in the Cytoplasm and the Heat Shock Response
2010
Crystal structure of methionyl-tRNAfMet transformylase complexed with the initiator formyl-methionyl-tRNAfMet
1998
The 'sequential allosteric ring' mechanism in the eukaryotic chaperonin-assisted folding of actin and tubulin
2001
The Sec61p Complex Mediates the Integration of a Membrane Protein by Allowing Lipid Partitioning of the Transmembrane Domain
2000
Yos9p Detects and Targets Misfolded Glycoproteins for ER-Associated Degradation
2005
How are tRNAs and mRNA arranged in the ribosome? An attempt to correlate the stereochemistry of the tRNA-mRNA interaction with constraints imposed by the ribosomal topography
1992
The ternary complex of aminoacylated tRNA and EF-Tu-GTP. Recognition of a bond and a fold
1996
Photocrosslinking demonstrates proximity of a 34 kDa membrane protein to different portions of preprolactin during translocation through the endoplasmic reticulum
1989
An expanding arsenal of experimental methods yields an explosion of insights into protein folding mechanisms
2009
Yeast Sec proteins interact with polypeptides traversing the endoplasmic reticulum membrane
1992
Ribosomal antibiotics: structural basis for resistance, synergism and selectivity
2004 StandoutNobel
Binding of Secretory Precursor Polypeptides to a Translocon Subcomplex Is Regulated by BiP
1997 StandoutNobel
Late events of translation initiation in bacteria: a kinetic analysis
2000
Signal Sequence Recognition and Protein Targeting to the Endoplasmic Reticulum Membrane
1994
The Oligomeric Distribution of SecYEG is Altered by SecA and Translocation Ligands
2005
Complexin and Ca2+ stimulate SNARE-mediated membrane fusion
2008
Signal Sequence Recognition in Posttranslational Protein Transport across the Yeast ER Membrane
1998
Sec61p-independent degradation of the tail-anchored ER membrane protein Ubc6p
2001
Protein Translocation: Tunnel Vision
1998
Sec61p and BiP directly facilitate polypeptide translocation into the ER
1992 StandoutNobel
Evolutionarily conserved binding of ribosomes to the translocation channel via the large ribosomal RNA
2000
Crystal structure of active elongation factor Tu reveals major domain rearrangements
1993 Nature
A protein complex required for signal-sequence-specific sorting and translocation
1994 Nature
Molecular Dynamics Studies of the Archaeal Translocon
2006
The nascent polypeptide-associated complex modulates interactions between the signal recognition particle and the ribosome
1996
Translocation gets a push
1994 StandoutNobel
Folding zones inside the ribosomal exit tunnel
2005
Structure at 2.8 Â resolution of F1-ATPase from bovine heart mitochondria
1994 StandoutNatureNobel
Major groove binding of the tRNA/mRNA complex to the 16 S ribosomal RNA decoding site 1 1Edited by D. E. Draper
1999
Posttranslational protein transport in yeast reconstituted with a purified complex of Sec proteins and Kar2p
1995
Signal peptides open protein-conducting channels in E. coli
1992
The bacterial SecY/E translocation complex forms channel-like structures similar to those of the eukaryotic sec61p complex
1999
A membrane component of the endoplasmic reticulum that may be essential for protein translocation.
1989
Nonexponential kinetics of a single tRNA Phe molecule under physiological conditions
1997
The Complete Atomic Structure of the Large Ribosomal Subunit at 2.4 Å Resolution
2000 StandoutScienceNobel
The Structure of Ribosomal RNA: A Three‐Dimensional Jigsaw Puzzle
1995
Exploring the nature of the translocon-assisted protein insertion
2012 StandoutNobel
Structural Insight into Nascent Polypeptide Chain–Mediated Translational Stalling
2009 StandoutScienceNobel
In Vivo Imaging of Membrane-Associated Glycans in Developing Zebrafish
2008 StandoutScienceNobel
Review
1998
Nascent polypeptide-associated complex protein prevents mistargeting of nascent chains to the endoplasmic reticulum.
