Citation Impact
Citing Papers
Targeting of HIF-α to the von Hippel-Lindau Ubiquitylation Complex by O 2 -Regulated Prolyl Hydroxylation
2001 StandoutScienceNobel
Identification of an oncoprotein- and UV-responsive protein kinase that binds and potentiates the c-Jun activation domain.
1993 Standout
Proteasome Involvement in Agonist-induced Down-regulation of μ and δ Opioid Receptors
2001
MAPKs: new JNK expands the group
1994
Models for the active site of vanadium-dependent haloperoxidases: insight into the solution structure of peroxo vanadium compounds
2000
Novel CDC2-related protein kinases produced in murine hematopoietic stem cells
1993
MAP kinase kinase from rabbit skeletal muscle A novel dual specificity enzyme showing homology to yeast protein kinases involved in pheromone‐dependent signal transduction
1992
Rotation of photoreceptor clusters in the developing drosophila eye requires the nemo gene
1994
Effects of vanadium complexes with organic ligands on glucose metabolism: a comparison study in diabetic rats
1999
Regulation of progression through the Gl phase of the cell cycle by the rum1+ gene
1994 StandoutNatureNobel
Recent progress in characterization of protein kinase cascades for phosphorylation of ribosomal protein S6
1991
Maintenance of functional equivalence during paralogous Hox gene evolution
2000 StandoutNatureNobel
Evidence for Multiple Activators for Stress-activated Protein Kinases/c-Jun Amino-terminal Kinases.
1995
A homologue of the MAP/ERK family of protein kinase genes is expressed in vegetative and in female reproductive organs of Petunia hybrida
1995
Identification of Two Essential Phosphorylated Threonine Residues In the Catalytic Domain of Mekk1
1997
The MAP kinase‐activated protein kinase 2 contains a proline‐rich SH3‐binding domain
1993
Identification of a signal for rapid export of proteins from the nucleus
1995 StandoutNobel
Nerve growth factor stimulates the tyrosine phosphorylation of MAP2 kinase in PC12 cells
1991
Components of a New Human Protein Kinase Signal Transduction Pathway
1995
Identification of insulin‐stimulated protein kinase‐1 as the rabbit equivalent of rskmo‐2
1993
Role of ERas in promoting tumour-like properties in mouse embryonic stem cells
2003 StandoutNatureNobel
Interleukin-1 activates a novel protein kinase cascade that results in the phosphorylation of hsp27
1994
Regulation of the ERK Subgroup of MAP Kinase Cascades Through G Protein-Coupled Receptors
1997
MAP kinase kinase kinase, MAP kinase kinase and MAP kinase
1994
ERK3 Is a Constitutively Nuclear Protein Kinase
1996
The mitogen-activated protein kinase activator
1992
ERKs: A family of protein-serine/threonine kinases that are activated and tyrosine phosphorylated in response to insulin and NGF
1991 Standout
ras mediates nerve growth factor receptor modulation of three signal-transducing protein kinases: MAP kinase, Raf-1, and RSK
1992
JNK1: A protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain
1994 Standout
The ubiquitin-proteasome proteolytic pathway
1994 StandoutNobel
In vivo coordination structural changes of a potent insulin-mimetic agent, bis(picolinato)oxovanadium(IV), studied by electron spin-echo envelope modulation spectroscopy
1999
Two co-existing mechanisms for nuclear import of MAP kinase: passive diffusion of a monomer and active transport of a dimer
1999
Control of MAP kinase activation by the mitogen-induced threonine/tyrosine phosphatase PAC1
1994 Nature
Syntheses, structures, stability, and insulin-like activities of peroxovanadium(V) complexes with a heteroligand
2001
Signaling Pathways Leading to Transcription and Translation Cooperatively Regulate the Transient Increase in Expression of c-Fos Protein
2001 StandoutNobel
Phosphorylation and activation of human tyrosine hydroxylase in vitro by mitogen‐activated protein (MAP) kinase and MAP‐kinase‐activated kinases 1 and 2
1993
Isolation of two members of the rat MAP kinase kinase gene family
1993
MKP-1 (3CH134), an immediate early gene product, is a dual specificity phosphatase that dephosphorylates MAP kinase in vivo
