Citation Impact
Citing Papers
Noncanonical Inflammasome Activation by Intracellular LPS Independent of TLR4
2013 Science
RIP3, an Energy Metabolism Regulator That Switches TNF-Induced Cell Death from Apoptosis to Necrosis
2009 StandoutScience
Listeria monocytogenes engineered to activate the Nlrc4 inflammasome are severely attenuated and are poor inducers of protective immunity
2011
A Salmonella Virulence Factor Activates the NOD1/NOD2 Signaling Pathway
2011
Innate Immune Activation Through Nalp3 Inflammasome Sensing of Asbestos and Silica
2008 StandoutScience
A key role for ATF3 in regulating mast cell survival and mediator release
2010
Inflammation-induced tumorigenesis in the colon is regulated by caspase-1 and NLRC4
2010
Trained immunity: A program of innate immune memory in health and disease
2016 StandoutScience
Crystal Structure of NLRC4 Reveals Its Autoinhibition Mechanism
2013 Science
Asc and Ipaf Inflammasomes Direct Distinct Pathways for Caspase-1 Activation in Response to Legionella pneumophila
2009
Cytoplasmic LPS Activates Caspase-11: Implications in TLR4-Independent Endotoxic Shock
2013 Science
Microbiota-induced activation of epithelial IL-6 signaling links inflammasome-driven inflammation with transmissible cancer
2013
Innate immune detection of the type III secretion apparatus through the NLRC4 inflammasome
2010
Inflammasome-Dependent Release of the Alarmin HMGB1 in Endotoxemia
2010
NAIP and Ipaf Control Legionella pneumophila Replication in Human Cells
2008
Multiple Nod-Like Receptors Activate Caspase 1 during Listeria monocytogenes Infection
2008
ASC/PYCARD and Caspase-1 Regulate the IL-18/IFN-γ Axis during Anaplasma phagocytophilum Infection
2007
Cutting Edge: Inflammasome Activation by Alum and Alum’s Adjuvant Effect Are Mediated by NLRP3
2008
Pannexin-1-Mediated Intracellular Delivery of Muramyl Dipeptide Induces Caspase-1 Activation via Cryopyrin/NLRP3 Independently of Nod2
2008
Listeria monocytogenes -Infected Human Peripheral Blood Mononuclear Cells Produce IL-1β, Depending on Listeriolysin O and NLRP3
2009
NLRP3/Cryopyrin Is Necessary for Interleukin-1β (IL-1β) Release in Response to Hyaluronan, an Endogenous Trigger of Inflammation in Response to Injury
2009
Group A Streptococcus Activates Type I Interferon Production and MyD88-dependent Signaling without Involvement of TLR2, TLR4, and TLR9
2008 StandoutNobel
The role of the inflammasome in cellular responses to toxins and bacterial effectors
2007
The S. Typhimurium Effector SopE Induces Caspase-1 Activation in Stromal Cells to Initiate Gut Inflammation
2009
Caspase-1 Activation of Lipid Metabolic Pathways in Response to Bacterial Pore-Forming Toxins Promotes Cell Survival
2006
Caspase‐1‐induced pyroptotic cell death
2011
Mutation of NLRC4 causes a syndrome of enterocolitis and autoinflammation
2014
Necroptosis and its role in inflammation
2015 StandoutNature
AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC
2009 StandoutNature
Differential Regulation of Caspase-1 Activation, Pyroptosis, and Autophagy via Ipaf and ASC in Shigella-Infected Macrophages
2007
Intestinal homeostasis and its breakdown in inflammatory bowel disease
2011 StandoutNature
NOD-like receptors (NLRs): bona fide intracellular microbial sensors
2008
Emerging inflammasome effector mechanisms
2011
Unravelling the pathogenesis of inflammatory bowel disease
2007 StandoutNature
Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity
2012 StandoutNature
Shared Principles in NF-κB Signaling
2008 Standout
Patterns of Pathogenesis: Discrimination of Pathogenic and Nonpathogenic Microbes by the Innate Immune System
2009
A role for mitochondria in NLRP3 inflammasome activation
2010 StandoutNature
The AIM2 inflammasome is critical for innate immunity to Francisella tularensis
2010
TLR5 and Ipaf: dual sensors of bacterial flagellin in the innate immune system
2007
Activation and regulation of the inflammasomes
2013 Standout
Recognition of microorganisms and activation of the immune response
2007 StandoutNature