1995
Determination of the Transmembrane Topology of Yeast Sec61p, an Essential Component of the Endoplasmic Reticulum Translocation Complex
1996
Ribosome binding to the endoplasmic reticulum: a 180-kD protein identified by crosslinking to membrane-bound ribosomes is not required for ribosome binding activity.
1991
Lateral sorting in model membranes by cholesterol-mediated hydrophobic matching
2011
Mutation of the mouse klotho gene leads to a syndrome resembling ageing.
1997 Standout
Polypeptide translocation across the endoplasmic reticulum membrane.
1992 StandoutNobel
Probing ribosome-nascent chain complexes produced in vivo by NMR spectroscopy
2009
Size, Motion, and Function of the SecY Translocon Revealed by Molecular Dynamics Simulations with Virtual Probes
2006
Differential but convergent functions of Ca 2+ binding to synaptotagmin-1 C 2 domains mediate neurotransmitter release
2009 StandoutNobel
Structural Features of the GroEL-GroES Nano-Cage Required for Rapid Folding of Encapsulated Protein
2006
Signal Sequence Recognition in Cotranslational Translocation by Protein Components of the Endoplasmic Reticulum Membrane
1998
Transfer RNA docking pair model in the ribosomal pre- and post- translocational states
1997
An E. coli Ribonucleoprotein Containing 4.5 S RNA Resembles Mammalian Signal Recognition Particle
1990 Science
Systematic probing of the environment of a translocating secretory protein during translocation through the ER membrane.
1994
Pore-forming activity and structural autoinhibition of the gasdermin family
2016 StandoutNature
Probing the SecYEG translocation pore size with preproteins conjugated with sizable rigid spherical molecules
2011 StandoutNobel
The Structural Basis of Ribosome Activity in Peptide Bond Synthesis
2000 StandoutScienceNobel
A second trimeric complex containing homologs of the Sec61p complex functions in protein transport across the ER membrane of S. cerevisiae.
1996
The signal sequence receptor, unlike the signal recognition particle receptor, is not essential for protein translocation
1992
Characterization of the proteasome interaction with the Sec61 channel in the endoplasmic reticulum
2007
Direct Visualization of A-, P-, and E-Site Transfer RNAs in the Escherichia coli Ribosome
1996 StandoutScienceNobel
Binding of ribosomes to the rough endoplasmic reticulum mediated by the Sec61p-complex.
1994
Access of proteinase K to partially translocated nascent polypeptides in intact and detergent-solubilized membranes.
1989
Secondary Structure Formation of a Transmembrane Segment in Kv Channels
2005
NAC covers ribosome-associated nascent chains thereby forming a protective environment for regions of nascent chains just emerging from the peptidyl transferase center.
1995
Molecular Chaperones in the Cytosol: from Nascent Chain to Folded Protein
2002 StandoutScience
Structural Determinants of Lateral Gate Opening in the Protein Translocon
2007
Cholera Toxin Is Exported from Microsomes by the Sec61p Complex
2000
The Signal Recognition Particle
2001
Illuminating Single Molecules in Condensed Matter
1999 StandoutScienceNobel
The signal sequence receptor has a second subunit and is part of a translocation complex in the endoplasmic reticulum as probed by bifunctional reagents.
1990
Antiribophorin antibodies inhibit the targeting to the ER membrane of ribosomes containing nascent secretory polypeptides.
1990
Signal Recognition Particle (SRP), a Ubiquitous Initiator of Protein Translocation
1995
Common Principles of Protein Translocation Across Membranes
1996 Science
Functional aspects of ribosomal architecture: symmetry, chirality and regulation
2004 StandoutNobel
Site-specific photocross-linking reveals that Sec61p and TRAM contact different regions of a membrane-inserted signal sequence.
1993
A precursor protein partly translocated into yeast mitochondria is bound to a 70 kd mitochondrial stress protein.