1993
Synergistic activation of SAPK1/JNK1 by two MAP kinase kinases in vitro
1998
Molecular Events Mediating T Cell Activation
1990
Pro-inflammatory Cytokines and Environmental Stress Cause p38 Mitogen-activated Protein Kinase Activation by Dual Phosphorylation on Tyrosine and Threonine
1995 Standout
A brain serine/threonine protein kinase activated by Cdc42 and Rac1
1994 Nature
How MAP Kinases Are Regulated
1995 Standout
A MAP kinase-dependent spindle assembly checkpoint in Xenopus egg extracts
1994
Protein kinase regulation: insights from crystal structure analysis
1994
The stress-activated protein kinase subfamily of c-Jun kinases
1994 StandoutNature
Cellular Stresses and Cytokines Activate Multiple Mitogen‐Activated‐Protein Kinase Kinase Homologues in PC12 and KB Cells
1996
Isolation and characterization of a tobacco cDNA clone encoding a putative MAP kinase
1993
Cloning and Characterization of a Human Protein Kinase with Homology to Ste20
1995
Purification and properties of extracellular regulated kinase 1, an insulin-stimulated microtubule-associated protein 2 kinase
1991
TPA‐induced activation of MAP kinase
1991
ERKs, extracellular signal-regulated MAP-2 kinases
1991
CaMKII regulates the frequency-response function of hippocampal synapses for the production of both LTD and LTP
1995 StandoutNobel
Activation of the Raf/MAP kinase cascade by the Ras-related protein TC21 is required for the TC21-mediated transformation of NIH 3T3 cells
1999
Sequence of pp42/MAP kinase, a serine/threonine kinase regulated by tyrosine phosphorylation
1991
MMK2, a novel alfalfa MAP kinase, specifically complements the yeast MPK1 function
1995
Phosphorylation and Functional Inactivation of TSC2 by Erk
2005 Standout
A novel kinase cascade triggered by stress and heat shock that stimulates MAPKAP kinase-2 and phosphorylation of the small heat shock proteins
1994 StandoutNobel
Evidence for communication between nerve growth factor and protein tyrosine phosphorylation
1990
Isolation of a cDNA encoding the rat MAP-kinase homolog of human p63mapk
1996
Ordered phosphorylation of p42mapk by MAP kinase kinase
1992
Dissection of the protein kinase cascade by which nerve growth factor activates MAP kinases
1991 Nature
Activation Mechanism of the MAP Kinase ERK2 by Dual Phosphorylation
1997
Mitogen-activated protein kinases: versatile transducers for cell signaling
1992
Heterogeneous expression of four MAP kinase isoforms in human tissues
1992
Kinase cascade conserved
1992
A Novel Kinase Cascade Mediated by Mitogen-activated Protein Kinase Kinase 6 and MKK3
1996
Active and Inactive Protein Kinases: Structural Basis for Regulation
1996
Purification and characterisation of the insulin‐stimulated protein kinase from rabbit skeletal muscle; close similarity to S6 kinase II
1991
Oncogenes and signal transduction
1991 Standout
Growth factor induced MEK activation is primarily mediated by an activator different from c-raf
1994
p42/p44 Mitogen-activated Protein Kinases Phosphorylate Hypoxia-inducible Factor 1α (HIF-1α) and Enhance the Transcriptional Activity of HIF-1
1999
Crystal structure of cyclin-dependent kinase 2
1993 Nature
Multiple modes of activation of the stress-responsive MAP kinase pathway in fission yeast
1997
Long-term potentiation in the hippocampus is blocked by tyrosine kinase inhibitors
1991 StandoutNatureNobel
In vitro effects on microtubule dynamics of purified Xenopus M phase-activated MAP kinase
1991 Nature
Multiple intercellular signalling systems control the development of the Caenorhabditis elegans vulva
1991 StandoutNatureNobel
A conserved kinase cascade for MAP kinase activation in yeast
1993
Developmental expression in the mouse nervous system of the p493F12 SAP kinase
1996
Molecular cloning and sequencing of a carp cDNA encoding mitogen-activated protein kinase kinase
1994
Molecular Cloning, Functional Expression in Escherichia coli, and Characterization of Multiple Mitogen‐Activated‐Protein Kinases from Tobacco
1995
