Citation Impact
Citing Papers
SuFEx-enabled, agnostic discovery of covalent inhibitors of human neutrophil elastase
2019 StandoutNobel
Protein Misfolding, Amyloid Formation, and Human Disease: A Summary of Progress Over the Last Decade
2017 Standout
Inhibiting Endoplasmic Reticulum (ER)-associated Degradation of Misfolded Yor1p Does Not Permit ER Export Despite the Presence of a Diacidic Sorting Signal
2007
Functional specialization of β-arrestin interactions revealed by proteomic analysis
2007 StandoutNobel
Sulfur [ 18 F]Fluoride Exchange Click Chemistry Enabled Ultrafast Late-Stage Radiosynthesis
2021 StandoutNobel
Signal integration in the endoplasmic reticulum unfolded protein response
2007 Standout
Membrane curvature regulates the spatial distribution of bulky glycoproteins
2022 StandoutNobel
Mechanism of Action and Clinical Application of Tafamidis in Hereditary Transthyretin Amyloidosis
2016
Covalent inhibitors of glycosidases and their applications in biochemistry and biology
2008
A Luminal Surveillance Complex that Selects Misfolded Glycoproteins for ER-Associated Degradation
2006
Ribonuclease A suggests how proteins self‐chaperone against amyloid fiber formation
2011
Imino sugar inhibitors for treating the lysosomal glycosphingolipidoses
2005
The Yin and Yang of protein folding
2005
The ubiquitylation machinery of the endoplasmic reticulum
2009 Nature
Chemoselective small molecules that covalently modify one lysine in a non-enzyme protein in plasma
2009
Glycosylation in Cellular Mechanisms of Health and Disease
2006 Standout
Partial Restoration of Mutant Enzyme Homeostasis in Three Distinct Lysosomal Storage Disease Cell Lines by Altering Calcium Homeostasis
2008
Treatment of Obesity with Celastrol
2015 Standout
Functional Amyloid Formation within Mammalian Tissue
2005
Sec24p and Sec16p cooperate to regulate the GTP cycle of the COPII coat
2011 StandoutNobel
A competition assay to identify amyloidogenesis inhibitors by monitoring the fluorescence emitted by the covalent attachment of a stilbene derivative to transthyretin
2010
Cryo-EM structure of the protein-conducting ERAD channel Hrd1 in complex with Hrd3
2017 StandoutNatureNobel
Dimeric Coiled-coil Structure of Saccharomyces cerevisiae Atg16 and Its Functional Significance in Autophagy
2009 StandoutNobel
Amyloid Formation by Human Carboxypeptidase D Transthyretin-like Domain under Physiological Conditions
2014
Gelsolin amyloidosis: genetics, biochemistry, pathology and possible strategies for therapeutic intervention
2012
Lysosomal storage disorders
2005
Metalloendoprotease cleavage triggers gelsolin amyloidogenesis
2005
Hsp90 Cochaperone Aha1 Downregulation Rescues Misfolding of CFTR in Cystic Fibrosis
2006
Endoplasmic Reticulum Stress and the Inflammatory Basis of Metabolic Disease
2010 Standout
Chemical and Biological Approaches Synergize to Ameliorate Protein-Folding Diseases
2008
Molecular chaperones in protein folding and proteostasis
2011 StandoutNature
Revealing the human mucinome
2022 StandoutNobel
Structural design of cage and coat scaffolds that direct membrane traffic
2007
A concise enantioselective synthesis of iminosugar derivatives
2006
Brown adipose tissue thermogenic adaptation requires Nrf1-mediated proteasomal activity
2018 StandoutNobel
