Standout Papers
- Tuning the Transcriptional Response to Hypoxia by Inhibiting Hypoxia-inducible Factor (HIF) Prolyl and Asparaginyl Hydroxylases (2016)
- Selective Small Molecule Probes for the Hypoxia Inducible Factor (HIF) Prolyl Hydroxylases (2013)
- Betti reaction enables efficient synthesis of 8-hydroxyquinoline inhibitors of 2-oxoglutarate oxygenases (2015)
- Potent and Selective Triazole-Based Inhibitors of the Hypoxia-Inducible Factor Prolyl-Hydroxylases with Activity in the Murine Brain (2015)
- Structure‐Activity Relationship and Crystallographic Studies on 4‐Hydroxypyrimidine HIF Prolyl Hydroxylase Domain Inhibitors (2019)
Citation Impact
Citing Papers
Histone demethylase KDM6A directly senses oxygen to control chromatin and cell fate
2019 StandoutScienceNobel
Lysine Acetylation Targets Protein Complexes and Co-Regulates Major Cellular Functions
2009 StandoutScience
Class I Histone Deacetylase Expression Has Independent Prognostic Impact in Human Colorectal Cancer: Specific Role of Class I Histone Deacetylases In vitro and In vivo
2008
Lack of activity of recombinant HIF prolyl hydroxylases (PHDs) on reported non-HIF substrates
2019 StandoutNobel
Identification of the haematopoietic stem cell niche and control of the niche size
2003 StandoutNature
Computational Stabilization of a Non‐Heme Iron Enzyme Enables Efficient Evolution of New Function
2024 StandoutNobel
Expansive discovery of chemically diverse structured macrocyclic oligoamides
2024 StandoutScienceNobel
Hierarchical Mechanisms for Direct Reprogramming of Fibroblasts to Neurons
2013 StandoutNobel
Hypoxia and intra-complex genetic suppressors rescue complex I mutants by a shared mechanism
2024 StandoutNobel
HIF Hydroxylase Pathways in Cardiovascular Physiology and Medicine
2015 StandoutNobel
FGF signaling in skeletal development
1998
Striking Oxygen Sensitivity of the Peptidylglycine α-Amidating Monooxygenase (PAM) in Neuroendocrine Cells
2015 StandoutNobel
Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases
2016 StandoutNobel
De Novo Macrocyclic Peptide Inhibitors of Hepatitis B Virus Cellular Entry
2018
An Overview of Naturally Occurring Histone Deacetylase Inhibitors
2014
Calcium's Role in Mechanotransduction during Muscle Development
2014 Standout
NF-κB in breast cancer cells promotes osteolytic bone metastasis by inducing osteoclastogenesis via GM-CSF
2006
Cell Signaling by Receptor Tyrosine Kinases
2010 Standout
Inhibition of 2-oxoglutarate dependent oxygenases
2011
Design and evaluation of 1,7-naphthyridones as novel KDM5 inhibitors
2016
Forming a Multinucleated Cell: Molecules That Regulate Myoblast Fusion
2004
Cancer Metastasis: Building a Framework
2006 Standout
Bone Morphogenetic Protein-2 Promotes Osteoblast Apoptosis through a Smad-independent, Protein Kinase C-dependent Signaling Pathway
2001
TGF-β1–induced migration of bone mesenchymal stem cells couples bone resorption with formation
2009 Standout
Fluid shear stress inhibits TNF‐α‐induced apoptosis in osteoblasts: A role for fluid shear stress‐induced activation of PI3‐kinase and inhibition of caspase‐3
2002
Cancer-associated 2-oxoglutarate analogues modify histone methylation by inhibiting histone lysine demethylases
2018
MMP-7 promotes prostate cancer-induced osteolysis via the solubilization of RANKL
2005
Pre- and post-conditional inhibition of prolyl-4-hydroxylase domain enzymes protects the heart from an ischemic insult
2015
Tumor Metastasis: Molecular Insights and Evolving Paradigms
2011 Standout
Linked T Cell Receptor and Cytokine Signaling Govern the Development of the Regulatory T Cell Repertoire
2008
Isolation of rare circulating tumour cells in cancer patients by microchip technology
2007 StandoutNature
HIF prolyl hydroxylase inhibitors for the treatment of renal anaemia and beyond
2015
FGF signaling pathways in endochondral and intramembranous bone development and human genetic disease
2002 Standout
