Standout Papers
Citation Impact
Citing Papers
Endosomal TLR signaling is required for anti-nucleic acid and rheumatoid factor autoantibodies in lupus
2009 StandoutNobel
CRACM1 Is a Plasma Membrane Protein Essential for Store-Operated Ca 2+ Entry
2006 StandoutScience
Cellular and Molecular Mechanisms of MT1-MMP-Dependent Cancer Cell Invasion
2016
Comprehensive Mapping of Long-Range Interactions Reveals Folding Principles of the Human Genome
2009 StandoutScience
Reactive Oxygen Species and Neutrophil Function
2016
Ror2 signaling regulates Golgi structure and transport through IFT20 for tumor invasiveness
2017 Standout
Hallmarks of Cancer: The Next Generation
2011 Standout
Computationally designed sensors detect endogenous Ras activity and signaling effectors at subcellular resolution
2024 StandoutNobel
Hematopoietic progenitor kinase 1 is a critical component of prostaglandin E2-mediated suppression of the anti-tumor immune response
2009 StandoutNobel
Caspase-cleaved HPK1 induces CD95L-independent activation-induced cell death in T and B lymphocytes
2007
Differential Membrane Localization of ERas and Rheb, Two Ras-related Proteins Involved in the Phosphatidylinositol 3-Kinase/mTOR Pathway
2005 StandoutNobel
EGFR Antagonists in Cancer Treatment
2008 Standout
Phosphorylation of ETS1 by Src Family Kinases Prevents Its Recognition by the COP1 Tumor Suppressor
2014 StandoutNobel
B1b Lymphocytes Confer T Cell-Independent Long-Lasting Immunity
2004 StandoutNobel
A forward-genetic approach for analysis of the immune system
2003 StandoutNobel
Derailed endocytosis: an emerging feature of cancer
2008
Molecular mechanisms of epithelial–mesenchymal transition
2014 Standout
Cell Signaling by Receptor Tyrosine Kinases
2010 Standout
ARF6-Regulated Shedding of Tumor Cell-Derived Plasma Membrane Microvesicles
2009
Function, structure and therapeutic potential of complement C5a receptors
2007
Non-random radial arrangements of interphase chromosome territories: evolutionary considerations and functional implications
2002
Shared Principles in NF-κB Signaling
2008 Standout
Recognition of microorganisms and activation of the immune response
2007 StandoutNature
Integrins Form an Expanding Diffusional Barrier that Coordinates Phagocytosis
2016 StandoutNobel
Hematopoietic Progenitor Kinase 1 Associates Physically and Functionally with the Adaptor Proteins B Cell Linker Protein and SLP-76 in Lymphocytes
2001
Survey of the year 2004 commercial optical biosensor literature
2005
Epidermal growth factor receptor: mechanisms of activation and signalling
2003
HPK1 competes with ADAP for SLP‐76 binding and via Rap1 negatively affects T‐cell adhesion
2010 StandoutNobel
Caspase-mediated Cleavage of Hematopoietic Progenitor Kinase 1 (HPK1) Converts an Activator of NFκB into an Inhibitor of NFκB
2001
Fc Receptors and Their Role in Immune Regulation and Autoimmunity
2005
Ras superfamily GEFs and GAPs: validated and tractable targets for cancer therapy?
