Standout Papers
- Monitoring synaptic transmission in primary neuronal cultures using local extracellular stimulation (2006)
- Activity-Dependent IGF-1 Exocytosis Is Controlled by the Ca2+-Sensor Synaptotagmin-10 (2011)
- Genetic analysis of synaptotagmin-7 function in synaptic vesicle exocytosis (2008)
- Genetic analysis of synaptotagmin 2 in spontaneous and Ca2+‐triggered neurotransmitter release (2006)
- Synaptotagmin-1 and -7 are functionally overlapping Ca 2+ sensors for exocytosis in adrenal chromaffin cells (2008)
- C-terminal ECFP Fusion Impairs Synaptotagmin 1 Function (2004)
- N-Glycosylation Is Essential for Vesicular Targeting of Synaptotagmin 1 (2004)
- Autonomous Function of Synaptotagmin 1 in Triggering Synchronous Release Independent of Asynchronous Release (2005)
- Impaired insulin secretion and glucose intolerance in synaptotagmin-7 null mutant mice (2008)
- Synaptotagmin-12, a synaptic vesicle phosphoprotein that modulates spontaneous neurotransmitter release (2006)
- Unexpected Ca 2+ -binding properties of synaptotagmin 9 (2004)
- Association of Neuronal Calcium Channels with Modular Adaptor Proteins (1999)
- Complexin Controls the Force Transfer from SNARE Complexes to Membranes in Fusion (2009)
- A Complexin/Synaptotagmin 1 Switch Controls Fast Synaptic Vesicle Exocytosis (2006)
- Push-and-pull regulation of the fusion pore by synaptotagmin-7 (2010)
Citation Impact
Citing Papers
Integrative genomic and functional analyses reveal neuronal subtype differentiation bias in human embryonic stem cell lines
2007 StandoutNobel
Alternative Zippering as an On-Off Switch for SNARE-Mediated Fusion
2009 StandoutScienceNobel
Doc2b Is a High-Affinity Ca 2+ Sensor for Spontaneous Neurotransmitter Release
2010 Science
How Synaptotagmin Promotes Membrane Fusion
2007 Science
Augmenting neurotransmitter release by enhancing the apparent Ca 2+ affinity of synaptotagmin 1
2005 StandoutNobel
In vitro system capable of differentiating fast Ca 2+ -triggered content mixing from lipid exchange for mechanistic studies of neurotransmitter release
2011 Nobel
Conformational Switch of Syntaxin-1 Controls Synaptic Vesicle Fusion
2008 StandoutScienceNobel
α-Synuclein Promotes SNARE-Complex Assembly in Vivo and in Vitro
2010 StandoutScienceNobel
A Clamping Mechanism Involved in SNARE-Dependent Exocytosis
2006 Science
Multiple intermediates in SNARE-induced membrane fusion
2006
Syntaxin N-terminal peptide motif is an initiation factor for the assembly of the SNARE–Sec1/Munc18 membrane fusion complex
2010
Direct conversion of fibroblasts to functional neurons by defined factors
2010 StandoutNatureNobel
Induction of human neuronal cells by defined transcription factors
2011 StandoutNatureNobel
Rab3-interacting Molecule γ Isoforms Lacking the Rab3-binding Domain Induce Long Lasting Currents but Block Neurotransmitter Vesicle Anchoring in Voltage-dependent P/Q-type Ca2+ Channels
2010
Structural and Mutational Analysis of Functional Differentiation between Synaptotagmins-1 and -7
2010 StandoutNobel
CSPα promotes SNARE-complex assembly by chaperoning SNAP-25 during synaptic activity
2010 StandoutNobel
RIM1 confers sustained activity and neurotransmitter vesicle anchoring to presynaptic Ca2+ channels
2007
Munc13 C2B domain is an activity-dependent Ca2+ regulator of synaptic exocytosis
2010 StandoutNobel
Understanding Synapses: Past, Present, and Future
2008 StandoutNobel
RIM Proteins Tether Ca2+ Channels to Presynaptic Active Zones via a Direct PDZ-Domain Interaction
2011 StandoutNobel
SV2B Regulates Synaptotagmin 1 by Direct Interaction
2004
Structural Determinants of Synaptobrevin 2 Function in Synaptic Vesicle Fusion
2006 StandoutNobel
Phosphatidylinositol Phosphates as Co-activators of Ca2+ Binding to C2 Domains of Synaptotagmin 1
2006 StandoutNobel
Cell biology of Ca2+-triggered exocytosis
2010 StandoutNobel