Functional Proteomics Reveals the Biochemical Niche of C. elegans DCR-1 in Multiple Small-RNA-Mediated Pathways
2006 StandoutNobel
A Family of Stress-Inducible GADD45-like Proteins Mediate Activation of the Stress-Responsive MTK1/MEKK4 MAPKKK
1998
A brain-specific activator of cyclin-dependent kinase 5
1994 StandoutNatureNobel
Mitogen-Activated Protein Kinase and Cytoskeleton in Mitogenic Signal Transduction
1992
CDC5 and CKII Control Adaptation to the Yeast DNA Damage Checkpoint
1997 StandoutNobel
WRM-1 Activates the LIT-1 Protein Kinase to Transduce Anterior/Posterior Polarity Signals in C. elegans
1999 StandoutNobel
Transformation of Mammalian Cells by Constitutively Active MAP Kinase Kinase
1994 StandoutScience
Swaying is a mutant allele of the proto-oncogene Wnt-1
1991 StandoutNobel
lin-35 and lin-53, Two Genes that Antagonize a C. elegans Ras Pathway, Encode Proteins Similar to Rb and Its Binding Protein RbAp48
1998 StandoutNobel
Phosphorylation of c-jun mediated by MAP kinases
1991 StandoutNature
Atomic structure of the MAP kinase ERK2 at 2.3 Å resolution
1994 Nature
Cloning and Characterization of MEK6, a Novel Member of the Mitogen-activated Protein Kinase Kinase Cascade
1996
Increased Expression of Protein Kinase Cβ Activates ERK3
1996
MOM-4, a MAP Kinase Kinase Kinase–Related Protein, Activates WRM-1/LIT-1 Kinase to Transduce Anterior/Posterior Polarity Signals in C. elegans
1999 StandoutNobel
The interaction of SV40 small tumor antigen with protein phosphatase 2A stimulates the map kinase pathway and induces cell proliferation
1993
Mechanisms of Signal Transduction to the Cell Nucleus
1990
Signaling in the Yeast Pheromone Response Pathway: Specific and High-Affinity Interaction of the Mitogen-Activated Protein (MAP) Kinases Kss1 and Fus3 with the Upstream MAP Kinase Kinase Ste7
1996
Evidence that extracellular signal-regulated kinases are the insulin-activated Raf-1 kinase kinases.
1992
Synthesis and Characterization of a Peroxovanadium(V) Complex Containing N-Carboxymethylhistidine as a Model for the Vanadium Haloperoxidase Enzymes
1998
The Stress Kinase Mitogen-Activated Protein Kinase Kinase (Mkk)7 Is a Negative Regulator of Antigen Receptor and Growth Factor Receptor–Induced Proliferation in Hematopoietic Cells
2001 StandoutNobel
ERK phosphorylation potentiates Elk-1-mediated ternary complex formation and transactivation.
1995
Signal transduction through extracellular signal-regulated kinase-like pp57 blocked in differentiated cells having low protein kinase C beta activity.
1993
An Osmosensing Signal Transduction Pathway in Yeast
1993 Science
Ras is essential for nerve growth factor- and phorbol ester-induced tyrosine phosphorylation of MAP kinases
1992
Defective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in Tlr4 Gene
1998 StandoutScienceNobel
Extracellular signal-regulated kinases 2 autophosphorylates on a subset of peptides phosphorylated in intact cells in response to insulin and nerve growth factor: analysis by peptide mapping.
1992
(4-Hydroxypyridine-2,6-dicarboxylato)oxovanadate(V)—a new insulin-like compound: chemistry, effects on myoblast and yeast cell growth and effects on hyperglycemia in rats with STZ-induced diabetes
2003
cDNA cloning of MAP kinase kinase reveals kinase cascade pathways in yeasts to vertebrates.
1993
Regulation and properties of extracellular signal-regulated protein kinases 1 and 2 in vitro.
1993
Epidermal growth factor (EGF) receptor T669 peptide kinase from 3T3-L1 cells is an EGF-stimulated "MAP" kinase.
1991
Mutation of the mouse klotho gene leads to a syndrome resembling ageing.
1997 Standout
Erks: their fifteen minutes has arrived.
1992
Integrin-dependent activation of MAP kinase: a link to shape-dependent cell proliferation.
1995
Ras recruits Raf-1 to the plasma membrane for activation by tyrosine phosphorylation.
1995
Molecular cloning, expression, and characterization of the human mitogen-activated protein kinase p44erk1.
1993
Tyrosine phosphorylation and activation of homologous protein kinases during oocyte maturation and mitogenic activation of fibroblasts.