2010
Antigen-Receptor Signaling to Nuclear Factor κB
2006
Focal adhesion proteins as markers of malignant transformation and prognostic indicators in breast carcinoma
2005
Biological Functions of Autophagy Genes: A Disease Perspective
2019 Standout
Rho GTPases in cell biology
2002 StandoutNature
Displacement of protein-bound aptamers with small molecules screened by fluorescence polarization
2008
Shedding light on the cell biology of extracellular vesicles
2018 Standout
Missing Pieces in the NF-κB Puzzle
2002 Standout
Autonomous regulation of osteosarcoma cell invasiveness by Wnt5a/Ror2 signaling
2009
Reactive oxygen species (ROS) as pleiotropic physiological signalling agents
2020 Standout
Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death
2012 Standout
Disruption of Fnip1 Reveals a Metabolic Checkpoint Controlling B Lymphocyte Development
2012 StandoutNobel
Bridging the Gap: Modulatory Roles of the Grb2-Family Adaptor, Gads, in Cellular and Allergic Immune Responses
2019
A Chromatin-Mediated Reversible Drug-Tolerant State in Cancer Cell Subpopulations
2010 Standout
Inhibition of cytohesins by SecinH3 leads to hepatic insulin resistance
2006 Nature
Partners in transcription: NFAT and AP-1
2001 Standout
Identifying the MAGUK Protein Carma-1 as a Central Regulator of Humoral Immune Responses and Atopy by Genome-Wide Mouse Mutagenesis
2003
Ras and relatives—job sharing and networking keep an old family together
2002
The P4-type ATPase ATP11C is essential for B lymphopoiesis in adult bone marrow
2011 StandoutNobel
Localized Diacylglycerol-dependent Stimulation of Ras and Rap1 during Phagocytosis
2009
Calcium signalling in lymphocytes
2003
Crk family adaptors–signalling complex formation and biological roles
2001
Hematopoietic progenitor kinase 1 negatively regulates T cell receptor signaling and T cell–mediated immune responses
2006
Prostaglandin E2 Activates HPK1 Kinase Activity via a PKA-dependent Pathway
2007
Tailoring T-cell receptor signals by proximal negative feedback mechanisms
2008
ARF proteins: roles in membrane traffic and beyond
2006
Reassessment of Exosome Composition
2019 Standout
Matrix Crosslinking Forces Tumor Progression by Enhancing Integrin Signaling
2009 Standout
The LAT Story: A Tale of Cooperativity, Coordination, and Choreography
2010
The 'ins' and 'outs' of podosomes and invadopodia: characteristics, formation and function
2011
Recruitment of the Actin-binding Protein HIP-55 to the Immunological Synapse Regulates T Cell Receptor Signaling and Endocytosis
2004
Neutrophil recruitment and function in health and inflammation
2013 Standout
Activation or suppression of NFκB by HPK1 determines sensitivity to activation‐induced cell death
2005
Inferences, questions and possibilities in Toll-like receptor signalling
2004 StandoutNatureNobel
Wnt/β-Catenin Signaling, Disease, and Emerging Therapeutic Modalities
2017 Standout
STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity
2009 StandoutNature
Activating Mutations in the Epidermal Growth Factor Receptor Underlying Responsiveness of Non–Small-Cell Lung Cancer to Gefitinib
2004 Standout
Vav Is Required for Cyclin D2 Induction and Proliferation of Mouse B Lymphocytes Activated via the Antigen Receptor
2001
Extracellular vesicles: Exosomes, microvesicles, and friends
2013 Standout
Functional Nucleic Acid Sensors
2009 Standout
Mechanisms and context underlying the role of autophagy in cancer metastasis
2018
Preparation of Poly(ethylene glycol)-Attached Dendrimers Encapsulating Photosensitizers for Application to Photodynamic Therapy
2007
Proteomic comparison defines novel markers to characterize heterogeneous populations of extracellular vesicle subtypes
2016 Standout
B Cell Signaling and Fate Decision
2009
Specificity and versatility of SH3 and other proline-recognition domains: structural basis and implications for cellular signal transduction
2005
Signaling inputs to invadopodia and podosomes
2013
A novel pathway down-modulating T cell activation involves HPK-1–dependent recruitment of 14-3-3 proteins on SLP-76
2007
TYPE I INTERFERONS (α/β) IN IMMUNITY AND AUTOIMMUNITY
2004 StandoutNobel
Hematopoietic progenitor kinase 1 supports apoptosis of T lymphocytes
2002
A therapeutic role for BLyS antagonists
2004
Synthesis of Sulfotyrosine‐Containing Peptides by Incorporating Fluorosulfated Tyrosine Using an Fmoc‐Based Solid‐Phase Strategy
2015 StandoutNobel
Activation of Hematopoietic Progenitor Kinase 1 Involves Relocation, Autophosphorylation, and Transphosphorylation by Protein Kinase D1
2005
Hematopoietic progenitor kinase 1 (HPK1) negatively regulates prostaglandin E2–induced fos gene transcription
2003
Analysis of an Ethylnitrosourea-generated Mouse Mutation Defines a Cell Intrinsic Role of Nuclear Factor κB2 in Regulating Circulating B Cell Numbers
2002
Mechanisms of Motility in Metastasizing Cells
2010
Classification of Intrinsically Disordered Regions and Proteins
2014 Standout
Ral-regulated interaction between Sec5 and paxillin targets Exocyst to focal complexes during cell migration
2008
Short Linear Motifs: Ubiquitous and Functionally Diverse Protein Interaction Modules Directing Cell Regulation
2014
Small-molecule synergist of the Wnt/β-catenin signaling pathway
2007
Signal Transduction Mediated by the T Cell Antigen Receptor: The Role of Adapter Proteins
2002
Conditional Deletion of Focal Adhesion Kinase Leads to Defects in Ventricular Septation and Outflow Tract Alignment
2007 StandoutNobel
Abnormal B lymphocyte development and autoimmunity in hypoxia-inducible factor 1α-deficient chimeric mice
2002 StandoutNobel
Single-Cell Mass Cytometry of Differential Immune and Drug Responses Across a Human Hematopoietic Continuum
2011 StandoutScience
Synergistic Regulation of Immunoreceptor Signaling by SLP-76-Related Adaptor Clnk and Serine/Threonine Protein Kinase HPK-1
2001
A Novel Mutation in CD83 Results in the Development of a Unique Population of CD4+ T Cells
2004 StandoutNobel
Insulin-like growth factor receptor I mediates resistance to anti-epidermal growth factor receptor therapy in primary human glioblastoma cells through continued activation of phosphoinositide 3-kinase signaling.