Synaptotagmin-1 functions as a Ca2+ sensor for spontaneous release
2009 StandoutNobel
Molecular determinants of presynaptic active zones
2000
Putting the clamps on membrane fusion: How complexin sets the stage for calcium‐mediated exocytosis
2007
Molecular mechanisms of COMPLEXIN fusion clamp function in synaptic exocytosis revealed in a new Drosophila mutant
2013
Distinct domains of complexin I differentially regulate neurotransmitter release
2007
Synaptotagmin-1 and Synaptotagmin-7 Trigger Synchronous and Asynchronous Phases of Neurotransmitter Release
2013 StandoutNobel
A complexin fusion clamp regulates spontaneous neurotransmitter release and synaptic growth
2007
Neurexins Physically and Functionally Interact with GABAA Receptors
2010 StandoutNobel
Differential regulation of evoked and spontaneous neurotransmitter release by C-terminal modifications of complexin
2012
Presynaptic Neurexin-3 Alternative Splicing trans-Synaptically Controls Postsynaptic AMPA Receptor Trafficking
2013 StandoutNobel
SNARE Requirements En Route to Exocytosis: from Many to Few
2012
SNARE Force Synchronizes Synaptic Vesicle Fusion and Controls the Kinetics of Quantal Synaptic Transmission
2010
Calcium Control of Neurotransmitter Release
2011
C-Terminal Complexin Sequence Is Selectively Required for Clamping and Priming But Not for Ca2+Triggering of Synaptic Exocytosis
2012 StandoutNobel
RIM1α and RIM1β Are Synthesized from Distinct Promoters of theRIM1Gene to Mediate Differential But Overlapping Synaptic Functions
2008 StandoutNobel
Presynaptic Ca2+ Channels Compete for Channel Type-Preferring Slots in Altered Neurotransmission Arising from Ca2+ Channelopathy
2004
SV2 Renders Primed Synaptic Vesicles Competent for Ca2+-Induced Exocytosis
2009 StandoutNobel
Neurotransmitter Release: The Last Millisecond in the Life of a Synaptic Vesicle
2013 StandoutNobel
Doc2 Supports Spontaneous Synaptic Transmission by a Ca2+-Independent Mechanism
2011
Synaptotagmin-2 Is Essential for Survival and Contributes to Ca 2+ Triggering of Neurotransmitter Release in Central and Neuromuscular Synapses
2006 StandoutNobel
Photonic structures in biology
2003 StandoutNature
SV2A and SV2C contain a unique synaptotagmin-binding site
2005
Complexin Has Opposite Effects on Two Modes of Synaptic Vesicle Fusion
2011
LTP Requires a Unique Postsynaptic SNARE Fusion Machinery
2013 StandoutNobel
ELKS2α/CAST Deletion Selectively Increases Neurotransmitter Release at Inhibitory Synapses
2009 StandoutNobel
Structure and function of SNARE and SNARE-interacting proteins
2005
Genetic Analysis of Mint/X11 Proteins: Essential Presynaptic Functions of a Neuronal Adaptor Protein Family
2006 StandoutNobel
The sequence of events that underlie quantal transmission at central glutamatergic synapses
2007
Genetic Analysis of Synaptotagmin C2 Domain Specificity in Regulating Spontaneous and Evoked Neurotransmitter Release
2013
Regulation of transmitter release by Ca2+ and synaptotagmin: insights from a large CNS synapse
2011
Complexin Maintains Vesicles in the Primed State in C. elegans
2011
Binding of the complexin N terminus to the SNARE complex potentiates synaptic-vesicle fusogenicity
2010
Rapid Single-Step Induction of Functional Neurons from Human Pluripotent Stem Cells
2013 StandoutNobel
Silence of Synaptotagmin VII inhibits release of dense core vesicles in PC12 cells
2009
Alteration of methamphetamine-induced striatal dopamine release in mint-1 knockout mice
2002
Synaptic vesicle fusion
2008
Complexin Controls Spontaneous and Evoked Neurotransmitter Release by Regulating the Timing and Properties of Synaptotagmin Activity
2012
Adenovirus‐mediated silencing of Synaptotagmin 9 inhibits Ca2+‐dependent insulin secretion in islets
2005
Camguk/CASK Enhances Ether-Á-Go-Go Potassium Current by a Phosphorylation-Dependent Mechanism
2005