1991
pp54 microtubule-associated protein-2 kinase requires both tyrosine and serine/threonine phosphorylation for activity
1991
Receptor-tyrosine-kinase- and Gβγ-mediated MAP kinase activation by a common signalling pathway
1995 StandoutNatureNobel
Regulation of Receptor Fate by Ubiquitination of Activated β 2 -Adrenergic Receptor and β-Arrestin
2001 StandoutScienceNobel
Isolation and characterization of two growth factor-stimulated protein kinases that phosphorylate the epidermal growth factor receptor at threonine 669
1991
Growth factor-induced activation of a kinase activity which causes regulatory phosphorylation of p42/microtubule-associated protein kinase.
1992
Chemistry and insulin-like properties of vanadium(IV) and vanadium(V) compounds1This manuscript summarizes the presentation given at the symposium ‘Biological Aspects of Vanadium Chemistry — Chemistry, Biochemistry and Therapeutic Applications of Vanadium Compounds’ and recently communicated in original research articles. The original research articles describing the experimental details of this work are given in Refs: [1–5].1
2000
Identification of a 42-kilodalton phosphotyrosyl protein as a serine(threonine) protein kinase by renaturation.
1990
Xenopus MAP kinase activator: identification and function as a key intermediate in the phosphorylation cascade.
1992
Suppression of activated Let-60 ras protein defines a role of Caenorhabditis elegans Sur-1 MAP kinase in vulval differentiation.
1994
Activation of mitogen-activated protein kinase and its activator by ras in intact cells and in a cell-free system.
1992
MAP kinase is constitutively activated in gip2 and src transformed rat 1a fibroblasts.
1992
Primary structure, expression, and signal-dependent tyrosine phosphorylation of a Drosophila homolog of extracellular signal-regulated kinase.
1992
Constitutive mutant and putative regulatory serine phosphorylation site of mammalian MAP kinase kinase (MEK1).
1994
Immunological characterization of avian MAP kinases: evidence for nuclear localization.
1992
Intracellular Signaling by Hydrolysis of Phospholipids and Activation of Protein Kinase C
1992 StandoutScience
Histidine-Containing Bisperoxovanadium(V) Compounds: Insight Into the Solution Structure by an ESI-MS and51V-NMR Comparative Study
1999
Impaired Long-Term Potentiation, Spatial Learning, and Hippocampal Development in fyn Mutant Mice
1992 StandoutScienceNobel
MAP kinase regulation — the oncogene connection
1992
Coordination chemistry of vanadium in metallopharmaceutical candidate compounds
2001
RAS and RAF-1 form a signalling complex with MEK-1 but not MEK-2.
1994
Constitutive activation of Mek1 by mutation of serine phosphorylation sites.
1994
Tyrosine Phosphorylation and Activation of Homologous Protein Kinases during Oocyte Maturation and Mitogenic Activation of Fibroblasts
1991
Molecular structure of a protein-tyrosine/threonine kinase activating p42 mitogen-activated protein (MAP) kinase: MAP kinase kinase.
1993
FUS3 phosphorylates multiple components of the mating signal transduction cascade: evidence for STE12 and FAR1.
1993
Mitogen-activated Swiss mouse 3T3 RSK kinases I and II are related to pp44mpk from sea star oocytes and participate in the regulation of pp90rsk activity.
1991
Human T-cell mitogen-activated protein kinase kinases are related to yeast signal transduction kinases.
1992
Requirements for Phosphorylation of Map Kinase During Meiosis in Xenopus Oocytes
1992 Science
Purification and characterization of mitogen-activated protein kinase activator(s) from epidermal growth factor-stimulated A431 cells.
1992
Regulation of Tetradecanoyl Phorbol Acetate-Induced Responses in NIH 3T3 Cells by GAP, the GTPase-Activating Protein Associated with p21c-ras
1992
c-Jun N-terminal phosphorylation correlates with activation of the JNK subgroup but not the ERK subgroup of mitogen-activated protein kinases.
1994
Nerve growth factor stimulates a protein kinase in PC-12 cells that phosphorylates microtubule-associated protein-2.
1990
Phosphorylation at Thr167 is required for Schizosaccharomyces pombe p34cdc2 function.
1991 StandoutNobel
MAPKAP kinase-2; a novel protein kinase activated by mitogen-activated protein kinase.
