Citation Impact
Citing Papers
A myocardium tropic adeno-associated virus (AAV) evolved by DNA shuffling and in vivo selection
2009
Chapter 4 Preparation of Isolated Rat Liver Cells
1976 Standout
Oligonucleotide conjugated multi-functional adeno-associated viruses
2018
Next generation of adeno-associated virus 2 vectors: Point mutations in tyrosines lead to high-efficiency transduction at lower doses
2008
Engineering adeno-associated viruses for clinical gene therapy
2014
Superior In vivo Transduction of Human Hepatocytes Using Engineered AAV3 Capsid
2016 StandoutNobel
In Vivo Selection Yields AAV-B1 Capsid for Central Nervous System and Muscle Gene Therapy
2016
Leishmaniasis
2018 Standout
AAV Capsid Structure and Cell Interactions
2011
Non-uniform refinement: adaptive regularization improves single-particle cryo-EM reconstruction
2020 Standout
Off-target-free gene delivery by affinity-purified receptor-targeted viral vectors
2015
Innovation by homologous recombination
2013 StandoutNobel
Quantification of adeno-associated virus particles and empty capsids by optical density measurement
2003
Mutations in the glutamate transporter EAAT2 gene do not cause abnormal EAAT2 transcripts in amyotrophic lateral sclerosis
1998 StandoutNobel
Tropism-modified AAV Vectors Overcome Barriers to Successful Cutaneous Therapy
2014
Glutamate uptake
2001 Standout
Adeno-associated virus (AAV) capsid genes isolated from rat and mouse liver genomic DNA define two new AAV species distantly related to AAV-5
2006
Development of next generation adeno-associated viral vectors capable of selective tropism and efficient gene delivery
2015
Structure/Function Relationships Responsible for Coenzyme Specificity and the Isomerase Activity of Human Type 1 3β-Hydroxysteroid Dehydrogenase/Isomerase
2003
New Substructure Filters for Removal of Pan Assay Interference Compounds (PAINS) from Screening Libraries and for Their Exclusion in Bioassays
2010 Standout
Microglial cell origin and phenotypes in health and disease
2011 Standout
Altering AAV tropism with mosaic viral capsids
2005
In situ immune response and mechanisms of cell damage in central nervous system of fatal cases microcephaly by Zika virus
2018 Standout
A Cas9 Ribonucleoprotein Platform for Functional Genetic Studies of HIV-Host Interactions in Primary Human T Cells
2016 StandoutNobel
Androgen synthesis in adrenarche
2008
DNA sequences of two expressed nuclear genes for human mitochondrial ADP/ATP translocase
1989 StandoutNobel
Evolution of a designed protein assembly encapsulating its own RNA genome
2017 StandoutNatureNobel
Random peptide libraries displayed on adeno-associated virus to select for targeted gene therapy vectors
2003
Glutamate neurotoxicity and diseases of the nervous system
1988 Standout
Non-viral vectors for gene-based therapy
2014 Standout
Metformin suppresses gluconeogenesis by inhibiting mitochondrial glycerophosphate dehydrogenase
2014 StandoutNature
Arginine 276 Controls the Directional Preference of AKR1C9 (Rat Liver 3α-Hydroxysteroid Dehydrogenase) in Human Embryonic Kidney 293 Cells
2005
PEGylation as a strategy for improving nanoparticle-based drug and gene delivery
2015 Standout
Reengineering a receptor footprint of adeno-associated virus enables selective and systemic gene transfer to muscle
2009
Abnormal glutamate metabolism in amyotrophic lateral sclerosis
1987
Genome Engineering Using Adeno-associated Virus: Basic and Clinical Research Applications
2015
Mitochondrial Transporters as Novel Targets for Intracellular Calcium Signaling
2007
Germline viral “fossils” guide in silico reconstruction of a mid-Cenozoic era marsupial adeno-associated virus
2016
AAV Hybrid Serotypes: Improved Vectors for Gene Delivery
2005
The Role of Glutamate Neurotoxicity in Hypoxic-Ischemic Neuronal Death
1990 Standout
DNA Shuffling of Adeno-associated Virus Yields Functionally Diverse Viral Progeny
2008