Lipid-Anchored SNAREs Lacking Transmembrane Regions Fully Support Membrane Fusion during Neurotransmitter Release
2013 StandoutNobel
A molecular machine for neurotransmitter release: synaptotagmin and beyond
2013 StandoutNobel
Syntaxin‐1 N‐peptide and Habc‐domain perform distinct essential functions in synaptic vesicle fusion
2012 StandoutNobel
Synaptic scaffolding molecule is involved in the synaptic clustering of neuroligin
2004
Synaptic Vesicles Position Complexin to Block Spontaneous Fusion
2013
X11α and X11β Interact with Presenilin-1 via Their PDZ Domains
2000
An autism‐associated point mutation in the neuroligin cytoplasmic tail selectively impairs AMPA receptor‐mediated synaptic transmission in hippocampus
2011 StandoutNobel
Accessory α-Helix of Complexin I Can Displace VAMP2 Locally in the Complexin–SNARE Quaternary Complex
2009
Regulation of the Ca2+/CaM-Responsive Pool of CaMKII by Scaffold-Dependent Autophosphorylation
2003
Distinct Neuronal Coding Schemes in Memory Revealed by Selective Erasure of Fast Synchronous Synaptic Transmission
2012 StandoutNobel
Postsynaptic Complexin Controls AMPA Receptor Exocytosis during LTP
2012 StandoutNobel
Complexin cross-links prefusion SNAREs into a zigzag array
2011 StandoutNobel
For Better or for Worse: Complexins Regulate SNARE Function and Vesicle Fusion
2008
Synaptotagmin Increases the Dynamic Range of Synapses by Driving Ca2+-Evoked Release and by Clamping a Near-Linear Remaining Ca2+ Sensor
2011
Mechanisms of membrane fusion: disparate players and common principles
2008
Calmodulin Suppresses Synaptotagmin-2 Transcription in Cortical Neurons*
2010 StandoutNobel
Doc2 Is a Ca2+ Sensor Required for Asynchronous Neurotransmitter Release
2011
Complexin Clamps Asynchronous Release by Blocking a Secondary Ca2+ Sensor via Its Accessory α Helix
2010 StandoutNobel
Calmodulin Controls Synaptic Strength via Presynaptic Activation of Calmodulin Kinase II
2010 StandoutNobel
DrosophilaCAKI/CMG Protein, a Homolog of Human CASK, Is Essential for Regulation of Neurotransmitter Vesicle Release
2005
Regulation of Membrane Fusion in Synaptic Excitation-Secretion Coupling: Speed and Accuracy Matter
2007
Distinct Domains of Complexins Bind SNARE Complexes and Clamp Fusion in Vitro
2008 StandoutNobel
A dual-Ca2+-sensor model for neurotransmitter release in a central synapse
2007 StandoutNatureNobel
Ultrastructural localization of mint1 at synapses in mouse hippocampus
2000
The CASK/Lin-2 Drosophila Homologue, Camguk, Could Play a Role in Epithelial Patterning and in Neuronal Targeting
2001
Synaptotagmin‐7 is a principal Ca2+ sensor for Ca2+‐induced glucagon exocytosis in pancreas
2009 StandoutNobel
CASK Functions as a Mg2+-Independent Neurexin Kinase
2008 StandoutNobel
Synaptotagmin-1, -2, and -9: Ca2+ Sensors for Fast Release that Specify Distinct Presynaptic Properties in Subsets of Neurons
2007 StandoutNobel
v-SNARE Actions during Ca2+-Triggered Exocytosis
2007
Subtle Interplay between Synaptotagmin and Complexin Binding to the SNARE Complex
2013
Systematic Mutagenesis of α-Synuclein Reveals Distinct Sequence Requirements for Physiological and Pathological Activities
2012 StandoutNobel
Neuroligins and neurexins: linking cell adhesion, synapse formation and cognitive function
2005
Comparative analysis of Drosophila and mammalian complexins as fusion clamps and facilitators of neurotransmitter release
2010
Solution Structure of the RIM1α PDZ Domain in Complex with an ELKS1b C-terminal Peptide
2005 StandoutNobel
Direct interaction of SNARE complex binding protein synaphin/complexin with calcium sensor synaptotagmin 1
2008
RIM Proteins Activate Vesicle Priming by Reversing Autoinhibitory Homodimerization of Munc13
2011 StandoutNobel
Modulation of Amyloid Precursor Protein Metabolism by X11α/Mint-1
2000
Activity-Dependent Validation of Excitatory versus Inhibitory Synapses by Neuroligin-1 versus Neuroligin-2
2007 StandoutNobel
