Citation Impact
Citing Papers
Protein Misfolding, Amyloid Formation, and Human Disease: A Summary of Progress Over the Last Decade
2017 Standout
Pathophysiology of Migraine: A Disorder of Sensory Processing
2017 Standout
Management of Hyperglycemia in Type 2 Diabetes: A Patient-Centered Approach
2012 Standout
The Molecular Basis of Distinct Aggregation Pathways of Islet Amyloid Polypeptide
2010
Structure of the PAPP-ABP5 complex reveals mechanism of substrate recognition
2022 StandoutNobel
Role of the normal gut microbiota
2015 Standout
Treatment of diabetes with vanadium salts: general overview and amelioration of nutritionally induced diabetes in thePsammomys obesus gerbil
2001
Leptin revisited: its mechanism of action and potential for treating diabetes
2012
Amylin: Pharmacology, Physiology, and Clinical Potential
2015
Time‐dependent insulin oligomer reaction pathway prior to fibril formation: Cooling and seeding
2009 StandoutNobel
The Pharmacology of Nitric Oxide in the Peripheral Nervous System of Blood Vessels
2003
Applications of genome editing technology in the targeted therapy of human diseases: mechanisms, advances and prospects
2020 Standout
Atomic structures of amyloid cross-β spines reveal varied steric zippers
2007 StandoutNature
Pramlintide acetate injection for the treatment of type 1 and type 2 diabetes mellitus
2007
Non-parallelism of islet amyloid polypeptide (amylin) and insulin gene expression in rat islets following dexamethasone treatment
1995
Animal models of human amyloidoses: Are transgenic mice worth the time and trouble?
2009
Type 2 diabetes as an inflammatory disease
2011 Standout
Identification of Hot Regions of the Aβ–IAPP Interaction Interface as High‐Affinity Binding Sites in both Cross‐ and Self‐Association
2010
Aspects on human amyloid forms and their fibril polypeptides
2005
Cellular, molecular, and tissue-level reactions to orthodontic force
2006 Standout
Neuroanatomical Localization, Pharmacological Characterization and Functions of CGRP, Related Peptides and Their Receptors
1997
Identifying Structural Features of Fibrillar Islet Amyloid Polypeptide Using Site-directed Spin Labeling
2004
3 The Genetics of Non-insulin-Dependent Diabetes Mellitus
1995
Management of hyperglycaemia in type 2 diabetes: a patient-centered approach. Position statement of the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD)
2012 Standout
Extensive islet amyloid formation is induced by development of Type II diabetes mellitus and contributes to its progression: pathogenesis of diabetes in a mouse model
1999
The Parallel Superpleated Beta-structure as a Model for Amyloid Fibrils of Human Amylin
2005
The Amyloid State of Proteins in Human Diseases
2012 Standout
Lessons from transgenic and knockout animals about noninsulin-dependent diabetes mellitus
1996
The biopsychosocial approach to chronic pain: Scientific advances and future directions.