Vector Design Tour de Force: Integrating Combinatorial and Rational Approaches to Derive Novel Adeno-associated Virus Variants
2014
Directed evolution of adeno-associated virus yields enhanced gene delivery vectors
2006
Virus entry: molecular mechanisms and biomedical applications
2004
Adeno-associated virus (AAV) vectors in cancer gene therapy
2016
The potential of adeno-associated viral vectors for gene delivery to muscle tissue
2014
Mucus-penetrating nanoparticles for drug and gene delivery to mucosal tissues
2008 Standout
The AAV Vector Toolkit: Poised at the Clinical Crossroads
2012
In Silico Reconstruction of the Viral Evolutionary Lineage Yields a Potent Gene Therapy Vector
2015
Progress and problems with the use of viral vectors for gene therapy
2003 Standout
Adeno-associated virus vector as a platform for gene therapy delivery
2019 Standout
Cofactors, redox state, and directional preferences of hydroxysteroid dehydrogenases
2007
Peroxisomal Bifunctional Protein Deficiency Revisited: Resolution of Its True Enzymatic and Molecular Basis
1999
Phase 1 Gene Therapy for Duchenne Muscular Dystrophy Using a Translational Optimized AAV Vector
2011
ResLog plots as an empirical metric of the quality of cryo-EM reconstructions
2014
Genome-Scale Identification of SARS-CoV-2 and Pan-coronavirus Host Factor Networks
2020 StandoutNobel
Complex I Is the Major Site of Mitochondrial Superoxide Production by Paraquat
2007 Standout
Directed Evolution of Adeno-associated Virus for Enhanced Gene Delivery and Gene Targeting in Human Pluripotent Stem Cells
2011
An ADIOL-ERβ-CtBP Transrepression Pathway Negatively Regulates Microglia-Mediated Inflammation
2011
AAV Vectors Vaccines Against Infectious Diseases
2014
Optimization of the Capsid of Recombinant Adeno-Associated Virus 2 (AAV2) Vectors: The Final Threshold?
2013
Excitatory Amino Acids as a Final Common Pathway for Neurologic Disorders
1994 Standout
An indomethacin analogue, N-(4-chlorobenzoyl)-melatonin, is a selective inhibitor of aldo-keto reductase 1C3 (type 2 3α-HSD, type 5 17β-HSD, and prostaglandin F synthase), a potential target for the treatment of hormone dependent and hormone independent malignancies
2007
AAV-ID: A Rapid and Robust Assay for Batch-to-Batch Consistency Evaluation of AAV Preparations
2017
A Controlled Trial of Riluzole in Amyotrophic Lateral Sclerosis
1994 Standout
Sub-2 Å Ewald curvature corrected structure of an AAV2 capsid variant
2018
Sequence of the bovine 2-oxoglutarate/malate carrier protein: structural relationship to other mitochondrial transport proteins
1990 StandoutNobel
PEG conjugation moderately protects adeno‐associated viral vectors against antibody neutralization
2005
Optogenetics in Neural Systems
2011 Standout
Design, synthesis and biological evaluation of bis(hydroxyphenyl) azoles as potent and selective non-steroidal inhibitors of 17β-hydroxysteroid dehydrogenase type 1 (17β-HSD1) for the treatment of estrogen-dependent diseases
2008
Gene transfer to the lung: Lessons learned from more than 2 decades of CF gene therapy
2008
The key role of 17β-hydroxysteroid dehydrogenases in sex steroid biology
1997
Bioengineered AAV Capsids with Combined High Human Liver Transduction In Vivo and Unique Humoral Seroreactivity
2017
Development of Virus-Like Particle Technology from Small Highly Symmetric to Large Complex Virus-Like Particle Structures
2013 Standout
Adeno-Associated Virus at 50: A Golden Anniversary of Discovery, Research, and Gene Therapy Success—A Personal Perspective
2015
The Unexpected Importance of the Primary Structure of the Hydrophobic Part of One-Component Ionizable Amphiphilic Janus Dendrimers in Targeted mRNA Delivery Activity
2022 StandoutNobel
Physiological Implications of Hydrogen Sulfide: A Whiff Exploration That Blossomed
2012 Standout
An arginine/histidine exchange transport system in vacuolar-membrane vesicles of Saccharomyces cerevisiae.