2002
STIM1 is a Ca2+ sensor that activates CRAC channels and migrates from the Ca2+ store to the plasma membrane
2005 StandoutNature
Surface Plasmon Resonance Sensors for Detection of Chemical and Biological Species
2008 Standout
B Cell Adaptor Containing Src Homology 2 Domain (Bash) Links B Cell Receptor Signaling to the Activation of Hematopoietic Progenitor Kinase 1
2001
Origins and Functions of B-1 Cells with Notes on the Role of CD5
2002
ARF1 regulates the Rho/MLC pathway to control EGF-dependent breast cancer cell invasion
2013
Accumulation of B Lymphocytes with a Naive, Resting Phenotype in a Subset of Hepatitis C Patients
2003 StandoutNobel
Hydronephrosis associated with antiurothelial and antinuclear autoantibodies in BALB/c-Fcgr2b −/− Pdcd1 −/− mice
2005 StandoutNobel
Dendrimers Designed for Functions: From Physical, Photophysical, and Supramolecular Properties to Applications in Sensing, Catalysis, Molecular Electronics, Photonics, and Nanomedicine
2010 Standout
Iκb Kinase α Is Essential for Mature B Cell Development and Function
2001
Genes, pathways and checkpoints in lymphocyte development and homeostasis
2005
Cutting Edge Commentary: Origins of B-1 Cells
2001
Matrix invasion by tumour cells: a focus on MT1-MMP trafficking to invadopodia
2009
Vav1 Is Essential for Mechanotactic Crawling and Migration of Neutrophils out of the Inflamed Microvasculature
2009
Works of Ari Hashimoto being referenced
Requirement for Arf6 in breast cancer invasive activities
2004
Regulation of Bin1 SH3 domain binding by phosphoinositides
2004
Neutrophil direction sensing and superoxide production linked by the GTPase-activating protein GIT2
2006
Shc Regulates Epidermal Growth Factor-induced Activation of the JNK Signaling Pathway
1999
The EGFR‐GEP100‐Arf6‐AMAP1 Signaling Pathway Specific to Breast Cancer Invasion and Metastasis†
2009
Cytogenetic mapping of 31 functional genes on chicken chromosomes by direct R-banding FISH
1999
Expression of AMAP1, an ArfGAP, provides novel targets to inhibit breast cancer invasive activities
2005
GEP100 links epidermal growth factor receptor signalling to Arf6 activation to induce breast cancer invasion
2007
Cutting Edge: Essential Role of Phospholipase C-γ2 in B Cell Development and Function
2000
HPK1 Is Activated by Lymphocyte Antigen Receptors and Negatively Regulates AP-1
2000
Requirement for Ras Guanine Nucleotide Releasing Protein 3 in Coupling Phospholipase C-γ2 to Ras in B Cell Receptor Signaling
2003
Involvement of Guanosine Triphosphatases and Phospholipase C-γ2 in Extracellular Signal–regulated Kinase, c-Jun NH2-terminal Kinase, and p38 Mitogen-activated Protein Kinase Activation by the B Cell Antigen Receptor
1998
Rab5c promotes AMAP1–PRKD2 complex formation to enhance β1 integrin recycling in EGF-induced cancer invasion
2012
Targeting AMAP1 and cortactin binding bearing an atypical src homology 3/proline interface for prevention of breast cancer invasion and metastasis
2006
Coupling Between B Cell Receptor and Phospholipase C-γ2 Is Essential for Mature B Cell Development
2003