2007 Standout
Type 2 diabetes mellitus
2015 Standout
Membrane mimetic systems in CryoEM: keeping membrane proteins in their native environment
2019 StandoutNobel
Inflammasomes: mechanism of action, role in disease, and therapeutics
2015 Standout
Transthyretin and Amyloid in the Islets of Langerhans in Type‐2 Diabetes
2008
Islet Amyloid: A Critical Entity in the Pathogenesis of Type 2 Diabetes
2004
Obesity and insulin resistance
2000 Standout
The relative contributions of insulin resistance and beta-cell dysfunction to the pathophysiology of Type 2 diabetes
2003 Standout
Molecular Mapping of the Recognition Interface between the Islet Amyloid Polypeptide and Insulin
2006
Polymorphic Fibrillar Assembly of Human Amylin
1997
Epigallocatechin-3-gallate rapidly remodels PAP85-120, SEM1(45-107), and SEM2(49-107) seminal amyloid fibrils
2015 StandoutNobel
Protein Misfolding, Functional Amyloid, and Human Disease
2006 Standout
From the Triumvirate to the Ominous Octet: A New Paradigm for the Treatment of Type 2 Diabetes Mellitus
2009 Standout
Mechanisms of Insulin Action and Insulin Resistance
2018 Standout
Type 2 diabetes: principles of pathogenesis and therapy
2005 Standout
Spontaneous Lipid Nanodisc Fomation by Amphiphilic Polymethacrylate Copolymers
2017
40 YEARS OF IGF1: IGF-binding proteins
2017
Islet Amyloid Polypeptide, Islet Amyloid, and Diabetes Mellitus
2011
Properties of Resveratrol:In VitroandIn VivoStudies about Metabolism, Bioavailability, and Biological Effects in Animal Models and Humans
2015 Standout
Human Islet Amyloid Polypeptide Oligomers Disrupt Cell Coupling, Induce Apoptosis, and Impair Insulin Secretion in Isolated Human Islets
2006
Insulin Resistance and the Polycystic Ovary Syndrome: Mechanism and Implications for Pathogenesis*
1997 Standout
Calcitonin Gene-Related Peptide Decreases Expression of HLA-DR and CD86 by Human Dendritic Cells and Dampens Dendritic Cell-Driven T Cell-Proliferative Responses Via the Type I Calcitonin Gene-Related Peptide Receptor
2000 StandoutNobel
Spontaneous diabetes mellitus in transgenic mice expressing human islet amyloid polypeptide.
1996
Islet amyloid-associated diabetes in obese A(vy)/a mice expressing human islet amyloid polypeptide.
1998
β-Cell Deficit and Increased β-Cell Apoptosis in Humans With Type 2 Diabetes
2003 Standout
beta-cell dysfunction and failure in type 2 diabetes: potential mechanisms.
2001
Islet Amyloid Develops Diffusely Throughout the Pancreas Before Becoming Severe and Replacing Endocrine Cells
2001
Resveratrol prevents the wasting disorders of mechanical unloading by acting as a physical exercise mimetic in the rat
2011
Reduced amylin release is a characteristic of impaired glucose tolerance and type 2 diabetes in Japanese Americans.
1998
Deletion of Pten in Pancreatic β-Cells Protects Against Deficient β-Cell Mass and Function in Mouse Models of Type 2 Diabetes
2010 StandoutNobel
Islet amyloid formation associated with hyperglycemia in transgenic mice with pancreatic beta cell expression of human islet amyloid polypeptide.
1996
Works of Arnold Leckström being referenced
Effect of insulin treatment on circulating islet amyloid polypeptide in patients with NIDDM
1997
Overexpression of Gly56/Gly80/Gly81-Mutant Insulin-Like Growth Factor-Binding Protein-3 in Transgenic Mice
2004
Increased Release of IAPP in Response to Long-Term High Fat Intake in Mice
1998
Involvement of Nitric Oxide and Peptides in the Inhibitory Non‐Adrenergic, Non‐Cholinergic (NANC) Response in Bovine Mesenteric Artery**
1993
Effects of beta cell granule components on human islet amyloid polypeptide fibril formation
1996
Renal Elimination of Islet Amyloid Polypeptide
1997
Treatment with a melanocortin agonist improves abnormal lipid metabolism in streptozotocin-induced diabetic mice
2011
Human islet amyloid polypeptide transgenic mice as a model of non‐insulin‐dependent diabetes mellitus (NIDDM)
1993
Islet amyloid polypeptide in Psammomys obesus (sand rat): effects of nutritionally induced diabetes and recovery on low-energy diet or vanadyl sulfate treatment.
1997
Islet amyloid polypeptide (amylin) is expressed in sensory neurons
1995
Tail suspension increases energy expenditure independently of the melanocortin system in miceThis article is one of a selection of papers published in a special issue celebrating the 125th anniversary of the Faculty of Medicine at the University of Manitoba.
2009