Activation of the inflammasome upon Francisella tularensis infection: interplay of innate immune pathways and virulence factors
2007
Inactivation of Conserved C. elegans Genes Engages Pathogen- and Xenobiotic-Associated Defenses
2012 StandoutNobel
Inflammatory caspases and inflammasomes: master switches of inflammation
2006
Intracellular pattern recognition receptors in the host response
2006 Nature
Pattern Recognition Receptors and Inflammation
2010 Standout
Innate recognition of intracellular bacteria
2006
The inflammasome: a danger sensing complex triggering innate immunity
2007
Phosphorylation of NLRC4 is critical for inflammasome activation
2012 Nature
AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA
2009 StandoutNature
The Caspase-1 Digestome Identifies the Glycolysis Pathway as a Target during Infection and Septic Shock
2007
Macrophage Activation Redirects Yersinia-Infected Host Cell Death from Apoptosis to Caspase-1-Dependent Pyroptosis
2007
Systems biology of innate immunity
2008
A crucial function of SGT1 and HSP90 in inflammasome activity links mammalian and plant innate immune responses
2007
NLR, the nucleotide-binding domain leucine-rich repeat containing gene family
2008
Critical role for Ipaf in Pseudomonas aeruginosa‐induced caspase‐1 activation
2007
Chemical probing reveals insights into the signaling mechanism of inflammasome activation
2010
Using the Acropora digitifera genome to understand coral responses to environmental change
2011 StandoutNature
Role of the Microbiota in Immunity and Inflammation
2014 Standout
Injection of Flagellin into the Host Cell Cytosol by Salmonella enterica Serotype Typhimurium
2007
NF-κB and the immune response
2006
Pannexin-1-Mediated Recognition of Bacterial Molecules Activates the Cryopyrin Inflammasome Independent of Toll-like Receptor Signaling
2007
Expansion and evolution of cell death programmes
2008
Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death
2012 Standout
NOD1 and NOD2 signalling links ER stress with inflammation
2016 StandoutNature
Innate immune recognition of bacterial ligands by NAIPs determines inflammasome specificity
2011 Nature
Caspase Functions in Cell Death and Disease
2013 Standout
The inflammasome: a caspase-1-activation platform that regulates immune responses and disease pathogenesis
2009 Standout
Immunity, Inflammation, and Cancer
2010 Standout
NLRC4-driven production of IL-1β discriminates between pathogenic and commensal bacteria and promotes host intestinal defense
2012
TRIF Licenses Caspase-11-Dependent NLRP3 Inflammasome Activation by Gram-Negative Bacteria
2012
Involvement of the AIM2, NLRC4, and NLRP3 Inflammasomes in Caspase-1 Activation by Listeria monocytogenes
2010
The PYRIN domain–only protein POP3 inhibits ALR inflammasomes and regulates responses to infection with DNA viruses
2014
Formation and Structure of a NAIP5-NLRC4 Inflammasome Induced by Direct Interactions with Conserved N- and C-terminal Regions of Flagellin
2012
Activation of the NALP3 inflammasome is triggered by low intracellular potassium concentration
2007
Nod-like proteins in immunity, inflammation and disease
2006
Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death
2015 StandoutNature
Inflammasomes: mechanism of assembly, regulation and signalling
2016 Standout
Targeted Peptidecentric Proteomics Reveals Caspase-7 as a Substrate of the Caspase-1 Inflammasomes
2008
Critical function for Naip5 in inflammasome activation by a conserved carboxy-terminal domain of flagellin
2008
Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores
2016 StandoutNature
Non-canonical inflammasome activation targets caspase-11
2011 StandoutNature
Sensing of bacteria: NOD a lonely job
2006
The NLRC4 inflammasome receptors for bacterial flagellin and type III secretion apparatus
2011 Nature
Inflammatory caspases are innate immune receptors for intracellular LPS
2014 StandoutNature
Caspase-11 increases susceptibility to Salmonella infection in the absence of caspase-1
2012 Nature