1992
Growth Factor-Induced Activation of a Kinase Activity Which Causes Regulatory Phosphorylation of p42/Microtubule-Associated Protein Kinase
1992
Phosphorylation at threonine-235 by a ras-dependent mitogen-activated protein kinase cascade is essential for transcription factor NF-IL6.
1993
β-Arrestin 2: A Receptor-Regulated MAPK Scaffold for the Activation of JNK3
2000 StandoutScienceNobel
The c-mos proto-oncogene protein kinase turns on and maintains the activity of MAP kinase, but not MPF, in cell-free extracts of Xenopus oocytes and eggs.
1993 StandoutNobel
Bipartite Ca 2+ -Binding Motif in C 2 Domains of Synaptotagmin and Protein Kinase C
1996 StandoutScienceNobel
Raf-1 and p21v-ras cooperate in the activation of mitogen-activated protein kinase.
1993
Stimulation of Protein Tyrosine Phosphorylation by NMDA Receptor Activation
1991 Science
Xenopus MAP kinase activator is a serine/threonine/tyrosine kinase activated by threonine phosphorylation.
1992
Mitogen-activated protein kinases p42mapk and p44mapk are required for fibroblast proliferation.
1993
MAP kinase activator from insulin-stimulated skeletal muscle is a protein threonine/tyrosine kinase.
1992
Regulation of V(D)J Recombination Activator Protein RAG-2 by Phosphorylation
1993 Science
Sustained activation of the mitogen-activated protein (MAP) kinase cascade may be required for differentiation of PC12 cells. Comparison of the effects of nerve growth factor and epidermal growth factor
1992
Activation of protein serine/threonine kinases p42, p63, and p87 in Rous sarcoma virus-transformed cells: signal transduction/transformation-dependent MBP kinases.
1992
PC12 cell neuronal differentiation is associated with prolonged p21ras activity and consequent prolonged ERK activity
1992
Tumor necrosis factor alpha rapidly activates the mitogen-activated protein kinase (MAPK) cascade in a MAPK kinase kinase-dependent, c-Raf-1-independent fashion in mouse macrophages.
1995
The conserved Schizosaccharomyces pombe kinase plo1, required to form a bipolar spindle, the actin ring, and septum, can drive septum formation in G1 and G2 cells.
1995
Identification of substrate recognition determinants for human ERK1 and ERK2 protein kinases.
1991
Regulation of the activity of MEK kinase 1 (MEKK1) by autophosphorylation within the kinase activation domain
1997
Mos stimulates MAP kinase in Xenopus oocytes and activates a MAP kinase kinase in vitro.
1993
Tobacco MAP Kinase: A Possible Mediator in Wound Signal Transduction Pathways
1995 Science
Partial purification of a mitogen-activated protein kinase kinase activator from bovine brain. Identification as B-Raf or a B-Raf-associated activity.
1994
Activation of p42 MAP kinase and the release of oocytes from cell cycle arrest.
1992
Stimulation of mitogen-activated protein kinase by oncogenic Ras p21 in Xenopus oocytes. Requirement for Ras p21-GTPase-activating protein interaction.
1992
The Chemistry and Biochemistry of Vanadium and the Biological Activities Exerted by Vanadium Compounds
2004 Standout
Purification of a murine protein-tyrosine/threonine kinase that phosphorylates and activates the Erk-1 gene product: relationship to the fission yeast byr1 gene product.
1992
Requirement for integration of signals from two distinct phosphorylation pathways for activation of MAP kinase
1990 Nature
A mitogen-activated protein (MAP) kinase activating factor in mammalian mitogen-stimulated cells is homologous to Xenopus M phase MAP kinase activator.
1992
pp54 microtubule-associated protein 2 kinase. A novel serine/threonine protein kinase regulated by phosphorylation and stimulated by poly-L-lysine.
1990
Xenopus M phase MAP kinase: isolation of its cDNA and activation by MPF.
1991
Activation of Mitogen-Activated Protein Kinase Kinase by v-Raf in NIH 3T3 Cells and in Vitro
1992 StandoutScience
Phosphorylation of Xenopus cyclins B1 and B2 is not required for cell cycle transitions.
1991
Multiple components in an epidermal growth factor-stimulated protein kinase cascade
1991
Repeated pulses of serotonin required for long-term facilitation activate mitogen-activated protein kinase in sensory neurons of Aplysia
1998 StandoutNobel
Phosphorylation of Xenopus mitogen-activated protein (MAP) kinase kinase by MAP kinase kinase kinase and MAP kinase.