Mints as Adaptors
2000 StandoutNobel
International Union of Pharmacology. XLVII. Nomenclature and Structure-Function Relationships of Voltage-Gated Sodium Channels
2005 Standout
Tilting the Balance between Facilitatory and Inhibitory Functions of Mammalian and Drosophila Complexins Orchestrates Synaptic Vesicle Exocytosis
2009
Membrane-Proximal Tryptophans of Synaptobrevin II Stabilize Priming of Secretory Vesicles
2012
Complexin and Ca2+ stimulate SNARE-mediated membrane fusion
2008
Synaptotagmin VII Is Targeted to Dense-core Vesicles and Regulates Their Ca2+-dependent Exocytosis in PC12 Cells
2004
A Gain-of-Function Mutation in Synaptotagmin-1 Reveals a Critical Role of Ca 2+ -Dependent Soluble N -Ethylmaleimide-Sensitive Factor Attachment Protein Receptor Complex Binding in Synaptic Exocytosis
2006 StandoutNobel
A Neuroligin-4 Missense Mutation Associated with Autism Impairs Neuroligin-4 Folding and Endoplasmic Reticulum Export
2009 StandoutNobel
Complexin Activates Exocytosis of Distinct Secretory Vesicles Controlled by Different Synaptotagmins
2013 StandoutNobel
Mechanisms and Function of Dendritic Exocytosis
2011
A role of complexin–lipid interactions in membrane fusion
2009
Membrane fusion
2008 StandoutNobel
Complexin-I Is Required for High-Fidelity Transmission at the Endbulb of Held Auditory Synapse
2009
A Multiprotein Trafficking Complex Composed of SAP97, CASK, Veli, and Mint1 Is Associated with Inward Rectifier Kir2 Potassium Channels
2004
hCASK and hDlg Associate in Epithelia, and Their Src Homology 3 and Guanylate Kinase Domains Participate in Both Intramolecular and Intermolecular Interactions
2000
Reluctant Vesicles Contribute to the Total Readily Releasable Pool in Glutamatergic Hippocampal Neurons
2005
Functional Specialization of Presynaptic Cav2.3 Ca2+ Channels
2003
α-Neurexins couple Ca2+ channels to synaptic vesicle exocytosis
2003 StandoutNatureNobel
CSPα knockout causes neurodegeneration by impairing SNAP‐25 function
2011 StandoutNobel
Differential Effects of SNAP-25 Deletion on Ca2+-Dependent and Ca2+-Independent Neurotransmission
2007 StandoutNobel
Neuroligin‐1 performs neurexin‐dependent and neurexin‐independent functions in synapse validation
2009 StandoutNobel
Synaptic transmission regulated by a presynaptic MALS/Liprin-α protein complex
2006
Differential dependence of phasic transmitter release on synaptotagmin 1 at GABAergic and glutamatergic hippocampal synapses
2008
THE SYNAPTIC VESICLE CYCLE
2004 StandoutNobel
Single-Molecule Studies of the Neuronal SNARE Fusion Machinery
2009 Nobel
The carboxy-terminal domain of complexin I stimulates liposome fusion
2009
Binding of the Munc13-1 MUN Domain to Membrane-Anchored SNARE Complexes
2008
Differential but convergent functions of Ca 2+ binding to synaptotagmin-1 C 2 domains mediate neurotransmitter release
2009 StandoutNobel
Postsynaptic N -methyl- d -aspartate receptor function requires α-neurexins
2004 StandoutNobel
Synaptotagmin VII Is Targeted to Secretory Organelles in PC12 Cells, Where It Functions as a High-Affinity Calcium Sensor
2005
MEMBRANE-ASSOCIATED GUANYLATE KINASES REGULATE ADHESION AND PLASTICITY AT CELL JUNCTIONS
2005
Deletion of CASK in mice is lethal and impairs synaptic function
2007 StandoutNobel
Role of the synaptobrevin C terminus in fusion pore formation
2010
Calcium-sensing beyond neurotransmitters: functions of synaptotagmins in neuroendocrine and endocrine secretion
2009
Munc18-1 binding to the neuronal SNARE complex controls synaptic vesicle priming
2009 StandoutNobel
Aberrant function and structure of retinal ribbon synapses in the absence of complexin 3 and complexin 4
2009
Association of β-catenin with the α-subunit of neuronal large-conductance Ca 2+ -activated K+ channels
2003
E-Syts, a family of membranous Ca 2+ -sensor proteins with multiple C 2 domains
2007 StandoutNobel