Pyroptosis: host cell death and inflammation
2009 Standout
Innate immunity in inflammatory bowel disease
2007
Origin and physiological roles of inflammation
2008 StandoutNature
Mycobacterium tuberculosis Prevents Inflammasome Activation
2008
TRPM2 links oxidative stress to NLRP3 inflammasome activation
2013
Inflammasome adaptors and sensors: intracellular regulators of infection and inflammation
2006
The Inflammasomes
2010 Standout
Mechanisms and Functions of Inflammasomes
2014 Standout
Function of Nod‐like receptors in microbial recognition and host defense
2008
Toll or Toll-Free Adjuvant Path Toward the Optimal Vaccine Development
2007
Phosphorylation of the adaptor ASC acts as a molecular switch that controls the formation of speck-like aggregates and inflammasome activity
2013
Inflammasomes as microbial sensors
2010
Newly described pattern recognition receptors team up against intracellular pathogens
2013
Toll-like receptor 2 on inflammatory monocytes induces type I interferon in response to viral but not bacterial ligands
2009
Intracellular NOD-like Receptors in Host Defense and Disease
2007
Bcl-2 and Bcl-XL Regulate Proinflammatory Caspase-1 Activation by Interaction with NALP1
2007
Caspase-11 Activation in Response to Bacterial Secretion Systems that Access the Host Cytosol
2013
Caspase-1-induced pyroptosis is an innate immune effector mechanism against intracellular bacteria
2010
Diverse mechanisms for inflammasome sensing of cytosolic bacteria and bacterial virulence
2015
NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals
2010 StandoutNature
Differential Requirement of P2X7 Receptor and Intracellular K+ for Caspase-1 Activation Induced by Intracellular and Extracellular Bacteria
2007
Intracellular NOD-like receptors in innate immunity, infection and disease
2007
Two distinct RNase activities of CRISPR-C2c2 enable guide-RNA processing and RNA detection
2016 StandoutNatureNobel
STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity
2009 StandoutNature
Differential Requirement for Caspase-1 Autoproteolysis in Pathogen-Induced Cell Death and Cytokine Processing
2010
Inflammasomes in health and disease
2012 StandoutNature
Chapter Thirteen Assembly, Purification, and Assay of the Activity of the ASC Pyroptosome
2008
Regulation of the Antimicrobial Response by NLR Proteins
2011
Host Innate Immune Receptors and Beyond: Making Sense of Microbial Infections
2008
Regulation of Legionella Phagosome Maturation and Infection through Flagellin and Host Ipaf
2006
Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin
2017 StandoutNature
The science of adjuvants
2007
Mucosal Administration of Flagellin Protects Mice from Streptococcus pneumoniae Lung Infection
2010
Nucleotide-Binding Oligomerization Domain-Like Receptors: Intracellular Pattern Recognition Molecules for Pathogen Detection and Host Defense
2006
Caspase-1 inflammasomes in infection and inflammation
2007
The Inflammasome NLRs in Immunity, Inflammation, and Associated Diseases
2011
Pivoting the Plant Immune System from Dissection to Deployment
2013 StandoutScience
The inflammasome in pathogen recognition and inflammation
2007
Systems analysis identifies an essential role for SHANK-associated RH domain-interacting protein (SHARPIN) in macrophage Toll-like receptor 2 (TLR2) responses
2011 StandoutNobel
GBP5 Promotes NLRP3 Inflammasome Assembly and Immunity in Mammals
2012 Science
NLRP3 recruitment by NLRC4 during Salmonella infection
2016
Redundant roles for inflammasome receptors NLRP3 and NLRC4 in host defense againstSalmonella
2010
Intestinal Bacteria and the Regulation of Immune Cell Homeostasis
2010
The Role of Potassium in Inflammasome Activation by Bacteria
2010
Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1β production
2008 StandoutNature
Pyroptotic cell death defends against intracellular pathogens
2015
Pore-forming activity and structural autoinhibition of the gasdermin family
2016 StandoutNature
Aggregation-Induced Emission: Together We Shine, United We Soar!