1993
Identification of multiple extracellular signal-regulated kinases (ERKs) with antipeptide antibodies.
1991
MsERK1: a mitogen-activated protein kinase from a flowering plant.
1993
The ksr-1 gene encodes a novel protein kinase involved in Ras-mediated signaling in C. elegans
1995 StandoutNobel
Definition of a consensus sequence for peptide substrate recognition by p44mpk, the meiosis-activated myelin basic protein kinase
1991
Identification and characterization of a new mammalian mitogen-activated protein kinase kinase, MKK2.
1993
UV-induced activation of AP-1 involves obligatory extranuclear steps including Raf-1 kinase.
1993
Tumor necrosis factor stimulates multiple serine/threonine protein kinases in Swiss 3T3 and L929 cells. Implication of casein kinase-2 and extracellular signal-regulated kinases in the tumor necrosis factor signal transduction pathway.
1992
Microtubule and chromatin behavior follow MAP kinase activity but not MPF activity during meiosis in mouse oocytes
1994
Regulation of Gene Expression in Hippocampal Neurons by Distinct Calcium Signaling Pathways
1993 Science
Defective regulation of mitogen-activated protein kinase activity in a 3T3 cell variant mitogenically nonresponsive to tetradecanoyl phorbol acetate.
1991
Design of vanadium compounds as insulin enhancing agents
2000
Mitogen-Activated Protein Kinase: Conservation of a Three-Kinase Module From Yeast to Human
1999 Standout
Signal transduction via the MAP kinases: proceed at your own RSK.
1993 Standout
Phorbol ester stimulates a protein-tyrosine/threonine kinase that phosphorylates and activates the Erk-1 gene product.
1992
A purified S6 kinase kinase from Xenopus eggs activates S6 kinase II and autophosphorylates on serine, threonine, and tyrosine residues.
1992
A phosphorylation site located in the NH2-terminal domain of c-Myc increases transactivation of gene expression.
1991
Microtubule-associated protein 2 kinases, ERK1 and ERK2, undergo autophosphorylation on both tyrosine and threonine residues: implications for their mechanism of activation.
1991
Molecular cloning and expression of a MAP kinase homologue from pea
1993
Activation of mitogen-activated protein (MAP) kinase by a MAP kinase-kinase.
1992
Mitogen activated protein (MAP) kinase transforms tau protein into an Alzheimer-like state.
1992
An Insulin-Stimulated Protein Kinase Similar to Yeast Kinases Involved in Cell Cycle Control
1990 Science
An array of insulin-activated, proline-directed serine/threonine protein kinases phosphorylate the p70 S6 kinase.
1992
Jun is phosphorylated by several protein kinases at the same sites that are modified in serum-stimulated fibroblasts.
1992
Inhibition of c-Jun DNA binding by mitogen-activated protein kinase.
1992
A role for autophosphorylation revealed by activated alleles of FUS3, the yeast MAP kinase homolog.
1994
Similarities between somatic cells overexpressing the mos oncogene and oocytes during meiotic interphase.
1994 StandoutNobel
Cloning and characterization of p97MAPK, a novel human homolog of rat ERK-3.
1994
Cell cycle arrest and c-mos
1992 StandoutNatureNobel
Mouse Erk-1 gene product is a serine/threonine protein kinase that has the potential to phosphorylate tyrosine.
1991
Raf-1 is a potential substrate for mitogen-activated protein kinase in vivo
1991
Salicylic acid activates a 48-kD MAP kinase in tobacco.
1997
Regulation of tetradecanoyl phorbol acetate-induced responses in NIH 3T3 cells by GAP, the GTPase-activating protein associated with p21c-ras.
1992
Signal transduction in Saccharomyces cerevisiae requires tyrosine and threonine phosphorylation of FUS3 and KSS1.
1992
Interleukin-1 activates p54 mitogen-activated protein (MAP) kinase/stress-activated protein kinase by a pathway that is independent of p21ras, Raf-1, and MAP kinase kinase.
1994
Thermolability of ubiquitin-activating enzyme from the mammalian cell cycle mutant ts85
1984 StandoutNobel
ERK6, a mitogen-activated protein kinase involved in C2C12 myoblast differentiation.