1984 StandoutNobel
Lymphocyte membrane potential assessed with fluorescent probes
1980 StandoutNobel
T-cell mitogens cause early changes in cytoplasmic free Ca2+ and membrane potential in lymphocytes
1982 StandoutNatureNobel
Glutamate metabolism and transport in rat brain mitochondria
1976
Dicarbocyanine fluorescent probes of membrane potential block lymphocyte capping, deplete cellular ATP and inhibit respiration of isolated mitochondria
1979
Minireview: Cellular Redox State Regulates Hydroxysteroid Dehydrogenase Activity and Intracellular Hormone Potency
2005
Adeno-Associated Virus Type 2 VP2 Capsid Protein Is Nonessential and Can Tolerate Large Peptide Insertions at Its N Terminus
2004
The Enzymes, Regulation, and Genetics of Bile Acid Synthesis
2003 Standout
One-Component Multifunctional Sequence-Defined Ionizable Amphiphilic Janus Dendrimer Delivery Systems for mRNA
2021 StandoutNobel
Discovery of a Non-Estrogenic Irreversible Inhibitor of 17β-Hydroxysteroid Dehydrogenase Type 1 from 3-Substituted-16β-(m-carbamoylbenzyl)-estradiol Derivatives
2013
Sequence of the bovine mitochondrial phosphate carrier protein: structural relationship to ADP/ATP translocase and the brown fat mitochondria uncoupling protein.
1987 StandoutNobel
Peroxisomal d -hydroxyacyl-CoA dehydrogenase deficiency: Resolution of the enzyme defect and its molecular basis in bifunctional protein deficiency
1998
Cryo-electron Microscopy Reconstruction and Stability Studies of the Wild Type and the R432A Variant of Adeno-associated Virus Type 2 Reveal that Capsid Structural Stability Is a Major Factor in Genome Packaging
2016
Capsid Antibodies to Different Adeno-Associated Virus Serotypes Bind Common Regions
2013
Abundant bacterial expression and reconstitution of an intrinsic membrane-transport protein from bovine mitochondria
1993 StandoutNobel
Isolation and functional reconstitution of the aspartate/glutamate carrier from mitochondria
1986
Ionizable lipid nanoparticles deliver mRNA to pancreatic β cells via macrophage-mediated gene transfer
2023 StandoutNobel
A parvovirus isolated from royal python (Python regius) is a member of the genus Dependovirus
2004
Molecular Characterization of Adeno-Associated Viruses Infecting Children
2005
Adeno-Associated Virus Structural Biology as a Tool in Vector Development
2013
Overcoming Preexisting Humoral Immunity to AAV Using Capsid Decoys
2013
Fiber Types in Mammalian Skeletal Muscles
2011 Standout
Genetic identification of HSD-1, a conserved steroidogenic enzyme that directs larval development inCaenorhabditis elegans
2008 StandoutNobel
Studies on the active transfer of reducing equivalents into mitochondria via the malate-aspartate shuttle
1975
Analysis of Past and Present Synthetic Methodologies on Medicinal Chemistry: Where Have All the New Reactions Gone?
2015 Standout
The Molecular Biology, Biochemistry, and Physiology of Human Steroidogenesis and Its Disorders
2011 Standout
Virus-mediated gene transfer to induce therapeutic angiogenesis: where do we stand?