1990
Protein Translocation Across the Bacterial Cytoplasmic Membrane
2007
Synaptotagmin activates membrane fusion through a Ca2+-dependent trans interaction with phospholipids
2007
Misfolded proteins are sorted by a sequential checkpoint mechanism of ER quality control
2004
Membrane Fusion: Grappling with SNARE and SM Proteins
2009 StandoutScienceNobel
Folding of Newly Translated Proteins In Vivo: The Role of Molecular Chaperones
2001
Protein translocation across the ER requires a functional GTP binding site in the alpha subunit of the signal recognition particle receptor.
1992
The beta subunit of the signal recognition particle receptor is a transmembrane GTPase that anchors the alpha subunit, a peripheral membrane GTPase, to the endoplasmic reticulum membrane.
1995
ANTIBIOTICS TARGETING RIBOSOMES: Resistance, Selectivity, Synergism, and Cellular Regulation
2005 StandoutNobel
Requirement of GTP Hydrolysis for Dissociation of the Signal Recognition Particle from Its Receptor
1991 Science
Alignment of Conduits for the Nascent Polypeptide Chain in the Ribosome-Sec61 Complex
1997 StandoutScienceNobel
Sec61p Serves Multiple Roles in Secretory Precursor Binding and Translocation into the Endoplasmic Reticulum Membrane
1998 StandoutNobel
GTP hydrolysis by complexes of the signal recognition particle and the signal recognition particle receptor.
1993
The intrinsic ability of ribosomes to bind to endoplasmic reticulum membranes is regulated by signal recognition particle and nascent-polypeptide-associated complex.
1995
Molecular Simulations of Cotranslational Protein Folding: Fragment Stabilities, Folding Cooperativity, and Trapping in the Ribosome
2006
Topological arrangement of two transfer RNAs on the ribosome
1983
Visualization of Trna Movements on theEscherichia coli70s Ribosome during the Elongation Cycle
2000 StandoutNobel
Structural Insights Into the Signal Recognition Particle
2004 StandoutNobel
Interaction between BiP and Sec63p is required for the completion of protein translocation into the ER of Saccharomyces cerevisiae.
1995 StandoutNobel
Post-translational protein translocation: not all hsc70s are created equal
1996
MODERN APPLICATIONS OF ANALYTICAL ULTRACENTRIFUGATION
1999
tRNA dynamics on the ribosome during translation
2004 Nobel
Transient Tertiary Structure Formation within the Ribosome Exit Port
2010
Signal sequence-dependent function of the TRAM protein during early phases of protein transport across the endoplasmic reticulum membrane.
1996
ER translocation intermediates are adjacent to a nonglycosylated 34-kD integral membrane protein.
1991
A large presecretory protein translocates both cotranslationally, using signal recognition particle and ribosome, and post-translationally, without these ribonucleoparticles, when synthesized in the presence of mammalian microsomes.
1990
Structure of trigger factor binding domain in biologically homologous complex with eubacterial ribosome reveals its chaperone action
2005 StandoutNobel
Ribosomal Crystallography: Initiation, Peptide Bond Formation, and Amino Acid Polymerization are Hampered by Antibiotics
2004 StandoutNobel
Signal recognition particle (SRP) stabilizes the translocation-competent conformation of pre-secretory proteins.
1988
The signal sequence of nascent preprolactin interacts with the 54K polypeptide of the signal recognition particle
1986 Nature
Signal sequence recognition and targeting of ribosomes to the endoplasmic reticulum by the signal recognition particle do not require GTP.
1994
Saccharomyces cerevisiae and Schizosaccharomyces pombe contain a homologue to the 54-kD subunit of the signal recognition particle that in S. cerevisiae is essential for growth.
1989
Determinants of carboxyl-terminal domain translocation during prion protein biogenesis
1994 StandoutNobel
Sequential action of mitochondrial chaperones in protein import into the matrix.
1991
Works of Arthur E. Johnson being referenced
The domains of a cholesterol-dependent cytolysin undergo a major FRET-detected rearrangement during pore formation
2005
A signal-anchor sequence stimulates signal recognition particle binding to ribosomes from inside the exit tunnel
2009
Photocross-linking of nascent chains to the STT3 subunit of the oligosaccharyltransferase complex
2003
Real-Time Fluorescence Detection of ERAD Substrate Retrotranslocation in a Mammalian In Vitro System
2007
The methionine-rich domain of the 54 kd protein subunit of the signal recognition particle contains an RNA binding site and can be crosslinked to a signal sequence.