From endoplasmic-reticulum stress to the inflammatory response
2008 StandoutNature
Glycosylation in health and disease
2019
Chemical Approaches To Perturb, Profile, and Perceive Glycans
2009 StandoutNobel
Mechanisms and Functions of Inflammasomes
2014 Standout
The Amyloid State of Proteins in Human Diseases
2012 Standout
Mechanisms for Insulin Resistance: Common Threads and Missing Links
2012 Standout
Aged vervet monkeys developing transthyretin amyloidosis with the human disease-causing Ile122 allele: a valid pathological model of the human disease
2011
The Transthyretin Amyloidoses: From Delineating the Molecular Mechanism of Aggregation Linked to Pathology to a Regulatory-Agency-Approved Drug
2012
XBP1 Links ER Stress to Intestinal Inflammation and Confers Genetic Risk for Human Inflammatory Bowel Disease
2008 Standout
An Adaptable Standard for Protein Export from the Endoplasmic Reticulum
2007
The Hallmarks of Aging
2013 Standout
Engineering domain fusion chimeras from I-OnuI family LAGLIDADG homing endonucleases
2012 StandoutNobel
Interleukin 1 receptor antagonist knockout mice show enhanced microglial activation and neuronal damage induced by intracerebroventricular infusion of human β-amyloid
2005
Amyloid formation by globular proteins under native conditions
2008
Cleaning Up: ER-Associated Degradation to the Rescue
2012
Therapeutic approaches to protein-misfolding diseases
2003 Nature
Protein Sequence Editing of SKN-1A/Nrf1 by Peptide:N-Glycanase Controls Proteasome Gene Expression
2019 StandoutNobel
Proline‐Catalyzed Mannich Reaction of Aldehydes with N‐Boc‐Imines
2006 StandoutNobel
Small RNAs are modified with N-glycans and displayed on the surface of living cells
2021 StandoutNobel
A Substructure Combination Strategy To Create Potent and Selective Transthyretin Kinetic Stabilizers That Prevent Amyloidogenesis and Cytotoxicity
2009
Transthyretin suppresses the toxicity of oligomers formed by misfolded proteins in vitro
2013
Prediction of amyloid aggregation in vivo
2011
A Fluorogenic Aryl Fluorosulfate for Intraorganellar Transthyretin Imaging in Living Cells and in Caenorhabditis elegans
2015 StandoutNobel
Click Chemistry for Drug Development and Diverse Chemical–Biology Applications
2013 Standout
Coping with Protein Quality Control Failure
2017
SuFEx Click Chemistry Enabled Late-Stage Drug Functionalization
2018 StandoutNobel
Supramolecular three-armed star polymers via cyclodextrin host–guest self-assembly
2012
New Glucocerebrosidase Inhibitors by Exploration of Chemical Diversity of N-Substituted Aminocyclitols Using Click Chemistry and in Situ Screening
2011
De Novo-Designed Enzymes as Small-Molecule-Regulated Fluorescence Imaging Tags and Fluorescent Reporters
2014 StandoutNobel
EGCG remodels mature α-synuclein and amyloid-β fibrils and reduces cellular toxicity
2010 Standout
Amphiphilic 1-Deoxynojirimycin Derivatives through Click Strategies for Chemical Chaperoning in N370S Gaucher Cells
2011
Tafamidis, a potent and selective transthyretin kinetic stabilizer that inhibits the amyloid cascade
2012
SuFEx Chemistry of Thionyl Tetrafluoride (SOF4) with Organolithium Nucleophiles: Synthesis of Sulfonimidoyl Fluorides, Sulfoximines, Sulfonimidamides, and Sulfonimidates
2018 StandoutNobel
Aggregation-Induced Emission: Together We Shine, United We Soar!