2007
KINETIC STUDY OF GLUTAMATE TRANSPORT IN RAT BRAIN MITOCHONDRIA
1977
The Assembly-Activating Protein Promotes Capsid Assembly of Different Adeno-Associated Virus Serotypes
2011
Immune responses to AAV vectors: overcoming barriers to successful gene therapy
2013
Anti-immunoglobulin, cytoplasmic free calcium, and capping in B lymphocytes.
1982 StandoutNobel
The metabolic significance of anion transport in mitochondria
1974
SCHEMA Computational Design of Virus Capsid Chimeras: Calibrating How Genome Packaging, Protection, and Transduction Correlate with Calculated Structural Disruption
2013
Calcium homeostasis in intact lymphocytes: cytoplasmic free calcium monitored with a new, intracellularly trapped fluorescent indicator.
1982 StandoutNobel
A Precise Chemical Strategy To Alter the Receptor Specificity of the Adeno‐Associated Virus
2016
Kinetic properties of aspartate transport in rat heart mitochondrial inner membranes
1979
New tools for automated high-resolution cryo-EM structure determination in RELION-3
2018 Standout
Site-Specific PEGylated Adeno-Associated Viruses with Increased Serum Stability and Reduced Immunogenicity
2017
Control of metabolism in brown adipose tissue
1970 StandoutNobel
Metabolism of glutamine and glutamate by rat liver mitochondria
1972 StandoutNobel
Interrelationships between malate-aspartate shuttle and citric acid cycle in rat heart mitochondria
1971
Targeted gene knock-in by homology-directed genome editing using Cas9 ribonucleoprotein and AAV donor delivery
2017 StandoutNobel
Adeno-Associated Virus Type 2 Capsids with Externalized VP1/VP2 Trafficking Domains Are Generated prior to Passage through the Cytoplasm and Are Maintained until Uncoating Occurs in the Nucleus
2006
Conditions for activity of glutaminase in kidney mitochondria
1970
Comparative Analysis of Adeno-Associated Virus Capsid Stability and Dynamics
2013
Applications of Fluorine in Medicinal Chemistry
2015 Standout
Adeno-associated viruses undergo substantial evolution in primates during natural infections
2003
Transport and Metabolism of Glutamate and Gaba in Neurons and Glial Cells
1981
The effect of lysine on gluconeogenesis from lactate in rat hepatocytes
1974
Nitrogen metabolism in the perfused rat liver
1970
Biochemical Factors Governing the Steady-State Estrone/Estradiol Ratios Catalyzed by Human 17β-Hydroxysteroid Dehydrogenases Types 1 and 2 in HEK-293 Cells
2009
Type 5 17β-Hydroxysteroid Dehydrogenase (AKR1C3) Contributes to Testosterone Production in the Adrenal Reticularis
2009
Discovery of Nonsteroidal 17β-Hydroxysteroid Dehydrogenase 1 Inhibitors by Pharmacophore-Based Screening of Virtual Compound Libraries
2008
Characterization of shuttle mechanisms for the transport of reducing equivalents into mitochondria
1973
Nontoxic nanopore electroporation for effective intracellular delivery of biological macromolecules
2019 StandoutNobel
Works of Arezki Azzi being referenced
Penetration of the mitochondrial membrane by glutamate and aspartate
1967
Structure-based Inhibitor Design for an Enzyme That Binds Different Steroids
2006
Leishmaniasis in the Middle East: Incidence and Epidemiology
2014
Structural basis of the multispecificity demonstrated by 17β-hydroxysteroid dehydrogenase types 1 and 5
2006
Estrone and estradiol C-16 derivatives as inhibitors of type 1 17β-hydroxysteroid dehydrogenase
2005
Studies on the three-dimensional structure of estrogenic 17 beta-hydroxysteroid dehydrogenase.
1996
Critical Residues for the Specificity of Cofactors and Substrates in Human Estrogenic 17β-Hydroxysteroid Dehydrogenase 1: Variants Designed from the Three-Dimensional Structure of the Enzyme
2001
The crystallogenesis of a human estradiol dehydrogenase-substrate complex
1996
The atomic structure of adeno-associated virus (AAV-2), a vector for human gene therapy
2002