1990
Nascent Membrane and Secretory Proteins Differ in FRET-Detected Folding Far inside the Ribosome and in Their Exposure to Ribosomal Proteins
2004
Close membrane-membrane proximity induced by Ca2+-dependent multivalent binding of synaptotagmin-1 to phospholipids
2006 StandoutNobel
The co‐translational folding and interactions of nascent protein chains: a new approach using fluorescence resonance energy transfer
2004
Arresting Pore Formation of a Cholesterol-dependent Cytolysin by Disulfide Trapping Synchronizes the Insertion of the Transmembrane β-Sheet from a Prepore Intermediate
2001
Assembly and Topography of the Prepore Complex in Cholesterol-dependent Cytolysins
2003
Fluorescence characterization of the interaction of various transfer RNA species with elongation factor Tu.cntdot.GTP: evidence for a new functional role for elongation factor Tu in protein biosynthesis
1990
The Cotranslational Integration of Membrane Proteins into the Phospholipid Bilayer Is a Multistep Process
1996
Monomer-Monomer Interactions Drive the Prepore to Pore Conversion of a β-Barrel-forming Cholesterol-dependent Cytolysin
2002
Co-translational Interactions of Apoprotein B with the Ribosome and Translocon during Lipoprotein Assembly or Targeting to the Proteasome
2001
Identification of Nascent Chain Interaction Sites on Trigger Factor
2007
Monomer-Monomer Interactions Propagate Structural Transitions Necessary for Pore Formation by the Cholesterol-dependent Cytolysins
2012
Mechanism of Membrane Insertion of a Multimeric β-Barrel Protein
2000
Disulfide-bond scanning reveals assembly state and β-strand tilt angle of the PFO β-barrel
2013
Sequential triage of transmembrane segments by Sec61α during biogenesis of a native multispanning membrane protein
2005
Stepwise Insertion and Inversion of a Type II Signal Anchor Sequence in the Ribosome-Sec61 Translocon Complex
2011
Both Lumenal and Cytosolic Gating of the Aqueous ER Translocon Pore Are Regulated from Inside the Ribosome during Membrane Protein Integration
1997
The signal sequence moves through a ribosomal tunnel into a noncytoplasmic aqueous environment at the ER membrane early in translocation
1993
Fluorescence Resonance Energy Transfer Analysis of Protein Translocase
2003
How Hydrophobic Is Alanine?
2003
BiP Maintains the Permeability Barrier of the ER Membrane by Sealing the Lumenal End of the Translocon Pore before and Early in Translocation
1998
Translation Arrest Requires Two-Way Communication between a Nascent Polypeptide and the Ribosome
2006
Fluorescence Approaches for Determining Protein Conformations, Interactions and Mechanisms at Membranes
2005
SRP Keeps Polypeptides Translocation-Competent by Slowing Translation to Match Limiting ER-Targeting Sites
2008
The Mechanism of Membrane Insertion for a Cholesterol-Dependent Cytolysin
1999
Protein translocation across the ER membrane: a fluorescent light at the end of the tunnel
1993
Specific Protein-Membrane Contacts Are Required for Prepore and Pore Assembly by a Cholesterol-dependent Cytolysin
2007
N-Linked Glycans Direct the Cotranslational Folding Pathway of Influenza Hemagglutinin
2003
The Cotranslational Contacts between Ribosome-bound Nascent Polypeptides and the Subunits of the Hetero-oligomeric Chaperonin TRiC Probed by Photocross-linking
2005
Cotranslational Protein Integration into the ER Membrane Is Mediated by the Binding of Nascent Chains to Translocon Proteins
2003
The Aqueous Pore through the Translocon Has a Diameter of 40–60 Å during Cotranslational Protein Translocation at the ER Membrane
1997
Fluorescence-detected assembly of the signal recognition particle: binding of the two SRP protein heterodimers to SRP RNA is noncooperative
1992
The ER Translocon and Retrotranslocation
2000