2015 Standout
Crystal structure of Toll-like receptor adaptor MAL/TIRAP reveals the molecular basis for signal transduction and disease protection
2011 StandoutNobel
Caspase-11 Protects Against Bacteria That Escape the Vacuole
2013 Science
Cryo-EM structure of the activated NAIP2-NLRC4 inflammasome reveals nucleated polymerization
2015 Science
Intracellular sensing of microbes and danger signals by the inflammasomes
2011
MDP-induced interleukin-1β processing requires Nod2 and CIAS1/NALP3
2007
NF-κB activation by the Toll-IL-1 receptor domain protein MyD88 adapter-like is regulated by caspase-1
2007
Cutting Edge: Mouse NAIP1 Detects the Type III Secretion System Needle Protein
2013
Copper induces cell death by targeting lipoylated TCA cycle proteins
2022 StandoutScience
Immune recognition of Pseudomonas aeruginosa mediated by the IPAF/NLRC4 inflammasome
2007
Regulation of Adaptive Immunity by the Innate Immune System
2010 StandoutScience
The NAIP –NLRC 4 inflammasome in innate immune detection of bacterial flagellin and type III secretion apparatus
2015
A Key Role for Redox Signaling in Rapid P2X7 Receptor-Induced IL-1β Processing in Human Monocytes
2008
Inflammasomes and Their Roles in Health and Disease
2012
Pseudomonas aeruginosa activates caspase 1 through Ipaf
2008
NLRP1-Dependent Pyroptosis Leads to Acute Lung Injury and Morbidity in Mice
2012
MyD88 signaling in nonhematopoietic cells protects mice against induced colitis by regulating specific EGF receptor ligands
2010 StandoutNobel
Recognition of Bacteria by Inflammasomes
2012
Nonclassical IL-1β Secretion Stimulated by P2X7 Receptors Is Dependent on Inflammasome Activation and Correlated with Exosome Release in Murine Macrophages
2007
Human NAIP and mouse NAIP1 recognize bacterial type III secretion needle protein for inflammasome activation
2013
Pannexin-1 Is Required for ATP Release during Apoptosis but Not for Inflammasome Activation
2011
Pathogenic Vibrio Activate NLRP3 Inflammasome via Cytotoxins and TLR/Nucleotide-Binding Oligomerization Domain-Mediated NF-κB Signaling
2010
Innate immunity to virus infection
2008
Unconventional Secretion, Unconventional Solutions
2013 StandoutScienceNobel
Reconfigurable asymmetric protein assemblies through implicit negative design
2022 StandoutScienceNobel
The microbial mimic poly IC induces durable and protective CD4+T cell immunity together with a dendritic cell targeted vaccine
2008 StandoutNobel
Structural and biochemical basis for induced self-propagation of NLRC4
2015 Science
Signaling Pathways Downstream of Pattern-Recognition Receptors and Their Cross Talk
2007
Works of April Clark being referenced
Cytoplasmic flagellin activates caspase-1 and secretion of interleukin 1β via Ipaf
2006
The Toll-Like Receptor Signaling Molecule Myd88 Contributes to Pancreatic Beta-Cell Homeostasis in Response to Injury
2009
Activating transcription factor 3 is a negative regulator of allergic pulmonary inflammation
2008