2015 Standout
Recent Developments in Isocyanide Based Multicomponent Reactions in Applied Chemistry
2005 Standout
Structure-Based Design of Functional Amyloid Materials
2014 StandoutNobel
Biological and Chemical Approaches to Diseases of Proteostasis Deficiency
2009
The Unfolded Protein Response: From Stress Pathway to Homeostatic Regulation
2011 StandoutScience
Biocompatible SuFEx Click Chemistry: Thionyl Tetrafluoride (SOF4)‐Derived Connective Hubs for Bioconjugation to DNA and Proteins
2019 StandoutNobel
Glyco- and Peptidomimetics from Three-Component Joullié−Ugi Coupling Show Selective Antiviral Activity
2004
Click Chemistry Approach to New N-Substituted Aminocyclitols as Potential Pharmacological Chaperones for Gaucher Disease
2010
Direct observation of kinetic traps associated with structural transformations leading to multiple pathways of S-layer assembly
2012 StandoutNobel
Classification of Intrinsically Disordered Regions and Proteins
2014 Standout
Small molecule probes to quantify the functional fraction of a specific protein in a cell with minimal folding equilibrium shifts
2014 StandoutNobel
Quantification of the Thermodynamically Linked Quaternary and Tertiary Structural Stabilities of Transthyretin and Its Disease-Associated Variants: The Relationship between Stability and Amyloidosis
2008
Adapting Proteostasis for Disease Intervention
2008 StandoutScience
Metal–Organic Polyhedral Core as a Versatile Scaffold for Divergent and Convergent Star Polymer Synthesis
2016 StandoutNobel
Identification of simple arylfluorosulfates as potent agents against resistant bacteria
2021 StandoutNobel
Toward Optimization of the Second Aryl Substructure Common to Transthyretin Amyloidogenesis Inhibitors Using Biochemical and Structural Studies
2009
Kinetic Stabilization of an Oligomeric Protein under Physiological Conditions Demonstrated by a Lack of Subunit Exchange: Implications for Transthyretin Amyloidosis
2005
Aromatic Sulfonyl Fluorides Covalently Kinetically Stabilize Transthyretin to Prevent Amyloidogenesis while Affording a Fluorescent Conjugate
2013 StandoutNobel
Potent Kinetic Stabilizers That Prevent Transthyretin-Mediated Cardiomyocyte Proteotoxicity
2011
A Stilbene That Binds Selectively to Transthyretin in Cells and Remains Dark until It Undergoes a Chemoselective Reaction To Create a Bright Blue Fluorescent Conjugate
2010
Native State Kinetic Stabilization as a Strategy To Ameliorate Protein Misfolding Diseases: A Focus on the Transthyretin Amyloidoses
2005
Enhanced sensitivity to DSS colitis caused by a hypomorphic Mbtps1 mutation disrupting the ATF6-driven unfolded protein response
2009 StandoutNobel
Biochemical and Structural Evaluation of Highly Selective 2-Arylbenzoxazole-Based Transthyretin Amyloidogenesis Inhibitors
2007
The Pathway by Which the Tetrameric Protein Transthyretin Dissociates
2005
Metabolite-initiated protein misfolding may trigger Alzheimer's disease
2004
Arylfluorosulfates Inactivate Intracellular Lipid Binding Protein(s) through Chemoselective SuFEx Reaction with a Binding Site Tyr Residue
2016 StandoutNobel
Asymmetric Enamine Catalysis
2007 StandoutNobel
Sulfur(VI) Fluoride Exchange (SuFEx)-Enabled High-Throughput Medicinal Chemistry
2020 StandoutNobel
A New Portal to SuFEx Click Chemistry: A Stable Fluorosulfuryl Imidazolium Salt Emerging as an “F−SO2+” Donor of Unprecedented Reactivity, Selectivity, and Scope
2017 StandoutNobel
“Inverse Drug Discovery” Strategy To Identify Proteins That Are Targeted by Latent Electrophiles As Exemplified by Aryl Fluorosulfates
2017 StandoutNobel
Works of Anu R. Sawkar being referenced
X-ray Structure of Human Acid-β-Glucosidase Covalently Bound to Conduritol-B-Epoxide
2005
Pharmacologic chaperoning as a strategy to treat Gaucher disease
2007
Gaucher Disease-Associated Glucocerebrosidases Show Mutation-Dependent Chemical Chaperoning Profiles
2005
The Biological and Chemical Basis for Tissue-Selective Amyloid Disease
2005
Therapeutic strategies to ameliorate lysosomal storage disorders – a focus on Gaucher disease
2006
Chemical Chaperones and Permissive Temperatures Alter the Cellular Localization of Gaucher Disease Associated Glucocerebrosidase Variants
2006
Discovery of a 3-Amino-6-phenyl-pyridazine Derivative as a New Synthetic Antineuroinflammatory Compound
2001
Isofagomine- and 2,5-Anhydro-2,5-imino-d -glucitol-Based Glucocerebrosidase Pharmacological Chaperones for Gaucher Disease Intervention
2006
Chemical chaperones increase the cellular activity of N370S β-glucosidase: A therapeutic strategy for Gaucher disease
2002