Hypoxia drives glucose transporter 3 expression through hypoxia-inducible transcription factor (HIF)–mediated induction of the long noncoding RNA NICI
2019 StandoutNobel
Hypoxia and the extracellular matrix: drivers of tumour metastasis
2014 StandoutNobel
Developmental regulation of the growth plate
2003 StandoutNature
Functional Role of G9a Histone Methyltransferase in Cancer
2015
Pharmacological targeting of the HIF hydroxylases – A new field in medicine development
2016 StandoutNobel
Anchor extension: a structure-guided approach to design cyclic peptides targeting enzyme active sites
2021 StandoutNobel
Matrix Metalloproteinases: Regulators of the Tumor Microenvironment
2010 Standout
Hypoxia Rescues Frataxin Loss by Restoring Iron Sulfur Cluster Biogenesis
2019 StandoutNobel
Paclitaxel plus Bevacizumab versus Paclitaxel Alone for Metastatic Breast Cancer
2007 Standout
Stochastic State Transitions Give Rise to Phenotypic Equilibrium in Populations of Cancer Cells
2011 Standout
Therapeutic application of histone deacetylase inhibitors for central nervous system disorders
2008
TGFβ in Cancer
2008 Standout
A Simple Enantioconvergent and Chemoenzymatic Synthesis of Optically Active α‐Substituted Amides
2011 StandoutNobel
Structural and Functional Analysis of JMJD2D Reveals Molecular Basis for Site-Specific Demethylation among JMJD2 Demethylases
2012
Ribosomal oxygenases are structurally conserved from prokaryotes to humans
2014 Nature
Tumour hypoxia causes DNA hypermethylation by reducing TET activity
2016 Nature
Amazing Diversity in Biochemical Roles of Fe(II)/2-Oxoglutarate Oxygenases
2018
A small molecule modulates Jumonji histone demethylase activity and selectively inhibits cancer growth
2013
Dynamic Combinatorial Chemistry Employing Boronic Acids/Boronate Esters Leads to Potent Oxygenase Inhibitors
2012 StandoutNobel
Tumor metastasis: mechanistic insights and clinical challenges
2006 Standout
Mechanisms of Bone Metastasis
2004 Standout
Fusobacterium nucleatum Promotes Chemoresistance to Colorectal Cancer by Modulating Autophagy
2017 Standout
Metastatic colonization by circulating tumour cells
2016 StandoutNature
Cancer-related inflammation
2008 StandoutNature
Expression of Interleukin 11 and Its Receptor and Their Prognostic Value in Human Breast Cancer
2006
EGLN1 Inhibition and Rerouting of α-Ketoglutarate Suffice for Remote Ischemic Protection
2016 StandoutNobel
Role of YAP/TAZ in mechanotransduction
2011 StandoutNature
Cell Signaling by Receptor Tyrosine Kinases
2000 Standout
Autochthonous tumors driven by Rb1 loss have an ongoing requirement for the RBP2 histone demethylase
2018 StandoutNobel
Crystal Structures of Protein-Bound Cyclic Peptides
2019
Breast cancer bone metastasis mediated by the Smad tumor suppressor pathway
2005
Phenotypic consequences of lung-specific inducible expression of FGF-3
2001 StandoutNobel
Clinical iron deficiency disturbs normal human responses to hypoxia
2016 StandoutNobel
Epigenetic Regulation by Histone Demethylases in Hypoxia
2015
Chromatin and oxygen sensing in the context of JmjC histone demethylases
2014
Screen-identified selective inhibitor of lysine demethylase 5A blocks cancer cell growth and drug resistance
2016
Nuclear entry and export of FIH are mediated by HIF1α and exportin1, respectively
2018 StandoutNobel
2-Oxoglutarate-Dependent Oxygenases
2018
Target-templated de novo design of macrocyclic d -/l -peptides: discovery of drug-like inhibitors of PD-1
2021
Hypoxia as a therapy for mitochondrial disease
2016 Science
RNA Display Methods for the Discovery of Bioactive Macrocycles
2018
Engineering Orthogonal Polypeptide GalNAc-Transferase and UDP-Sugar Pairs
2019 StandoutNobel
Synthetic Organic Electrochemical Methods Since 2000: On the Verge of a Renaissance
2017 Standout
Biology and targeting of the Jumonji-domain histone demethylase family in childhood neoplasia: a preclinical overview
2019
