Antonio Laghezza

Allosteric Pathways in the PPARγ-RXRα nuclear receptor complex

The re-emergence of natural products for drug discovery in the genomics era

Structural basis for the activation of PPARγ by oxidized fatty acids

Targeting nanoparticles for diagnosis and therapy of bone tumors: Opportunities and challenges

Polyacetylenes from Notopterygium incisum–New Selective Partial Agonists of Peroxisome Proliferator-Activated Receptor-Gamma

Cancer drug resistance: an evolving paradigm

CLC Chloride Channels and Transporters: From Genes to Protein Structure, Pathology and Physiology

Natural product agonists of peroxisome proliferator-activated receptor gamma (PPARγ): a review

Key role of the REC lobe during CRISPR–Cas9 activation by ‘sensing’, ‘regulating’, and ‘locking’ the catalytic HNH domain

Peroxisome proliferator-activated receptor structures: Ligand specificity, molecular switch and interactions with regulators

Dietary α-Eleostearic Acid Ameliorates Experimental Inflammatory Bowel Disease in Mice by Activating Peroxisome Proliferator-Activated Receptor-γ

Pharmacophore-driven identification of PPARγ agonists from natural sources

Pharmaceutical and medicinal significance of sulfur (SVI)-Containing motifs for drug discovery: A critical review

Structural Insight into PPARγ Activation Through Covalent Modification with Endogenous Fatty Acids

Sulphonamides: Deserving class as MMP inhibitors?

Control of apoptosis by the BCL-2 protein family: implications for physiology and therapy

Chloride channels as drug targets

Endosome maturation

Sensors and regulators of intracellular pH

Structural insights for the design of new PPARgamma partial agonists with high binding affinity and low transactivation activity

Discovery and resupply of pharmacologically active plant-derived natural products: A review

N-Acetylfarnesylcysteine Is a Novel Class of Peroxisome Proliferator-activated Receptor γ Ligand with Partial and Full Agonist Activity in Vitro and in Vivo

3d Transition Metals for C–H Activation

Fiber Types in Mammalian Skeletal Muscles

Synthetic Organic Electrochemical Methods Since 2000: On the Verge of a Renaissance

Hybrid assemblies of ATP-sensitive K ⁺ channels determine their muscle-type-dependent biophysical and pharmacological properties

An efficient electrochemical synthesis of β-keto sulfones from sulfinates and 1,3-dicarbonyl compounds

Rational Design of Bisphosphonate Lipid-like Materials for mRNA Delivery to the Bone Microenvironment

Chemistry and Biology Of Multicomponent Reactions

Synthesis of 2-aminobenzoxazoles via copper-catalyzed electrophilic amination of benzoxazoles with O-benzoyl hydroxylamines

OPLS3: A Force Field Providing Broad Coverage of Drug-like Small Molecules and Proteins

Discovery of Potent Myeloid Cell Leukemia 1 (Mcl-1) Inhibitors Using Fragment-Based Methods and Structure-Based Design

Discovery of 1,1′-Biphenyl-4-sulfonamides as a New Class of Potent and Selective Carbonic Anhydrase XIV Inhibitors

Catalyst‐ and Reagent‐Free Electrochemical Azole C−H Amination

Bone-Seeking Matrix Metalloproteinase-2 Inhibitors Prevent Bone Metastatic Breast Cancer Growth

Dualistic actions of cromakalim and new potent 2H‐1,4‐benzoxazine derivatives on the native skeletal muscle K_ATP channel

Structural requisites of 2‐(p‐chlorophenoxy)propionic acid analogues for activity on native rat skeletal muscle chloride conductance and on heterologously expressed CLC‐1

Synthesis, SAR, and Biological Evaluation of α‐Sulfonylphosphonic Acids as Selective Matrix Metalloproteinase Inhibitors

Resveratrol and Its Metabolites Bind to PPARs

Biphenyl Sulfonylamino Methyl Bisphosphonic Acids as Inhibitors of Matrix Metalloproteinases and Bone Resorption

Insights into the Mechanism of Partial Agonism

Structural Insight into Peroxisome Proliferator-Activated Receptor γ Binding of Two Ureidofibrate-Like Enantiomers by Molecular Dynamics, Cofactor Interaction Analysis, and Site-Directed Mutagenesis

ChemInform Abstract: Convenient Synthesis of Some 3‐Phenyl‐1‐benzofuran‐2‐carboxylic Acid Derivatives as New Potential Inhibitors of CLC‐Kb Channels.

Synthesis, Biological Evaluation, and Molecular Modeling Investigation of New Chiral Fibrates with PPARα and PPARγ Agonist Activity

Convenient Synthesis of Some 3-Phenyl-1-benzofuran-2-carboxylic Acid Derivatives as New Potential Inhibitors of CLC-Kb Channels

Crystal Structure of the Peroxisome Proliferator-Activated Receptor γ (PPARγ) Ligand Binding Domain Complexed with a Novel Partial Agonist: A New Region of the Hydrophobic Pocket Could Be Exploited for Drug Design

Molecular switch for CLC-K Cl ⁻ channel block/activation: Optimal pharmacophoric requirements towards high-affinity ligands