1996
Activation of MEK family kinases requires phosphorylation of two conserved Ser/Thr residues.
1994
Extracellular signal-regulated kinases: ERKs in progress.
1991
The coordination chemistry of vanadium as related to its biological functions
1999
Signal transduction within the nucleus by mitogen-activated protein kinase.
1992
Regulation of the Ets-Related Transcription Factor Elf-1 by Binding to the Retinoblastoma Protein
1993 StandoutScienceNobel
Identification of the sites in MAP kinase kinase-1 phosphorylated by p74raf-1.
1994
Mammalian Mitogen-Activated Protein Kinase Signal Transduction Pathways Activated by Stress and Inflammation
2001 Standout
Cell Cycle Tyrosine Phosphorylation of p34cdc2 and a Microtubule- Associated Protein Kinase Homolog in Xenopus Oocytes and Eggs
1991
Metabolism of ubiquitinated histones.
1981 StandoutNobel
A yeast mitogen-activated protein kinase homolog (Mpk1p) mediates signalling by protein kinase C.
1993
Epidermal growth factor induces phosphorylation of extracellular signal-regulated kinase 2 via multiple pathways.
1993
Complexes of Ras⋅GTP with Raf-1 and Mitogen-Activated Protein Kinase Kinase
1993 Science
Vanadium Compounds as Insulin Mimics
1999
Okadaic acid activates p42 mitogen-activated protein kinase (MAP kinase; ERK-2) in B-lymphocytes but inhibits rather than augments cellular proliferation: contrast with phorbol 12-myristate 13-acetate
1993
Cell cycle tyrosine phosphorylation of p34cdc2 and a microtubule-associated protein kinase homolog in Xenopus oocytes and eggs.
1991
Nuclear localization and regulation of erk- and rsk-encoded protein kinases.
1992
The mitogen-activated protein kinase signal transduction pathway
1993 Standout
Tpl-2 acts in concert with Ras and Raf-1 to activate mitogen-activated protein kinase.
1994
Oncogenic ras triggers the activation of 42-kDa mitogen-activated protein kinase in extracts of quiescent Xenopus oocytes.
1992
ERK1 and ERK2, two microtubule-associated protein 2 kinases, mediate the phosphorylation of tyrosine hydroxylase at serine-31 in situ.
1992
Nuclear Localization and Regulation of erk-and rsk-Encoded Protein Kinases
1992
Works of Anthony Rossomando being referenced
Autophosphorylation in vitro of recombinant 42-kilodalton mitogen-activated protein kinase on tyrosine.
1991
Identification of the regulatory phosphorylation sites in pp42/mitogen-activated protein kinase (MAP kinase).
1991
A 42-kD tyrosine kinase substrate linked to chromaffin cell secretion exhibits an associated MAP kinase activity and is highly related to a 42-kD mitogen-stimulated protein in fibroblasts.
1990
Biochemical characterization of a family of serine/threonine protein kinases regulated by tyrosine and serine/threonine phosphorylations.
1991
Mitogen-activated protein kinase kinase 1 (MKK1) is negatively regulated by threonine phosphorylation.
1994
Renaturation and partial peptide sequencing of mitogen-activated protein kinase (MAP kinase) activator from rabbit skeletal muscle
1992
Identification by mass spectrometry of threonine 97 in bovine myelin basic protein as a specific phosphorylation site for mitogen-activated protein kinase.
1990
Identification of Tyr-185 as the site of tyrosine autophosphorylation of recombinant mitogen-activated protein kinase p42mapk.
1992
Assignment of the Ly-6--Ril-1--Sis--H-30--Pol-5/Xmmv-72--Ins-3--Krt-1--Int-1--Gdc-1 region to mouse chromosome 15
1987
Evidence that pp42, a major tyrosine kinase target protein, is a mitogen-activated serine/threonine protein kinase.
1989
Mitogen-Activated Protein Kinase Kinase 1 (MKK1) Is Negatively Regulated by Threonine Phosphorylation
1994
Synthesis, Structure, and Biological Activity of a New Insulinomimetic Peroxovanadium Compound: Bisperoxovanadium Imidazole Monoanion
1997
The phorbol ester-dependent activator of the mitogen-activated protein kinase p42mapk is a kinase with specificity for the threonine and tyrosine regulatory sites.
1992
Evidence for a major cluster of lymphocyte differentiation antigens on murine chromosome 2.
1982