RIM genes differentially contribute to organizing presynaptic release sites
2012 StandoutNobel
Distinct roles for two synaptotagmin isoforms in synchronous and asynchronous transmitter release at zebrafish neuromuscular junction
2010
Conflicting Views on the Membrane Fusion Machinery and the Fusion Pore
2009
Membrane Fusion: Grappling with SNARE and SM Proteins
2009 StandoutScienceNobel
Neurons generated by direct conversion of fibroblasts reproduce synaptic phenotype caused by autism-associated neuroligin-3 mutation
2013 StandoutNobel
Synaptotagmin Isoforms Couple Distinct Ranges of Ca2+, Ba2+, and Sr2+Concentration to SNARE-mediated Membrane Fusion
2005
Piccolo and bassoon maintain synaptic vesicle clustering without directly participating in vesicle exocytosis
2010 StandoutNobel
Complexins facilitate neurotransmitter release at excitatory and inhibitory synapses in mammalian central nervous system
2008
Multiple Mechanisms for the Potentiation of AMPA Receptor-Mediated Transmission by α-Ca2+/Calmodulin-Dependent Protein Kinase II
2002
Different Effects on Fast Exocytosis Induced by Synaptotagmin 1 and 2 Isoforms and Abundance But Not by Phosphorylation
2006 StandoutNobel
RIM1α phosphorylation at serine-413 by protein kinase A is not required for presynaptic long-term plasticity or learning
2008 StandoutNobel
Synaptotagmins I and IX function redundantly in regulated exocytosis but not endocytosis in PC12 cells
2007
A role for Mints in transmitter release: Mint 1 knockout mice exhibit impaired GABAergic synaptic transmission
2003 StandoutNobel
Deconstructing complexin function in activating and clamping Ca 2+ -triggered exocytosis by comparing knockout and knockdown phenotypes
2013 StandoutNobel
Concurrent Binding of Complexin and Synaptotagmin to Liposome-Embedded SNARE Complexes
2009
Complexin II plays a positive role in Ca 2+ -triggered exocytosis by facilitating vesicle priming
2008
CASK Participates in Alternative Tripartite Complexes in which Mint 1 Competes for Binding with Caskin 1, a Novel CASK-Binding Protein
2002 StandoutNobel
Works of Anton Maximov being referenced
Complexin Controls the Force Transfer from SNARE Complexes to Membranes in Fusion
2009 StandoutScienceNobel
C-terminal ECFP Fusion Impairs Synaptotagmin 1 Function
2004 StandoutNobel
N-Glycosylation Is Essential for Vesicular Targeting of Synaptotagmin 1
2004 StandoutNobel
Classification of PDZ domains
2001
Monitoring synaptic transmission in primary neuronal cultures using local extracellular stimulation
2006 StandoutNobel
Genetic analysis of synaptotagmin 2 in spontaneous and Ca2+‐triggered neurotransmitter release
2006 StandoutNobel
Functional Properties of a New Voltage-dependent Calcium Channel α2δ Auxiliary Subunit Gene (CACNA2D2)
2000
Activity-Dependent IGF-1 Exocytosis Is Controlled by the Ca2+-Sensor Synaptotagmin-10
2011 StandoutNobel
Association of Neuronal Calcium Channels with Modular Adaptor Proteins
1999 StandoutNobel
Autonomous Function of Synaptotagmin 1 in Triggering Synchronous Release Independent of Asynchronous Release
2005 StandoutNobel
A Complexin/Synaptotagmin 1 Switch Controls Fast Synaptic Vesicle Exocytosis
2006 StandoutNobel
Genetic analysis of synaptotagmin-7 function in synaptic vesicle exocytosis
2008 StandoutNobel
Synaptotagmin-12, a synaptic vesicle phosphoprotein that modulates spontaneous neurotransmitter release
2006 StandoutNobel
Push-and-pull regulation of the fusion pore by synaptotagmin-7
2010 StandoutNobel
Synaptotagmin-1 and -7 are functionally overlapping Ca 2+ sensors for exocytosis in adrenal chromaffin cells
2008 StandoutNobel
Unexpected Ca 2+ -binding properties of synaptotagmin 9
2004 StandoutNobel
Impaired insulin secretion and glucose intolerance in synaptotagmin-7 null mutant mice
2008 StandoutNobel
PDZ domains: More than just a glue
2001
Synaptic Targeting of N-Type Calcium Channels in Hippocampal Neurons
2002