Epigenetic conversion of conventional T cells into regulatory T cells by CD28 signal deprivation
2020 StandoutNobel
HDACs and HDAC Inhibitors in Cancer Development and Therapy
2016
The RaPID Platform for the Discovery of Pseudo-Natural Macrocyclic Peptides
2021
Display Selection of Exotic Macrocyclic Peptides Expressed under a Radically Reprogrammed 23 Amino Acid Genetic Code
2018
Methylation of hypoxia-inducible factor (HIF)-1α by G9a/GLP inhibits HIF-1 transcriptional activity and cell migration
2018 StandoutNobel
De Novo Carborane-Containing Macrocyclic Peptides Targeting Human Epidermal Growth Factor Receptor
2019 StandoutNobel
Impaired bone development and increased mesenchymal progenitor cells in calvaria of RB1 −/− mice
2008
Chemistry and Biology Of Multicomponent Reactions
2012 Standout
Molecular Biology of Bone Metastasis
2007
New Approach to 1,4‐Benzoxazin‐3‐ones by Electrochemical C−H Amination
2017
Vorinostat-Like Molecules as Structural, Stereochemical, and Pharmacological Tools
2010
The Bump-and-Hole Tactic: Expanding the Scope of Chemical Genetics
2018
Jumonji C Demethylases in Cellular Senescence
2019
Works of Anthony Tumber being referenced
Highly selective inhibition of histone demethylases by de novo macrocyclic peptides
2017
Studies on the Interaction of the Histone Demethylase KDM5B with Tricarboxylic Acid Cycle Intermediates
2017
Tuning the Transcriptional Response to Hypoxia by Inhibiting Hypoxia-inducible Factor (HIF) Prolyl and Asparaginyl Hydroxylases
2016 StandoutNobel
Potent and Selective Triazole-Based Inhibitors of the Hypoxia-Inducible Factor Prolyl-Hydroxylases with Activity in the Murine Brain
2015 StandoutNobel
Multiple Extracellular Signals Promote Osteoblast Survival and Apoptosis1
1997
Inhibition of Histone Demethylases by 4‐Carboxy‐2,2′‐Bipyridyl Compounds
2011
Breast cancer cells induce osteoclast formation by stimulating host IL‐11 production and downregulating granulocyte/macrophage colony‐stimulating factor
2004
Human breast-cancer cells stimulate the fusion, migration and resorptive activity of osteoclasts in bone explants
2001
Inhibition of the histone demethylase JMJD2E by 3-substituted pyridine 2,4-dicarboxylates
2010
Autocrine signals promote osteoblast survival in culture
2000
Advances and challenges in understanding histone demethylase biology
2016
Development of homogeneous luminescence assays for histone demethylase catalysis and binding
2010
Linking of 2‐Oxoglutarate and Substrate Binding Sites Enables Potent and Highly Selective Inhibition of JmjC Histone Demethylases
2012
A Cell‐Permeable Ester Derivative of the JmjC Histone Demethylase Inhibitor IOX1
2014
Structure-activity studies of a macrocyclic peptide inhibitor of histone lysine demethylase 4A
2018
The histone deacetylase inhibitor PXD101 synergises with 5-fluorouracil to inhibit colon cancer cell growth in vitro and in vivo
2006
A Selective Inhibitor and Probe of the Cellular Functions of Jumonji C Domain-Containing Histone Demethylases
2011
Pan-Histone Demethylase Inhibitors Simultaneously Targeting Jumonji C and Lysine-Specific Demethylases Display High Anticancer Activities
2013
A Series of Potent CREBBP Bromodomain Ligands Reveals an Induced‐Fit Pocket Stabilized by a Cation–π Interaction
2014
Stromelysin (MMP-3) Synthesis Is Up-Regulated in Estrogen-Deficient Mouse Osteoblasts In Vivo and In Vitro
1999
Selective Small Molecule Probes for the Hypoxia Inducible Factor (HIF) Prolyl Hydroxylases
2013 StandoutNobel
The Roles of Jumonji-Type Oxygenases in Human Disease
2014
Inhibitors of both the N -methyl lysyl- and arginyl-demethylase activities of the JmjC oxygenases
2018
Determination of the class and isoform selectivity of small-molecule histone deacetylase inhibitors
2007
A Series of Potent CREBBP Bromodomain Ligands Reveals an Induced‐Fit Pocket Stabilized by a Cation–π Interaction
2014
Identification of the KDM2/7 Histone Lysine Demethylase Subfamily Inhibitor and its Antiproliferative Activity
2013