Structural insights into the membrane-anchoring mechanism of a cholesterol-dependent cytolysin
2002
Membrane-dependent conformational changes initiate cholesterol-dependent cytolysin oligomerization and intersubunit β-strand alignment
2004
Revealing the Topography of Cellular Membrane Domains by Combined Atomic Force Microscopy/Fluorescence Imaging
2006
Effects of nucleotide- and aurodox-induced changes in elongation factor Tu conformation upon its interactions with aminoacyl transfer RNA. A fluorescence study
1990
Inhibition of Protein Translocation across the Endoplasmic Reticulum Membrane by Sterols
2001
Exploring the capacity of trigger factor to function as a shield for ribosome bound polypeptide chains
2005
Secretory proteins move through the endoplasmic reticulum membrane via an aqueous, gated pore
1994
Signal Recognition Particle Binds to Ribosome-bound Signal Sequences with Fluorescence-detected Subnanomolar Affinity That Does Not Diminish as the Nascent Chain Lengthens
2003
Time-resolved fluorescence studies on the ternary complex formed between bacterial elongation factor Tu, guanosine 5'-triphosphate, and phenylalanyl-tRNAPhe
1989
Macromolecular arrangement in the aminoacyl-tRNA.cntdot.elongation factor Tu.cntdot.GTP ternary complex. A fluorescence energy transfer study
1995
A new role for BiP
2002
Cholesterol Exposure at the Membrane Surface Is Necessary and Sufficient to Trigger Perfringolysin O Binding
2009
Sequence-specific Retention and Regulated Integration of a Nascent Membrane Protein by the Endoplasmic Reticulum Sec61 Translocon
2008
A model for the aminoacyl-tRNA binding site of eukaryotic elongation factor 1 alpha.
1992
Role of 4.5 S RNA in Assembly of the Bacterial Signal Recognition Particle with Its Receptor
2000 Science
Structural elements of the cholesterol-dependent cytolysins that are responsible for their cholesterol-sensitive membrane interactions
2007
The molecular mechanisms underlying BiP-mediated gating of the Sec61 translocon of the endoplasmic reticulum
2005
Structure of bovine blood-coagulation factor Va. Determination of the subunit associations, molecular weights, and asymmetries by analytical ultracentrifugation
1984
Protein translocation across the endoplasmic reticulum membrane: identification by photocross-linking of a 39-kD integral membrane glycoprotein as part of a putative translocation tunnel.
1989
The Interaction of the Chaperonin Tailless Complex Polypeptide 1 (Tcp1) Ring Complex (Tric) with Ribosome-Bound Nascent Chains Examined Using Photo-Cross-Linking
2000
Identification of a Membrane-Spanning Domain of the Thiol-Activated Pore-Forming Toxin Clostridium perfringens Perfringolysin O: An α-Helical to β-Sheet Transition Identified by Fluorescence Spectroscopy
1998
The Mechanism of Pore Assembly for a Cholesterol-Dependent Cytolysin: Formation of a Large Prepore Complex Precedes the Insertion of the Transmembrane β-Hairpins
2000
The Translocon: A Dynamic Gateway at the ER Membrane
1999
A nascent membrane protein is located adjacent to ER membrane proteins throughout its integration and translation.
1991
Distance moved by transfer RNA during translocation from the A site to the P site on the ribosome
1982
Photocrosslinking of the signal sequence of nascent preprolactin to the 54-kilodalton polypeptide of the signal recognition particle.
1986
Protein translocation at the ER membrane: A complex process becomes more so
1997
Identification of a histidine residue near the aminoacyl transfer ribonucleic acid binding site of elongation factor Tu
1981
N,iε-Acetyllysine transfer ribonucleic acid: a biologically active analogue of aminoacyl transfer ribonucleic acids
1976
Only two amino acids are essential for cytolytic toxin recognition of cholesterol at the membrane surface
2010